Wei Chien Huang

Summary

Affiliation: China Medical University
Country: Taiwan

Publications

  1. pmc Beyond NF-κB activation: nuclear functions of IκB kinase α
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital, Taichung, 40447, Taiwan
    J Biomed Sci 20:3. 2013
  2. doi request reprint Induction of Akt activity by chemotherapy confers acquired resistance
    Wei Chien Huang
    Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, and Department of Biotechnology, Asia University, Taichung, Taiwan
    J Formos Med Assoc 108:180-94. 2009
  3. pmc Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
    J Biol Chem 286:20558-68. 2011
  4. doi request reprint Hepatitis B virus X protein induces IKKα nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells
    Wei Chien Huang
    Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
    J Cell Physiol 227:1446-54. 2012
  5. doi request reprint Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells
    Te Chun Hsia
    Department of Internal Medicine, China Medical University and Hospital, Taichung, Taiwan
    Mol Pharmacol 83:857-69. 2013
  6. pmc Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides
    Yung luen Yu
    Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, Taiwan
    PLoS ONE 8:e61362. 2013
  7. pmc Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells
    Yun Ju Chen
    Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 6:e21428. 2011
  8. pmc Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital Taichung 404, Taiwan Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan The Ph D program for Cancer Biology and Drug Discovery, China Medical University Taichung 404, Taiwan Department of Biotechnology, Asia University Taichung 413, Taiwan
    Am J Transl Res 5:441-9. 2013
  9. pmc Cancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinoma
    Chen Shiou Wu
    The PhD Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan
    PLoS ONE 7:e39466. 2012
  10. pmc BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan The Ph D program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan Department of Biotechnology, Asia University, Taichung, Taiwan
    PLoS ONE 8:e83627. 2013

Collaborators

Detail Information

Publications11

  1. pmc Beyond NF-κB activation: nuclear functions of IκB kinase α
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital, Taichung, 40447, Taiwan
    J Biomed Sci 20:3. 2013
    ..This review highlights major advances in the studies of the nuclear functions of IKKα and the mechanisms of IKKα nuclear translocation. Understanding the nuclear activity is essential for targeting IKKα for therapeutics...
  2. doi request reprint Induction of Akt activity by chemotherapy confers acquired resistance
    Wei Chien Huang
    Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, and Department of Biotechnology, Asia University, Taichung, Taiwan
    J Formos Med Assoc 108:180-94. 2009
    ..These regulatory mechanisms may limit the efficacy of PI3K/Akt-targeted therapy; therefore, disruption of these mechanisms may be an effective strategy for development of novel anti-cancer therapies...
  3. pmc Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
    J Biol Chem 286:20558-68. 2011
    ....
  4. doi request reprint Hepatitis B virus X protein induces IKKα nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells
    Wei Chien Huang
    Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
    J Cell Physiol 227:1446-54. 2012
    ..Taken together, our findings shed light on the molecular mechanism of IKKα nuclear translocation and provide a potential role of nuclear IKKα in HBx-mediated hepatocellular carcinoma (HCC) progression...
  5. doi request reprint Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells
    Te Chun Hsia
    Department of Internal Medicine, China Medical University and Hospital, Taichung, Taiwan
    Mol Pharmacol 83:857-69. 2013
    ..These findings also shed new light on the molecular mechanism of COX-2 mRNA stabilization by EGFR in a kinase-independent manner...
  6. pmc Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides
    Yung luen Yu
    Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, Taiwan
    PLoS ONE 8:e61362. 2013
    ..Our study reveals a drug candidate with translational potential for the future development of safe and effective therapeutic for EGFR TKI resistance in TNBC...
  7. pmc Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells
    Yun Ju Chen
    Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan
    PLoS ONE 6:e21428. 2011
    ....
  8. pmc Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital Taichung 404, Taiwan Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan The Ph D program for Cancer Biology and Drug Discovery, China Medical University Taichung 404, Taiwan Department of Biotechnology, Asia University Taichung 413, Taiwan
    Am J Transl Res 5:441-9. 2013
    ..These findings suggested exogenous overexpression of SGLT1 can function normally but may not be consistently detectable at its formula weight due to its gel-shift behavior by forming the SDS-resistant aggregates...
  9. pmc Cancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinoma
    Chen Shiou Wu
    The PhD Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan
    PLoS ONE 7:e39466. 2012
    ..Glycan microarray analysis provides a powerful tool for high-sensitivity and high-throughput detection of serum antibodies against CACAs, which may be valuable serum biomarkers for the early detection of persons at high risk for HCC...
  10. pmc BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib
    Wei Chien Huang
    Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan The Ph D program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan Department of Biotechnology, Asia University, Taichung, Taiwan
    PLoS ONE 8:e83627. 2013
    ..These results suggest not only that BCRP/ABCG2 is a potential predictor for the sorafenib sensitivity in HCC, but also that blockage of BCRP/ABCG2 may be a potential strategy to increase the response of HCC cells to sorafenib. ..
  11. doi request reprint ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells
    Shih Chang Tsai
    Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan, ROC
    Int J Oncol 41:2065-72. 2012
    ..AITC is a potential agent for applcation in the treatment of human breast cancer...