Han Pin Kuo

Summary

Country: Taiwan

Publications

  1. pmc Feasibility of bispectral index-guided propofol infusion for flexible bronchoscopy sedation: a randomized controlled trial
    Yu Lun Lo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    PLoS ONE 6:e27769. 2011
  2. pmc Concomitant active tuberculosis prolongs survival in non-small cell lung cancer: a study in a tuberculosis-endemic country
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    PLoS ONE 7:e33226. 2012
  3. pmc Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes: a study in a tuberculosis-endemic country
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan
    PLoS ONE 6:e16877. 2011
  4. pmc Endobronchial mucosa invasion predicts survival in patients with small cell lung cancer
    Pai Chien Chou
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    PLoS ONE 7:e47613. 2012
  5. pmc The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial
    Ting Yu Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan
    PLoS ONE 8:e62744. 2013
  6. doi request reprint A mobile telephone-based interactive self-care system improves asthma control
    W T Liu
    Dept of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Eur Respir J 37:310-7. 2011
  7. ncbi request reprint Effect of sensory neuropeptides on mucus secretion from cultured goblet cells
    H H Chen
    Department of the Second Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R O C
    Changgeng Yi Xue Za Zhi 21:283-90. 1998
  8. ncbi request reprint Pulmonary arteriovenous malformation of Osler-Weber-Rendu syndrome diagnosed by endobronchial ultrasound
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Respirology 12:295-8. 2007
  9. ncbi request reprint Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis
    H P Kuo
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Respir Crit Care Med 161:192-9. 2000
  10. ncbi request reprint Lipopolysaccharide enhances substance P-mediated neutrophil adherence to epithelial cells and cytokine release
    H P Kuo
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Respir Crit Care Med 162:1891-7. 2000

Collaborators

Detail Information

Publications74

  1. pmc Feasibility of bispectral index-guided propofol infusion for flexible bronchoscopy sedation: a randomized controlled trial
    Yu Lun Lo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    PLoS ONE 6:e27769. 2011
    ..The bispectral index (BIS) correlates well with the level of consciousness. The aim of this study was to show that BIS-guided propofol infusion is safe and may provide better sedation, benefiting the patients and bronchoscopists...
  2. pmc Concomitant active tuberculosis prolongs survival in non-small cell lung cancer: a study in a tuberculosis-endemic country
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    PLoS ONE 7:e33226. 2012
    ..This study compares the survival and immunological cell profile in TBLC over NSCLC alone...
  3. pmc Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes: a study in a tuberculosis-endemic country
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan
    PLoS ONE 6:e16877. 2011
    ..This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET...
  4. pmc Endobronchial mucosa invasion predicts survival in patients with small cell lung cancer
    Pai Chien Chou
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    PLoS ONE 7:e47613. 2012
    ..This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion...
  5. pmc The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial
    Ting Yu Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan
    PLoS ONE 8:e62744. 2013
    ..brain. This pilot study aims to evaluate the feasibility and optimal TCI regimen for flexible bronchoscopy (FB) sedation...
  6. doi request reprint A mobile telephone-based interactive self-care system improves asthma control
    W T Liu
    Dept of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Eur Respir J 37:310-7. 2011
    ..The mobile telephone-based interactive self-care system provides a convenient and practical self-monitoring and -management of asthma, and improves asthma control...
  7. ncbi request reprint Effect of sensory neuropeptides on mucus secretion from cultured goblet cells
    H H Chen
    Department of the Second Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R O C
    Changgeng Yi Xue Za Zhi 21:283-90. 1998
    ..This study was designed to explore whether the effect of capsaicin or neuropeptides on goblet cell secretion is direct or secondary to other airway responses...
  8. ncbi request reprint Pulmonary arteriovenous malformation of Osler-Weber-Rendu syndrome diagnosed by endobronchial ultrasound
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Respirology 12:295-8. 2007
    ..EBUS can be used as a good diagnostic tool for determining the nature of peripheral lung lesions such as in this case, and EBUS may be of practical tool to investigate a lung mass when a vascular component is suspected...
  9. ncbi request reprint Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis
    H P Kuo
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Respir Crit Care Med 161:192-9. 2000
    ..In conclusion, enhanced NO generation by AM of TB patients plays an autoregulatory role in amplifying the synthesis of proinflammatory cytokines, probably through NF-kappaB activation...
  10. ncbi request reprint Lipopolysaccharide enhances substance P-mediated neutrophil adherence to epithelial cells and cytokine release
    H P Kuo
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Respir Crit Care Med 162:1891-7. 2000
    ..Neutrophil adherence to epithelial cells may release serine protease to induce IL-1beta and TNF-alpha release and their synthesis...
  11. ncbi request reprint The impact of delirium on the survival of mechanically ventilated patients
    Shu Min Lin
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Crit Care Med 32:2254-9. 2004
    ..To revalidate a means of assessing delirium in intensive care unit patients and to investigate the independent effect of delirium on the mortality of mechanically ventilated patients...
  12. ncbi request reprint Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway
    Hao Cheng Chen
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, 199 Tun Hwa N Road, Taipei 10507, Taiwan, ROC
    J Biomed Sci 11:49-58. 2004
    ..Tyrosine kinase and PKC are implicated in neutrophil elastase activation of the MAPK pathway...
  13. doi request reprint Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway
    Chun Hua Wang
    Pulmonary Disease Research Center, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Allergy Clin Immunol 129:1367-76. 2012
    ..Fibrocytes from patients with COA have a greater capacity for proliferation and differentiation...
  14. doi request reprint CD14(+)S100A9(+) monocytic myeloid-derived suppressor cells and their clinical relevance in non-small cell lung cancer
    Po Hao Feng
    Pulmonary Research Center, Chang Gung Medical Foundation, Chang Gung University, 199, Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 186:1025-36. 2012
    ..Myeloid-derived suppressor cells (MDSCs) are a heterogeneous family of myeloid cells that suppress T-cell immunity in tumor-bearing hosts. Their clinical relevance remains unclear...
  15. doi request reprint Echoic features as predictors of diagnostic yield of endobronchial ultrasound-guided transbronchial lung biopsy in peripheral pulmonary lesions
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    Ultrasound Med Biol 37:1755-61. 2011
    ..In conclusion, EBUS features are feasible predictors of diagnostic yield of TBLB in peripheral lung lesions...
  16. ncbi request reprint Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment
    Chien Ying Liu
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Chang Gung University, 199 Tunhwa N Road, Taipei 105, Taiwan, ROC
    J Biomed Sci 10:746-56. 2003
    ..Furthermore, the rapidity of the transition emphasizes the importance of the prompt clearance of apoptotic neutrophils before they progress to secondary necrosis at the site of lung inflammation...
  17. ncbi request reprint Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway
    Kang Yun Lee
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa N Rd, Taipei, Taiwan
    Am J Respir Cell Mol Biol 35:407-14. 2006
    ..These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma...
  18. doi request reprint Tracheal torsion assessed by a computer-generated 3-dimensional image analysis predicts tracheal self-expandable metallic stent fracture
    Chih Teng Yu
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, and School of Medicine, Chang Gung University, Taipei, Taiwan
    J Thorac Cardiovasc Surg 140:769-76. 2010
    ....
  19. ncbi request reprint Ventilator-induced injury augments interleukin-1beta production and neutrophil sequestration in lipopolysaccharide-treated lungs
    Shu Min Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    Shock 28:453-60. 2007
    ..High Vt MV in LPS-injured lung causes synergistic production of IL-1beta and sequestration of neutrophil via ICAM-1-dependent effects...
  20. doi request reprint Factors leading to tracheobronchial self-expandable metallic stent fracture
    Fu Tsai Chung
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 136:1328-35. 2008
    ..This retrospective study was to determine factors that contribute to self-expandable metallic stent fracture in patients with tracheobronchial disease...
  21. doi request reprint Diagnostic value of endobronchial ultrasonography for pulmonary tuberculosis
    Shu Min Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 138:179-84. 2009
    ....
  22. doi request reprint Subsequent chemotherapy improves survival outcome in advanced non-small-cell lung cancer with acquired tyrosine kinase inhibitor resistance
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    Clin Lung Cancer 11:51-6. 2010
    ..Our objective was to assess the survival outcome of patients with NSCLC with or without subsequent chemotherapy after acquired TKI resistance...
  23. ncbi request reprint Human neutrophil-derived elastase induces airway smooth muscle cell proliferation
    Chien Da Huang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, 199 Tun Hwa N Rd, Taipei, Taiwan, ROC
    Life Sci 74:2479-92. 2004
    ..Our results demonstrate that HNE is mitogenic for ASM cells by increasing cyclin D1 activity through ERK signaling pathway...
  24. ncbi request reprint High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan
    Shiu Feng Huang
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei, Taiwan
    Clin Cancer Res 10:8195-203. 2004
    ..Detection of EGFR mutations has become an important issue for therapeutic decision-making in non-small cell lung cancer...
  25. ncbi request reprint Reduced nuclear factor-κB repressing factor: a link toward systemic inflammation in COPD
    Kang Yun Lee
    Dept of Thoracic Medicine Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa North Road, Taipei, Taiwan
    Eur Respir J 40:863-73. 2012
    ..NRF expression is reduced in PBMCs of stable COPD patients, probably through oxidative stress, leading to increased production of IL-8/CXCL8 and potentially chronic systemic inflammation...
  26. ncbi request reprint The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derived alpha-defensin-1 on human bronchial and alveolar epithelial cells
    Chien Ying Liu
    Department of Thoracic Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Life Sci 80:749-58. 2007
    ..These findings suggest that neutrophil-derived alpha-defensin-1 has pro-inflammatory and apoptotic effects in human bronchial and alveolar epithelial cells, which are concentration-dependent and may be associated with ER activity...
  27. pmc Matrix metalloproteinase-1 polymorphism (-1607G) and disease severity in non-cystic fibrosis bronchiectasis in Taiwan
    Meng Heng Hsieh
    Department of Thoracic Medicine, Chang Gung Medical Foundation, Taipei, Taiwan
    PLoS ONE 8:e66265. 2013
    ..Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis...
  28. doi request reprint Matrix metalloproteinase-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population
    Chien Da Huang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Asthma 46:41-6. 2009
    ..We investigated whether MMP-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population...
  29. pmc Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Br J Pharmacol 138:1147-55. 2003
    ..The anti-inflammatory properties of theophylline include an inhibition of circulating progenitor cells...
  30. ncbi request reprint Diagnostic value of endobronchial ultrasound-guided transbronchial lung biopsy in peripheral lung cancers
    Mei Chen Yang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 103:124-9. 2004
    ..This study evaluated whether endobronchial ultrasound (EBUS) may help localize and improve the diagnostic yield of bronchoscopic transbronchial lung biopsy in peripheral lung cancer...
  31. ncbi request reprint Endogenous nitric oxide downregulates the Bcl-2 expression of eosinophils through mitogen-activated protein kinase in bronchial asthma
    Suh Hwa Maa
    School of Nursing, Chang Gung University, Taipei, Taiwan
    J Allergy Clin Immunol 112:761-7. 2003
    ..Mitogen-activated protein kinase (MAPK) is implicated in regulating eosinophil apoptosis by modulating Bcl-2 expression. NO-induced cell apoptosis is associated with an inhibition of Bcl-2 expression...
  32. ncbi request reprint Erlotinib treatment in patients with advanced lung adenocarcinoma with CISH-positive and CISH-negative EGFR gene alterations
    Ming Mo Hou
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 5 Fu Shin Street, Kwei Shan, Taoyuan 333, Taiwan, R O C
    Anticancer Res 32:1107-12. 2012
    ..This study was conducted to compare the responsiveness of CISH-positive and CISH-negative lung adenocarcinomas to erlotinib...
  33. ncbi request reprint Efficacy and tolerability of salmeterol/fluticasone propionate versus fluticasone propionate in asthma patients: a randomized, double-blind study
    Yu Sung Lee
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkuo, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 34:382-94. 2011
    ..We compared the efficacy and tolerability of SAL/FP (50/250 μg) with fluticasone propionate (FP) 250 μg administrated twice daily for 2 weeks in treating patients with mild to moderate asthma...
  34. ncbi request reprint Tumor necrosis factor-alpha induces caspase-independent cell death in human neutrophils via reactive oxidants and associated with calpain activity
    Hao Cheng Chen
    Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199, Tun Hwa North Road, Taipei, 105, Taiwan
    J Biomed Sci 13:261-73. 2006
    ..These results demonstrate that, in human neutrophils, TNF-alpha-induces a caspase-independent cell death signal, which is related to calpain and oxidative activities and cannot be rescued by the growth factor-related signaling mechanism...
  35. doi request reprint Incidence and outcome of healthcare-associated Acinetobacter baumannii in chronically ventilated patients in a tertiary care hospital in Taiwan
    Horng Chyuan Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, Taiwan
    Am J Med Sci 341:361-6. 2011
    ..Most studies related to healthcare-associated infection with Acinetobacter baumannii (HAIA) are on acutely ventilated patients. Little is known regarding the incidence and outcomes of HAIA in chronically ventilated patients...
  36. doi request reprint Low-dose weekly docetaxel is as tolerable as pemetrexed in previously treated advanced non-small-cell lung cancer
    Fu Tsai Chung
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taipei, Taiwan, ROC
    Chemotherapy 57:147-55. 2011
    ..We conducted this retrospective study to compare the efficacy and toxicity of weekly low-dose docetaxel versus tri-weekly pemetrexed for previously treated advanced NSCLC...
  37. doi request reprint Endobronchial ultrasound increases the diagnostic yields of polymerase chain reaction and smear for pulmonary tuberculosis
    Shu Min Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 139:1554-60. 2010
    ..Our objective was to determine the contribution of endobronchial ultrasound in the diagnostic yields of acid-fast bacillus smear, nucleic acid amplification tests, and culture in bronchoalveolar lavage fluid for pulmonary tuberculosis...
  38. ncbi request reprint Six-month nocturnal nasal positive pressure ventilation improves respiratory muscle capacity and exercise endurance in patients with chronic hypercapnic respiratory failure
    Ling Ling Chiang
    School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
    J Formos Med Assoc 105:459-67. 2006
    ..This study was designed to investigate the effects of 6 months of nocturnal nasal positive pressure ventilation (NNPPV) on respiratory muscle function and exercise capacity in patients with chronic respiratory failure...
  39. doi request reprint The endothelin A receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor
    Chih Ming Weng
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Respir Crit Care Med 188:298-308. 2013
    ..Endothelin-1 (ET-1) induces matrix-associated gene expression through the ETA receptor (ETAR) and promotes fibroblast differentiation. However, the mechanism of fibrocyte differentiation remains unclear...
  40. pmc Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study
    Chieh Mo Lin
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan
    PLoS ONE 7:e44842. 2012
    ..The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy...
  41. doi request reprint Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer
    Fu Tsai Chung
    Pulmonary Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan, Republic of China
    Int J Cancer 131:E227-35. 2012
    ..08-6.5; p = 0.03 and OR, 0.14; 95% CI, 0.03-0.56; p = 0.006, respectively). TAMs are related to treatment response irrespective of EGFR mutation and can independently predict survival in advanced NSCLC treated with an EGFR-TKI...
  42. pmc Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Respir Res 6:42. 2005
    ..Persistent high-resolution computed tomography (HRCT) abnormalities occur in SARS patients up to 40 days after recovery...
  43. pmc An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study
    Fu Tsai Chung
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, NO, 199 Tun Hwa N, Rd, Taipei City 10507, Taiwan
    J Cardiothorac Surg 6:46. 2011
    ..We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases...
  44. ncbi request reprint Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways
    Chien Huang Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 450:1-9. 2002
    ..Both events required activation of upstream tyrosine kinase and PKC...
  45. pmc Extravascular lung water correlates multiorgan dysfunction syndrome and mortality in sepsis
    Fu Tsai Chung
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taipei, Taiwan, Republic of China
    PLoS ONE 5:e15265. 2010
    ..This study was designated to investigate whether increased extravascular lung water index (EVLWI) may correlate multiple organ dysfunction syndrome (MODS) and mortality in sepsis...
  46. doi request reprint Increased circulating fibrocytes in asthma with chronic airflow obstruction
    Chun Hua Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 178:583-91. 2008
    ..We hypothesized that this effect may result from increased activity of circulating fibroblast-like progenitor cells (fibrocytes) that could home to the airway mucosal wall...
  47. ncbi request reprint Diagnosis of peripheral lung cancer with three echoic features via endobronchial ultrasound
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung School of Medicine, 199 Tun Hwa N Rd, Taipei, Taiwan
    Chest 132:922-9. 2007
    ..Therefore, EBUS may be also useful in the differential diagnosis of malignant lesions of the lung...
  48. doi request reprint Remove airway ultraflex stents by flexible bronchoscope
    Fu Tsai Chung
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taipei, Taiwan, Republic of China
    Am J Med Sci 343:267-72. 2012
    ..Despite removal of airway metallic stents by rigid bronchoscope was presented, there are few reports describing such removal by flexible bronchoscope...
  49. ncbi request reprint Cytoprotective response of A1, a Bcl-2 homologue expressed in mature human neutrophils and promyelocytic HL-60 cells, to oxidant stress-induced cell death
    Chien Ying Liu
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 11:214-27. 2004
    ..Thus, our results suggest a cytoprotective role of A1 in mature human neutrophils under oxidant stresses in host defense and inflammation...
  50. ncbi request reprint Eosinophils from asthmatics release IL-5 in an autocrine fashion to prevent apoptosis through upregulation of Bcl-2 expression
    Chien Da Huang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Asthma 42:395-403. 2005
    ..This study demonstrates that eosinophils from asthmatics release IL-5 in an autocrine fashion to act on their own IL-5 receptors in prevention of apoptosis through the upregulation of Bcl-2 expression...
  51. ncbi request reprint A modified goal-directed protocol improves clinical outcomes in intensive care unit patients with septic shock: a randomized controlled trial
    Shu Min Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa North Road, Taipei, Taiwan
    Shock 26:551-7. 2006
    ..With central venous oxygen saturation measurement to detect tissue perfusion, the clinical outcomes may be further improved...
  52. pmc Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: a prospective controlled study
    Shu Chuan Ho
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa North Road, Taipei, Taiwan
    Respir Res 14:22. 2013
    ..We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training...
  53. doi request reprint Airway ultraflex stenting in esophageal cancer with esophagorespiratory fistula
    Fu Tsai Chung
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taipei, Taiwan, Republic of China
    Am J Med Sci 344:105-9. 2012
    ..Esophagorespiratory fistula (ERF) caused by esophageal cancer has a poor prognosis. This study describes the clinical effects of airway ultraflex stenting as an alternative method for ERF caused by esophageal cancer...
  54. doi request reprint Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer
    Chien Ying Liu
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, and School of Medicine, Chang Gung University, No 199, Tun Hwa North Road, Taipei 105, Taiwan
    J Cancer Res Clin Oncol 136:35-45. 2010
    ..In the present study, we explored the clinical relevance of CD11b+/CD14⁻/CD15+/CD33+ MDSCs and the association of MDSCs with CD8+ cytotoxic T lymphocytes in patients with non-small-cell lung cancer (NSCLC)...
  55. doi request reprint Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure
    Chun Hua Wang
    1Pulmonary Disease Research Center, Chang Gung Memorial Hospital, Linkou, Chang Gung University, College of Medicine, Taoyuan, Taiwan 2Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University, College of Medicine, Taoyuan, Taiwan 3Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan 4Department of Thoracic Medicine, Chang Gung Memorial Hospital, Cha Yi, Taiwan 5Chang Gung Children s Hospital, Linkou, Taiwan
    Crit Care Med 42:313-21. 2014
    ..Severe H1N1 pneumonia with acute respiratory failure results in infiltration of lungs due to the presence of hyperactive immune cells. Rapamycin and corticosteroids inhibit this immune response by blocking the activation of T and B cells...
  56. ncbi request reprint Effect of endogenous nitric oxide on hyperoxia and tumor necrosis factor-alpha-induced leukosequestration and proinflammatory cytokine release in rat airways
    Horng Chyuan Lin
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Crit Care Med 31:508-16. 2003
    ..To investigate the effects of endogenous nitric oxide on hyperoxia and tumor necrosis factor-alpha-induced leukosequestration and proinflammatory cytokine release in rat airways...
  57. ncbi request reprint Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis
    Han Pin Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa N Rd, Taipei, Taiwan
    Tuberculosis (Edinb) 88:262-7. 2008
    ..1G genotypes of MMP-1 polymorphism were associated with a greater risk of developing tracheobronchial stenosis through up-regulation of MMP-1 activity...
  58. doi request reprint Endobronchial ultrasound-guided transbronchial biopsy and brushing: a comparative evaluation for the diagnosis of peripheral pulmonary lesions
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan
    Eur J Cardiothorac Surg 45:894-8. 2014
    ..This study compared yields of TBB and bronchial washing (TBBW) with those of TBBW plus bronchial brushing and analysed the associations between clinical and echoic features and yield...
  59. ncbi request reprint Erlotinib-associated near-fatal interstitial pneumonitis in a patient with relapsed lung adenocarcinoma
    Chun Liang Chou
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 33:100-5. 2010
    ..The case presented suggests that the outcome of erlotinib-associated pulmonary toxicity with acute respiratory failure may be favorable with adequate early management...
  60. doi request reprint Inadequate antimicrobial treatment for nosocomial infection is a mortality risk factor for systemic lupus erythematous patients admitted to intensive care unit
    Po Hao Feng
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Am J Med Sci 340:64-8. 2010
    ..This study aimed to determine if inadequate antimicrobial treatment is an independent risk factor for mortality in SLE patients in the ICU...
  61. doi request reprint Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis
    Shu Min Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan
    Crit Care Med 36:683-9. 2008
    ....
  62. ncbi request reprint G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells
    Chien Da Huang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 12:763-76. 2005
    ....
  63. ncbi request reprint The effects of ciprofloxacin on chest radiographic regression in patients with drug intolerance or resistant tuberculosis
    Chao Kai Yang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei
    Chang Gung Med J 27:292-9. 2004
    ..The aim of this study was to identify the clinical efficacy of ciprofloxacin as a second-line anti-tuberculosis agent in pulmonary tuberculosis patients with drug intolerance or resistance...
  64. ncbi request reprint An open-label, randomized comparison of levofloxacin and amoxicillin/clavulanate plus clarithromycin for the treatment of hospitalized patients with community-acquired pneumonia
    Ting Yu Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 30:321-32. 2007
    ..Anti-pneumococcal fluoroquinolone has been used to treat community-acquired pneumonia (CAP) frequently because of its broad antimicrobial spectrum...
  65. ncbi request reprint Cross-talk between bradykinin and epidermal growth factor in regulating IL-6 production in human airway smooth muscle cells
    Po Hao Feng
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 33:92-9. 2010
    ..In this study, we tested whether there is cross-talk between BK and EGF in the regulation of IL-6 gene expression in ASM cells...
  66. doi request reprint Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients
    Shu Min Lin
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taipei 333, Taiwan
    J Crit Care 23:372-9. 2008
    ..The aim of the study was to investigate the risk factors of developing early-onset delirium in mechanically ventilated patients and determine the subsequent clinical outcomes...
  67. ncbi request reprint Domiciliary positive expiratory pressure improves pulmonary function and exercise capacity in patients with chronic obstructive pulmonary disease
    Chien Ling Su
    School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
    J Formos Med Assoc 106:204-11. 2007
    ..This study assessed how positive expiratory pressure (PEP) affected pulmonary function, functional capacity, and subjective cough difficulty in individuals with chronic obstructive pulmonary diseases (COPD)...
  68. ncbi request reprint Conscious sedation reduces patient discomfort and improves satisfaction in flexible bronchoscopy
    Yung Lun Ni
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 33:443-52. 2010
    ..In Taiwan, the general FB practice involves local anesthesia only. This study aimed to assess the benefits and risks of conscious sedation in diagnostic FB...
  69. ncbi request reprint Zafirlukast improves pulmonary function in patients with moderate persistent asthma receiving regular inhaled steroids: a prospective randomized control study
    Chung Jen Huang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Chang Gung Med J 26:554-60. 2003
    ..Zafirlukast is a leukotriene receptor antagonist that was invented to treat patients with chronic asthma...
  70. ncbi request reprint Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer
    Meng Heng Hsieh
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Lung Cancer 53:311-22. 2006
    ..An analysis of the various EGFR mutations and the response patterns was also performed and compared with recently published reports on EGFR mutation and gefitinib responsiveness...
  71. ncbi request reprint Asthma control in asthmatic patients treated for lung cancer
    Chung Hsing Hsieh
    Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 34:35-43. 2011
    ..The present study was conducted to test the hypothesis that nonsmall cell lung cancer (NSCLC) has an impact on control of asthma, a wellknown Th2-predominant inflammatory disease...
  72. pmc Association Between Emphysema Score, Six-Minute Walk and Cardiopulmonary Exercise Tests in COPD
    Li Fei Chen
    Pulmonary Medicine Research Center, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, 199 Tun Hwa North Road, Taipei, Taiwan
    Open Respir Med J 6:104-10. 2012
    ..Six minute walk test (6MWT) and cardiopulmonary exercise test (CPET) can determine functional status...
  73. doi request reprint Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor
    Shu Chuan Ho
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Immunol 183:411-20. 2009
    ..Hence, we describe a novel negative regulatory mechanism of NE-induced NRF, which is restricted to hASM and mediates the suppression of IL-8/CXCL8 expression...
  74. doi request reprint High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded access program study previously treated with chemotherapy
    Reury Perng Perng
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Lung Cancer 62:78-84. 2008
    ..An open label phase II study was conducted in Taiwanese patients with NSCLC to evaluate its efficacy...