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Genomes and GenesSpecies | Marie LinSummaryAffiliation: Mackay Memorial Hospital Country: Taiwan Publications
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Publications
Compatibility testing without a centrifuge: the slide Polybrene methodMarie Lin
Immunohematology Reference Laboratory, Mackay Memorial Hospital, 92 Section 2, Chuong Shan North Road, Taipei, Taiwan
Transfusion 44:410-3. 2004..SP is particularly suitable for use in developing countries where, due to limited resources, centrifuges and biologic reagents may not be readily available...- The origin of Minnan and Hakka, the so-called "Taiwanese", inferred by HLA studyM Lin
Transfusion Medicine Research Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 57:192-9. 2001..These observations suggests that this haplotype is the most well-conserved ancient haplotype of the Yueh... 
Association of HLA class I with severe acute respiratory syndrome coronavirus infectionMarie Lin
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
BMC Med Genet 4:9. 2003....
Genetic variation in the vascular endothelial growth factor gene is associated with biliary atresiaHung Chang Lee
Department of Pediatrics, Mackay Memorial Hospital, Taipei Medical University, Nursing and Management College, Taipei, Taiwan
J Clin Gastroenterol 44:135-9. 2010..We aimed to study the relationship between genetic variations of the VEGF gene and susceptibility to BA using both case-control and family-based methodologies...- The -590 C/T and 8375 A/G interleukin-4 polymorphisms are not associated with Kawasaki disease in Taiwanese childrenFu Yuan Huang
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Hum Immunol 69:52-7. 2008..These results suggest that IL-4 -590 C/T and 8375 A/G SNPs do not confer a relevant role in the susceptibility or CAL development of KD in Taiwanese children... - Lack of association of the vascular endothelial growth factor gene polymorphisms with Kawasaki disease in Taiwanese childrenFu Yuan Huang
Department of Pediatrics, Mackay Memorial Hospital, 45, Min Sheng Rd, Tamshui 25115, Taipei, Taiwan
J Clin Immunol 28:322-8. 2008..This study hypothesized that specific VEGF gene polymorphisms and their haplotypes are associated with KD susceptibility and CAL development in Taiwanese children... - Genetic variability of interleukin4 gene in Taiwanese children with biliary atresiaHung Chang Lee
Department of Pediatrics, Mackay Memorial Hospital, New Taipei City, Taiwan
Cytokine 57:402-5. 2012..These results suggest that the tested polymorphisms of IL4 gene are unlikely to contribute significantly to BA susceptibility in Taiwanese children... - A novel IGnT allele responsible for the adult i phenotypeMarie Lin
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 46:1982-7. 2006..The molecular basis revealed for this adult i case agrees with the proposed molecular genetic mechanism, accounting for the partial association of the adult i phenotype with congenital cataracts... - Genetic polymorphisms in the CD40 ligand gene and Kawasaki diseaseFu Yuan Huang
Department of Pediatrics, Mackay Memorial Hospital, 45, Min Sheng Rd, Tamshui, 25115 Taipei, Taiwan
J Clin Immunol 28:405-10. 2008.... - Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in TaiwaneseShih Chia Liu
Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei, Taiwan
J Rheumatol 34:674-80. 2007..To investigate the association of predisposing and protective HLA-DRB1 alleles with rheumatoid arthritis (RA) and its clinical markers in a Taiwanese population... - Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese childrenSuei Tsau Tsai
Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan
J Pediatr Endocrinol Metab 21:665-72. 2008..The CTLA4 gene is involved in the activity of T cells... - Association of polymorphisms in the Interleukin-18 gene with susceptibility to biliary atresiaHung Chang Lee
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
J Pediatr Gastroenterol Nutr 52:607-11. 2011..In this study, we investigated whether polymorphisms of the IL18 gene were associated with susceptibility to BA... - Association of an IL-4 gene haplotype with Graves disease in children: experimental study and meta-analysisYann Jinn Lee
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Hum Immunol 72:256-61. 2011..Our study showed an association between the IL-4 gene and GD in children, but only using a haplotype-based method, suggesting that this might be a better approach than evaluating individual SNPs... - Anti-"Mi(a)" immunization is associated with HLA-DRB1*0901Chen Chung Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 49:472-8. 2009..Anti-"Mi(a)" is one of the most important irregular red blood cell antibodies found in Taiwan. The aim of this study was to investigate whether specific HLA-DRB1 alleles are associated with anti-"Mi(a)" production... - CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese womenTsung Hsien Su
Department of Gynecology and Obstetrics, Mackay Memorial Hospital, Tamshui, Taipei, Taiwan
Carcinogenesis 28:1237-40. 2007..Our results suggest that the -318 C/T variant in the promoter region of the CTLA-4 gene is associated with HPV-16-associated CSCC in Taiwanese women... - Traces of archaic mitochondrial lineages persist in Austronesian-speaking Formosan populationsJean A Trejaut
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
PLoS Biol 3:e247. 2005.... - The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataractsLung Chih Yu
Transfusion Medicine Laboratory, Mackay Memorial Hospital, and the Institute of Biochemical Sciences, College of Science, National Taiwan University, Taipei, Taiwan
Blood 101:2081-8. 2003..The results also suggest that the human blood group I gene should be reassigned to the IGnTC form, not the IGnTB form, as described previously... - Investigation of cytotoxic T-lymphocyte-associated protein 4 gene polymorphisms in symptomatic gallstone diseaseShou Chuan Shih
Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
Hum Immunol 72:355-8. 2011..No significant associations between symptomatic GSD and these 3 SNPs were observed. Our data suggest that CTLA4-318 C/T, +49 A/G, and CT60 A/G SNPs do not confer increased susceptibility to symptomatic GSD... 
Comprehensive genotyping in two homogeneous Graves' disease samples reveals major and novel HLA association allelesPei Lung Chen
Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan
PLoS ONE 6:e16635. 2011....- Genetic affinities between the Yami tribe people of Orchid Island and the Philippine Islanders of the Batanes archipelagoJun Hun Loo
Transfusion Medicine and Molecular Anthropology Research Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
BMC Genet 12:21. 2011..Then mitochondrial DNA polymorphism was also analyzed to determine the matrilineal relationships between Yami, Ivatan, and other East Asian populations... - Association of interferon-gamma gene polymorphisms in Taiwanese children with biliary atresiaHung Chang Lee
Departments of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
J Clin Immunol 30:68-73. 2010..Interferon-gamma (IFN-gamma) is a key cytokine that affects immune-mediated inflammatory responses... - A novel A allele with 664G>A mutation identified in a family with the Am phenotypeMarie Lin
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 45:63-9. 2005..CONCLUSION: A novel A allele with 664G>A mutation was demonstrated in a pedigree with the Am phenotype. The mechanism leading to the formation of the Am phenotype still awaits elucidation... - Primary autoimmune neutropenia in children in TaiwanLin Yen Wang
Pediatric Hematology Oncology, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College, Taipei, Taiwan
Transfusion 49:1003-6. 2009..This study reviewed our experience with autoimmune neutropenia in children and investigated possible associations with HLA-DR and HLA-DQ alleles... - Genetic variations of HLA-DRB1 and susceptibility to Kawasaki disease in Taiwanese childrenFu Yuan Huang
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Hum Immunol 68:69-74. 2007..If immunogenetic determinants are involved in this disease and its complications in Taiwanese children, they must involve genes other than HLA-DRB1... - HLA-DQB1*0317 is a novel allele with an unusual DR-DQ haplotypeC C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 69:370-2. 2007..HLA-DQB1*0317 may have arisen by gene conversion from the DQB1*030302 backbone, leading to one amino acid change from Leu to Gly at codon 26... - A novel HLA-DRB1 allele, DRB*090202, is identified in a Taiwanese familyC C Chu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taiwan
Tissue Antigens 74:262-3. 2009..Human leukocyte antigen-DRB1*090202 has two synonymous nucleotide substitutions with DRB1*090201 at codons 57 and 58, which may be the result of a gene conversion... - Diversity of HLA among Taiwan's indigenous tribes and the Ivatans in the PhilippinesC C Chu
Transfusion Medicine Research Laboratory and Immunohematology Reference Laboratory, Mackay Memorial Hospital, 92, Sec. 2 Chung-Shan N. Road, Taipei, Taiwan
Tissue Antigens 58:9-18. 2001.... - Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinomaJean Trejaut
Mackay Memorial Hospital, 45 Min Sheng Road, Tamsui 25115, Taiwan
Chin J Cancer 30:96-105. 2011..Outstanding findings were obtained on the routes of migration that occurred along with the spread of NPC during the settlement of insular Asia. The results of this analysis will be discussed using a conceptual approach... - Molecular genetics of the blood group I system and the regulation of I antigen expression during erythropoiesis and granulopoiesisLung Chih Yu
Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan
Curr Opin Hematol 18:421-6. 2011..The molecular genetics of the blood group I system and the regulation mechanism for I antigen expression in postnatal red blood cells are intriguing. This review summarizes their elucidation and recent findings... - Taiwan experience suggests that RhD typing for blood transfusion is unnecessary in southeast Asian populationsMarie Lin
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 46:95-8. 2006.... - HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysisYuh Cheng Yang
Department of Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
Hum Immunol 67:331-40. 2006..Larger studies may be needed, particularly in various ethnic groups, to further substantiate these associations... - Identification of a novel HLA-B allele, B*460102, in three Taiwanese individualsC C Chu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 73:374-5. 2009..We here report a new human leukocyte antigen (HLA)-B allele, B*460102, which differs from B*460101 by synonymous substitution at the third nucleotide of codon 74 (GAC-->GAT) and independently found in three Taiwanese individuals... - A novel HLA-DRB1 allele, DRB*1611, is identified in two Taiwanese individualsC C Chu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 74:175-6. 2009..Human leukocyte antigen (HLA)-DRB1*1611 has one nucleotide change at codon 14 (GAG-->AAG) from DRB1*160201, resulting in a coding change from Glu to Lys... - Molecular analysis of HLA-DRB1 allelic associations with systemic lupus erythematous and lupus nephritis in TaiwanC F Pan
Departments of Nephrology, Mackay Memorial Hospital, Taipei Departments of Mackay Medicine, Nursing and Management College, Taipei, Taiwan
Lupus 18:698-704. 2009..In Taiwanese people, the DRB1*0301 and DRB1*1501 alleles are significant risk factors for SLE, while the DRB1*1202 allele is protective for LN... - Identification of a novel human leukocyte antigen-B allele, B*4048, in TaiwanC-C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 68:180-1. 2006 - Identification of two new HLA-DRB1 alleles: HLA-DRB1*1350 and DRB1*140502Z X Chen
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 64:300-3. 2004..However, it causes no change in amino acid sequence and would therefore not have direct clinical implications... - Thomsen-Friedenreich activation in infants with necrotizing enterocolitis in TaiwanLin Yen Wang
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 51:1972-6. 2011..However, no data are available on the frequency of T activation in infants with NEC in Taiwan... - Identification of HLA-B*9521 in TaiwanC C Chu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taiwan
Tissue Antigens 74:445-6. 2009..We here report a new HLA-B allele, B*9521, which differs from B*1544 at codon 67 (TCC-->TGC)... - Identification of a new HLA-DRB1 allele, HLA-DRB1*0436C C Chu
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 63:279-81. 2004..These substitutions constitute a motif that is also seen in other DRB1*11 alleles. It is possible that the new allele resulted from a gene conversion event... - A*1126: a novel HLA-A11 variant identified by sequence-based typing methodC-C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 68:263-5. 2006 - Identification of two novel HLA-DRB1 alleles, DRB1*0903 and DRB1*1145C J Liu
Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 64:99-101. 2004..Two complete exon 2 sequences of those new alleles had been deposited in the EMBL Sequence Database under accession number AY465114 and AY465115, respectively... - Identification of two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, in two Taiwanese individualsH L Lee
Transfusion Medicine and Molecular Anthropology Research Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Int J Immunogenet 35:423-6. 2008.... - A newly identified HLA-C allele: Cw*1210, and confirmation of HLA-Cw*080102C C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 66:61-3. 2005.... - A novel HLA-A2 variant, A*9203, identified by sequence-based typingC C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Int J Immunogenet 34:13-5. 2007..Since this substitution motif is also seen in A*11 and A*03, it is likely that a gene conversion event from A*11 or A*03 to a A*0207 backbone may have been the process used in generating HLA-A*9203... - Molecular genetic analysis for the B(3) alleleLung-Chih Yu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Tamshui, Taipei, Taiwan
Blood 100:1490-2. 2002..The B(3) transcript without exon 3 predicts a B-transferase product that lacks 19 amino acids in the N-terminal segment... - A novel HLA-B allele, B*5612, identified by sequence-based typing methodC-C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taiwan
Int J Immunogenet 33:343-5. 2006..As this sequence motif was not found in the Asian population, it is likely that HLA-B*5612 is the product of a complex mechanism of implying a dual gene conversion event... - The use of genotyping to predict the phenotypes of human platelet antigens 1 through 5 and of neutrophil antigens in TaiwanC C Chu
Transfusion Medicine Research Laboratory and the Immunohematology Reference Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 41:1553-8. 2001..In Taiwan, all of the HNA-1 null found was due to the deletion of the FCGR3B gene, and this deletion may be widely distributed in the Ami tribe... - Identification of HLA-B*5410 in TaiwanC C Chu
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 73:611-2. 2009..A new human leukocyte antigen-B allele, B*5410, has been detected in Taiwan. It has one nucleotide change from B*5401 at codon 156 (CTG-->CGG), resulting in one amino acid change (L-->R)... - A novel HLA-DRB1 allele, DRB1*0832, identified by sequence-based typing methodC W Dang
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 70:527-9. 2007..Human leukocyte antigen-DRB1*0832 may have arisen by gene conversion from a DRB1*080302 backbone, leading to amino acid changes at codons 26, 28, 30, 32, 37, and 38... - Polymorphism and distribution of the Secretor alpha(1,2)-fucosyltransferase gene in various Taiwanese populationsL C Yu
Transfusion Medicine Research Laboratory, the Immunohematology Reference Laboratory, and the Blood Bank, Mackay Memorial Hospital, Taipei, Taiwan
Transfusion 41:1279-84. 2001..The distribution of various Lewis phenotypes among the Taiwanese population groups has been shown to vary considerably... - Cytokine gene polymorphisms in TaiwanJ A Trejaut
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 64:492-9. 2004..Little differences were observed between the Minnan and the Hakka. On the other hand, the Minnan and Hakka showed significant differences with the indigenous people... - Two novel HLA-DRB1 alleles identified using a sequence-based typing: HLA-DRB1*1443 and HLA-DRB1*1351*C C Chu
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Tissue Antigens 64:308-10. 2004..Both new alleles present unique polymorphisms, which have not been seen among other DRB1 alleles and which have no known effect on peptide binding... - Molecular basis of the Kell-null phenotype: a mutation at the splice site of human KEL gene abolishes the expression of Kell blood group antigensL C Yu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taipei 251, Taiwan
J Biol Chem 276:10247-52. 2001..The segment contains all of the known positions responsible for characterizing different Kell antigens, and this explains the lack of all Kell antigens in Ko red cells... - Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigenL C Yu
Transfusion Medicine Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Blood 98:3840-5. 2001.... - The molecular basis for the B(A) allele: an amino acid alteration in the human histoblood group B alpha-(1,3)-galactosyltransferase increases its intrinsic alpha-(1,3)-N-acetylgalactosaminyltransferase activityL C Yu
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
Biochem Biophys Res Commun 262:487-93. 1999..This new B(A) allele shows that not only the four critical residues but also the neighboring areas may influence the specificity of the A and B transferases... - Change in demographic picture and increase of drug resistance in pulmonarytuberculosis in a 10-year interval in TaiwanT C Y Tsao
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
Infection 30:75-80. 2002..This study was designed to compare the change in demographics, medical characteristics and drug resistance of patients with active pulmonary tuberculosis (TB) between two time periods within a 10-year interval... - Alloimmunization among patients with transfusion-dependent thalassemia in TaiwanL-Y Wang
Division of Pediatric Hematology-Oncology, Mackay Memorial Hospital, Taipei, Taiwan
Transfus Med 16:200-3. 2006..Alloimmunization to erythrocyte antigens is a frequent complication in transfusion-dependent thalassemia... - The incidence and significance of anti-"Mia" in TaiwanR E Broadberry
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
Transfusion 34:349-52. 1994..CONCLUSION: It may be important to include the Mill phenotype in the antibody screening of sera from Chinese patients... - Effects of financing smoking cessation outpatient services in TaiwanF C Chang
Bureau of Health Promotion, Department of Health, Taiwan, 2, Chang ching Street, Shin juang City, Taipei, Taiwan
Tob Control 17:183-9. 2008..This study assesses the effects of a 2005 increase in funding for smoking cessation services on provider participation, patient utilisation of smoking cessation services and cessation outcome at a six-month follow-up... - Frequencies of the JKnull (IVS5-1g>a) allele in Taiwanese, Fujian, Filipino, and Indonesian populationsMarie Lin
Transfusion 48:1768. 2008 - Climate change and postglacial human dispersals in southeast AsiaPedro Soares
Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
Mol Biol Evol 25:1209-18. 2008..This suggests that global warming and sea-level rises at the end of the Ice Age, 15,000-7,000 years ago, were the main forces shaping modern human diversity in the region... - HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinolShuen Iu Hung
Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
Proc Natl Acad Sci U S A 102:4134-9. 2005..Our results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese. In particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition... - Molecular genetic analysis for the Ae1 and A3 allelesChien-Feng Sun
Department of Clinical Pathology, Chang-Gung Memorial Hospital, Taoyuan County, Taiwan
Transfusion 43:1138-44. 2003..CONCLUSION: The results suggest an association of the Ael*IVS6+5G-->A allele with the Ael phenotype in Taiwanese people. The mechanism defining how the Ael*IVS6+5G-->A allele leads to the Ael phenotype awaits elucidation... - Haplotype frequencies of nine Y-chromosome STR loci in the Taiwanese Han populationLi-Chin Tsai
Department of Forensic Science, Central Police University, 56 Shu-Jen Road, Kwei-San, Taoyuan, 33334, Taiwan, ROC
Int J Legal Med 116:179-83. 2002..The haplotype diversity (99.99%) and discrimination capacity (88.5%) were calculated. A family study of 109 father/son pairs in 100 families showed 2 mutational events in the DYS389II locus and 1 in the DYS392 locus... - The CBLB gene and Graves' disease in childrenChia Ching Chen
Department of Pediatrics, Chiayi Christian Hospital, Chiayi, Taiwan
J Pediatr Endocrinol Metab 18:1119-26. 2005..This study demonstrates that the C/T polymorphism in exon 10 of the CBLB gene is not associated with Graves' disease in children... - Immunoglobulin allotypes among Taiwan aborigines: evidence of malarial selection could affect studies of population affinityMoses S Schanfield
Department of Human Genetics. University of Michigan, Ann Arbor, USA
Hum Biol 74:363-79. 2002....