Hsiao Ling Chen

Summary

Affiliation: Chung Shan Medical University
Country: Taiwan

Publications

  1. ncbi request reprint Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Taichung, Taiwan, R O C
    J Am Coll Nutr 22:36-42. 2003
  2. ncbi request reprint Inhibitory effects of a soluble dietary fiber from Amorphophallus konjac on cytotoxicity and DNA damage induced by fecal water in Caco-2 cells
    Shu Lan Yeh
    School of Nutrition, Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan, ROC
    Planta Med 73:1384-8. 2007
  3. ncbi request reprint Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial
    Hsiao Ling Chen
    Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan 402
    J Am Coll Nutr 27:102-8. 2008
  4. ncbi request reprint Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults
    Hsiao Ling Chen
    Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan
    Nutrition 22:1112-9. 2006
  5. doi request reprint Comparative effects of cellulose and soluble fibers (pectin, konjac glucomannan, inulin) on fecal water toxicity toward Caco-2 cells, fecal bacteria enzymes, bile acid, and short-chain fatty acids
    Hsiao Ling Chen
    School of Nutrition, Chung Shan Medical University, and Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan
    J Agric Food Chem 58:10277-81. 2010
  6. ncbi request reprint Unhydrolyzed and hydrolyzed konjac glucomannans modulated cecal and fecal microflora in Balb/c mice
    Hsiao Ling Chen
    School of Nutrition, Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Nutrition 21:1059-64. 2005
  7. doi request reprint Antioxidative and hepatoprotective effects of fructo-oligosaccharide in d-galactose-treated Balb/cJ mice
    Hsiao Ling Chen
    School of Nutrition, Chung Shan Medical University, Taichung City, Taiwan, ROC
    Br J Nutr 105:805-9. 2011
  8. ncbi request reprint Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, People s Republic of China
    Nutrition 19:646-51. 2003
  9. ncbi request reprint Fiber intake and food selection of the elderly in Taiwan
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Chung Shan Medical University, Republic of China, Taichung, Taiwan, Republic of China
    Nutrition 19:332-6. 2003
  10. doi request reprint Fructo-oligosaccharide systemically diminished D-galactose-induced oxidative molecule damages in BALB/cJ mice
    Chien Hsun Hsia
    Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC
    Br J Nutr 107:1787-92. 2012

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Taichung, Taiwan, R O C
    J Am Coll Nutr 22:36-42. 2003
    ..6 g/day) for 28 days on blood lipid and glucose levels in hyperlipidemic type 2 diabetic patients and the possible mechanism for the reductions in blood lipid levels...
  2. ncbi request reprint Inhibitory effects of a soluble dietary fiber from Amorphophallus konjac on cytotoxicity and DNA damage induced by fecal water in Caco-2 cells
    Shu Lan Yeh
    School of Nutrition, Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan, ROC
    Planta Med 73:1384-8. 2007
    ..FF: fiber free FO: oligofructose KGM: konjac glucomannan...
  3. ncbi request reprint Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial
    Hsiao Ling Chen
    Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan 402
    J Am Coll Nutr 27:102-8. 2008
    ..In addition, the mechanisms by which KGM modulated the bowel habit were explored...
  4. ncbi request reprint Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults
    Hsiao Ling Chen
    Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan
    Nutrition 22:1112-9. 2006
    ..Konjac glucomannan (KGM) has been shown to relieve constipation, which could be associated with increased stool bulk and improved colonic ecology...
  5. doi request reprint Comparative effects of cellulose and soluble fibers (pectin, konjac glucomannan, inulin) on fecal water toxicity toward Caco-2 cells, fecal bacteria enzymes, bile acid, and short-chain fatty acids
    Hsiao Ling Chen
    School of Nutrition, Chung Shan Medical University, and Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan
    J Agric Food Chem 58:10277-81. 2010
    ....
  6. ncbi request reprint Unhydrolyzed and hydrolyzed konjac glucomannans modulated cecal and fecal microflora in Balb/c mice
    Hsiao Ling Chen
    School of Nutrition, Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Nutrition 21:1059-64. 2005
    ..Short-chain fatty acid concentrations in cecal content were also determined...
  7. doi request reprint Antioxidative and hepatoprotective effects of fructo-oligosaccharide in d-galactose-treated Balb/cJ mice
    Hsiao Ling Chen
    School of Nutrition, Chung Shan Medical University, Taichung City, Taiwan, ROC
    Br J Nutr 105:805-9. 2011
    ....
  8. ncbi request reprint Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, People s Republic of China
    Nutrition 19:646-51. 2003
    ..This study investigated the effects of a Taiwanese yam, Dioscorea japonica Thunb var. pseudojaponica Yamamoto, on upper gut function and lipid metabolism in adult Balb/c mice...
  9. ncbi request reprint Fiber intake and food selection of the elderly in Taiwan
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Chung Shan Medical University, Republic of China, Taichung, Taiwan, Republic of China
    Nutrition 19:332-6. 2003
    ..We assessed fiber intakes and determined the major food categories that contribute to dietary fiber intakes in the Taiwanese elderly. We also examined the association between fiber intake and health status...
  10. doi request reprint Fructo-oligosaccharide systemically diminished D-galactose-induced oxidative molecule damages in BALB/cJ mice
    Chien Hsun Hsia
    Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC
    Br J Nutr 107:1787-92. 2012
    ..c. DG treatment in younger BALB/cJ mice resembled the oxidative status in older mice. FO supplementation systemically prevented DG-induced oxidative stress, probably through its fermentation products and prebiotic effect...
  11. doi request reprint Long-term supplementation of isomalto-oligosaccharides improved colonic microflora profile, bowel function, and blood cholesterol levels in constipated elderly people--a placebo-controlled, diet-controlled trial
    Chi Hua Yen
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Nutrition 27:445-50. 2011
    ..We also assessed whether the effect of IO was sustained after its withdrawal...
  12. doi request reprint Konjac glucomannan and inulin systematically modulate antioxidant defense in rats fed a high-fat fiber-free diet
    Wen Tzu Wu
    School of Nutrition, Chung Shan Medical University, Taichung, Taiwan
    J Agric Food Chem 59:9194-200. 2011
    ..These results suggest that in vivo utilization of KGM and inulin stimulated both local and systemic antioxidative defense systems in rats...
  13. doi request reprint Effects of konjac glucomannan on putative risk factors for colon carcinogenesis in rats fed a high-fat diet
    Wen Tzu Wu
    School of Nutrition, Chung Shan Medical University, Taichung, Taiwan
    J Agric Food Chem 59:989-94. 2011
    ..Therefore, the present study suggests that KGM potentially attenuated the high fat-induced risk in colon carcinogenesis...
  14. doi request reprint Beneficial effects of fructo-oligosaccharides supplementation on fecal bifidobacteria and index of peroxidation status in constipated nursing-home residents--a placebo-controlled, diet-controlled trial
    Chi Hua Yen
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Nutrition 27:323-8. 2011
    ..The associations of fecal bifidobacteria and blood measurements were also examined...
  15. pmc Imprinted genes and satellite loci are differentially methylated in bovine somatic cell nuclear transfer clones
    Chih Jie Shen
    1 Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung, 402, Taiwan
    Cell Reprogram 15:413-24. 2013
    ..Our data suggest that the reprogramming of the methylation-controlled regions between the imprinted genes and satellite loci are differences and may be involved with additional mechanisms that need further elucidation...
  16. pmc Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury
    Shih Tao Wen
    Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 8:e75383. 2013
    ..Intravenous administration of AFSCs may offer a new therapeutic strategy for acute lung injury (ALI), for which efficient treatments are currently unavailable. ..
  17. pmc Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury
    Chih Ching Yen
    Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 6:e26870. 2011
    ..The results encourage the use of an aerosol therapy with EC-SOD in intensive care units to reduce oxidative injury in patients with severe hypoxemic respiratory failure, including acute respiratory distress syndrome (ARDS)...
  18. doi request reprint Ameliorative effects of konjac glucomannan on human faecal β-glucuronidase activity, secondary bile acid levels and faecal water toxicity towards Caco-2 cells
    Wen Tzu Wu
    School of Nutrition, Chung Shan Medical University, No 110, Section 1, Jianguo North Road, Taichung City 402, Taiwan, ROC
    Br J Nutr 105:593-600. 2011
    ....
  19. pmc FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration
    Cheng Wei Lai
    Department of Life Sciences, Agricultural Biotechnology Center, iEGG center, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 9:e90818. 2014
    ..coli RrmJ and conserves the heat shock protein properties. Moreover, FTSJ2 possesses suppressive effects on the invasion and migration of cancer cells. ..
  20. pmc Methylation target array for rapid analysis of CpG island hypermethylation in multiple tissue genomes
    Chuan Mu Chen
    Department of Life Sciences, National Chung Hsing University, Taiwan, Republic of China
    Am J Pathol 163:37-45. 2003
    ..This novel approach thus provides an additional avenue for assessing clinicopathological consequences of DNA hypermethylation in breast cancer...
  21. pmc Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness
    Hsu Chung Liu
    Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Kuo Kuang Rd, Taichung, 402, Taiwan
    Allergy Asthma Clin Immunol 9:21. 2013
    ..It has not been clearly demonstrated whether milk from transgenic animals expressing recombinant allergens has immunomodulatory effects on allergic asthma...
  22. doi request reprint Treadmill running upregulates the expression of acetylcholine receptor in rat gastrocnemius following botulinum toxin A injection
    Sen Wei Tsai
    Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan
    J Orthop Res 31:125-31. 2013
    ..The expression of genes associated with neurite and AChR regeneration following treadmill exercise was upregulated, which may have contributed to enhanced recovery of gastrocnemius strength...
  23. pmc Differential differences in methylation status of putative imprinted genes among cloned swine genomes
    Chih Jie Shen
    Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 7:e32812. 2012
    ..Understanding the aberrant pattern of gene imprinting would permit improvements in future cloning techniques...
  24. doi request reprint Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice
    Yu Tang Tung
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    Mol Nutr Food Res 55:1036-43. 2011
    ..We investigated the inhibition of pulmonary tumor formation through treatment with curcumin in transgenic mice...
  25. doi request reprint Application of porcine lipase secreted by pichia pastoris to improve fat digestion and growth performance of postweaning piglets
    Fang Chueh Liu
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    J Agric Food Chem 58:3322-9. 2010
    ..These results suggested that the porcine lipase protein yielded by transformed yeast cells may improve fat digestibility and enhance the growth performance in postweaning piglets...
  26. ncbi request reprint Fructo-oligosaccharide attenuates the production of pro-inflammatory cytokines and the activation of JNK/Jun pathway in the lungs of D-galactose-treated Balb/cJ mice
    Shu Lan Yeh
    School of Nutrition, Chung Shan Medical University, No 110, Sec 1 Jianguo N Rd, Taichung, Taiwan, ROC
    Eur J Nutr 53:449-56. 2014
    ..This study determined the effects of long-term D-galactose (DG) injection on the lung pro-inflammatory and fibrotic status and whether fructo-oligosaccharide (FO) could attenuate such effects...
  27. ncbi request reprint Effects of konjac glucomannan, inulin and cellulose on acute colonic responses to genotoxic azoxymethane
    Wen Tzu Wu
    School of Nutrition, Chung Shan Medical University, No 110, Sec 1 Jianguo N Rd, Taichung City 402, Taiwan
    Food Chem 155:304-10. 2014
    ..This study suggested that soluble fibres were more effective than cellulose on ameliorating AOM-induced genotoxicity by up-regulating antioxidant enzyme genes, and enhancing epithelium apoptosis by down-regulating Bcl-2. ..
  28. doi request reprint Production of recombinant porcine colipase secreted by Pichia pastoris and its application to improve dietary fat digestion and growth of postweaning piglets
    Fang Chueh Liu
    Dept of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    Biotechnol Prog 24:1333-41. 2008
    ..16.37 mg/dL; P < 0.0001). These experimental data suggest that the use of recombinant porcine colipase as a dietary supplement provides an alternative approach for improving fat digestion and enhancing growth in postweaning piglets...
  29. ncbi request reprint Hypocholesterolaemic effects of milk-kefir and soyamilk-kefir in cholesterol-fed hamsters
    Je Ruei Liu
    Department of Biotechnology, National Formosa University, Taiwan
    Br J Nutr 95:939-46. 2006
    ..These findings demonstrate that soyamilk-kefir may be considered to be among the more promising food components in terms of preventing CVD through its hypocholesterolaemic action...
  30. ncbi request reprint Synthetic porcine lactoferricin with a 20-residue peptide exhibits antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans
    Hsiao Ling Chen
    Department of Molecular Biotechnology, Da Yeh University, Changhwa, Taiwan
    J Agric Food Chem 54:3277-82. 2006
    ..LFcin P-20 was 4 times more effective than human lactoferricin (LFcin H-20), but slightly less effective than bovine lactoferricin (LFcin B-20)...
  31. ncbi request reprint Recombinant porcine lactoferrin expressed in the milk of transgenic mice enhances offspring growth performance
    Shinn Chih Wu
    Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan
    J Agric Food Chem 55:4670-7. 2007
    ..Furthermore, this enhanced growth performance in suckling mice was proportional to the concentration of pLF present in milk...
  32. doi request reprint Recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonatal mice from a lethal challenge with enterovirus type 71
    Hsiao Ling Chen
    Department of Molecular Biotechnology, Da Yeh University, Changhwa 51501, Taiwan
    Vaccine 26:891-8. 2008
    ..Our data suggest that oral intake of pLF-enriched milk exhibited the ability to prevent infection with EV71. The study also provides an animal model for validating the protective effects of pLF...
  33. doi request reprint Effects of reflexotherapy on acute postoperative pain and anxiety among patients with digestive cancer
    Shiow Luan Tsay
    Graduate Institute of Nursing, National Taipei College of Nursing, Taipei, Taiwan
    Cancer Nurs 31:109-15. 2008
    ..05). Findings from this study provide nurses with an additional treatment to offer postoperative digestive cancer patients...
  34. ncbi request reprint Production of recombinant porcine lactoferrin exhibiting antibacterial activity in methylotrophic yeast, Pichia pastoris
    Hsiao Ling Chen
    Department of Molecular Biotechnology, Da Yeh University, Changhwa, Taiwan
    J Mol Microbiol Biotechnol 8:141-9. 2004
    ..Our results suggested that the methylotrophic yeast-inducible system is suitable for large-scale production of active antibacterial rPLF glycoprotein...