Shih Hsien Hsu


Affiliation: Kaohsiung Medical University
Country: Taiwan


  1. Wang L, Chiou S, Chai C, Hsi E, Yokoyama K, Wang S, et al. Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression. Cancer Res. 2017;77:4065-4077 pubmed publisher
    ..i>Cancer Res; 77(15); 4065-77. ©2017 AACR. ..
  2. Wang L, Wang S, Chiou S, Liu K, Chai C, Chiang C, et al. TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial-mesenchymal transition and metastasis in liver cancer. Oncogene. 2018;: pubmed publisher
    ..Our findings highlight the importance of acetylation signaling in the SPZ1-TWIST1-BRD4 axis in the mediation of EMT and its regulation during tumor initiation and metastasis. ..
  3. Chiou S, Wang L, Huang S, Chai C, Wang S, Liao Y, et al. Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling. Carcinogenesis. 2014;35:2357-64 pubmed publisher
    ..Therefore, Wls may provide a potential future therapeutic target, particularly for patients who do not respond to existing therapies and suffer relapse. ..
  4. Chen C, Yen C, Wang H, Yang H, Tang J, Huang H, et al. Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage. Toxins (Basel). 2016;8: pubmed
    ..Taken together, we infer that TFB can selectively inhibit cell proliferation of oral cancer cells through apoptosis, ROS generation, mitochondrial membrane depolarization, and DNA damage. ..
  5. Liu K, Wang L, Hsu S. Modification of Epigenetic Histone Acetylation in Hepatocellular Carcinoma. Cancers (Basel). 2018;10: pubmed publisher
  6. Hsu S, Wang L, Lee K, Chen Y, Liu K, Suen J, et al. Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma. Cancer Res. 2013;73:508-18 pubmed publisher
    ..Together, our results highlight ISX as an important regulator in hepatoma progression with significant potential as a prognostic and therapeutic target in HCCs. ..
  7. Wang L, Chiou S, Liao Y, Jong Y, Hsu S. Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy. Kaohsiung J Med Sci. 2014;30:229-34 pubmed publisher
    ..These results clearly suggested that cellular SMN proteins regulated miR-9 expression and that miR-9 expression was related to SMA severity. Thus, miR-9 may be a marker for SMA prognosis. ..