Wen Hsiung Chan

Summary

Affiliation: Chung Yuan Christian University
Country: Taiwan

Publications

  1. ncbi Citrinin induces apoptosis in mouse embryonic stem cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    IUBMB Life 60:171-9. 2008
  2. ncbi Hazardous apoptotic effects of 2-bromopropane on maturation of mouse oocytes, fertilization, and fetal development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan E Mail Tel 886 3 265 3515
    Int J Mol Sci 11:4361-80. 2010
  3. ncbi Protective effects of resveratrol on ethanol-induced apoptosis in embryonic stem cells and disruption of embryonic development in mouse blastocysts
    Lien Hung Huang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 242:109-22. 2007
  4. ncbi Ochratoxin a inhibits mouse embryonic development by activating a mitochondrion-dependent apoptotic signaling pathway
    Yan Der Hsuuw
    Department of Life Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
    Int J Mol Sci 14:935-53. 2013
  5. ncbi Injurious Effects of Emodin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Int J Mol Sci 13:13911-25. 2012
  6. ncbi Dosage effects of ginkgolide B on ethanol-induced cell death in human hepatoma G2 cells
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Ann N Y Acad Sci 1095:388-98. 2007
  7. ncbi Cytotoxic effect of CdSe quantum dots on mouse embryonic development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, China
    Acta Pharmacol Sin 29:259-66. 2008
  8. ncbi Effect of citrinin on mouse embryonic development in vitro and in vivo
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Reprod Toxicol 24:120-5. 2007
  9. ncbi Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 103:1144-57. 2008
  10. ncbi Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Toxicol Lett 205:285-92. 2011

Collaborators

  • Jau Song Yu
  • Fu Jen Huang
  • Kun Hsiung Lee
  • Chih Ping Chen
  • Yan Der Hsuuw
  • Mei Hui Chang
  • Yan-Der Hsuuw
  • Nion Heng Shiao
  • Yu Ting Huang
  • Ching Yu Lai
  • Ying Jing Chang
  • Hsiao Chen Tu
  • Po Wn Li
  • Jui Ming Yeh
  • Ming Shu Hsieh
  • Mei Hui Ni
  • Pin Zhen Lu
  • Lien Hung Huang
  • Hsin Jung Wu
  • Chen-Kang Chang
  • Chen Kang Chang
  • Shao Chung Chang
  • Tai Hung Kuo
  • Ji Hao Chang
  • Yen Chih Liu
  • Shyh Liang Lou
  • Tzong Fu Kuo
  • Chih Ching Wu
  • Chih-Ching Wu
  • Kun Yi Chien
  • Kun-Yi Chien
  • Mei-Hui Ni
  • Lien-Hung Huang
  • Nion-Heng Shiao
  • Hsin-Jung Wu
  • Lan Chi Shieh
  • Lan-Chi Shieh
  • Hung-Fu Tseng
  • Hung Fu Tseng

Detail Information

Publications45

  1. ncbi Citrinin induces apoptosis in mouse embryonic stem cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    IUBMB Life 60:171-9. 2008
    ..On the basis of these findings, we propose a model for CTN-induced cell injury signalling cascades in embryonic stem cells and blastocysts...
  2. ncbi Hazardous apoptotic effects of 2-bromopropane on maturation of mouse oocytes, fertilization, and fetal development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan E Mail Tel 886 3 265 3515
    Int J Mol Sci 11:4361-80. 2010
    ..These results collectively confirm the hazardous effects of 2-BP on embryos derived from pretreated oocytes...
  3. ncbi Protective effects of resveratrol on ethanol-induced apoptosis in embryonic stem cells and disruption of embryonic development in mouse blastocysts
    Lien Hung Huang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 242:109-22. 2007
    ..These changes were blocked by pretreatment with resveratrol. Based on these results, we propose a model for the protective effect of resveratrol on ethanol-induced cell injury in blastocysts and ESC-B5 cells...
  4. ncbi Ochratoxin a inhibits mouse embryonic development by activating a mitochondrion-dependent apoptotic signaling pathway
    Yan Der Hsuuw
    Department of Life Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
    Int J Mol Sci 14:935-53. 2013
    ..In addition, OTA induces apoptosis-mediated injury of mouse blastocysts, via reactive oxygen species (ROS) generation, and promotes mitochondrion-dependent apoptotic signaling processes that impair subsequent embryonic development...
  5. ncbi Injurious Effects of Emodin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Int J Mol Sci 13:13911-25. 2012
    ..Notably, pretreatment with a caspase-3-specific inhibitor effectively prevented emodin-triggered injury effects, suggesting that impairment of embryo development occurs via a caspase-dependent apoptotic process...
  6. ncbi Dosage effects of ginkgolide B on ethanol-induced cell death in human hepatoma G2 cells
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Ann N Y Acad Sci 1095:388-98. 2007
    ....
  7. ncbi Cytotoxic effect of CdSe quantum dots on mouse embryonic development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, China
    Acta Pharmacol Sin 29:259-66. 2008
    ..The aim of this study was to examine the cytotoxic effect of quantum dots (QD), a novel luminescent material, on early post-implantation embryonic development...
  8. ncbi Effect of citrinin on mouse embryonic development in vitro and in vivo
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Reprod Toxicol 24:120-5. 2007
    ..The extent to which CTN may have teratogenic potential in early human development is not known...
  9. ncbi Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 103:1144-57. 2008
    ..necrosis) in HUVECs, and both ROS and NO played important roles in MG/HG-induced apoptosis of these cells...
  10. ncbi Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Toxicol Lett 205:285-92. 2011
    ..However, the extent to which sanguinarine exerts teratogenic effects on early human development is not known at present, and further studies are required to establish effective protection strategies against its cytotoxic effects...
  11. ncbi Effects of citrinin on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, 32023, Taiwan
    Toxicol Lett 180:28-32. 2008
    ..To our knowledge, this is the first study investigating the impact of CTN on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  12. ncbi Impact of genistein on maturation of mouse oocytes, fertilization, and fetal development
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200, Chung Pei Road, Chung Li 32023, Taiwan
    Reprod Toxicol 28:52-8. 2009
    ..To our knowledge, this is the first study investigating the impact of GNT on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  13. ncbi Cytotoxic effects of 2-bromopropane on embryonic development in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E Mail Tel 886 3 2653515
    Int J Mol Sci 11:731-44. 2010
    ..Our results collectively indicate that in vitro exposure to 2-BP induces apoptosis, suppresses implantation rates after transfer to host mice, and retards early postimplantation development...
  14. ncbi Photodynamic Treatment Induces an Apoptotic Pathway Involving Calcium, Nitric Oxide, p53, p21-Activated Kinase 2, and c-Jun N-Terminal Kinase and Inactivates Survival Signal in Human Umbilical Vein Endothelial Cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E Mail Tel 886 3 2653515
    Int J Mol Sci 12:1041-59. 2011
    ....
  15. ncbi Resveratrol Protects against 2-Bromopropane-Induced Apoptosis and Disruption of Embryonic Development in Blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E Mail Tel 886 3 2653515
    Int J Mol Sci 12:4991-5010. 2011
    ..Our results collectively imply that 2-BP triggers the mitochondrion-dependent apoptotic pathway via ROS generation, and the antioxidant activity of resveratrol prevents 2-BP-induced toxicity...
  16. ncbi Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Biochem J 404:317-26. 2007
    ....
  17. ncbi Effect of genistein on mouse blastocyst development in vitro
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan, China
    Acta Pharmacol Sin 28:238-45. 2007
    ..To examine the cytotoxic effects of genistein, an isoflavone compound, on early postimplantation embryonic development in vitro...
  18. ncbi Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200 Chung Pai Road, 32023 Chung Li, Taiwan
    Toxicol Lett 161:1-9. 2006
    ..Thus our findings support the possibility that appropriate dosage of resveratrol aids in decreasing the toxic effect of ethanol...
  19. ncbi Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 94:1267-79. 2005
    ..The results of this report collectively imply the involvement of oxidative stress in high glucose-induced apoptosis and alterations in attachment ability. Moreover, resveratrol blocks these events by virtue of its antioxidant property...
  20. ncbi Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China
    J Cell Biochem 92:200-12. 2004
    ....
  21. ncbi Ginkgolides induce apoptosis and decrease cell numbers in mouse blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Biochem Biophys Res Commun 338:1263-7. 2005
    ..These novel findings provide important new insights into the effect of Ginkgo biloba extracts on mouse blastocysts...
  22. ncbi Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells
    Wen Hsiung Chan
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan 32023
    Ann N Y Acad Sci 1042:372-8. 2005
    ..The results demonstrate that curcumin significantly attenuates MG-induced ROS formation, and suggest that ROS triggers cytochrome c release, caspase activation, and subsequent apoptotic biochemical changes...
  23. ncbi Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Hum Reprod 21:2985-95. 2006
    ..Here, we report more detailed examinations of the cytotoxic effects of ginkgolide B on mouse embryonic stem cells (ESCs) and blastocysts and their subsequent development in vitro and in vivo...
  24. ncbi Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China
    J Cell Biochem 90:327-38. 2003
    ....
  25. ncbi Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan, China
    Acta Pharmacol Sin 27:1192-8. 2006
    ..To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids...
  26. ncbi CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals
    Wen Hsiung Chan
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 167:191-200. 2006
    ....
  27. ncbi Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2
    Wen Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    J Cell Biochem 100:1056-69. 2007
    ..Collectively, these results reveal for the first time that MG treatment triggers apoptosis in osteoblasts via specific apoptotic signaling, and causes BMD loss in vivo...
  28. ncbi Injury effects of ginkgolide B on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo
    Nion Heng Shiao
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 188:63-9. 2009
    ..To our knowledge, this is the first study to investigate the impact of GKB on maturation of mouse oocytes, fertilization, and sequential embryonic development...
  29. ncbi Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
    Hsin Jung Wu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200, Chung Pei Road, Chung Li 32023, Taiwan, ROC
    Toxicol In Vitro 21:335-42. 2007
    ..These results collectively suggest that oxidative stress plays a role in MG-induced cell injury, and that genistein blocks these effects by virtue of its antioxidant properties, consequently preventing cell apoptosis...
  30. ncbi Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts
    Yan-Der Hsuuw
    Department of Animal Science, National Pingtung University of Science and Technology, Taiwan, Republic of China
    J Cell Physiol 205:379-86. 2005
    ..The results support the hypothesis that curcumin inhibits MG-induced apoptosis in mouse ESC-B5 cells and blastocysts by blocking ROS formation and subsequent apoptotic biochemical events...
  31. ncbi Dosage effects of curcumin on cell death types in a human osteoblast cell line
    Wen-Hsiung Chan
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Food Chem Toxicol 44:1362-71. 2006
    ..Overall, our results signify that curcumin dosage treatment determines the possible effect on ROS generation, intracellular ATP levels, and cell apoptosis or necrosis in osteoblast cells...
  32. ncbi Epicatechin gallate decreases the viability and subsequent embryonic development of mouse blastocysts
    Hsiao Chen Tu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Taiwan J Obstet Gynecol 49:174-80. 2010
    ....
  33. ncbi Impact effects of puerarin on mouse embryonic development
    Chia Chi Chen
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan
    Reprod Toxicol 28:530-5. 2009
    ..The extent to which puerarin may have teratogenic potential in early human development is not yet known...
  34. ncbi Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells
    Yan Der Hsuuw
    Department of Life Science, National Pingtung University of Science and Technology, Pingtung, Taiwan
    Ann N Y Acad Sci 1171:501-8. 2009
    ..Experiments using caspase-3 inhibitors and antisense oligonucleotides against PAK2 showed that caspase-3 activation is required for PAK2 activation and both of these activations are required for GKB-induced apoptosis in ESC-B5 cells...
  35. ncbi Epigallocatechin gallate dose-dependently induces apoptosis or necrosis in human MCF-7 cells
    Yan Der Hsuuw
    Department of Bioscience Technology, Chung Yuan Christian University, Chung Li, Taiwan
    Ann N Y Acad Sci 1095:428-40. 2007
    ....
  36. ncbi Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line
    Yu Ting Huang
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Environ Toxicol 24:343-56. 2009
    ..On the basis of these results, we propose a signaling cascade model for CTN-induced apoptosis in human osteoblasts involving ROS, JNK, caspases, and PAK2...
  37. ncbi Methylglyoxal has injurious effects on maturation of mouse oocytes, fertilization, and fetal development, via apoptosis
    Ying Jing Chang
    Department of Bioscience Technology, Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 193:217-23. 2010
    ..Finally, pretreatment with a caspase-3-specific inhibitor effectively prevented MG-triggered injury effects, suggesting that embryo impairment by MG occurs via a caspase-dependent apoptotic process...
  38. ncbi GSK-3 mediates the okadaic acid-induced modification of collapsin response mediator protein-2 in human SK-N-SH neuroblastoma cells
    Mei Hui Ni
    Graduate Institute of Basic Medical Sciences, Medical College of Chang Gung University, Tao Yuan, Taiwan, Republic of China
    J Cell Biochem 103:1833-48. 2008
    ....
  39. ncbi Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles
    Po Wn Li
    Chung Yuan Christian University, Chung Li, Taiwan
    Toxicol Lett 197:82-7. 2010
    ..The results collectively show that nanoAg has the potential to induce embryo cytotoxicity. Further studies are required to establish effective protection strategies against the cytotoxic effects of these nanoparticles...
  40. ncbi Emodin induces embryonic toxicity in mouse blastocysts through apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 299:25-32. 2012
    ..These results collectively indicate that emodin has the potential to induce embryonic cytotoxicity...
  41. ncbi Hazardous Effects of Curcumin on Mouse Embryonic Development through a Mitochondria-Dependent Apoptotic Signaling Pathway
    Chia Chi Chen
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan E Mails C C C M S H
    Int J Mol Sci 11:2839-55. 2010
    ..In addition, curcumin induces apoptotic injury effects on mouse blastocysts through ROS generation, and further promotes mitochondria-dependent apoptotic signaling processes to impair sequent embryonic development...
  42. ncbi Caffeine Induces Cell Death via Activation of Apoptotic Signal and Inactivation of Survival Signal in Human Osteoblasts
    Pin Zhen Lu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan 32023
    Int J Mol Sci 9:698-718. 2008
    ....
  43. ncbi Cytotoxic Effects of CdSe Quantum Dots on Maturation of Mouse Oocytes, Fertilization, and Fetal Development
    Ming Shu Hsieh
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Int J Mol Sci 10:2122-35. 2009
    ..To our knowledge, this is the first study to report the negative impact of CdSe-core QDs on mouse oocyte development. Moreover, surface modification of CdSe-core QDs with ZnS effectively prevented this cytotoxicity...
  44. ncbi Injurious Effects of Curcumin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis
    Chia Chi Chen
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan E mail
    Int J Mol Sci 13:4655-72. 2012
    ..Finally, pretreatment with a caspase-3-specific inhibitor effectively prevented curcumin-triggered injury effects, suggesting that embryo impairment by curcumin occurs mainly via a caspase-dependent apoptotic process...
  45. ncbi Higher LDL oxidation at rest and after a rugby game in weekend warriors
    Chen Kang Chang
    Department of Nutrition and Health Science, Fooyin Institute of Technology, Kaohsiung, Taiwan
    Ann Nutr Metab 46:103-7. 2002
    ..The results are compared with those of sedentary controls (CON, n = 10) and trained rugby players (TR, n = 15)...