Tsung Ming Lee

Summary

Country: Taiwan

Publications

  1. ncbi request reprint Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty
    Tsung Ming Lee
    National Taiwan University College of Medicine, Department of Internal Medicine, Cardiology Section, National Taiwan University Hospital, Taipei, Taiwan
    Circulation 105:334-40. 2002
  2. ncbi request reprint Increased dispersion of ventricular repolarization during head-up tilt test late after orthotopic heart transplantation in humans
    Tsung Ming Lee
    College of Medicine, National Taiwan University, Department of Internal Medicine, National Taiwan University Hospital, Taipei
    Pacing Clin Electrophysiol 25:768-75. 2002
  3. ncbi request reprint Additive effects of combined blockade of AT1 receptor and HMG-CoA reductase on left ventricular remodeling in infarcted rats
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and National Taiwan University Hospital, 252 Wu Hsing St, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 291:H1281-9. 2006
  4. ncbi request reprint Association of gliclazide and left ventricular mass in type 2 diabetic patients
    Nan Hung Pan
    Cardiology Section, Department of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan
    Diabetes Res Clin Pract 74:121-8. 2006
  5. doi request reprint Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Tainan Municipal An Nan Hospital China Medical University, Tainan, Taiwan
    J Mol Med (Berl) 92:43-51. 2014
  6. doi request reprint K ATP channel agonists preserve connexin43 protein in infarcted rats by a protein kinase C-dependent pathway
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    J Cell Mol Med 16:776-88. 2012
  7. ncbi request reprint Effects of pravastatin on cardiomyocyte hypertrophy and ventricular vulnerability in normolipidemic rats after myocardial infarction
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Chi Mei Medical Center, 901, Chung Hwa Road, Yang Kan City, Tainan, 710, Taiwan, ROC
    J Mol Cell Cardiol 35:1449-59. 2003
  8. ncbi request reprint Adjunctive 17beta-estradiol administration reduces infarct size by altered expression of canine myocardial connexin43 protein
    Tsung Ming Lee
    Departments of Internal Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Cardiovasc Res 63:109-17. 2004
  9. ncbi request reprint Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins
    Tsung Ming Lee
    Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 285:H1650-9. 2003
  10. ncbi request reprint Impairment of myocardial protection in type 2 diabetic patients
    Tsung Ming Lee
    National Taiwan University College of Medicine, Department of Internal Medicine, Cardiology Section, National Taiwan University Hospital, Taipei, Taiwan 10002
    J Clin Endocrinol Metab 88:531-7. 2003

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty
    Tsung Ming Lee
    National Taiwan University College of Medicine, Department of Internal Medicine, Cardiology Section, National Taiwan University Hospital, Taipei, Taiwan
    Circulation 105:334-40. 2002
    ....
  2. ncbi request reprint Increased dispersion of ventricular repolarization during head-up tilt test late after orthotopic heart transplantation in humans
    Tsung Ming Lee
    College of Medicine, National Taiwan University, Department of Internal Medicine, National Taiwan University Hospital, Taipei
    Pacing Clin Electrophysiol 25:768-75. 2002
    ..However, whether increased dispersion of ventricular repolarization is related to cardiac death late after operation warrants further investigation in a large and long-term trial...
  3. ncbi request reprint Additive effects of combined blockade of AT1 receptor and HMG-CoA reductase on left ventricular remodeling in infarcted rats
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and National Taiwan University Hospital, 252 Wu Hsing St, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 291:H1281-9. 2006
    ..Pravastatin administration provided favorable ventricular remodeling, probably through decreased tissue endothelin-1 level. In contrast, olmesartan-related attenuated cardiomyocyte hypertrophy is independent of endothelin-1 pathway...
  4. ncbi request reprint Association of gliclazide and left ventricular mass in type 2 diabetic patients
    Nan Hung Pan
    Cardiology Section, Department of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan
    Diabetes Res Clin Pract 74:121-8. 2006
    ..55). Our findings demonstrated for the first time that in addition to its primary hypoglycemia, gliclazide may have an additional effect on reducing left ventricular mass, possibly through attenuation of free radical formation...
  5. doi request reprint Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Tainan Municipal An Nan Hospital China Medical University, Tainan, Taiwan
    J Mol Med (Berl) 92:43-51. 2014
    ..These results indicate that chronic use of estradiol after infarction attenuates cardiac fibrosis by inhibiting RhoA/ROCK/cofilin pathway, which is exerted through membrane ERα-mediated receptor mechanism...
  6. doi request reprint K ATP channel agonists preserve connexin43 protein in infarcted rats by a protein kinase C-dependent pathway
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    J Cell Mol Med 16:776-88. 2012
    ..Chronic use of K(ATP) channel agonists after infarction, resulting in enhanced connexin43 level through a PKC(ε)-dependent pathway, may attenuate the arrhythmogenic response to programmed electrical stimulation...
  7. ncbi request reprint Effects of pravastatin on cardiomyocyte hypertrophy and ventricular vulnerability in normolipidemic rats after myocardial infarction
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Chi Mei Medical Center, 901, Chung Hwa Road, Yang Kan City, Tainan, 710, Taiwan, ROC
    J Mol Cell Cardiol 35:1449-59. 2003
    ....
  8. ncbi request reprint Adjunctive 17beta-estradiol administration reduces infarct size by altered expression of canine myocardial connexin43 protein
    Tsung Ming Lee
    Departments of Internal Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Cardiovasc Res 63:109-17. 2004
    ....
  9. ncbi request reprint Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins
    Tsung Ming Lee
    Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 285:H1650-9. 2003
    ..73, P < 0.0001). This result demonstrated that the cardioprotective effect of troglitazone as an antioxidant may be associated with reduced phosphorylation of myocardial connexin43 protein...
  10. ncbi request reprint Impairment of myocardial protection in type 2 diabetic patients
    Tsung Ming Lee
    National Taiwan University College of Medicine, Department of Internal Medicine, Cardiology Section, National Taiwan University Hospital, Taipei, Taiwan 10002
    J Clin Endocrinol Metab 88:531-7. 2003
    ..Restitution of a preconditioning response in glimepiride-treated patients may be the potential beneficial mechanism...
  11. ncbi request reprint Differential role of K(ATP) channels activated by conjugated estrogens in the regulation of myocardial and coronary protective effects
    Tsung Ming Lee
    National Taiwan University College of Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Circulation 107:49-54. 2003
    ..We sought to determine whether the protective effect of estrogen extends to epicardial coronary artery with attenuated vasoconstriction in patients after angioplasty by activation of such channels...
  12. doi request reprint Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Chi Mei Medical Center, Tainan, Taiwan
    Free Radic Biol Med 50:1461-70. 2011
    ..Xanthine oxidase inhibition ameliorates sympathetic innervation and arrhythmias possibly via inhibition of the peroxynitrite-mediated nerve growth factor pathway...
  13. ncbi request reprint Effect of pravastatin on sympathetic reinnervation in postinfarcted rats
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University, 252 Wu Hsing Street, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 293:H3617-26. 2007
    ..Chronic use of pravastatin after infarction, resulting in attenuated sympathetic reinnervation by the activation of K(ATP) channels, may modify the arrhythomogenic response to programmed electrical stimulation...
  14. ncbi request reprint Effect of pravastatin on left ventricular mass in the two-kidney, one-clip hypertensive rats
    Tsung Ming Lee
    Cardiology Section, Dept of Medicine, Taipei Medical University, Chi Mei Medical Center, Taipei, 110, Taiwan
    Am J Physiol Heart Circ Physiol 291:H2705-13. 2006
    ..Pravastatin is endowed with cardiac antihypertrophic properties probably through activation of K(ATP) channels, independent of lipid and hemodynamic changes...
  15. doi request reprint Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats
    Tsung Ming Lee
    Dept of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 294:H1871-9. 2008
    ..Independent of their hemodynamic effects, a chronic use of either ET(A) or ET(A)/ET(B) antagonists may modify the arrhythmogenic response to programmed electrical stimulation...
  16. ncbi request reprint Effect of ischaemic preconditioning on regional release of inflammatory markers
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Chi Mei Medical Centre, Taipei Medical University, Tainan, Taiwan
    Clin Sci (Lond) 109:267-76. 2005
    ..Therefore, in addition to its primary effect on cardioprotection, IP may also provide beneficial anti-inflammatory effects on the interaction between platelets and neutrophils...
  17. ncbi request reprint Inhibition of histone deacetylase on ventricular remodeling in infarcted rats
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and Chi Mei Medical Center, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 293:H968-77. 2007
    ..Inhibition of HDAC by VPA or tributyrin can attenuate ventricular remodeling after infarction. This might provide a worthwhile therapeutic target...
  18. ncbi request reprint Effects of pravastatin on ventricular remodeling by activation of myocardial KATP channels in infarcted rats: role of 70-kDa S6 kinase
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Taipei Medical University and Chi Mei Medical Center, Taipei, Taiwan
    Basic Res Cardiol 102:171-82. 2007
    ..Activation of K(ATP) channels by pravastatin administration can attenuate ventricular remodeling through a S6 kinase-dependent pathway after infarction...
  19. ncbi request reprint Physiological concentration of 17beta-estradiol on sympathetic reinnervation in ovariectomized infarcted rats
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Taipei Medical University and Hospital, 252, Wu Hsing Street, Taipei, 110, Taiwan
    Endocrinology 149:1205-13. 2008
    ..Chronic administration of E2 after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation...
  20. ncbi request reprint Effect of pravastatin on left ventricular mass by activation of myocardial K ATP channels in hypercholesterolemic rabbits
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Chi Mei, Medical Center, Taipei Medical University, 901 Chung Hwa Road, Yang Kan City, Tainan 710, Taiwan
    Atherosclerosis 176:273-8. 2004
    ..The antihypertropic effects of pravastatin may be related to activation of K(ATP) channels, and result in an amelioration of cardiomyocyte hypertrophy development by an atherogenic diet...
  21. ncbi request reprint Effect of pravastatin on development of left ventricular hypertrophy in spontaneously hypertensive rats
    Tsung Ming Lee
    Cardiology Section, Dept of Medicine, Taipei Medical Univ and Hospital, 252 Wu Hsing St, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 289:H220-7. 2005
    ....
  22. ncbi request reprint Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts
    Chang Her Tsai
    Department of Surgery, Cardiology Section, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Pharmacol Exp Ther 301:234-40. 2002
    ....
  23. doi request reprint Cardiac sympathetic hyperinnervation in deoxycorticosterone acetate-salt hypertensive rats
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan
    Clin Sci (Lond) 123:445-57. 2012
    ..DOCA-salt rats treated with NAC attenuate sympathetic hyperinnervation and thus show a beneficial effect on arrhythmogenic response to programmed electrical stimulation...
  24. doi request reprint 17beta-Estradiol decreases vulnerability to ventricular arrhythmias by preserving connexin43 protein in infarcted rats
    Chien Chang Chen
    Cardiology Section, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
    Eur J Pharmacol 629:73-81. 2010
    ....
  25. pmc Both PKA and Epac pathways mediate N-acetylcysteine-induced Connexin43 preservation in rats with myocardial infarction
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Tainan Municipal An Nan Hospital China Medical University, Tainan, Taiwan Department of Medicine, China Medical University, Taichung, Taiwan Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 8:e71878. 2013
    ....
  26. ncbi request reprint Effect of estrogen on coronary vasoconstriction in patients undergoing coronary angioplasty
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Int J Cardiol 101:465-72. 2005
    ..We sought to determine whether estrogen administration can affect coronary vasomotor tone in patients after angioplasty by reducing 8-iso-prostaglandin (PG) F(2alpha) concentrations, a bioactive product of lipid peroxidation...
  27. ncbi request reprint Effect of simvastatin on left ventricular mass in hypercholesterolemic rabbits
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Am J Physiol Heart Circ Physiol 288:H1352-8. 2005
    ....
  28. ncbi request reprint Effect of pravastatin on proteinuria in patients with well-controlled hypertension
    Tsung Ming Lee
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Hypertension 40:67-73. 2002
    ....
  29. doi request reprint Effect of sildenafil on ventricular arrhythmias in post-infarcted rat hearts
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan
    Eur J Pharmacol 690:124-32. 2012
    ..These data indicate that sildenafil after infarction attenuated sympathetic hyperinnervation and arrhythmias by activation of mitochondrial K(ATP) channels through a guanylyl cyclase-cGMP-independent pathway...
  30. doi request reprint Effect of pravastatin on nephroprotection in deoxycorticosterone acetate-salt hypertensive rats
    Chih Sen Kang
    Department of Cardiovascular Medicine, Min Sheng General Hospital, Taoyuan, Taipei, Taiwan
    J Hypertens 27:2232-43. 2009
    ..The current study was undertaken to assess the effect of pravastatin on the progression of renal impairment in deoxycorticosterone acetate (DOCA)-salt hypertensive rats...
  31. ncbi request reprint Add-on and withdrawal effect of pravastatin on proteinuria in hypertensive patients treated with AT receptor blockers
    Tsung Ming Lee
    Cardiology Section, Department of Internal Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Kidney Int 68:779-87. 2005
    ....
  32. ncbi request reprint Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients
    Tsung Ming Lee
    Cardiology Section, Dept of Medicine, Taipei Medical Univ and Hospital, 252 Wu Hsing St, Taipei 110, Taiwan
    Am J Physiol Heart Circ Physiol 292:H608-13. 2007
    ..Patients treated with gliclazide may have a beneficial effect in attenuating ventricular mass...
  33. doi request reprint Usefulness of C-reactive protein and interleukin-6 as predictors of outcomes in patients with chronic obstructive pulmonary disease receiving pravastatin
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Am J Cardiol 101:530-5. 2008
    ..In conclusion, these data reinforce hs-CRP as a significant surrogate marker in COPD and underscore an important guide to the efficacy of treatment in COPD trials...
  34. ncbi request reprint Granulocyte colony-stimulating factor increases sympathetic reinnervation and the arrhythmogenic response to programmed electrical stimulation after myocardial infarction in rats
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Am J Physiol Heart Circ Physiol 297:H512-22. 2009
    ....
  35. doi request reprint Effect of N-acetylcysteine on sympathetic hyperinnervation in post-infarcted rat hearts
    Tsung Ming Lee
    Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan
    Cardiovasc Res 85:137-46. 2010
    ..The purpose of this study was to determine whether N-acetylcysteine (NAC) attenuates cardiac sympathetic hyperinnervation through replenishment of glutathione in infarcted rats...
  36. ncbi request reprint Effects of distension of urinary bladder on coronary conduit and resistance vessels in hyperlipidemic patients
    Tsung Ming Lee
    National Taiwan University College of Medicine, Department of Internal Medicine, and National Taiwan University Hospital, Taipei
    Clin Cardiol 25:467-73. 2002
    ..The effect of such distension on the coronary circulation in hyperlipidemic patients, a condition with impaired endothelial function, remains unknown...
  37. doi request reprint Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    J Am Coll Cardiol 51:1309-18. 2008
    ..The purpose of this study was to determine whether ATP-sensitive potassium (K(ATP)) channel agonists exert a beneficial effect on the structural, functional, and molecular features of the remodeling heart in infarcted rats...
  38. ncbi request reprint Association of pravastatin and left ventricular mass in hypercholesterolemic patients: role of 8-iso-prostaglandin f2alpha formation
    Tsung Ming Lee
    Departments of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cardiovasc Pharmacol 40:868-74. 2002
    ....
  39. doi request reprint Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    Clin Sci (Lond) 116:497-505. 2009
    ..47, P=0.01). In conclusion, pravastatin significantly improved exercise tolerance, and decreased PH and dyspnoea during exercise in COPD patients with PH, probably by inhibiting ET-1 synthesis...
  40. ncbi request reprint Pharmacologic preconditioning of estrogen by activation of the myocardial adenosine triphosphate-sensitive potassium channel in patients undergoing coronary angioplasty
    Tsung Ming Lee
    Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Am Coll Cardiol 39:871-7. 2002
    ..The purpose of this study was to determine whether administration of estrogen produces cardioprotective effects in patients undergoing coronary angioplasty...
  41. doi request reprint Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia
    Chien Chang Chen
    Institute of Biomedical Engineering, National Cheng Kung University, and Divison of Cardiovascular Surgery, Chia Yi Christian Hospital, Chia Yi City, Taiwan
    Am J Physiol Heart Circ Physiol 301:H1107-17. 2011
    ..Uric acid lowering without inhibition of superoxide and endothelin-1 may not have an effect on remodeling. Chronic administration of allopurinol, ABT-627, and tempol is associated with attenuated ventricular remodeling...
  42. doi request reprint Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43
    Chien Chang Chen
    Department of Cosmetic Science, Chia Nan University of Pharmacy Science, Tainan, Taiwan
    J Appl Physiol (1985) 109:541-52. 2010
    ....
  43. doi request reprint Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats
    Tsung Ming Lee
    aDepartment of Medicine, Cardiology Section, Tainan Municipal An Nan Hospital China Medical University, Tainan bDepartment of Medicine, China Medical University, Taichung cDepartment of Medicine, School of Medicine, Fu Jen Catholic University dDepartment of Neurosurgery, China Medical University Beigan Hospital, Yunlin eDepartment of Neurosurgery, Tainan Municipal An Nan Hospital China Medical University, Tainan fDivision of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital gDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Hypertens 32:795-805. 2014
    ..We assessed whether selective endothelin receptor blockers can attenuate renal fibrosis by inhibiting RhoA/ROCK axis in DOCA-salt rats...
  44. ncbi request reprint Effect of nicorandil on proteinuria in well controlled hypertensive patients
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    J Hypertens 27:618-25. 2009
    ..The effect of nicorandil on proteinuria in hypertensive patients well controlled by antihypertensive agents containing a low dose of valsartan has not been studied...
  45. ncbi request reprint Differential effect of phosphodiesterase-3 inhibitors on sympathetic hyperinnervation in healed rat infarcts
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Tainan Municipal An Nan Hospital China Medical University
    Circ J 78:366-76. 2014
    ....