Yao Chi Chuang

..Recently botulinum neurotoxin application was extended to prostate disorders. Why would a urologist want to target the prostate?..

..To investigate the mechanisms and urodynamic effects of a potent and selective prostaglandin E(2) (PGE(2)) receptor subtype 4 (EP4) antagonist, MF191, on cyclophosphamide (CYP) or PGE(2)-induced bladder overactivity in rats...

..This manuscript compares the efficacy and safety of duloxetine with placebo in Taiwanese women with SUI...

..We evaluated the safety and efficacy of intravesical liposomes, a mucosal protective agent, compared to oral pentosan polysulfate sodium for interstitial cystitis/painful bladder syndrome...

..To investigate the potential utility of botulinum toxin A (BoNT-A) bladder injections in patients with radiation cystitis and bacillus Calmette-Guérin (BCG)-induced chemical cystitis...

..EP4 receptor, a subtype of PGE(2) receptors, mediates tissue inflammation and hypersensitivity...

..We investigated the effect of intraprostatic botulinum toxin A administration on pain reaction and cyclooxygenase-2 expression in a capsaicin induced prostatitis model in rats...

..Urine excreted after oral ingestion of solifenacin provides a localized pharmacological advantage for the treatment of the overactive bladder syndrome...

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..However, its poor aqueous solubility presents challenges in formulating biocompatible instillations to justify the investigation of liposomes as vehicle for tacrolimus...

..We compare the efficacy and safety of monopolar transurethral resection of the prostate (TURP) with high-intensity diode laser in combination with bipolar TURP (DL + b-TURP) in the treatment of large prostates...

..The analgesic and anti-inflammatory properties of botulinum toxin type A (BoNT-A) was tested in this model...

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..To study the role of sensory dysfunction of bladder mucosa in bladder oversensitivity of rats with metabolic syndrome...

..Intravesical LPs treatment is safe and its efficacy has sustained duration. Furthermore large-scale, placebo-controlled studies are warranted to assess the efficacy for this promising new treatment for IC/PBS...

..Diabetes is a common risk factor for overactive bladder (OAB) syndrome and erectile dysfunction (ED)...

..Erectile dysfunction (ED) is a frequent comorbidity in men with diabetes and is frequently overlooked in routine clinical evaluation. Albuminuria, a marker of endothelial dysfunction, may link to ED...

..To compare the perioperative and oncologic outcome between hand-assisted nephroureterectomy (HARNU) and transurethral bladder cuff incision-assisted nephroureterectomy (TUINU), which manage the bladder cuff with different methods...

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..We evaluated the efficacy and outcome of laser photoselective vaporization of prostate (PVP) in patients with voiding difficulty due to prostatic obstruction induced by advanced prostate cancer (PC)...

..In this study we developed a gene gun method for the transfer of POMC cDNA in vivo and investigated its therapeutic effect on acetic acid induced bladder hyperactivity in rats...

..To evaluate the efficacy and safety of a 200-W high-intensity diode laser in the treatment of benign prostatic hyperplasia...

..We present our clinical experiences of two recently introduced vaporization laser systems: the GreenLight High Performance System (HPS) laser (532 nm, 120 W) and the Diolas LFD diode laser (980 nm, 200 W)...

..In the present study, we review our clinical experiences using Resonance stent in treating malignant and benign ureteral obstruction...

..These results support the clinical application of BTX-A for the treatment of interstitial cystitis and other types of visceral pain...

..We review the biological action of BoNT in bladder and prostate, and present the techniques and results of the clinical studies with BoNT in the lower urinary tract...

..To evaluate overactive bladder (OAB, dry and wet) and the associated risk factors of OAB wet (with incontinence) in type 2 diabetes...

..Hereby, we review the use of mesenchymal stem cell therapy for SUI and the experience with the development of muscle-derived stem cells...

..To analyse retrospectively the morbidity and efficacy of high-dose rate (HDR) brachytherapy in patients who had a previous transurethral resection of the prostate (TURP)...

..We studied bladder motor dysfunction and searched for markers of neurogenic and myogenic alterations among fructose fed rats with or without abnormal voiding behavior...

..Modest, noncytotoxic affronts to urothelial barrier function can result in dramatic irritative responses. This model may be useful in the study of bladder irritation and hyperactivity...

..However, the prognosis of radical cystectomy in dialysis patients has rarely been reported. This study investigates the long-term outcome of radical cystectomy in dialysis patients with bladder urothelial carcinoma...

..These results support potential clinical application of PPE gene gun delivery system for the treatment of bladder pain and other types of visceral pain...

..CONCLUSIONS: BTX-A injected into the prostate is a promising treatment for patients with small prostates and symptomatic BPH...

..BTX-A may potentially be the drug that has dual actions on the static and dynamic components of benign prostatic hyperplasia...

..The mechanisms of relief of symptoms might not depend totally on the volume shrinkage; the inhibitory effect on the smooth muscle tone and aberrant sensory function might also be important...

..It is important to remember that the application of BoNT in the prostate is not approved by the regulatory agencies and caution should be applied until larger randomized clinical studies are completed...

..We hypothesize that LPs might enhance the barrier properties of a dysfunctional uroepithelium and increase resistance to irritant penetration. Thus, intravesical LP administration could be a novel treatment of patients with IC...