Shyi Jang Shin

Summary

Affiliation: Kaohsiung Medical University
Country: Taiwan

Publications

  1. pmc Association between insulin resistance and development of microalbuminuria in type 2 diabetes: a prospective cohort study
    Chih Cheng Hsu
    Division of Health Policy Research and Development, Institute of Population Health Sciences, National Health Research Institutes, Taiwan
    Diabetes Care 34:982-7. 2011
  2. pmc Prospective randomized controlled trial to evaluate effectiveness of registered dietitian-led diabetes management on glycemic and diet control in a primary care setting in Taiwan
    Meng Chuan Huang
    Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Diabetes Care 33:233-9. 2010
  3. pmc The association of pioglitazone and urinary tract disease in type 2 diabetic Taiwanese: bladder cancer and chronic kidney disease
    Mei Yueh Lee
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung, Taiwan Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    PLoS ONE 9:e85479. 2014
  4. ncbi request reprint The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance
    Chiao Ling Wang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    J Hum Genet 51:124-8. 2006
  5. doi request reprint The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
    Chih Wen Wang
    Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Liver Int 31:1326-31. 2011
  6. doi request reprint The outcomes of glucose abnormalities in pre-diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapy
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Liver Int 32:962-9. 2012
  7. doi request reprint Vascular endothelial growth factor polymorphisms and extent of coronary atherosclerosis in Chinese population with advanced coronary artery disease
    Tsung Hsien Lin
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Hypertens 23:960-6. 2010
  8. doi request reprint Pegylated interferon plus ribavirin therapy improves pancreatic β-cell function in chronic hepatitis C patients
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Liver Int 31:1155-62. 2011
  9. ncbi request reprint Higher frequency of apolipoprotein E2 allele in type 2 diabetic patients with nephropathy in Taiwan
    Ming Chia Hsieh
    Department of Internal Medicine, Kaohsiung Medical University, Taiwan
    J Nephrol 15:368-73. 2002
  10. ncbi request reprint Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: an epidemiological link with virological implication
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Gastroenterol 102:1237-43. 2007

Collaborators

Detail Information

Publications59

  1. pmc Association between insulin resistance and development of microalbuminuria in type 2 diabetes: a prospective cohort study
    Chih Cheng Hsu
    Division of Health Policy Research and Development, Institute of Population Health Sciences, National Health Research Institutes, Taiwan
    Diabetes Care 34:982-7. 2011
    ..An association between insulin resistance and microalbuminuria in type 2 diabetes has often been found in cross-sectional studies. We aimed to reassess this relationship in a prospective Taiwanese cohort of type 2 diabetic subjects...
  2. pmc Prospective randomized controlled trial to evaluate effectiveness of registered dietitian-led diabetes management on glycemic and diet control in a primary care setting in Taiwan
    Meng Chuan Huang
    Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Diabetes Care 33:233-9. 2010
    ....
  3. pmc The association of pioglitazone and urinary tract disease in type 2 diabetic Taiwanese: bladder cancer and chronic kidney disease
    Mei Yueh Lee
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung, Taiwan Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    PLoS ONE 9:e85479. 2014
    ..Although studies have shown an association between pioglitazone and bladder cancer, the associated factors have not been identified. The aim of this study was to investigate the factors that may link pioglitazone to bladder cancer...
  4. ncbi request reprint The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance
    Chiao Ling Wang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    J Hum Genet 51:124-8. 2006
    ..The present study indicates that the hOGG1 gene Cys/Cys variant is associated with a significant decrease in insulin sensitivity in subjects with normal glucose tolerance...
  5. doi request reprint The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
    Chih Wen Wang
    Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Liver Int 31:1326-31. 2011
    ..However, whether there is an association between PNPLA3 I148M and insulin resistance and NAFLD in a normoglycaemic population is still unknown...
  6. doi request reprint The outcomes of glucose abnormalities in pre-diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapy
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Liver Int 32:962-9. 2012
    ..Pre-diabetes is a risk factor for type 2 diabetes mellitus (DM) development. This study aimed to elucidate the impact of treatment response on sequential changes in glucose abnormalities in pre-diabetic chronic hepatitis C (CHC) patients...
  7. doi request reprint Vascular endothelial growth factor polymorphisms and extent of coronary atherosclerosis in Chinese population with advanced coronary artery disease
    Tsung Hsien Lin
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Hypertens 23:960-6. 2010
    ..We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis...
  8. doi request reprint Pegylated interferon plus ribavirin therapy improves pancreatic β-cell function in chronic hepatitis C patients
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Liver Int 31:1155-62. 2011
    ..However, the impact of PegIFN/RBV therapy on both IR and β-cell function in CHC patients has rarely been investigated...
  9. ncbi request reprint Higher frequency of apolipoprotein E2 allele in type 2 diabetic patients with nephropathy in Taiwan
    Ming Chia Hsieh
    Department of Internal Medicine, Kaohsiung Medical University, Taiwan
    J Nephrol 15:368-73. 2002
    ..Three different apo E alleles (epsilon2, epsilon3 and epsilon4) produce apo E isoproteins, apo E2, apo E3 and apo E4. Thus, the apo E gene polymorphism may be associated with DN...
  10. ncbi request reprint Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: an epidemiological link with virological implication
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Gastroenterol 102:1237-43. 2007
    ..This study aimed to elucidate the link between T2DM and viral hepatitis infections, especially HCV infection. It also aimed to analyze the associated virological characteristics and implication...
  11. ncbi request reprint Decreased insulin secretion and insulin sensitivity are associated with liver function in subjects with fasting glucose between 100 and 109 mg/dL in Taiwanese population
    Jeng Yueh Hsiao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University, Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Pancreas 35:343-7. 2007
    ..The secondary aim was to investigate IR and beta-cell function assessed by homeostasis model assessment (HOMA-IR and HOMA-%B, respectively) in subjects with fasting plasma glucose (FPG) between 100 and 109 mg/dL...
  12. doi request reprint Reappraisal of the characteristics of glucose abnormalities in patients with chronic hepatitis C infection
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Gastroenterol 103:1933-40. 2008
    ..It also aimed to investigate the related clinical, virological, and histological features of glucose abnormalities in HCV infection...
  13. doi request reprint Elevated serum retinol-binding protein 4 concentrations are associated with renal dysfunction and uric acid in type 2 diabetic patients
    Yu Hung Chang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Diabetes Metab Res Rev 24:629-34. 2008
    ..Therefore, this study attempted to further investigate the relationship among serum RBP4, serum uric acid, and the severity of albuminuria in diabetic patients...
  14. pmc Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling
    Chao Hung Chen
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    J Biol Chem 287:9694-707. 2012
    ..In conclusion, this study indicates that the increase of apo-/holo-RBP4 concentration may influence STRA6 signaling, finally causing apoptosis...
  15. doi request reprint The 8-oxoguanine glycosylase I (hOGG1) Ser326Cys variant affects the susceptibility to multi-vessel disease in Taiwan coronary artery disease patients
    Chiao Ling Wang
    Graduate Institute of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, ROC
    Thromb Res 126:319-23. 2010
    ..806], p<0.005; OR: 2.44 [95%:1.276~4.651], p<0.001). In the present study, hOGG1 Ser(326)Cys polymorphism is a novel genetic marker to be independently associated with the development and severity of CAD in Taiwanese population...
  16. ncbi request reprint Effects of pravastatin on superoxide and fibronectin production of mesangial cells induced by low-density lipoprotein
    Hung Chun Chen
    Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kidney Blood Press Res 25:2-6. 2002
    ..Our results indicate that pravastatin may have a direct effect as an antioxidant and suppresses the fibronectin synthesis of glomerular mesangial cells independent of its hypolipidemic effect...
  17. ncbi request reprint Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus
    Ming Chia Hsieh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    Metabolism 56:745-50. 2007
    ..09; 95% confidence interval, 1.12-3.91; P = .02). Our results suggest that the CETP B1B1 genotype is a strong genetic predictor of CAD in Taiwanese with type 2 diabetes mellitus...
  18. doi request reprint Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes
    Tusty Jiuan Hsieh
    Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Taiwan, Republic of China
    Cell Biol Toxicol 27:397-411. 2011
    ..In conclusion, betel nut extract and arecoline have diabetogenic potential on adipocytes that may result in insulin resistance and diabetes at least in part via the obstruction of insulin signaling and the blockage of lipid storage...
  19. doi request reprint Serum osteoprotegerin and tumor necrosis factor related apoptosis inducing-ligand (TRAIL) are elevated in type 2 diabetic patients with albuminuria and serum osteoprotegerin is independently associated with the severity of diabetic nephropathy
    Yu Hung Chang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Metabolism 60:1064-9. 2011
    ..Our results suggested that serum OPG may be a marker for the severity of diabetic nephropathy. Further studies are necessary to investigate the role of elevated serum OPG in the pathogenesis of diabetic nephropathy...
  20. doi request reprint Albuminuria is the stronger risk factor for peripheral arterial disease than eGFR decline in a type 2 diabetic Taiwanese population
    Mei Yueh Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
    Kidney Blood Press Res 33:352-9. 2010
    ....
  21. doi request reprint Increased ferritin concentrations correlate with insulin resistance in female type 2 diabetic patients
    Fung Jung Yu
    Department of Gastroenterology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, RO China
    Ann Nutr Metab 61:32-40. 2012
    ....
  22. ncbi request reprint Significant correlations between severe fatty liver and risk factors for metabolic syndrome
    Pi Jung Hsiao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Kaohsiung Medical University Hospital, Faculty of Medicine, Kaohsiung Medical University, Taiwan
    J Gastroenterol Hepatol 22:2118-23. 2007
    ..The aim of this study was to investigate the relationship between the severity of the fatty liver, classified by US, and the degree of metabolic disorders with insulin resistance...
  23. doi request reprint Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease
    Tsung Hsien Lin
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan
    Clin Chim Acta 411:1688-93. 2010
    ..This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD)...
  24. doi request reprint Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea
    Kun Der Lin
    Graduate Institute of Medicine, Kaohsiung Medical University Hospital, Taiwan
    Transl Res 151:309-14. 2008
    ....
  25. ncbi request reprint Inhibition of corneal angiogenesis by local application of vasostatin
    Pei Chang Wu
    Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Mol Vis 11:28-35. 2005
    ..This study was designed to investigate the effects of the locally supplied endogenous angiogenesis inhibitor vasostatin (VS) on corneal angiogenesis...
  26. ncbi request reprint Metabolic risk factors in southern Taiwanese with impaired fasting glucose of 100 to 109 mg/dL
    Wei Wen Hung
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Metabolism 56:528-32. 2007
    ..The 2003 criteria increased the prevalence of IFG and identified more IGT and diabetes. However, the increase of cardiovascular risks among newly identified IFG100 subjects came from those who concomitantly had IGT...
  27. doi request reprint The association of diabetes mellitus with liver, colon, lung, and prostate cancer is independent of hypertension, hyperlipidemia, and gout in Taiwanese patients
    Mei Yueh Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Metabolism 61:242-9. 2012
    ..The most common cancers were liver, colon, lung, breast, and prostate cancer; and except for breast cancer, their incidences increased independently of hypertension, dyslipidemia, and gout in patients with diabetes...
  28. ncbi request reprint SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes
    Hsing Yi Lin
    Kaohsiung Medical University Hospital, 100 Shih Chuan 1st Rd, Kaohsiung 80708, Taiwan
    Diabetes 56:1177-80. 2007
    ..CONCLUSIONS-This study indicates that the SUMO4 gene M55V variant is associated with severity of diabetic nephropathy in patients with type 2 diabetes...
  29. ncbi request reprint Effectiveness of comprehensive diabetes care program in Taiwanese with type 2 diabetes
    Kai Jen Tien
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan
    Diabetes Res Clin Pract 79:276-83. 2008
    ..To assess continuing diabetic education in Taiwan, we evaluated the impact of comprehensive diabetes care program for Taiwanese people with type 2 diabetes...
  30. doi request reprint Apolipoprotein E polymorphism and the progression of diabetic nephropathy in type 2 diabetes
    Kai Jen Tien
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan, ROC
    Am J Nephrol 33:231-8. 2011
    ..Three different apo E alleles (E2, E3 and E4) produce apo E isoproteins, which regulate the metabolism of lipoproteins. This study investigated the apo E polymorphisms as a prognostic factor for the development of diabetic nephropathy (DN)...
  31. pmc The hOGG1 Ser326Cys gene polymorphism and the risk of coronary ectasia in the Chinese population
    Po Chao Hsu
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
    Int J Mol Sci 15:1671-82. 2014
    ..03). In conclusion, our study suggests that the hOGG1 Ser326Cys gene variant might play a role in susceptibility to the development of CE. ..
  32. ncbi request reprint Effects of specific endothelin-1 receptor antagonists on proliferation and fibronectin production of glomerular mesangial cells stimulated with Angiotensin II
    Hung Tien Kuo
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 22:371-6. 2006
    ..Our results indicate that Ang-II is an active stimulant for the proliferation and fibronectin production of mesangial cells, and the effect is partly suppressed mainly by ET-1 type A receptor antagonists...
  33. ncbi request reprint Atrial natriuretic peptide attenuates high glucose-activated transforming growth factor-beta, Smad and collagen synthesis in renal proximal tubular cells
    Chao Sheng Lo
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Cell Biochem 103:1999-2009. 2008
    ..This is the first study to demonstrate that activation of TGF-beta1, Smad and collagen synthesis stimulated by high glucose can also be inhibited by exogenous ANP in renal tubular epithelial cells...
  34. doi request reprint Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review
    Yu Hung Chang
    Department of Internal Medicine, Lee s Endocrinology Clinic, Pingtung, Taiwan
    Diabetes Metab Res Rev 27:515-27. 2011
    ..No publication bias was found by the Egger test. Our study suggests that the use of visfatin may be promising for predicting obesity, diabetes status, insulin resistance, metabolic syndrome and cardiovascular disease...
  35. doi request reprint Suppression of Glutamine:fructose-6-phosphate amidotransferase-1 inhibits adipogenesis in 3T3-L1 adipocytes
    Tusty Jiuan Hsieh
    Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    J Cell Physiol 227:108-15. 2012
    ..Our results suggest that GFAT-1 plays a critical role in modulating adipogenesis via the regulation of protein O-GlcNAcylation in adipocytes...
  36. ncbi request reprint Pravastatin suppress superoxide and fibronectin production of glomerular mesangial cells induced by oxidized-LDL and high glucose
    Hung Chun Chen
    Department of Internal Medicine, Kaohsiung Medical University, 100 Shih Chuan First Road, Kaohsiung 80708, Taiwan, ROC
    Atherosclerosis 160:141-6. 2002
    ..Our results indicate that pravastatin may effect as an antioxidant and may suppress fibronectin synthesis of glomerular mesangial cells in diabetic patients with hyperlipidemia...
  37. ncbi request reprint Fulminant type 1 diabetes mellitus leading to fetal loss in a pregnant Chinese woman
    Mei Yueh Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, San Ming Area, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 26:316-20. 2010
    ..We describe a case of diabetic ketoacidosis that lead to fetal loss during week 33 of gestation in a woman who had normal glucose tolerance 11 days previously. We believe this represents a case of fulminant type 1 diabetes...
  38. ncbi request reprint A novel mutation of transferrin receptor 2 in a Taiwanese woman with type 3 hemochromatosis
    Pi Jung Hsiao
    Division of Endocrinology and Metabolism, Department of Internal Medical, Kaohsiung Medical University, Taiwan, ROC
    J Hepatol 47:303-6. 2007
    ..This case reminds physicians in Asia to keep in mind that hemochromatosis could be a rare cause of DM...
  39. doi request reprint Diabetes-related kidney, eye, and foot disease in Taiwan: an analysis of the nationwide data for 2000-2009
    Yu Yao Huang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan
    J Formos Med Assoc 111:637-44. 2012
    ..Diabetes is one of the leading causes of dialysis, blindness, and amputation worldwide. However, the prevalence of diabetes-related kidney, eye, and foot diseases has not been investigated in national surveys...
  40. doi request reprint Blockade of the renin-angiotensin system ameliorates apelin production in 3T3-L1 adipocytes
    Wei Wen Hung
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan
    Cardiovasc Drugs Ther 25:3-12. 2011
    ..Apelin, another adipokine, has been found able to restore glucose tolerance in obese and insulin-resistant mice. Because they are both involved in metabolic disorders, there may be an interaction between the two adipokines...
  41. ncbi request reprint Acute suppurative thyroiditis with deep neck infection: a case report
    Kai Jen Tien
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Thyroid 17:467-9. 2007
    ..The culture of the abscess showed Streptococcus viridans. He recovered gradually after parenteral antibiotics and surgical intervention...
  42. ncbi request reprint Emphysematous cystitis, a rare complication of urinary tract infection in a male diabetic patient: a case report
    Shih Chieh Hsin
    Division of Endocrinology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 19:132-5. 2003
    ..Treatment of the emphysematous cystitis consisted of adequate urinary drainage, empirical antibiotic therapy, and strict blood sugar control. The patient recovered satisfactorily after 9 days of hospitalization...
  43. ncbi request reprint Acute brachial artery thrombosis: a rare complication of diabetic ketoacidosis
    Kun Der Lin
    Division of Endocrinology and Metabolism, Kaohsiung Medical University Chun Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 22:44-8. 2006
    ..After emergency treatment, including insulin therapy and surgical thrombectomy, the brachial artery was rescued and her prognosis was good...
  44. doi request reprint Associations between dietary patterns and kidney function indicators in type 2 diabetes
    Chih Cheng Hsu
    Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan Department of Health Services Administration, China Medical University and Hospital, Taichung, Taiwan
    Clin Nutr 33:98-105. 2014
    ..Dietary patterns link to risks for chronic diseases. Few studies explore relationships between dietary patterns and kidney function in adult type 2 diabetes in Asian...
  45. ncbi request reprint High blood glucose and osmolality, but not high urinary glucose and osmolality, affect neuronal nitric oxide synthase expression in diabetic rat kidney
    Ming Chia Hsieh
    Department of Internal Medicine, Kaohsiung Medical University, Taiwan
    J Lab Clin Med 141:200-9. 2003
    ..In conclusion, our results indicate that nNOS mRNA expression in the kidneys of diabetic rats is directly affected by high blood glucose/osmolality but not by high urinary glucose or osmolality...
  46. ncbi request reprint Vascular endothelial growth factor gene polymorphisms in thyroid cancer
    Pi Jung Hsiao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
    J Endocrinol 195:265-70. 2007
    ..15, 95% CI=0.81-1.62, P=0.435). The other two SNPs did not show significant results. The A allele of the SNP rs699947 increased the risk of thyroid cancer development and regional lymph node metastasis in men...
  47. ncbi request reprint Insulinoma-associated transient hypothalamus-pituitary-adrenal axis impairment and amelioration by steroid therapy and surgical intervention: a case report
    Yu Hung Chang
    Department of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, 100 Shin Chuan 1st Road, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 23:526-30. 2007
    ..We treated her adrenal insufficiency and prevented serious hypoglycemia by giving her prednisolone. The impairment in her hypothalamus-pituitary-adrenal axis and her serious hypoglycemia recovered after excision of the tumor...
  48. pmc Pioglitazone retrieves hepatic antioxidant DNA repair in a mice model of high fat diet
    Pi Jung Hsiao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    BMC Mol Biol 9:82. 2008
    ..Oxidative DNA repair was detected by immunohistochemical staining and western blotting of OGG1 expression...
  49. pmc Poverty increases type 2 diabetes incidence and inequality of care despite universal health coverage
    Chih Cheng Hsu
    Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    Diabetes Care 35:2286-92. 2012
    ..We aimed to delineate whether income disparity is associated with diabetes incidence and inequality of care under a national health insurance (NHI) program in Asia...
  50. ncbi request reprint Beta-hydroxybutyrate-induced growth inhibition and collagen production in HK-2 cells are dependent on TGF-beta and Smad3
    Jinn Yuh Guh
    Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kidney Int 64:2041-51. 2003
    ..Transforming growth factor beta (TGF-beta) and tubulopathy are important in diabetic nephropathy. Thus, the role of TGF-beta and the downstream Smad3 in beta-HB-induced effects in the human proximal tubule (HK-2 cell) was studied...
  51. pmc Congenital and environmental factors associated with adipocyte dysregulation as defects of insulin resistance
    Chao Ping Wang
    Division of Cardiology, Department of Internal Medicine, E Da Hospital, I Shou University, Kaohsiung, 82445 Taiwan
    Rev Diabet Stud 4:77-84. 2007
    ..The metabolic syndrome is a modern disease resulting adipocyte dysmetabolism resulting from the paradox of the slow human evolution combined with rapid environmental changes...
  52. doi request reprint Cholesteryl ester transfer protein B1B1 genotype is associated with a parental history of cardiovascular diseases in Taiwanese people
    Ming Chia Hsieh
    Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Med Princ Pract 17:143-8. 2008
    ..To investigate the association between family history of cardiovascular disease (CVD) and cholesteryl ester transfer protein (CETP) TaqIB polymorphism in Taiwanese subjects...
  53. ncbi request reprint Circulating adiponectin level is associated with major adverse cardiovascular events in type 2 diabetic patients with coronary artery disease
    Wei Chin Hung
    Division of Cardiology, Department of Internal Medicine, E Da Hospital, I Shou University, Kaohsiung, Taiwan
    Endocr J 57:793-802. 2010
    ..This indicates that plasma ADPN may have potential roles in high risk T2DM patients with ischemic heart disease...
  54. ncbi request reprint Risk of endophthalmitis after cataract surgery using different protocols for povidone- iodine preoperative disinfection
    Pei Chang Wu
    Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
    J Ocul Pharmacol Ther 22:54-61. 2006
    ....
  55. ncbi request reprint Down-regulation of adrenal neuronal nitric oxide synthase mRNAs and proteins after deoxycorticosterone acetate-salt treatment in rats
    Feng Jie Lai
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Steroid Biochem Mol Biol 101:197-203. 2006
    ..7-fold down-regulated after DOCA-salt treatment. Our results indicated that the down-regulation of adrenal nNOS synthesis might be associated with the inactivation of adrenal function in face of volume expansion...
  56. doi request reprint Local action of endogenous renal tubular atrial natriuretic peptide
    Chao Sheng Lo
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Cell Physiol 219:776-86. 2009
    ..J. Cell. Physiol. 219: 776-786, 2009. (c) 2009 Wiley-Liss, Inc...
  57. ncbi request reprint Endothelin-1 antisense oligonucleotide suppresses the proliferation of glomerular mesangial cells stimulated with angiotensin-II
    Jia Jung Lee
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 23:170-5. 2007
    ..Our results indicate that ET-1 AON effectively suppresses the ET-1 production and the Ang-II-stimulated proliferation of mesangial cells, and therefore may offer treatment for proliferative glomerulonephritis...
  58. doi request reprint Serum retinol-binding protein 4 is inversely correlated with disease severity of chronic hepatitis C
    Jee Fu Huang
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Hepatol 50:471-8. 2009
    ..Recently, retinol-binding protein 4 (RBP4) has been reported as a protein contributing to IR. This study aimed to assess the correlation between RBP4 and disease severity of chronic HCV infection (CHC)...
  59. doi request reprint Diabetic muscle infarction in association with terlipressin therapy: a case report
    Yu Hung Chang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 25:25-8. 2009
    ..Magnetic resonance imaging suggested acute muscle infarction. We performed a muscle biopsy and the pathologist reported that the muscle was necrotic. After 5 days of bed rest, the patient was able to walk and was discharged uneventfully...