Dong Chi Ku

Summary

Affiliation: Chia-Nan University of Pharmacy and Science
Country: Taiwan

Publications

  1. ncbi request reprint Inhibition of low-density lipoprotein oxidation and oxidative burst in polymorphonuclear neutrophils by caffeic acid and hispidin derivatives isolated from sword brake fern (Pteris ensiformis Burm.)
    Hsiu An Wei
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Agric Food Chem 55:10579-84. 2007
  2. doi request reprint Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate
    Mei Chun Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Ethnopharmacol 120:196-203. 2008
  3. doi request reprint Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,5,6,7,8,3',4'-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor
    Mei Chun Kou
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Food Funct 4:602-9. 2013
  4. pmc Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism
    Ta Chin Lin
    Department of Gynecology, Obstetrics, and Infertility, Kuo General Hospital, NO, 22, Section 2, Ming Sheng Road, Tainan, 70054, Taiwan
    BMC Med Genet 7:36. 2006
  5. ncbi request reprint Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gertn.)
    Ming Jiuan Wu
    Institute of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 717, ROC
    Am J Chin Med 31:687-98. 2003
  6. ncbi request reprint Immunomodulatory properties of Grifola frondosa in submerged culture
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    J Agric Food Chem 54:2906-14. 2006
  7. ncbi request reprint Antioxidant activity of Glossogyne tenuifolia
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    J Agric Food Chem 53:6305-12. 2005
  8. ncbi request reprint Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.)
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, 60 Erh Hen Rd, Sec 1, Jen Te, Tainan 717, Taiwan
    J Ethnopharmacol 98:73-81. 2005
  9. ncbi request reprint Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.)
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 717
    Am J Chin Med 32:681-93. 2004
  10. ncbi request reprint Anti-inflammatory and antiviral effects of Glossogyne tenuifolia
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Life Sci 76:1135-46. 2005

Collaborators

  • Zong Tsi Chen
  • Shiming Li
  • Min Hsiung Pan
  • Ying Jan Wang
  • Yung Husan Chen
  • Ming Jiuan Wu
  • Lisu Wang
  • Tzi Wei Lian
  • Jui Hung Yen
  • Ching Yi Weng
  • Mei Chun Kuo
  • Mei Chun Kou
  • Ya Hsuan Lo
  • Tso Lin Cheng
  • Yi Chen Tu
  • Choi Lan Ha
  • Chi Tang Ho
  • Jing Ting Hong
  • Jeng Dian Su
  • Ning Ping Foo
  • Chien Yu Chang
  • Hsiu An Wei
  • Su Yun Cheng
  • Ta Chin Lin
  • Yu Ching Weng
  • Hsiou Yu Ding
  • Shih Hang Fu
  • Meng Han Lin
  • Yu Hsuan Lee
  • Shu huei Lin
  • I Jen Huang
  • Jui Mei Yen
  • Tsung Cheng Kuo
  • Shu Yuan Chiou
  • Kum Bing Gong
  • Jing Ting Hung
  • Shu Fen Liang
  • Wei Sen Lin
  • Mei Chuan Kou
  • Pei Jong Wu
  • Chia Lin Huang

Detail Information

Publications24

  1. ncbi request reprint Inhibition of low-density lipoprotein oxidation and oxidative burst in polymorphonuclear neutrophils by caffeic acid and hispidin derivatives isolated from sword brake fern (Pteris ensiformis Burm.)
    Hsiu An Wei
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Agric Food Chem 55:10579-84. 2007
    ..These findings indicate that sword brake fern may prevent atherosclerosis via inhibition of both LDL oxidation and ROS production...
  2. doi request reprint Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate
    Mei Chun Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Ethnopharmacol 120:196-203. 2008
    ..This study was to investigate the innate immunity augmentation effects of different fractions prepared from hot water extracts of submerged cultured Antrodia camphorata (AC)...
  3. doi request reprint Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,5,6,7,8,3',4'-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor
    Mei Chun Kou
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Food Funct 4:602-9. 2013
    ..Furthermore, 5-OH-HxMF may have hypolipidemic activity due to its up-regulating hepatic LDLR expression...
  4. pmc Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism
    Ta Chin Lin
    Department of Gynecology, Obstetrics, and Infertility, Kuo General Hospital, NO, 22, Section 2, Ming Sheng Road, Tainan, 70054, Taiwan
    BMC Med Genet 7:36. 2006
    ..We also tried to assess whether the particular identity of Gly972Arg/Ala513Pro polymorphic alleles of the IRS-1 gene mutation can be used as an appropriate diagnostic indicator for PCOS...
  5. ncbi request reprint Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gertn.)
    Ming Jiuan Wu
    Institute of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 717, ROC
    Am J Chin Med 31:687-98. 2003
    ..In addition, the extract also exhibited concentration-dependent antioxidant activities against hemoglobin-induced linoleic acid peroxidation and Fenton reaction-mediated plasmid DNA oxidation...
  6. ncbi request reprint Immunomodulatory properties of Grifola frondosa in submerged culture
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    J Agric Food Chem 54:2906-14. 2006
    ..These results imply that the relatively low molecular mass polysaccharides isolated from mycelia of G. frondosa can enhance innate immunity in vitro and therefore may serve as biological response modifiers...
  7. ncbi request reprint Antioxidant activity of Glossogyne tenuifolia
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    J Agric Food Chem 53:6305-12. 2005
    ..Moreover, luteolin-7-glucoside may serve as the active principal of GT...
  8. ncbi request reprint Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.)
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, 60 Erh Hen Rd, Sec 1, Jen Te, Tainan 717, Taiwan
    J Ethnopharmacol 98:73-81. 2005
    ..These results suggest that SBF attenuates inflammatory mediator synthesis of activated macrophages partially through a NF-kappaB-dependent pathway. The immunomodulatory activity of SBF supports its traditional health promotion effect...
  9. ncbi request reprint Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.)
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 717
    Am J Chin Med 32:681-93. 2004
    ..The antioxidant activity of the MEAB may partially explain its anti-inflammatory and anti-hepatotoxic effects...
  10. ncbi request reprint Anti-inflammatory and antiviral effects of Glossogyne tenuifolia
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Life Sci 76:1135-46. 2005
    ..093 mg/ml. We concluded that GT exerted combinatorial anti-inflammatory and antiviral effects, and the multiple actions may underlie its traditional hepatoprotective function...
  11. ncbi request reprint Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappa B
    Ming Jiuan Wu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC
    J Biomed Sci 11:186-99. 2004
    ..We conclude that GT inhibits NF-kappa B-mediated gene expression and downregulates inflammatory mediator production in murine macrophages...
  12. ncbi request reprint Antiatherogenic effects of kaempferol and rhamnocitrin
    Yi Chen Tu
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    J Agric Food Chem 55:9969-76. 2007
    ..Current evidences indicate that kaempferol and rhamnocitrin not only protect LDL from oxidation but also prevent atherogenesis through suppressing macrophage uptake of oxLDL...
  13. doi request reprint Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells
    Ya Hsuan Lo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Biochim Biophys Acta 1801:114-26. 2010
    ..The effect is different from that of NOB, from which DTF is derived. This study thus significantly enhanced our understanding on how DTF may be beneficial against atherogenesis...
  14. ncbi request reprint Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis
    Mei Chun Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan
    Appl Microbiol Biotechnol 75:769-75. 2007
    ..Our results indicate that the immunomodulatory components of submerged cultured C. sinensis mainly reside in the culture filtrate...
  15. doi request reprint Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages
    Tzi Wei Lian
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Biochim Biophys Acta 1781:601-9. 2008
    ..In conclusion, flavonols may play a role in ameliorating atherosclerosis...
  16. doi request reprint Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells
    Jing Ting Hong
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
    Toxicol Appl Pharmacol 237:59-68. 2009
    ..Taking together, the above findings suggest that kaempferol and rhamnocitrin can augment cellular antioxidant defense capacity, at least in part, through regulation of HO-1 expression and MAPK signal transduction...
  17. doi request reprint 3',4'-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells
    Jeng Dian Su
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Free Radic Biol Med 52:126-41. 2012
    ..Furthermore, modulation of PI3K/Akt signaling is involved in channeling the DTF stimulus for cell survival against oxidative insults...
  18. doi request reprint α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β
    Ning Ping Foo
    Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan
    Toxicology 282:39-46. 2011
    ..These effects could be mediated by the MAPK and PI3K/Akt pathways. According to our current results, LA may have a beneficial role in the treatment of chronic liver diseases caused by ongoing hepatic damage...
  19. ncbi request reprint Ganoderma lucidum mycelia enhance innate immunity by activating NF-kappaB
    Mei Chun Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan, ROC
    J Ethnopharmacol 103:217-22. 2006
    ..6 mg/ml) activated kappaB DNA binding activity in RAW264.7 cells. These results provide supporting evidences for the immunomodulatory effect of Ganoderma lucidum mycelia...
  20. ncbi request reprint Immunomodulatory effect of Glossogyne tenuifolia in murine peritoneal macrophages and splenocytes
    Choi Lan Ha
    Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Ethnopharmacol 107:116-25. 2006
    ..Collectively, the results suggest that GT inhibits proinflammatory mediator synthesis in activated murine peritoneal macrophages and splenocytes, in part through NF-kappaB-dependent pathways...
  21. ncbi request reprint CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population
    Yu Ching Weng
    Clinical Laboratory, SinLau Children Hospital, Taiwan, ROC
    Ann Clin Lab Sci 35:259-64. 2005
    ..In conclusion, we provide evidence that CT60 SNP is associated with susceptibility to GD in the Taiwanese population...
  22. ncbi request reprint New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm
    Yung Husan Chen
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Molecules 13:255-66. 2008
    ..Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively...
  23. doi request reprint Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice
    Lisu Wang
    Department of Environmental and Occupational Health, Medical College, Cheng Kung University, Tainan 701, Taiwan
    J Pharm Pharmacol 60:237-43. 2008
    ..These results suggested that oral administration of submerged cultivated G. frondosa mixture may enhance host innate immunity against foreign pathogens without eliciting adverse inflammatory response...
  24. ncbi request reprint Distinctive antioxidant and antiinflammatory effects of flavonols
    Lisu Wang
    Department of Environmental and Occupational Health, Medical College, Cheng Kung University, Tainan 701, Taiwan
    J Agric Food Chem 54:9798-804. 2006
    ..This result indicates that flavonols, despite structural similarity, have different antioxidant and antiinflammatory effects...