Cheng Wen Lin

Summary

Country: Taiwan

Publications

  1. ncbi request reprint Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91 Hsueh Shih Road, Taichung 404, Taiwan, ROC
    Antiviral Res 68:36-42. 2005
  2. ncbi request reprint Binding interaction of SARS coronavirus 3CL(pro) protease with vacuolar-H+ ATPase G1 subunit
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91, Hsueh Shih Road, Taichung 404, Taiwan
    FEBS Lett 579:6089-94. 2005
  3. ncbi request reprint Characterization of trans- and cis-cleavage activity of the SARS coronavirus 3CLpro protease: basis for the in vitro screening of anti-SARS drugs
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91, Hsueh Shih Road, Taichung 404, Taiwan, ROC
    FEBS Lett 574:131-7. 2004
  4. doi request reprint Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis
    Shih Yin Chen
    Genetic Center, Department of Medical Research, China Medical University Hospital, Graduate Institute of Chinese Medical Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan
    Rheumatol Int 32:1165-9. 2012
  5. ncbi request reprint Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, Taiwan, ROC
    Virus Res 116:106-13. 2006
  6. doi request reprint Correlation between TGF-β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease
    Shih Wen Li
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan
    Proteomics 12:3193-205. 2012
  7. doi request reprint Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages
    Yu Jen Jou
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Clin Chim Acta 412:1357-65. 2011
  8. doi request reprint Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC
    Eur J Med Chem 62:206-13. 2013
  9. doi request reprint Severe acute respiratory syndrome coronavirus papain-like protease suppressed alpha interferon-induced responses through downregulation of extracellular signal-regulated kinase 1-mediated signalling pathways
    Shih Wein Li
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, ROC
    J Gen Virol 92:1127-40. 2011
  10. doi request reprint Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Virus Res 137:49-55. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91 Hsueh Shih Road, Taichung 404, Taiwan, ROC
    Antiviral Res 68:36-42. 2005
    ..Only two phenolic compounds aloe emodin and hesperetin dose-dependently inhibited cleavage activity of the 3CLpro, in which the IC50 was 366 microM for aloe emodin and 8.3 microM for hesperetin in the cell-based assay...
  2. ncbi request reprint Binding interaction of SARS coronavirus 3CL(pro) protease with vacuolar-H+ ATPase G1 subunit
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91, Hsueh Shih Road, Taichung 404, Taiwan
    FEBS Lett 579:6089-94. 2005
    ..Moreover, loading cells with SNARF-1 pH-sensitive dye showed that the intracellular pH in 3CL(pro)-expressing cells was significantly lower as compared to mock cells...
  3. ncbi request reprint Characterization of trans- and cis-cleavage activity of the SARS coronavirus 3CLpro protease: basis for the in vitro screening of anti-SARS drugs
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91, Hsueh Shih Road, Taichung 404, Taiwan, ROC
    FEBS Lett 574:131-7. 2004
    ..The results will be useful for the rational development of the anti-SARS drugs...
  4. doi request reprint Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis
    Shih Yin Chen
    Genetic Center, Department of Medical Research, China Medical University Hospital, Graduate Institute of Chinese Medical Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan
    Rheumatol Int 32:1165-9. 2012
    ..The study suggested that OGG1 polymorphisms (rs159153 and rs3219008) are associated with RA progression and that these may be used as molecular markers of RA...
  5. ncbi request reprint Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, Taiwan, ROC
    Virus Res 116:106-13. 2006
    ..Our results provide an insight into the protein interaction network of the JEV NS2B-NS3 protease in human brain...
  6. doi request reprint Correlation between TGF-β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease
    Shih Wen Li
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan
    Proteomics 12:3193-205. 2012
    ..Results point to SARS-CoV PLpro triggering TGF-β1 production via ubiquitin proteasome, p38 MAPK, and ERK1/2-mediated signaling...
  7. doi request reprint Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages
    Yu Jen Jou
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Clin Chim Acta 412:1357-65. 2011
    ..Oral squamous cell carcinoma (OSCC) is one of the most frequent malignancies worldwide. Early diagnosis can mean adequate treatment and increase survival...
  8. doi request reprint Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC
    Eur J Med Chem 62:206-13. 2013
    ..Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F. gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections...
  9. doi request reprint Severe acute respiratory syndrome coronavirus papain-like protease suppressed alpha interferon-induced responses through downregulation of extracellular signal-regulated kinase 1-mediated signalling pathways
    Shih Wein Li
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, ROC
    J Gen Virol 92:1127-40. 2011
    ..Overall results proved downregulation of ERK1 by ubiquitin proteasomes and suppression of interaction between ERK1 and STAT1 as type I IFN antagonist function of SARS-CoV PLpro...
  10. doi request reprint Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Virus Res 137:49-55. 2008
    ..Therefore, these results show that JEV NS4A without the C-terminal 2K domain is associated with modulation of the IFN response and the interaction of JEV NS4A with RNA helicase DDX42 could be important for JE pathogenesis...
  11. doi request reprint Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer
    Yu Jen Jou
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Anal Chim Acta 681:41-8. 2010
    ..We have identified salivary transferrin as a biomarker for the detection of early stage oral cancer. This finding provides a promising basis for the development of a non-invasive diagnostic test for early stage oral cancer...
  12. ncbi request reprint Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, ROC
    Virus Res 127:88-94. 2007
    ..Our results might be useful for development of inhibitors that block the interaction between NS2B and NS3...
  13. ncbi request reprint Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells
    Tsuey Ching Yang
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Microbes Infect 12:643-51. 2010
    ..These results are suggestive of an oxidative stress-pathway as a key element of JE pathogenesis...
  14. pmc Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 8:e67572. 2013
    ..This SNP had a significant protective influence on AIDS progression, and polymorphisms of the ZNRD1 gene may play a role in the pathogenesis of HIV-1 infection. ..
  15. doi request reprint Molecular epidemiology of the 2005 enterovirus 71 outbreak in central Taiwan
    Yu Ching Lan
    Department of Health Risk Management, China Medical University, Taichung City, Taiwan
    Scand J Infect Dis 43:354-9. 2011
    ..Here we present the clinical, genotypic, and epidemiological baseline data for the 2005 Taichung outbreak...
  16. ncbi request reprint Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91, Hsueh Shih Road, Taichung 404, Taiwan
    J Virol Methods 143:65-72. 2007
    ..This study provides insights into the mechanism of the kaposin A protein pathology, in which the interactions of kaposin A protein with cellular proteins might allow alteration of fundamental cellular processes...
  17. ncbi request reprint Phenotypic and genotypic characterization of the neurovirulence and neuroinvasiveness of a large-plaque attenuated Japanese encephalitis virus isolate
    Suh Chin Wu
    Department of Life Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC
    Microbes Infect 5:475-80. 2003
    ..Elucidating the molecular basis of virulence of flaviviruses can provide valuable information for live-attenuated vaccine development...
  18. doi request reprint Inhibition of hedgehog signaling induces monocytic differentiation of HL-60 cells
    Li Yuan Bai
    College of Medicine, China Medical University, Taichung, Taiwan
    Leuk Lymphoma 53:1196-202. 2012
    ..Further investigations should determine the clinical application of modulating the Shh pathway in the treatment of hematological malignancies...
  19. doi request reprint Epidemiology of pandemic influenza A/H1N1 virus during 2009-2010 in Taiwan
    Yu Ching Lan
    Department of Health Risk Management, School of Public, China Medical University, Taichung, Taiwan
    Virus Res 177:46-54. 2013
    ..Phylogenetic evidence indicated transmission clusters and multiple independent clades of co-circulating influenza A and B strains in Taiwan...
  20. pmc Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan School of Chinese Medicine, China Medical University, Taichung, Taiwan
    PLoS ONE 8:e81384. 2013
    ..25; 95% CI = 0.14-0.46). Our results suggest that a polymorphism of the GRIN3A gene may play a role in KD pathogenesis. ..
  21. doi request reprint The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, No 2 Yuh Der Road, Taichung 404, Taiwan
    J Clin Immunol 30:643-8. 2010
    ..The studies in DNA repair deficiencies in SLE patients have been recently investigated...
  22. ncbi request reprint Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    FEMS Immunol Med Microbiol 46:375-80. 2006
    ..This finding is likely to be responsible for virus-induced apoptotic signalling...
  23. doi request reprint Repeated colonization by multi-drug-resistant Acinetobacter calcoaceticus-A. baumannii complex and changes in antimicrobial susceptibilities in surgical intensive care units
    Cheng Mao Ho
    Graduate Institute of Clinical Medical Science, School of Medicine, China Medical University, Taichung, Taiwan
    Surg Infect (Larchmt) 14:43-8. 2013
    ..A nosocomial outbreak of multi-drug-resistant Acinetobacter calcoaceticus-A. baumannii (MDR-ACB) complex infection occurred in a newly constructed building at a 2,500-bed tertiary medical center in Taiwan...
  24. ncbi request reprint Identification of mimotopes of the Japanese encephalitis virus envelope protein using phage-displayed combinatorial peptide library
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan
    J Mol Microbiol Biotechnol 8:34-42. 2004
    ..The results of our study could provide useful information on the development of effective mimotope-based vaccines and diagnostic kits for the JEV infection...
  25. ncbi request reprint Inactivation of mrcA gene derepresses the basal-level expression of L1 and L2 β-lactamases in Stenotrophomonas maltophilia
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan
    J Antimicrob Chemother 66:2033-7. 2011
    ....
  26. pmc SmeOP-TolCSm efflux pump contributes to the multidrug resistance of Stenotrophomonas maltophilia
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Antimicrob Agents Chemother 58:2405-8. 2014
    ....
  27. ncbi request reprint Studies on Cytotoxic Constituents from the Leaves of Elaeagnus oldhamii Maxim. in Non-Small Cell Lung Cancer A549 Cells
    Chi Ren Liao
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
    Molecules 19:9515-34. 2014
    ..87 ± 1.94 μg/mL, at 48 h of MTT asssay). The result suggested that the five compounds might be responsible for its clinical anti-lung cancer effect. ..
  28. doi request reprint Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma
    Chih Ho Lai
    Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan
    Clin Chim Acta 411:984-91. 2010
    ..Identification of tumor biomarkers to assist early diagnosis and monitoring of disease progression may potentially decrease the mortality and morbidity associated with oral cancer...
  29. pmc Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16
    Ching Ying Wang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
    Evid Based Complement Alternat Med 2012:503165. 2012
    ..88 μg/mL) and CVA16 (IC(50) = 42.91 μg/mL). Moreover, K. gracilis leaf extract is a safe antienteroviral agent with the inactivation of viral 2A protease and reduction of IL-6 and RANTES expressions...
  30. doi request reprint Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan
    Chao Hsien Chen
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    FEMS Immunol Med Microbiol 61:356-8. 2011
    ..The study examines the prevalence of HHV-8 DNA in PBMCs in Taiwanese leukemia and can be applied in further epidemiological studies...
  31. ncbi request reprint Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, ROC
    Biotechnol Lett 30:205-14. 2008
    ....
  32. doi request reprint Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Int J Antimicrob Agents 32:355-9. 2008
    ..Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses...
  33. doi request reprint OSU-03012 sensitizes TIB-196 myeloma cells to imatinib mesylate via AMP-activated protein kinase and STAT3 pathways
    Li Yuan Bai
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan
    Leuk Res 34:816-20. 2010
    ..Combined treatments targeting c-Kit, AMPK and STAT3 may be a potential strategy for treating patients with myeloma...
  34. doi request reprint Aortoesophageal fistula with a history of graft treatment for thoracic aortic aneurysm
    Chen Sheng Lin
    Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Chin Med Assoc 71:100-2. 2008
    ..CTA is a useful diagnostic tool in patients suspected of having AEF. Rapid identification of AEF is important for definitive treatment and increases the likelihood of survival...
  35. doi request reprint Comparative prevalence of plasma human herpesvirus 8 DNA in sexual contact and intravenous injection routes of HIV transmission
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University Hospital, Taichung, Taiwan
    FEMS Immunol Med Microbiol 52:428-30. 2008
    ..The study suggested that detection of plasma HHV-8 DNA could be important for monitoring replicating HHV-8 in HIV-infected patients, and may have use as a marker for the diagnosis of HHV-8 infection in blood-borne transmission...
  36. doi request reprint Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and -negative patients
    Tsuey Ching Yang
    Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91, Hsueh Shih Road, Taichung, 404, Taiwan
    Biotechnol Lett 31:629-37. 2009
    ..This study assessed the sensitivity and specificity of ORF66 and ORFK12 for the detection of HHV-8 antibodies, providing novel antigens for the diagnosis of HHV-8 infection and epidemiology of HHV-8 seroprevalence...
  37. ncbi request reprint Novel cell adhesive glycosaminoglycan-binding proteins of Japanese encephalitis virus
    Suh Chin Wu
    Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan, Republic of China
    Biomacromolecules 5:2160-4. 2004
    ..The present studies demonstrate the recombinant GAG-binding proteins of JEV stimulate cell adhesive and proliferation with a potential for applications in tissue engineering...
  38. ncbi request reprint Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C-like protease
    Chien Chen Lai
    Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan
    Proteomics 7:1446-60. 2007
    ..The study provides system-level insights into the interaction of SARS CoV 3CLpro with host cells, which will be helpful in elucidating the molecular basis of SARS CoV pathogenesis...