Wen Hsiung Chan

Summary

Affiliation: Chung Yuan Christian University
Country: Taiwan

Publications

  1. doi request reprint Citrinin induces apoptosis in mouse embryonic stem cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    IUBMB Life 60:171-9. 2008
  2. pmc Hazardous apoptotic effects of 2-bromopropane on maturation of mouse oocytes, fertilization, and fetal development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan E Mail Tel 886 3 265 3515
    Int J Mol Sci 11:4361-80. 2010
  3. ncbi request reprint Protective effects of resveratrol on ethanol-induced apoptosis in embryonic stem cells and disruption of embryonic development in mouse blastocysts
    Lien Hung Huang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 242:109-22. 2007
  4. pmc Characterization of apoptosis induced by emodin and related regulatory mechanisms in human neuroblastoma cells
    Fu Jen Huang
    Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
    Int J Mol Sci 14:20139-56. 2013
  5. pmc Ochratoxin a inhibits mouse embryonic development by activating a mitochondrion-dependent apoptotic signaling pathway
    Yan Der Hsuuw
    Department of Life Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
    Int J Mol Sci 14:935-53. 2013
  6. pmc Injurious Effects of Emodin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Int J Mol Sci 13:13911-25. 2012
  7. ncbi request reprint Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200 Chung Pai Road, 32023 Chung Li, Taiwan
    Toxicol Lett 161:1-9. 2006
  8. ncbi request reprint Dosage effects of ginkgolide B on ethanol-induced cell death in human hepatoma G2 cells
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Ann N Y Acad Sci 1095:388-98. 2007
  9. ncbi request reprint Effect of citrinin on mouse embryonic development in vitro and in vivo
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Reprod Toxicol 24:120-5. 2007
  10. ncbi request reprint Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 103:1144-57. 2008

Collaborators

  • Fu Jen Huang
  • Jau Song Yu
  • Hong Yo Kang
  • Kun Hsiung Lee
  • Chih Ping Chen
  • Yan Der Hsuuw
  • Mei Hui Chang
  • Ming Shu Hsieh
  • Nion Heng Shiao
  • Yu Ting Huang
  • Ching Yu Lai
  • Hsiao Chen Tu
  • Po Wn Li
  • Ying Jing Chang
  • Jui Ming Yeh
  • Chen Kang Chang
  • Mei Hui Ni
  • Pin Zhen Lu
  • Hsin Jung Wu
  • Lien Hung Huang
  • Shao Chung Chang
  • Tai Hung Kuo
  • Ji Hao Chang
  • Tzong Fu Kuo
  • Yen Chih Liu
  • Shyh Liang Lou
  • Kun Yi Chien
  • Chih Ching Wu
  • Hung Fu Tseng
  • Lan Chi Shieh

Detail Information

Publications50

  1. doi request reprint Citrinin induces apoptosis in mouse embryonic stem cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    IUBMB Life 60:171-9. 2008
    ..On the basis of these findings, we propose a model for CTN-induced cell injury signalling cascades in embryonic stem cells and blastocysts...
  2. pmc Hazardous apoptotic effects of 2-bromopropane on maturation of mouse oocytes, fertilization, and fetal development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan E Mail Tel 886 3 265 3515
    Int J Mol Sci 11:4361-80. 2010
    ..These results collectively confirm the hazardous effects of 2-BP on embryos derived from pretreated oocytes...
  3. ncbi request reprint Protective effects of resveratrol on ethanol-induced apoptosis in embryonic stem cells and disruption of embryonic development in mouse blastocysts
    Lien Hung Huang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 242:109-22. 2007
    ..These changes were blocked by pretreatment with resveratrol. Based on these results, we propose a model for the protective effect of resveratrol on ethanol-induced cell injury in blastocysts and ESC-B5 cells...
  4. pmc Characterization of apoptosis induced by emodin and related regulatory mechanisms in human neuroblastoma cells
    Fu Jen Huang
    Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
    Int J Mol Sci 14:20139-56. 2013
    ..Based on the collective results, we propose a model for an emodin-triggered apoptotic signaling cascade that sequentially involves ROS, Ca²⁺, NO, p53, caspase-9 and caspase-3...
  5. pmc Ochratoxin a inhibits mouse embryonic development by activating a mitochondrion-dependent apoptotic signaling pathway
    Yan Der Hsuuw
    Department of Life Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
    Int J Mol Sci 14:935-53. 2013
    ..In addition, OTA induces apoptosis-mediated injury of mouse blastocysts, via reactive oxygen species (ROS) generation, and promotes mitochondrion-dependent apoptotic signaling processes that impair subsequent embryonic development...
  6. pmc Injurious Effects of Emodin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Int J Mol Sci 13:13911-25. 2012
    ..Notably, pretreatment with a caspase-3-specific inhibitor effectively prevented emodin-triggered injury effects, suggesting that impairment of embryo development occurs via a caspase-dependent apoptotic process...
  7. ncbi request reprint Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200 Chung Pai Road, 32023 Chung Li, Taiwan
    Toxicol Lett 161:1-9. 2006
    ..Thus our findings support the possibility that appropriate dosage of resveratrol aids in decreasing the toxic effect of ethanol...
  8. ncbi request reprint Dosage effects of ginkgolide B on ethanol-induced cell death in human hepatoma G2 cells
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Ann N Y Acad Sci 1095:388-98. 2007
    ....
  9. ncbi request reprint Effect of citrinin on mouse embryonic development in vitro and in vivo
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Reprod Toxicol 24:120-5. 2007
    ..The extent to which CTN may have teratogenic potential in early human development is not known...
  10. ncbi request reprint Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 103:1144-57. 2008
    ..necrosis) in HUVECs, and both ROS and NO played important roles in MG/HG-induced apoptosis of these cells...
  11. doi request reprint Cytotoxic effect of CdSe quantum dots on mouse embryonic development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, China
    Acta Pharmacol Sin 29:259-66. 2008
    ..The aim of this study was to examine the cytotoxic effect of quantum dots (QD), a novel luminescent material, on early post-implantation embryonic development...
  12. doi request reprint Effects of citrinin on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, 32023, Taiwan
    Toxicol Lett 180:28-32. 2008
    ..To our knowledge, this is the first study investigating the impact of CTN on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  13. doi request reprint Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Toxicol Lett 205:285-92. 2011
    ..However, the extent to which sanguinarine exerts teratogenic effects on early human development is not known at present, and further studies are required to establish effective protection strategies against its cytotoxic effects...
  14. pmc Photodynamic Treatment Induces an Apoptotic Pathway Involving Calcium, Nitric Oxide, p53, p21-Activated Kinase 2, and c-Jun N-Terminal Kinase and Inactivates Survival Signal in Human Umbilical Vein Endothelial Cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E Mail Tel 886 3 2653515
    Int J Mol Sci 12:1041-59. 2011
    ....
  15. doi request reprint Impact of genistein on maturation of mouse oocytes, fertilization, and fetal development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200, Chung Pei Road, Chung Li 32023, Taiwan
    Reprod Toxicol 28:52-8. 2009
    ..To our knowledge, this is the first study investigating the impact of GNT on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  16. pmc Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Biochem J 404:317-26. 2007
    ....
  17. ncbi request reprint Effect of genistein on mouse blastocyst development in vitro
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan, China
    Acta Pharmacol Sin 28:238-45. 2007
    ..To examine the cytotoxic effects of genistein, an isoflavone compound, on early postimplantation embryonic development in vitro...
  18. ncbi request reprint Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 100:1056-69. 2007
    ..Collectively, these results reveal for the first time that MG treatment triggers apoptosis in osteoblasts via specific apoptotic signaling, and causes BMD loss in vivo...
  19. ncbi request reprint Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China
    J Cell Biochem 90:327-38. 2003
    ....
  20. ncbi request reprint Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China
    J Cell Biochem 92:200-12. 2004
    ....
  21. ncbi request reprint Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 94:1267-79. 2005
    ..The results of this report collectively imply the involvement of oxidative stress in high glucose-induced apoptosis and alterations in attachment ability. Moreover, resveratrol blocks these events by virtue of its antioxidant property...
  22. ncbi request reprint Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan 32023
    Ann N Y Acad Sci 1042:372-8. 2005
    ..The results demonstrate that curcumin significantly attenuates MG-induced ROS formation, and suggest that ROS triggers cytochrome c release, caspase activation, and subsequent apoptotic biochemical changes...
  23. pmc Resveratrol Protects against 2-Bromopropane-Induced Apoptosis and Disruption of Embryonic Development in Blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E Mail Tel 886 3 2653515
    Int J Mol Sci 12:4991-5010. 2011
    ..Our results collectively imply that 2-BP triggers the mitochondrion-dependent apoptotic pathway via ROS generation, and the antioxidant activity of resveratrol prevents 2-BP-induced toxicity...
  24. ncbi request reprint Ginkgolides induce apoptosis and decrease cell numbers in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Biochem Biophys Res Commun 338:1263-7. 2005
    ..These novel findings provide important new insights into the effect of Ginkgo biloba extracts on mouse blastocysts...
  25. ncbi request reprint Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Hum Reprod 21:2985-95. 2006
    ..Here, we report more detailed examinations of the cytotoxic effects of ginkgolide B on mouse embryonic stem cells (ESCs) and blastocysts and their subsequent development in vitro and in vivo...
  26. ncbi request reprint Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan, China
    Acta Pharmacol Sin 27:1192-8. 2006
    ..To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids...
  27. ncbi request reprint CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals
    Wen Hsiung Chan
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 167:191-200. 2006
    ....
  28. pmc Cytotoxic effects of 2-bromopropane on embryonic development in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Int J Mol Sci 11:731-44. 2010
    ..Our results collectively indicate that in vitro exposure to 2-BP induces apoptosis, suppresses implantation rates after transfer to host mice, and retards early postimplantation development...
  29. ncbi request reprint Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts
    Yan Der Hsuuw
    Department of Animal Science, National Pingtung University of Science and Technology, Taiwan, Republic of China
    J Cell Physiol 205:379-86. 2005
    ..The results support the hypothesis that curcumin inhibits MG-induced apoptosis in mouse ESC-B5 cells and blastocysts by blocking ROS formation and subsequent apoptotic biochemical events...
  30. ncbi request reprint Dosage effects of curcumin on cell death types in a human osteoblast cell line
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Food Chem Toxicol 44:1362-71. 2006
    ..Overall, our results signify that curcumin dosage treatment determines the possible effect on ROS generation, intracellular ATP levels, and cell apoptosis or necrosis in osteoblast cells...
  31. doi request reprint Injury effects of ginkgolide B on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo
    Nion Heng Shiao
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 188:63-9. 2009
    ..To our knowledge, this is the first study to investigate the impact of GKB on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  32. ncbi request reprint Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
    Hsin Jung Wu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200, Chung Pei Road, Chung Li 32023, Taiwan, ROC
    Toxicol In Vitro 21:335-42. 2007
    ..These results collectively suggest that oxidative stress plays a role in MG-induced cell injury, and that genistein blocks these effects by virtue of its antioxidant properties, consequently preventing cell apoptosis...
  33. doi request reprint Impact effects of puerarin on mouse embryonic development
    Chia Chi Chen
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Reprod Toxicol 28:530-5. 2009
    ..The extent to which puerarin may have teratogenic potential in early human development is not yet known...
  34. doi request reprint Epicatechin gallate decreases the viability and subsequent embryonic development of mouse blastocysts
    Hsiao Chen Tu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Taiwan J Obstet Gynecol 49:174-80. 2010
    ....
  35. doi request reprint Retinoic acid influences the embryoid body formation in mouse embryonic stem cells by induction of caspase and p38 MAPK/JNK-mediated apoptosis
    Fu Jen Huang
    Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Environ Toxicol 28:190-200. 2013
    ..The process of EB formation (mimicking the early postimplantation embryo development) is regulated by RA-induced apoptosis through the activation of caspase and P38 MAPK/JNK pathway...
  36. doi request reprint Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells
    Yan Der Hsuuw
    Department of Life Science, National Pingtung University of Science and Technology, Pingtung, Taiwan
    Ann N Y Acad Sci 1171:501-8. 2009
    ..Experiments using caspase-3 inhibitors and antisense oligonucleotides against PAK2 showed that caspase-3 activation is required for PAK2 activation and both of these activations are required for GKB-induced apoptosis in ESC-B5 cells...
  37. doi request reprint Effect of curcumin on in vitro early post-implantation stages of mouse embryo development
    Fu Jen Huang
    Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Eur J Obstet Gynecol Reprod Biol 166:47-51. 2013
    ..This study was designed to examine the embryotoxic potential of the curcumin at the blastocyst stage and during early post-implantation development of mouse embryos in vitro...
  38. doi request reprint Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line
    Yu Ting Huang
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Environ Toxicol 24:343-56. 2009
    ..On the basis of these results, we propose a signaling cascade model for CTN-induced apoptosis in human osteoblasts involving ROS, JNK, caspases, and PAK2...
  39. doi request reprint Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles
    Po Wn Li
    Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 197:82-7. 2010
    ..The results collectively show that nanoAg has the potential to induce embryo cytotoxicity. Further studies are required to establish effective protection strategies against the cytotoxic effects of these nanoparticles...
  40. doi request reprint Methylglyoxal has injurious effects on maturation of mouse oocytes, fertilization, and fetal development, via apoptosis
    Ying Jing Chang
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 193:217-23. 2010
    ..Finally, pretreatment with a caspase-3-specific inhibitor effectively prevented MG-triggered injury effects, suggesting that embryo impairment by MG occurs via a caspase-dependent apoptotic process...
  41. pmc Impact of methylglyoxal and high glucose co-treatment on human mononuclear cells
    Ming Shu Hsieh
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan 32023
    Int J Mol Sci 10:1445-64. 2009
    ..The results collectively suggest that the treatment dosage of MG and glucose determines the mode of cell death (apoptosis vs. necrosis) of HMNCs, and that both ROS and NO play important roles in MG/HG-induced apoptosis...
  42. ncbi request reprint Epigallocatechin gallate dose-dependently induces apoptosis or necrosis in human MCF-7 cells
    Yan Der Hsuuw
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Ann N Y Acad Sci 1095:428-40. 2007
    ....
  43. doi request reprint Emodin induces embryonic toxicity in mouse blastocysts through apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 299:25-32. 2012
    ..These results collectively indicate that emodin has the potential to induce embryonic cytotoxicity...
  44. doi request reprint Impact of dihydrolipoic acid on mouse embryonic stem cells and related regulatory mechanisms
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Environ Toxicol 28:87-97. 2013
    ..These results provide important information in terms of dosage safety and biocompatibility of DHLA to facilitate its further use as a precursor for biomaterial preparation...
  45. pmc Hazardous Effects of Curcumin on Mouse Embryonic Development through a Mitochondria-Dependent Apoptotic Signaling Pathway
    Chia Chi Chen
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan E Mails C C C M S H
    Int J Mol Sci 11:2839-55. 2010
    ..In addition, curcumin induces apoptotic injury effects on mouse blastocysts through ROS generation, and further promotes mitochondria-dependent apoptotic signaling processes to impair sequent embryonic development...
  46. ncbi request reprint GSK-3 mediates the okadaic acid-induced modification of collapsin response mediator protein-2 in human SK-N-SH neuroblastoma cells
    Mei Hui Ni
    Graduate Institute of Basic Medical Sciences, Medical College of Chang Gung University, Tao Yuan, Taiwan, Republic of China
    J Cell Biochem 103:1833-48. 2008
    ....
  47. pmc Cytotoxic effects of CdSe quantum dots on maturation of mouse oocytes, fertilization, and fetal development
    Ming Shu Hsieh
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Int J Mol Sci 10:2122-35. 2009
    ..To our knowledge, this is the first study to report the negative impact of CdSe-core QDs on mouse oocyte development. Moreover, surface modification of CdSe-core QDs with ZnS effectively prevented this cytotoxicity...
  48. pmc Caffeine Induces Cell Death via Activation of Apoptotic Signal and Inactivation of Survival Signal in Human Osteoblasts
    Pin Zhen Lu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan 32023
    Int J Mol Sci 9:698-718. 2008
    ....
  49. pmc Injurious Effects of Curcumin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis
    Chia Chi Chen
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E mail
    Int J Mol Sci 13:4655-72. 2012
    ..Finally, pretreatment with a caspase-3-specific inhibitor effectively prevented curcumin-triggered injury effects, suggesting that embryo impairment by curcumin occurs mainly via a caspase-dependent apoptotic process...
  50. ncbi request reprint Higher LDL oxidation at rest and after a rugby game in weekend warriors
    Chen Kang Chang
    Department of Nutrition and Health Science, Fooyin Institute of Technology, Kaohsiung, Taiwan
    Ann Nutr Metab 46:103-7. 2002
    ..The results are compared with those of sedentary controls (CON, n = 10) and trained rugby players (TR, n = 15)...