Chi Rei Wu


Affiliation: China Medical University
Country: Taiwan


  1. Lin L, Tsai F, Lan W, Cheng Y, Lee S, Wu C. Steroid-Enriched Fraction of Achyranthes bidentata Protects Amyloid β Peptide 1-40-Induced Cognitive Dysfunction and Neuroinflammation in Rats. Mol Neurobiol. 2019;: pubmed publisher
    ..The action mechanism is due to decreasing oxidative stress and neuroinflammation through modulating ERK pathway, NF-κB phosphorylation, and translocation in Aβ 1-40-induced AD rat model. ..
  2. Chang H, Liu K, Teng C, Lai S, Yang S, Ching H, et al. Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3β Phosphorylation and Oxidative Stress. Nutrients. 2019;11: pubmed publisher
  3. Lin M, Lee M, Huang H, Cheng T, Cheng Y, Wu C. Cuscuta chinensis and C. campestris Attenuate Scopolamine-Induced Memory Deficit and Oxidative Damage in Mice. Molecules. 2018;23: pubmed publisher
    ..campestris has better potential than C. chinensis. In addition, we provided evidence that the seeds of C. campestris can be used as Cuscutae Semen in Traditional Chinese Medicine. ..
  4. Wu C, Chang H, Cheng Y, Lan W, Yang S, Ching H. Aqueous Extract of Davallia mariesii Attenuates 6-Hydroxydopamine-Induced Oxidative Damage and Apoptosis in B35 Cells Through Inhibition of Caspase Cascade and Activation of PI3K/AKT/GSK-3β Pathway. Nutrients. 2018;10: pubmed publisher
  5. request reprint
    Wu C, Chang C, Hsieh P, Lin L, Ching H. Psoralen and isopsoralen, two coumarins of Psoraleae Fructus, can alleviate scopolamine-induced amnesia in rats. Planta Med. 2007;73:275-8 pubmed
  6. Wu C, Lin L, Hsieh C, Wang W, Lin Y, Hsieh M. Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats. J Ethnopharmacol. 2008;117:403-7 pubmed publisher
    ..Therefore, we demonstrated that the ameliorating effects of CM on scopolamine-induced performance impairment may be related to activating the adrenal gland and central acetylcholingeric neuron, instead of peripheral nervous system. ..
  7. Zhao Z, Chang J, Lin L, Tsai F, Chang H, Wu C. Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl?-Induced Acute Liver Damage in C57BL/6 Mice. Int J Mol Sci. 2018;19: pubmed publisher
  8. Sorra K, Chen C, Chang C, Pusuluri S, Mukkanti K, Wu C, et al. Synthesis, anticonvulsant, sedative and anxiolytic activities of novel annulated pyrrolo[1,4]benzodiazepines. Int J Mol Sci. 2014;15:16500-10 pubmed publisher
    ..There was no significant difference in potency between PBDT 13 and diazepam, and we proposed that the action mechanism of PBDT 13 could be similar to that of diazepam via benzodiazepine receptors. ..
  9. Wu C, Lin H, Su M. Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer's disease-like rat model: relevance for amyloid deposition and central neurotransmitter function. BMC Complement Altern Med. 2014;14:202 pubmed publisher
    ..We suggest that CT extract, containing enough echinacoside and acteoside, ameliorated the cognitive dysfunction caused by A? 1-42 via blocking amyloid deposition, reversing cholinergic and hippocampal dopaminergic neuronal function. ..

More Information


  1. Lin Y, Chang C, Wu C. Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents. BMC Complement Altern Med. 2015;15:10 pubmed publisher
    ..Its antinociceptive and anti-inflammatory mechanism might be related to peripheral nociceptive pathway such as prostaglandins. ..
  2. Lin Y, Chang C, Wu C. Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents. BMC Complement Altern Med. 2016;16:456 pubmed
    ..The antitussive mechanism of MXGST is related to partially relaxing the bronchial smooth muscle by blocking acetylcholinergic and histaminergic receptors. ..
  3. Shiao Y, Su M, Lin H, Wu C. Acteoside and Isoacteoside Protect Amyloid ? Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo. Int J Mol Sci. 2017;18: pubmed publisher
  4. Shiao Y, Su M, Lin H, Wu C. Echinacoside ameliorates the memory impairment and cholinergic deficit induced by amyloid beta peptides via the inhibition of amyloid deposition and toxicology. Food Funct. 2017;8:2283-2294 pubmed publisher