Chun Ching Lin

Summary

Country: Taiwan

Publications

  1. ncbi request reprint Anti-hypercholesterolaemia, antioxidant activity and free radical scavenger effects of traditional Chinese medicine prescriptions used for stroke
    C C Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, Republic of China
    J Pharm Pharmacol 52:1387-93. 2000
  2. ncbi request reprint Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth
    Chun Ching Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Clin Exp Pharmacol Physiol 31:65-9. 2004
  3. ncbi request reprint Antioxidant and antiviral activities of Euphorbia thymifolia L
    Chun Ching Lin
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    J Biomed Sci 9:656-64. 2002
  4. ncbi request reprint Antioxidant activity of extracts of peh-hue-juwa-chi-cao in a cell free system
    Chun Ching Lin
    Graduate Institute of Natural Products, College of Pharmacy Kaohsiung Medical University, Kaohsiung, Taiwan, R O C
    Am J Chin Med 32:339-49. 2004
  5. ncbi request reprint Antioxidant activity of Cinnamomum cassia
    Chun Ching Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Phytother Res 17:726-30. 2003
  6. ncbi request reprint Antioxidant and free radical scavenging effects of the tannins of Terminalia catappa L
    C C Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Anticancer Res 21:237-43. 2001
  7. ncbi request reprint Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells
    Shu Jing Wu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Eur J Pharmacol 518:96-106. 2005
  8. ncbi request reprint Ellipticine induces apoptosis through p53-dependent pathway in human hepatocellular carcinoma HepG2 cells
    Yu Chun Kuo
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Life Sci 78:2550-7. 2006
  9. ncbi request reprint The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, Kaohsiung 807, Taiwan
    Life Sci 75:1231-42. 2004
  10. ncbi request reprint Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats
    Feng Lin Yen
    Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Ethnopharmacol 111:123-8. 2007

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Anti-hypercholesterolaemia, antioxidant activity and free radical scavenger effects of traditional Chinese medicine prescriptions used for stroke
    C C Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, Republic of China
    J Pharm Pharmacol 52:1387-93. 2000
    ..From these results, it seems probable that these prescriptions may be effective in the prevention and therapy of stroke and ischaemia...
  2. ncbi request reprint Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth
    Chun Ching Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Clin Exp Pharmacol Physiol 31:65-9. 2004
    ..6. The results of the present study suggest that the C. chinensis extract and its major constituents berberine and coptisine possess active antihepatoma and antileukaemia activities...
  3. ncbi request reprint Antioxidant and antiviral activities of Euphorbia thymifolia L
    Chun Ching Lin
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    J Biomed Sci 9:656-64. 2002
    ..Besides antioxidant activities, 3-O-galloyl-4,6-(S)-HHDP-D-glucose and EtOAc fraction also showed anti-HSV-2 activity. Thus, E. thymifolia was concluded to possess antioxidant and anti-HSV-2 activities...
  4. ncbi request reprint Antioxidant activity of extracts of peh-hue-juwa-chi-cao in a cell free system
    Chun Ching Lin
    Graduate Institute of Natural Products, College of Pharmacy Kaohsiung Medical University, Kaohsiung, Taiwan, R O C
    Am J Chin Med 32:339-49. 2004
    ....
  5. ncbi request reprint Antioxidant activity of Cinnamomum cassia
    Chun Ching Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Phytother Res 17:726-30. 2003
    ..16 mg/mL vs 0.27 mg/mL) and in xanthine oxidase inhibition test (IC(50) = 0.09 mg/mL vs 0.19 mg/mL). The present study concludes that EECC could be used as a good source of antioxidant in the dietary supplement...
  6. ncbi request reprint Antioxidant and free radical scavenging effects of the tannins of Terminalia catappa L
    C C Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Anticancer Res 21:237-43. 2001
    ..The results indicated that all of these components showed potent antioxidant activity. Punicalagin and punicalin were the most abundant components and had the strongest anti-oxidative effects of this group of tannins...
  7. ncbi request reprint Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells
    Shu Jing Wu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Eur J Pharmacol 518:96-106. 2005
    ..Taken together, these studies suggest that PEITC is an apoptotic inducer that acts on the mitochondria and the feedback amplification loop of caspase-8/Bid pathways in PLC/PRF/5 cells...
  8. ncbi request reprint Ellipticine induces apoptosis through p53-dependent pathway in human hepatocellular carcinoma HepG2 cells
    Yu Chun Kuo
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Life Sci 78:2550-7. 2006
    ..Taken together, ellipticine decreased the cell growth and induced apoptosis in HepG2 cell...
  9. ncbi request reprint The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, Kaohsiung 807, Taiwan
    Life Sci 75:1231-42. 2004
    ..Taken together, our study suggests that the induction of p53 and activity of the Fas/FasL apoptotic system may participate in the antiproliferative activity of Saikosaponin D in A549 cells...
  10. ncbi request reprint Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats
    Feng Lin Yen
    Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Ethnopharmacol 111:123-8. 2007
    ..In conclusion, these data suggest that the ethanolic extract of Cuscuta chinensis can prevent hepatic injuries from APAP-induced hepatotoxicity in rats and this is likely mediated through its antioxidant activities...
  11. ncbi request reprint Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury
    Chi Feng Liu
    Medical Research Institute, Taipei Medical University, Taipei, Taiwan, ROC
    Planta Med 68:510-4. 2002
    ....
  12. ncbi request reprint The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection
    Chien Min Yang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan
    J Ethnopharmacol 110:555-8. 2007
    ..No toxic effect towards the host cell was observed at the antiviral concentrations. In conclusion, geraniin and 1346TOGDG were found to inhibit HSV-1 and HSV-2 multiplication at different magnitudes of potency...
  13. ncbi request reprint Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer a549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiway
    Clin Exp Pharmacol Physiol 31:414-8. 2004
    ..4. Taken together, the results indicate that the p53 and Fas/FasL apoptotic system may participate in the antiproliferative activity of ISL in A549 cells...
  14. ncbi request reprint Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells
    Po Lin Kuo
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan
    Life Sci 72:23-34. 2002
    ....
  15. ncbi request reprint Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, 807, Taiwan, ROC
    Cancer Lett 213:213-21. 2004
    ..Saikosaponin d therefore decreased the cell proliferation and inducted apoptosis both in p53-positive Hep G2 and p53-negative Hep 3B cells...
  16. ncbi request reprint Physalis peruviana extract induces apoptosis in human Hep G2 cells through CD95/CD95L system and the mitochondrial signaling transduction pathway
    Shu Jing Wu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Cancer Lett 215:199-208. 2004
    ..Taken together, the present results suggest that EEPP-induced Hep G2 cell apoptosis was possibly mediated through the CD95/CD95L system and the mitochondrial signaling transduction pathway...
  17. ncbi request reprint Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line
    Jung San Chang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical Univeristy, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 31:716-22. 2004
    ..Gossypol had no effect on the distribution of A549 cells within the phases of the cell cycle. In conclusion, gossypol inhibited A549 cells mainly by induction of the Fas/FasL apoptotic pathway, but not the p53 and p21/WAF1 pathway...
  18. ncbi request reprint Putranjivain A from Euphorbia jolkini inhibits both virus entry and late stage replication of herpes simplex virus type 2 in vitro
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung
    J Antimicrob Chemother 53:577-83. 2004
    ..To investigate the in vitro antiviral properties of putranjivain A, isolated from the whole plant of Euphorbia jolkini Bioss (Euphorbiaceae)...
  19. ncbi request reprint Antiviral activities of extracts and selected pure constituents of Ocimum basilicum
    Lien Chai Chiang
    Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 32:811-6. 2005
    ..5. With SI values greater than 200, the potential use of ursolic acid for treating infection with CVB1 and EV71 merits further investigation...
  20. ncbi request reprint Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species
    Lien Chai Chiang
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Planta Med 69:705-9. 2003
    ..The present study concludes that saikosaponin c exhibits anti-HBV activity and saikosaponin d possesses potent cytotoxicity against human hepatocellular carcinoma cells...
  21. ncbi request reprint The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats
    Shang Shing Chaung
    Department of Pharmacy, Kaohsiung Municipal Ta Tung Hospital, Kaohsiung, Taiwan, Republic of China
    Phytother Res 17:784-91. 2003
    ..sinense. The present results conclude that L. sinense possesses a hepatoprotective efficacy, and is relatively safe in rats...
  22. ncbi request reprint Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway
    Shu Jing Wu
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan, ROC
    Life Sci 77:938-51. 2005
    ..These results conclude that Cin triggers apoptosis in PLC/PRF/5 cells could be through the activation of pro-apoptotic Bcl-2 family (Bax and Bid) proteins and MAPK signaling pathway...
  23. ncbi request reprint Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction
    Wen Huei Chang
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Planta Med 68:302-6. 2002
    ..Altogether, our data suggested that the effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction and Bcl-2 regulation...
  24. ncbi request reprint The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
    Po Lin Kuo
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Life Sci 71:1879-92. 2002
    ..These findings suggest that aloe-emodin may be useful in liver cancer prevention...
  25. ncbi request reprint Effects of vitamin E on the cinnamaldehyde-induced apoptotic mechanism in human PLC/PRF/5 cells
    Shu Jing Wu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 31:770-6. 2004
    ..Pretreatment with vitamin E markedly prevented cinnamaldehyde-mediated apoptosis, which was associated with the modulation of XIAP, cIAP-1, cIAP-2, Bcl-2 and Bax protein activity...
  26. ncbi request reprint In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica
    Lien Chai Chiang
    Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan, ROC
    Am J Chin Med 31:225-34. 2003
    ..Further investigations to elucidate the active component(s) of P. asiatica and P. major and to evaluate their clinical application are warranted...
  27. ncbi request reprint Mechanism of action of the suppression of herpes simplex virus type 2 replication by pterocarnin A
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, 807 Kaohsiung, Taiwan, ROC
    Microbes Infect 6:738-44. 2004
    ..The various modes of action of pterocarnin A in interfering with certain steps of viral infection thus merit further investigation...
  28. ncbi request reprint In vitro anti-leukemic and antiviral activities of traditionally used medicinal plants in Taiwan
    Lien Chai Chiang
    Department of Microbiology, College of Medicine, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Am J Chin Med 32:695-704. 2004
    ..It was, therefore, concluded that the HW extract of tested medicinal plants exhibited anti-leukemic and antiviral activities at different magnitudes of potency...
  29. ncbi request reprint Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos
    Sue Jing Wu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Phytother Res 18:1008-12. 2004
    ..These results also suggest that LB extract is a good source of antioxidant agent in the daily dietary supplement...
  30. ncbi request reprint Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Science, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Taiwan, ROC
    Antiviral Res 55:447-55. 2002
    ..This study concludes that casuarinin possesses anti-herpesvirus activity in inhibiting viral attachment and penetration, and also disturbing the late event(s) of infection...
  31. ncbi request reprint Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, Kaohsiung 807, Taiwan, ROC
    Cancer Lett 212:53-60. 2004
    ..Taken together, p53 and Fas/FasL apoptotic system may participate in the antiproliferative activity of acacetin in A549 cells...
  32. ncbi request reprint Xiao chai hu tang inhibits CVB1 virus infection of CCFS-1 cells through the induction of Type I interferon expression
    Pei Wen Cheng
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, Kaohsiung 807, Taiwan
    Int Immunopharmacol 6:1003-12. 2006
    ..It interfered the early stage of viral replication (prophylactic effect) and viral replication after infection (therapeutic effect) through the induction of Type I interferon expression...
  33. ncbi request reprint Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats
    Kuo Liang Lu
    Institute of Chinese Pharmaceutical Sciences, China Medical College, 91 Hsueh Shih Road, 404 Taichung, Taiwan, ROC
    Phytother Res 16:S45-50. 2002
    ..The pretreatment of animals with IL, extract (0.3-2.0 g/kg orally) significantly inhibited the acute elevation of serum transaminases, as well as the hepatotoxin-induced histopathological changes in the livers of the experimental rats...
  34. ncbi request reprint Casuarinin protects cultured MDCK cells from hydrogen peroxide-induced oxidative stress and DNA oxidative damage
    Ching Hsein Chen
    Department of Medical Technology, Fooyin University, Ta Liao, Kaohsiung Hsien, Taiwan, ROC
    Planta Med 70:1022-6. 2004
    ..The data suggest that casuarinin attenuates H2O2-induced oxidative stress, decreases DNA oxidative damage and prevents the depletion of intracellular GSH in MDCK cells...
  35. ncbi request reprint Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan, Republic of China
    J Pharmacol Exp Ther 313:333-44. 2005
    ..Together, these results imply a critical role for ERK1/2 and p38 but not JNK, p53, and Fas/Fas ligand in asiatic acid-induced S-G2/M arrest and apoptosis of human breast cancer cells...
  36. ncbi request reprint Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro
    Jung San Chang
    Graduate Institute of Medicine, College of Medicine, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Am J Chin Med 32:717-25. 2004
    ..05). In summary, our experiment implied that C. officinalis might be a candidate for chemopreventive agent against HCC through the antioxidant and anti-neoplastic effects...
  37. doi request reprint Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats
    Feng Lin Yen
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Food Chem Toxicol 46:1771-7. 2008
    ..In conclusion, we suggest that the nanoparticles system can be applied to overcome other water poorly soluble herbal medicines and furthermore to decrease the treatment dosage...
  38. ncbi request reprint Hippomanin A from acetone extract of Phyllanthus urinaria inhibited HSV-2 but not HSV-1 infection in vitro
    Chien Min Yang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan
    Phytother Res 21:1182-6. 2007
    ..Corilagin, however, inhibited neither HSV-1 nor HSV-2 replication. The similarity between corilagin and hippomanin A in structure, but difference in antiviral activity, therefore, merit further investigation...
  39. ncbi request reprint Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro
    Chien Min Yang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, No 100, Shin Chuan 1 st Road, Kaohsiung Medical University, 807 Kaohsiung, Taiwan, ROC
    Antiviral Res 67:24-30. 2005
    ..Therefore, the acetone, ethanol and methanol extracts of P. urinaria were concluded to likely inhibit HSV-2 infection through disturbing the early stage of virus infection and through diminishing the virus infectivity...
  40. ncbi request reprint Antioxidant and free radical scavenging activities of Terminalia chebula
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Science, Kaohsiung Medical University, Taiwan
    Biol Pharm Bull 26:1331-5. 2003
    ..chebula exhibited antioxidant activity at different magnitudes of potency. The antioxidant activity of each pure compound was derived from different pathways and was suggested to be specific...
  41. ncbi request reprint In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R O C
    Planta Med 69:953-6. 2003
    ..It is concluded that PB233'OG exhibits various modes of action in its anti-HSV-2 effects...
  42. ncbi request reprint Hepatoprotective effects of Chai-Hu-Ching-Kan-Tang on acetaminophen-induced acute liver injury in rats
    Tzu Hsiang Lin
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Am J Chin Med 35:69-79. 2007
    ..5 mg/kg silymarin (a commercial hepatoprotective agent). Taken together, these results suggest that aqueous extract of CHCKT possesses potent hepatoprotective effects agianst APAP-induced liver injury in rats...
  43. doi request reprint The in vitro anti-herpes simplex virus type-1 and type-2 activity of Long Dan Xie Gan Tan, a prescription of traditional Chinese medicine
    Hua Yew Cheng
    Department of Cosmetic Applications and Management, Tung Fang Institute of Technology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Chemotherapy 54:77-83. 2008
    ..The prescription is primarily used to treat the disorders induced by damp-heat in the liver and the gall bladder...
  44. ncbi request reprint Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity
    Chien Min Yang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 32:346-9. 2005
    ..3. In summary, the EtOAc extract and 3OG46HG of E. thymifolia are concluded to inhibit HSV-2 multiplication by reducing virus infectivity...
  45. ncbi request reprint The antiproliferative activity of saponin-enriched fraction from Bupleurum Kaoi is through Fas-dependent apoptotic pathway in human non-small cell lung cancer A549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Taiwan
    Biol Pharm Bull 27:1112-5. 2004
    ..Taken together, our study suggests that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of SEF in A549 cells...
  46. ncbi request reprint Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles
    Tzu Hui Wu
    Graduate Institute of Pharmaceutical Science, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Int J Pharm 346:160-8. 2008
    ..In addition, the antioxidant activity of the QUEN was more effective than pure QU on DPPH scavenging, anti-superoxide formation, superoxide anion scavenging, and anti-lipid peroxidation...
  47. ncbi request reprint Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells
    Den En Shieh
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Life Sci 74:2279-90. 2004
    ..It implies that emodin could be a useful chemotherapeutical agent for treatment of hepatocellular carcinoma (HCC)...
  48. ncbi request reprint Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice
    Chi Feng Liu
    National Taipei College of Nursing, Taipei Medical University, Taiwan, ROC
    J Biomed Sci 9:299-302. 2002
    ..The renal protective mechanism of TMP was attributed, in part, to its prominent superoxide scavenging effect, which protects the kidney from superoxide-induced renal damage...
  49. ncbi request reprint Antiviral effect of cimicifugin from Cimicifuga foetida against human respiratory syncytial virus
    Kuo Chih Wang
    Graduate Institute of Natural Products, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Taiwan
    Am J Chin Med 40:1033-45. 2012
    ..Taken together, these results indicate that cimicifugin is an efficient antiviral agent against RSV infection. We suggest that cimicifugin might be useful for the management of RSV pathogenesis...
  50. ncbi request reprint Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin
    Ching Hsein Chen
    Department of Medical Technology, Fooyin University, Ta Liao, Kaohsiung, Taiwan, ROC
    Planta Med 69:1119-24. 2003
    ..Taken together, we suggest that shikonin-induced apoptosis of SK-Hep-1 cells proceeds by an oxidative stress-mediated pathway...
  51. ncbi request reprint Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100 Shin Chuan 1st Road, Kaohsiung 807, Taiwan, ROC
    Cancer Lett 221:77-89. 2005
    ..EAC therefore decreased the cell growth and induced apoptosis both in Hep G2 and PLC/PRF/5 cells...
  52. ncbi request reprint Ethanol extract of Polygonum cuspidatum inhibits hepatitis B virus in a stable HBV-producing cell line
    Jung San Chang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan First Road, Kaohsiung 807, Taiwan
    Antiviral Res 66:29-34. 2005
    ..Further purification of the active compounds, identification and modification of their structures to improve the efficacy and decrease the cytotoxicity are required...
  53. ncbi request reprint Antiviral activity of eight commonly used medicinal plants in Taiwan
    Lien Chai Chiang
    Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Chin Med 31:897-905. 2003
    ..Three extracts inhibited only ADV infection whereas one extract blocked only HSV infection. These results suggested that the aforementioned medicinal plants merit further investigation...
  54. ncbi request reprint Antiviral properties of prodelphinidin B-2 3'-O-gallate from green tea leaf
    Hua Yew Cheng
    Graduate Institute of Pharmaceutical Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    Antivir Chem Chemother 13:223-9. 2002
    ..Thus, prodelphinidin B-2 3'-O-gallate was concluded to possess antiviral activity with mechanism of inhibiting viral attachment and penetration, and disturbing the late stage of viral infection...
  55. ncbi request reprint Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan, ROC
    Biochem Pharmacol 67:823-9. 2004
    ..Taken together, our study suggests that the induction of p53 and activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of acacetin in Hep G2 cells...
  56. ncbi request reprint Anti-Herpes simplex virus activity of Bidens pilosa and Houttuynia cordata
    Lien Chai Chiang
    Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Am J Chin Med 31:355-62. 2003
    ..Both drugs had selective indexes above 1.04. H. cordata had better effect against HSV-2 than HSV-1, and had a low ED50 against HSV-2. We suggest that H. cordata might be a useful medicinal plant against infection of HSV-2...
  57. ncbi request reprint Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, 807, Taiwan
    Life Sci 75:2303-16. 2004
    ..Taken together, our study indicated that UA might be a potential chemopreventive agent for lung cancer...
  58. ncbi request reprint Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions
    Chi Feng Liu
    National Taipei College of Nursing, Taiwan, ROC
    Am J Chin Med 30:245-54. 2002
    ..It was concluded that the gastric protective mechanism of PEE was due, at least in part, to its ability to inhibit LPO, and hence indirectly protect the gastric mucosa from oxidative stress...
  59. ncbi request reprint Anti-inflammatory and hepatoprotective activity of peh-hue-juwa-chi-cao in male rats
    Chun Ching Lin
    Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan
    Am J Chin Med 30:225-34. 2002
    ....
  60. ncbi request reprint A kampo medicine, Yin-Chiao-san, prevents bleomycin-induced pulmonary injury in rats
    Feng Lin Yen
    Graduate Institute of Pharmaceutical Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Phytother Res 21:251-8. 2007
    ..Thus, YCS exhibited a preventive effect in BLM-induced PF and it is suggested that YCS may be applied to attenuate the side effects of BLM in chemotherapy...
  61. ncbi request reprint Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities
    Feng Lin Yen
    Department of Fragrance and Cosmetics, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Agric Food Chem 58:7376-82. 2010
    ..05). Consequently, we suggest that CURN can be used to reduce the dosage of CUR and improve its bioavailability and merits further investigation for therapeutic applications...
  62. ncbi request reprint Cinnamaldehyde-Induced Apoptosis in Human Hepatoma PLC/PRF/5 Cells Involves the Mitochondrial Death Pathway and is Sensitive to Inhibition by Cyclosporin A and z-VAD-fmk
    Liang Tzung Lin
    School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No 100 Shih chuan 1st Road, Kaohsiung 807, Taiwan
    Anticancer Agents Med Chem 13:1565-74. 2013
    ..Taken together, these results suggested that CIN is an apoptotic inducer that acts on the mitochondrial death pathway in PLC/PRF/5 cells and its effect could be blocked by CsA and z-VAD-fmk. ..
  63. doi request reprint Anti-viral activity of water extract of Paeonia lactiflora pallas against human respiratory syncytial virus in human respiratory tract cell lines
    Tzeng Jih Lin
    Department of Emergency Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Am J Chin Med 41:585-99. 2013
    ..lactiflora stimulated IFN-β secretion without any effect on TNF-α secretion. Therefore, P. lactiflora could be beneficial at preventing HRSV infection by inhibiting viral attachment, internalization, and stimulating IFN secretion...
  64. ncbi request reprint Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells
    Pei Wen Zheng
    Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, ROC
    Life Sci 76:1367-79. 2005
    ..The conclusion of this study is the apigenin induced p53 expression which caused cell cycle arrest and apoptosis. These findings suggest that apigenin has strong potential for development as an agent for preventing cervical cancer...
  65. ncbi request reprint Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Planta Med 71:130-4. 2005
    ..These results demonstrated that ISL treatment inhibited the NF-kappaB cell survival-signaling pathway and induced apoptotic cell death in Hep G2 cells...
  66. ncbi request reprint In vitro anti-herpes simplex viruses and anti-adenoviruses activity of twelve traditionally used medicinal plants in Taiwan
    Lien Chai Chiang
    Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Biol Pharm Bull 26:1600-4. 2003
    ..It was concluded that the twelve traditionally used medicinal plants in Taiwan possessed antiviral activity, and some of them merit further investigation...
  67. ncbi request reprint Antioxidant activities of Physalis peruviana
    Sue Jing Wu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan
    Biol Pharm Bull 28:963-6. 2005
    ..97 microg/ml vs. 20.68 microg/ml). The present study concludes that ethanol extracts of PP possess good antioxidant activities, and the highest antioxidant properties were obtained from the 95% EtOH PP...
  68. doi request reprint Hydrolysable tannins of tropical almond show antifibrotic effects in TGF-β1-induced hepatic stellate cells
    Hsin Ying Chuang
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Taiwan
    J Sci Food Agric 91:2777-84. 2011
    ..The expression of Smad2, Smad3, Smad4, collagen I(α1)/III, and plasminogen activator inhibitor 1 (PAI-1) mRNAs was determined by reverse-transcription polymerase chain reaction and their protein levels were assessed by western blotting...
  69. ncbi request reprint Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride
    Song Chow Lin
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 9:401-9. 2002
    ..lappa treatment. The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to other unknown protective mechanism(s)...
  70. ncbi request reprint Characteristics and antioxidant activities of silymarin nanoparticles
    Wen Chan Hsu
    School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    J Nanosci Nanotechnol 12:2022-7. 2012
    ..The present study concludes that silymarin nanoparticles have an improved physicochemical property as demonstrated by an increased solubility and enhanced antioxidant activities...
  71. ncbi request reprint Cimicifuga foetida L. inhibited human respiratory syncytial virus in HEp-2 and A549 cell lines
    Kuo Chih Wang
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung, Taiwan
    Am J Chin Med 40:151-62. 2012
    ..However, C. foetida did not stimulate TNF-α secretion. Therefore, C. foetida could be useful in managing HRSV infection. This is the first evidence to support that C. foetida possesses antiviral activity...
  72. ncbi request reprint Resveratrol arrests cell cycle and induces apoptosis in human hepatocellular carcinoma Huh-7 cells
    Pei Chi Liao
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Med Food 13:1415-23. 2010
    ..These results suggest that resveratrol could be an important chemoprevention agent for hepatoma of hepatitis C virus infection...
  73. doi request reprint Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process
    Cheng Wei Tzeng
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Agric Food Chem 59:5073-80. 2011
    ..05). According to these findings, we concluded that KAEN could be a low-dose alternative to KAE in health food and future clinical research...
  74. ncbi request reprint Bupleurum kaoi inhibits Coxsackie B virus type 1 infection of CCFS-1 cells by induction of type I interferons expression
    Pei Wen Cheng
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Food Chem Toxicol 45:24-31. 2007
    ..In conclusion, BK possessed antiviral activity against CVB1 infection. It interfered the early stage of viral replication and viral replication after infection through the induction of type I interferon expression...
  75. ncbi request reprint Anti-hyperlipidemic activity of spider brake (Pteris multifida) with rats fed a high cholesterol diet
    Tzu Ching Wang
    Department of Management and Utilization, Fengshan Tropical Horticultural Experiment Branch, Agricultural Research Institute, Fengshan, Kaohsiung, Taiwan, ROC
    Pharm Biol 48:221-6. 2010
    ..6%, 10.6%, 23.7%, 9.7%, and 3.4% respectively. The results showed that LSB could cause not only a reduction in CH and TG, but also could increase the excretion of lipids and metabolic by-products via the intestinal tract...
  76. ncbi request reprint Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway
    Po Lin Kuo
    Department of Biotechnology, Cell Biology Laboratory, Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC
    Anticancer Drugs 18:555-62. 2007
    ..Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of pterocarnin A in MCF-7 cells...
  77. ncbi request reprint Sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line
    Jung San Chang
    Department of Health Care Administration, Chung Hwa University of Medical Technology, Tainan Hsien, Taiwan, ROC
    Am J Chin Med 35:341-51. 2007
    ..Therefore, the anti-HBV activity of sho-saiko-to might not be mediated by saikosaponin. Sho-saiko-to could be supplementary to nucleotide analogues to minimize the recurrence of viremia after its discontinuation...
  78. ncbi request reprint Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl(4)-induced acute liver failure
    Feng Lin Yen
    Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100, Shih Chuan 1st Road, Kaohsiung, 807, Taiwan
    Pharm Res 26:893-902. 2009
    ..A novel naringenin-loaded nanoparticles system (NARN) was developed to resolve the restricted bioavailability of naringenin (NAR) and to enhance its hepatoprotective effects in vivo on oral administration...
  79. pmc Curcumin nanoparticles ameliorate ICAM-1 expression in TNF-α-treated lung epithelial cells through p47 (phox) and MAPKs/AP-1 pathways
    Feng Lin Yen
    Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    PLoS ONE 8:e63845. 2013
    ..Our results indicate that curcumin-loaded polyvinylpyrrolidone nanoparticles may potentially serve as an anti-inflammatory drug for the treatment of respiratory diseases...
  80. doi request reprint Prenylated flavonoids from Artocarpus altilis: antioxidant activities and inhibitory effects on melanin production
    Wen Chun Lan
    Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Phytochemistry 89:78-88. 2013
    ..These results suggest that flavonoids isolated from A. altilis may be candidate antioxidants and/or skin-whitening agents. However, further investigations are required to determine their mechanisms of action...
  81. ncbi request reprint 4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line
    Kuo Chih Wang
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Phytomedicine 16:882-6. 2009
    ..0015), but not the virus-induced IFN production. Therefore, its cytoprotective activity against RSV was not mediated by interferon. In conclusion, 4-methoxycinnamaldehyde might be helpful to manage the disease induced by RSV infection...
  82. doi request reprint Sheng-Ma-Ge-Gen-Tang (Shoma-kakkon-to) inhibited cytopathic effect of human respiratory syncytial virus in cell lines of human respiratory tract
    Kuo Chih Wang
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 80708, Taiwan
    J Ethnopharmacol 135:538-44. 2011
    ..Sheng-Ma-Ge-Gen-Tang (SMGGT; Shoma-kakkon-to) has been used against pediatric viral infection for thousands of year in ancient China. However, it is unknown whether SMGGT is effective against human respiratory syncytial virus (HRSV)...
  83. pmc Renal protective effect of xiao-chai-hu-tang on diabetic nephropathy of type 1-diabetic mice
    Chun Ching Lin
    School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Evid Based Complement Alternat Med 2012:984024. 2012
    ..XCHT, therefore merits further investigation for application to improve renal functions in diabetic disorders...
  84. ncbi request reprint Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin and chi-li-saan as a bone substitute
    Chun Hsu Yao
    Department of Radiological Technology Chung Tai Institute of Health Science and Technology, Taichung, Taiwan, ROC
    Am J Chin Med 30:471-82. 2002
    ..Therefore, the GTGC composite could serve as a useful substitute when repairing bone defects...
  85. ncbi request reprint Antioxidative natural product protect against econazole-induced liver injuries
    Chi Feng Liu
    National Taipei College of Nursing, Taipei 112, Taiwan
    Toxicology 196:87-93. 2004
    ..It could be postulated that the hepatoprotective effect of PEE may be, at least in part, due to their inhibitory ability on membrane lipid peroxidation and free radical formation or due to their free radical scavenging ability...
  86. ncbi request reprint Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo
    Ya Ling Hsu
    Cell Biology Laboratory, Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Gastroenterol Hepatol 23:e290-9. 2008
    ..Our study reports here for the first time the anticancer effect of HLJDT in two human liver cancer cell lines, Hep G2 and PLC/PRF/5...
  87. ncbi request reprint Yin Chen Hao Tang, a Chinese prescription, inhibits both herpes simplex virus type-1 and type-2 infections in vitro
    Hua Yew Cheng
    Department of Cosmetic Applications and Management, Tung Fang Institute of Technology, 829 Kaohsiung County, Taiwan
    Antiviral Res 77:14-9. 2008
    ..In summary, the water extract of YCHT was concluded to inhibit infections by HSV-1 and HSV-2 and this effect was likely mediated through direct inactivation of the virus infectivity...
  88. ncbi request reprint The evaluation of reno- and hepatoprotective effects of huai-shan-yao (Rhizome Dioscoreae)
    Shih Chang Lee
    Department of Food Science, National Chung Hsing University, Taichung, Taiwan, ROC
    Am J Chin Med 30:609-16. 2002
    ....
  89. ncbi request reprint Prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra inhibits proliferation of A549 carcinoma cells via blocking cell cycle progression and inducing apoptosis
    Po Lin Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Eur J Pharmacol 501:41-8. 2004
    ..Our study reports here for the first time that the induction of p21/WAF1 and activity of the Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of PB233'OG in A549 cells...
  90. ncbi request reprint In vitro anti-hepatoma activity of fifteen natural medicines from Canada
    Liang Tzung Lin
    Department of Microbiology and Immunology, McGill University, Canada
    Phytother Res 16:440-4. 2002
    ..C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies...
  91. ncbi request reprint Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells
    Po Lin Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Planta Med 71:237-43. 2005
    ..Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of casuarinin in MCF-7 cells...
  92. ncbi request reprint Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells
    Lien Chai Chiang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Cancer Lett 237:207-14. 2006
    ..The present study concludes that the anti-hepatoma activity of apigenin is as effective as 5-FU and its apoptotic mechanism might be mediated through the p53-dependent pathway and the induction of p21 expression...
  93. ncbi request reprint Putranjivain A from Euphorbia jolkini inhibits proliferation of human breast adenocarcinoma MCF-7 cells via blocking cell cycle progression and inducing apoptosis
    Po Lin Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Toxicol Appl Pharmacol 213:37-45. 2006
    ..Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of putranjivain A in MCF-7 cells...
  94. ncbi request reprint Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells
    Ai Yu Shen
    Basic Medical Science Education Center, Fooyin University Ta Liao, Kaohsiung County, Taiwan
    Am J Chin Med 33:747-58. 2005
    ....
  95. ncbi request reprint Protective effect of propolis ethanol extract on ethanol-induced renal toxicity: an in-vivo study
    Chi Feng Liu
    National Taipei College of Nursing, Taipei, 112, Taiwan
    Am J Chin Med 33:779-86. 2005
    ..It was concluded that the renal protective mechanism of PEE could be contributed, at least in part, to its prominent superoxide scavenging effect; hence, it could protect, indirectly, the kidney from superoxide-induced renal damages...
  96. ncbi request reprint ent-Epiafzelechin-(4alpha-->8)-epiafzelechin extracted from Cassia javanica inhibits herpes simplex virus type 2 replication
    Hua Yew Cheng
    Department of Cosmetic Applications and Management, Tung Fang Institute of Technology, 829 Kaohsiung County, Taiwan
    J Med Microbiol 55:201-6. 2006
    ..It also disturbed virus attachment but the inhibitory effect was minor. In summary, the conclusion of this study was that EEE exhibits various modes of action in suppressing HSV-2 multiplication...
  97. ncbi request reprint Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines
    Lean Teik Ng
    Department of Biotechnology, Tajen University, Pingtung, Taiwan
    Am J Chin Med 34:125-35. 2006
    ..The effect of TET on cell cycle progression was found to vary with the type of hepatoma cells, suggesting the genetic make-up of the cells play an important role in the response to drug treatment...
  98. ncbi request reprint Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells
    Po Lin Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Food Chem Toxicol 44:1316-26. 2006
    ....
  99. ncbi request reprint Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn
    Po Lin Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Anticancer Drugs 16:409-15. 2005
    ..Our study reports here for the first time that the induction of p53 and the activity of the Fas/FasL apoptotic system may participate in the antiproliferative activity of casuarinin in A549 cells...
  100. ncbi request reprint San-Zhong-Kui-Jian-Tang, a traditional Chinese medicine prescription, inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis
    Ya Ling Hsu
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Biol Pharm Bull 29:2388-94. 2006
    ..Taken together, our study suggests that the induction of p21/WAF1 and activity of the mitochondrial apoptotic system may participate in the antiproliferative activity of SZKJY in human breast cancer cells...
  101. ncbi request reprint Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway
    Ya Ling Hsu
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Food Chem Toxicol 45:1249-57. 2007
    ..Our results indicate that EAC inhibits the activation of NF-kappaB, and may provide a molecular basis for drug development using EAC as an anti-invasive agent in the prevention and treatment of cancer...