Chun Ching Lin
Affiliation: Kaohsiung Medical University
Ng L, Lin L, Chen C, Chen H, Wu S, Lin C. Anti-melanogenic effects of ?-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells. Phytomedicine. 2014;21:978-83 pubmed publisher
..These data provide insight to ?T3's effect and the targeting of ERK signaling for treatment against melanogenesis. ..
Lin L, Chung C, Hsu W, Chang S, Hung T, Shields J, et al
. Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. J Hepatol. 2015;62:541-8 pubmed publisher
..Due to its potency, SSb2 may be of value for development as an antagonist of HCV entry and could be explored as prophylactic treatment during the course of liver transplantation. ..
Hsu W, Chang S, Lin L, Li C, Richardson C, Lin C, et al
. Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry. Antiviral Res. 2015;118:139-47 pubmed publisher
..Due to their potency and ability to target HCV early viral entry, LS-UW and GA may be of value for further development as prospective antivirals against HCV. ..
Tzeng C, Tzeng W, Lin L, Lee C, Yen F, Lin C. Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system. Phytomedicine. 2016;23:528-40 pubmed publisher
..The research provided a basis of ArtN could be explored as a low-dose alternative of artocarpin in anticancer treatment and research applications. ..
Chung C, Liu C, Burnouf T, Wang G, Chang S, Jassey A, et al
. Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry. Antiviral Res. 2016;130:58-68 pubmed publisher
..This is the first report characterizing P.Â urinaria and its bioactive compound LOD as potent HCV entry inhibitors, which merit further evaluation for development as candidate antiviral agents against hepatitis C. ..
Ko H, Tsai Y, Yen M, Lin C, Liang C, Yang T, et al
. Norartocarpetin from a folk medicine Artocarpus communis plays a melanogenesis inhibitor without cytotoxicity in B16F10 cell and skin irritation in mice. BMC Complement Altern Med. 2013;13:348 pubmed publisher
..Norartocarpetin is one of the antioxidant and antityrosinase activity compound in Artocarpus communis; however, the cytotoxicity, skin irritation and antimelanogenesis mechanisms of norartocarpetin have not been investigated yet...