Guan Jhong Huang

Summary

Affiliation: China Medical University
Country: Taiwan

Publications

  1. pmc Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    PLoS ONE 7:e35922. 2012
  2. doi request reprint Anti-inflammatory activities of aqueous extract of Mesona procumbens in experimental mice
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Sci Food Agric 92:1186-93. 2012
  3. doi request reprint α-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:5702-6. 2011
  4. ncbi request reprint Inhibition of reactive nitrogen species in vitro and ex vivo by trypsin inhibitor from sweet potato 'Tainong 57' storage roots
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences and Department of Physiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 55:6000-6. 2007
  5. doi request reprint Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsueh Shih Road, Taichung City 404, Taiwan
    J Agric Food Chem 58:9468-75. 2010
  6. doi request reprint Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of Actinidia callosa var. ephippioides
    Jung Chun Liao
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Am J Chin Med 40:1047-62. 2012
  7. doi request reprint Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice
    Tien Ning Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 59:9112-9. 2011
  8. ncbi request reprint Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities
    Po Chow Hsieh
    Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsueh Shih Road, Taichung, Taiwan
    Am J Chin Med 39:349-65. 2011
  9. ncbi request reprint Hepatoprotective effect of Crossostephium chinensis (L.) Makino in rats
    Tien Ning Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, Taiwan
    Am J Chin Med 39:503-21. 2011
  10. doi request reprint Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo
    Chi Luan Wen
    Taiwan Seed Improvement and propagation Station, Council of Agriculture, Propagation Technology Section, Taichung, Taiwan
    J Ethnopharmacol 137:575-84. 2011

Collaborators

Detail Information

Publications42

  1. pmc Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    PLoS ONE 7:e35922. 2012
    ..This study presents the potential utilization of inotilone, as a lead for the development of anti-inflammatory drugs...
  2. doi request reprint Anti-inflammatory activities of aqueous extract of Mesona procumbens in experimental mice
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Sci Food Agric 92:1186-93. 2012
    ..Serum nitric oxide (NO), tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were also evaluated...
  3. doi request reprint α-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:5702-6. 2011
    ..The importance of finding effective antidiabetic therapeutics led us to further investigate natural compounds...
  4. ncbi request reprint Inhibition of reactive nitrogen species in vitro and ex vivo by trypsin inhibitor from sweet potato 'Tainong 57' storage roots
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences and Department of Physiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 55:6000-6. 2007
    ..85 microg/mL. The present study suggested that TI had an efficient reactive nitrogen species scavenging ability. TI might be a potential effective NO and ONOO- scavenger useful for the prevention of NO- and ONOO--involved diseases...
  5. doi request reprint Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsueh Shih Road, Taichung City 404, Taiwan
    J Agric Food Chem 58:9468-75. 2010
    ..These findings suggest that hispolon may be used as an antimetastatic agent...
  6. doi request reprint Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of Actinidia callosa var. ephippioides
    Jung Chun Liao
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Am J Chin Med 40:1047-62. 2012
    ..The above experimental data indicated that the stem of ACE is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds...
  7. doi request reprint Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice
    Tien Ning Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 59:9112-9. 2011
    ..Also, taraxeren-3-one could affect the production of NO and TNF-α and, therefore, affect the anti-inflammatory effects...
  8. ncbi request reprint Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities
    Po Chow Hsieh
    Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsueh Shih Road, Taichung, Taiwan
    Am J Chin Med 39:349-65. 2011
    ....
  9. ncbi request reprint Hepatoprotective effect of Crossostephium chinensis (L.) Makino in rats
    Tien Ning Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, Taiwan
    Am J Chin Med 39:503-21. 2011
    ..In LC-MS-MS analysis, the chromatograms of CCW with good hepatoprotective activities were established. Scopoletin may be an important bioactive compound in CCW...
  10. doi request reprint Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo
    Chi Luan Wen
    Taiwan Seed Improvement and propagation Station, Council of Agriculture, Propagation Technology Section, Taichung, Taiwan
    J Ethnopharmacol 137:575-84. 2011
    ..This study aimed to explore the folk use of Antrodia cinnamomea on pharmacological grounds to characterize the scientific basis of anti-inflammatory activity...
  11. doi request reprint Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae)
    Ming Jyh Sheu
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Ethnopharmacol 126:332-8. 2009
    ..This study investigated the analgesic and anti-inflammatory effects of a water extract of Trachelospermum jasminoides (WET) in ICR mice...
  12. doi request reprint Chemical characterization and in vivo anti-inflammatory activities of Actinidia callosa var. ephippioides via suppression of proinflammatory cytokines
    Jung Chun Liao
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Am J Chin Med 41:405-23. 2013
    ..Actinidia callosa var. ephippioides have the potential to provide a therapeutic approach to inflammation-associated disorders...
  13. doi request reprint Defensin protein from sweet potato (Ipomoea batatas [L.] Lam 'Tainong 57') storage roots exhibits antioxidant activities in vitro and ex vivo
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Food Chem 135:861-7. 2012
    ..2±0.1μM). These findings mean that cysteine residue is most important in antioxidant activities. It was suggested that SPD1 might contribute its antioxidant activities against hydroxyl and peroxyl radicals...
  14. doi request reprint Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the λ-carrageenan-induced paw edema model
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
    Food Chem Toxicol 50:1485-93. 2012
    ....
  15. doi request reprint Anti-inflammatory activities of 6β-acetoxy-7α-hydroxyroyleanone from Taiwania cryptomerioides Hayata ex vivo and in vivo
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:11211-8. 2011
    ....
  16. doi request reprint Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 60:1673-81. 2012
    ..7 cells and Carr-injected mice, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neutrophil infiltration of Carr-injected paws may be involved in the beneficial effects of imperatorin...
  17. doi request reprint Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, Republic of China
    J Agric Food Chem 58:7445-52. 2010
    ..The anti-inflammatory mechanisms of ST1 might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver through the suppression of TNF-alpha and NO...
  18. doi request reprint Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation
    Guan Jhong Huang
    College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:7104-13. 2011
    ..These findings establish a mechanistic link between the MAPK pathway and hispolon-induced cell cycle arrest and apoptosis in Hep3B cells...
  19. doi request reprint Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima
    Shyh Shyun Huang
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Ethnopharmacol 147:395-405. 2013
    ..However, there is no scientific evidence which supports the use in the literature...
  20. ncbi request reprint Growth inhibition and induction of apoptosis in NB4 promyelocytic leukemia cells by trypsin inhibitor from sweet potato storage roots
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences and Department of Physiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 55:2548-53. 2007
    ..These results demonstrated that TI induces NB4 cell apoptosis through the inhibition of cell growth and the activation of the pathway of caspase-3 and -8 cascades...
  21. doi request reprint Diterpenoids with anti-inflammatory activity from the wood of Cunninghamia konishii
    Yu Chang Chen
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Molecules 18:682-9. 2013
    ..8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs...
  22. pmc The Effect of the Aerial Part of Lindera akoensis on Lipopolysaccharides (LPS)-Induced Nitric Oxide Production in RAW264.7 Cells
    Chung Ping Yang
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
    Int J Mol Sci 14:9168-81. 2013
    ..All of the compounds isolated from Lindera akoensis showed that in vitro anti-inflammatory activity decreases the LPS-stimulated production of nitric oxide (NO) in RAW 264.7 cell, with IC50 values of 4.1-413.8 µM...
  23. doi request reprint Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung 40402, Taiwan, Republic of China
    J Nat Prod 75:54-9. 2012
    ..The present study suggests that the anti-inflammatory mechanisms of 1 might be related to a decrease of inflammatory cytokines and an increase of antioxidant enzyme activity...
  24. ncbi request reprint Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway
    Pei Yu Chou
    Department of Life Science, National Chung Hsing University, Taichung, 402, Taiwan
    Am J Chin Med 39:803-15. 2011
    ..Our results demonstrated that the most important regulators of trilinolein-induced apoptosis are Bcl-2 family and caspase-3, which are associated with cytochrome c release and dephosphorylation on the Akt signaling pathway...
  25. ncbi request reprint Hepatoprotective and Antioxidant Effects of Ethanol Extract from Phellinus merrillii on carbon tetrachloride-induced liver damage
    Heng Yuan Chang
    Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91, Hsueh Shih Road, Taichung 404, Taiwan
    Am J Chin Med 35:793-804. 2007
    ..7%) in the liver. Pretreatment with PM significantly reduced the all these antioxidant enzyme activities. Therefore, we verified that ethanol extract of PM has the hepatoprotective and antioxidant capacities on rats...
  26. doi request reprint Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury
    Guan Jhong Huang
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Food Chem 141:3020-7. 2013
    ..Therefore, we speculate that TR1 and TR2 protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms...
  27. ncbi request reprint Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem
    Zhen Rung Lai
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan
    Am J Chin Med 39:1275-90. 2011
    ..gracilis. The above experimental data indicated that the stem of K. gracilis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds...
  28. doi request reprint Antimicrobial, dehydroascorbate reductase, and monodehydroascorbate reductase activities of defensin from sweet potato [Ipomoea batatas (L.) Lam. 'Tainong 57'] storage roots
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences, Department of Physiology, School of Medicine, and School of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Agric Food Chem 56:2989-95. 2008
    ..SPD1 was also shown to inhibit the growth of both fungi and bacteria. SPD1 is apparently the first reported plant defensin exhibiting DHA and MDA activities in vitro...
  29. pmc Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo
    Jung Chun Liao
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Evid Based Complement Alternat Med 2012:129152. 2012
    ..Overall, the results showed that EAAC demonstrated antioxidant, antinociceptive, and anti-inflammatory activity, which supports previous claims of the traditional use for inflammation and pain...
  30. doi request reprint A new butanolide compound from the aerial part of Lindera akoensis with anti-inflammatory activity
    Chung Ping Yang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
    Molecules 17:6585-92. 2012
    ..These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC₅₀ values of 1.4-179.9 μM...
  31. ncbi request reprint Antioxidant and antiproliferative activities of Crossostephium chinensis (L.) Makino
    Tien Ning Chang
    Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
    Am J Chin Med 37:797-814. 2009
    ..CCW exhibited good antiproliferative activity. These results indicated that CCW might be used as a potential source of natural antioxidants and as an anti-tumor agent...
  32. pmc Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Evid Based Complement Alternat Med 2012:480714. 2012
    ..Therefore, we speculate that hispolon protects rats from liver damage through their prophylactic redox balancing ability and anti-inflammation capacity...
  33. pmc Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice
    Shyh Shyun Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Evid Based Complement Alternat Med 2011:895857. 2011
    ..The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver...
  34. ncbi request reprint Ethanol extract of Dunaliella salina induces cell cycle arrest and apoptosis in A549 human non-small cell lung cancer cells
    Ming Jyh Sheu
    Department of Physiology, China Medical University, Taichung City, Taiwan, ROC
    In Vivo 22:369-78. 2008
    ..Bax expression was also elevated by treatment with EDS. Our data suggested that EDS could influence the antiproliferative effects and induce cell cycle G0/G1 arrest and apoptosis of A549 lung cancer cells...
  35. pmc Involvement of Heme Oxygenase-1 Participates in Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Hibiscus taiwanensis
    Shu Ling Liu
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Evid Based Complement Alternat Med 2012:132859. 2012
    ..These findings demonstrated that AHT has excellent anti-inflammatory activities in vitro and in vivo and thus it has great potential to be used as a source for natural health products...
  36. pmc Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice
    Heng Yuan Chang
    Institute of Chinese Pharmaceutical Sciences, Taichung 40402, Taiwan
    Evid Based Complement Alternat Med 2011:478246. 2011
    ..It probably exerts anti-inflammatory effects through the suppression of TNF-α and NO...
  37. doi request reprint A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan, ROC
    Eur J Med Chem 48:371-8. 2012
    ..7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms...
  38. doi request reprint Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy
    Te Ling Lu
    School of Pharmacy, China Medical University, Taichung, Taiwan
    Biochem Biophys Res Commun 398:26-31. 2010
    ..Meanwhile, inhibition of Hsc70 using siRNA attenuated hispolon-induced MDM2 downregulation. Our study provides the first example of the ability of hispolon to mediate MDM2 downregulation in lysosomes through the CMA pathway...
  39. pmc New Anti-Inflammatory Aromatic Components from Antrodia camphorata
    Yu Chang Chen
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Int J Mol Sci 14:4629-39. 2013
    ..The IC(50) values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively...
  40. pmc Antioxidant and Anti-Inflammatory Properties of Longan (Dimocarpus longan Lour.) Pericarp
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 402, Taiwan
    Evid Based Complement Alternat Med 2012:709483. 2012
    ..Overall, the results showed that WLP might serve as a natural antioxidant and inflammatory inhibitor...
  41. doi request reprint Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells
    Te Ling Lu
    School of Pharmacy, China Medical University, Taichung, Taiwan
    Food Chem Toxicol 47:2013-21. 2009
    ..In conclusion, hispolon ubiquitinates and downregulates MDM2 via MDM2-recruited activated ERK1/2. Therefore, hispolon may be a potential anti-tumor agent in breast and bladder cancers...
  42. doi request reprint Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice
    Bor Sen Wang
    Department of Applied Life Science and Health, Chia Nan University of Pharmacy and Science, 60, Erh Jen Road, Sec 1, Jen Te, Tainan 717, Taiwan, ROC
    Food Chem 138:751-6. 2013
    ..Further, WOE also decreased the number of acetic acid-induced writhing responses and formalin-induced pain in the late phase in mice. Overall, the results showed that WOE might serve as a natural source of anti-inflammatory compounds...