Wen Hsiung Chan

Summary

Affiliation: Chung Yuan Christian University
Country: Taiwan

Publications

  1. Chan W. Citrinin induces apoptosis in mouse embryonic stem cells. IUBMB Life. 2008;60:171-9 pubmed publisher
    ..On the basis of these findings, we propose a model for CTN-induced cell injury signalling cascades in embryonic stem cells and blastocysts. ..
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    Chan W, Wu C, Yu J. Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. J Cell Biochem. 2003;90:327-38 pubmed
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    Chan W, Wu H. Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells. J Cell Biochem. 2004;92:200-12 pubmed
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    Chan W, Hsuuw Y. Dosage effects of ginkgolide B on ethanol-induced cell death in human hepatoma G2 cells. Ann N Y Acad Sci. 2007;1095:388-98 pubmed
  5. Chan W. Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts. Toxicol Lett. 2011;205:285-92 pubmed publisher
    ..However, the extent to which sanguinarine exerts teratogenic effects on early human development is not known at present, and further studies are required to establish effective protection strategies against its cytotoxic effects. ..
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    Chan W. Ginkgolides induce apoptosis and decrease cell numbers in mouse blastocysts. Biochem Biophys Res Commun. 2005;338:1263-7 pubmed
    ..These novel findings provide important new insights into the effect of Ginkgo biloba extracts on mouse blastocysts. ..
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    Chan W. Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts. Hum Reprod. 2006;21:2985-95 pubmed
    ..Our results reveal for the first time that ginkgolide B retards the proliferation and development of mouse ESCs and blastocysts in vitro and causes developmental injury in vivo. ..
  8. Chan W. Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts. Biochem J. 2007;404:317-26 pubmed
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    Chan W, Shiao N. Effect of citrinin on mouse embryonic development in vitro and in vivo. Reprod Toxicol. 2007;24:120-5 pubmed
    ..The extent to which CTN may have teratogenic potential in early human development is not known. ..

More Information

Publications14

  1. Chan W, Shiao N. Cytotoxic effect of CdSe quantum dots on mouse embryonic development. Acta Pharmacol Sin. 2008;29:259-66 pubmed publisher
    ..The aim of this study was to examine the cytotoxic effect of quantum dots (QD), a novel luminescent material, on early post-implantation embryonic development...
  2. Chan W. Impact of genistein on maturation of mouse oocytes, fertilization, and fetal development. Reprod Toxicol. 2009;28:52-8 pubmed publisher
    ..To our knowledge, this is the first study investigating the impact of GNT on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  3. Huang C, Chan W. Rhein Induces Oxidative Stress and Apoptosis in Mouse Blastocysts and Has Immunotoxic Effects during Embryonic Development. Int J Mol Sci. 2017;18: pubmed publisher
    ..These results collectively show that rhein has the potential to induce embryonic cytotoxicity and induce oxidative stress and immunotoxicity during the development of mouse embryos. ..
  4. Huang C, Chan W. Protective Effects of Liquiritigenin against Citrinin-Triggered, Oxidative-Stress-Mediated Apoptosis and Disruption of Embryonic Development in Mouse Blastocysts. Int J Mol Sci. 2017;18: pubmed publisher
  5. Chan W. Effects of citrinin on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo. Toxicol Lett. 2008;180:28-32 pubmed publisher
    ..To our knowledge, this is the first study investigating the impact of CTN on maturation of mouse oocytes, fertilization, and sequential embryonic development...