Yi Jen Chen


Country: Taiwan


  1. Chang C, Li S, Chen Y, Huang S, Chen S, Chen Y. Histone deacetylase inhibition attenuates atrial arrhythmogenesis in sterile pericarditis. Transl Res. 2018;200:54-64 pubmed publisher
    ..In conclusion, a pericardiotomy increased fibrosis and arrhythmogenesis in PVs and the LA, which were prevented by HDAC inhibition. ..
  2. Chung C, Lin Y, Chen Y, Kao Y, Yeh Y, Chen Y. Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrial fibroblasts with modulation of nitric oxide synthesis and calcium homeostasis. J Mol Cell Cardiol. 2018;123:128-138 pubmed publisher
    ..Rivaroxaban (100-300 nmol/L) regulates atrial fibroblast activity and atrial fibrosis by increasing NO production and decreasing Ca2+ entry through inhibition of PAR signaling. ..
  3. Chang C, Cheng C, Chen Y, Higa S, Huang J, Chen S, et al. Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node. Eur J Pharmacol. 2018;833:462-471 pubmed publisher
    ..05). In conclusion, Factor Xa inhibitors reduce PV spontaneous activities and may modulate occurrence of atrial fibrillation by inhibiting PAR1 and reducing the INa-late in PVs. ..
  4. Lkhagva B, Chang S, Chen Y, Kao Y, Lin Y, Chiu C, et al. Histone deacetylase inhibition reduces pulmonary vein arrhythmogenesis through calcium regulation. Int J Cardiol. 2014;177:982-9 pubmed publisher
    ..Moreover, MPT0E014-treated rabbits had less AF and shorter AF duration than control rabbits. In conclusions, HDAC inhibition reduced PV arrhythmogenesis and AF inducibility with modulation on calcium homeostasis. ..
  5. Chang C, Cheng C, Yang T, Chen Y, Lin Y, Chen S, et al. Selective and non-selective non-steroidal anti-inflammatory drugs differentially regulate pulmonary vein and atrial arrhythmogenesis. Int J Cardiol. 2015;184:559-67 pubmed publisher
    ..Selective and non-selective NSAIDs differentially modulate PV and atrial electrophysiological characteristics. Celecoxib increased PV triggered activity through enhancement of the NCX current, which contributed to its arrhythmogenesis. ..
  6. Tsai W, Lu Y, Chen Y, Chang C, Kao Y, Lin Y, et al. Ablation of androgen receptor gene triggers right ventricular outflow tract ventricular tachycardia. Int J Cardiol. 2015;189:172-81 pubmed publisher
    ..However, ARKO and WT RVOT myocytes exhibit similar Ca(2+)i transients and SR Ca(2+) content, and less expression of calsequestrin. ARKO changes RVOT electrophysiology and Ca(2+) homeostasis with increased ventricular arrhythmogenesis. ..
  7. Huang S, Chen Y, Kao Y, Hsieh M, Chen Y, Chen W, et al. Renal failure induces atrial arrhythmogenesis from discrepant electrophysiological remodeling and calcium regulation in pulmonary veins, sinoatrial node, and atria. Int J Cardiol. 2016;202:846-57 pubmed publisher
    ..Advanced RF increases atrial arrhythmia by modulating the distinctive electrophysiological characteristics of the PV, LA, and SAN. ..
  8. Huang J, Chen Y, Lee T, Kao Y, Chazo T, Chen S, et al. Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes. Peptides. 2016;78:91-8 pubmed publisher
    ..This study demonstrates GLP-1 may regulate HL-1 cell arrhythmogenesis through modulating calcium handling proteins. ..
  9. Cheng W, Kao Y, Chen S, Chen Y. Pathophysiology of cancer therapy-provoked atrial fibrillation. Int J Cardiol. 2016;219:186-94 pubmed publisher
    ..In this review, we provide succinct potential mechanisms of AF genesis in cancer patients. ..

More Information


  1. Chang C, Cheng C, Chen Y, Kao Y, Chen S, Chen Y. Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: Therapeutic implications in atrial arrhythmogenesis. Int J Cardiol. 2016;221:529-36 pubmed publisher
    ..GJ dysfunction modulates SAN and PV electrical activity, which may contribute to atrial arrhythmogenesis. GJ enhancer has a therapeutic potential in SAN dysfunction and atrial arrhythmogenesis. ..
  2. Kao Y, Hsu J, Chen Y, Lin Y, Lkhagva B, Chen S, et al. ZFHX3 knockdown increases arrhythmogenesis and dysregulates calcium homeostasis in HL-1 atrial myocytes. Int J Cardiol. 2016;210:85-92 pubmed publisher
    ..ZFHX3 knock-down in atrial myocytes dysregulated calcium homeostasis and increased atrial arrhythmogenesis, which may contribute to the occurrence of AF. ..
  3. Li S, Kao Y, Chung C, Chen W, Cheng W, Chen Y. Activated p300 acetyltransferase activity modulates aortic valvular calcification with osteogenic transdifferentiation and downregulation of Klotho. Int J Cardiol. 2017;232:271-279 pubmed publisher
    ..Activated HAT activity of p300 modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation. P300 inhibition is a potential therapeutic target for AV calcification. ..
  4. Lu Y, Cheng C, Tsai C, Lin Y, Lee T, Chen Y, et al. Discrepant effects of heart failure on electrophysiological property in right ventricular outflow tract and left ventricular outflow tract cardiomyocytes. Clin Sci (Lond). 2017;131:1317-1327 pubmed publisher
    ..In conclusion, RVOT and LVOT cardiomyocytes had distinctive electrophysiological characteristics. HF differentially modulates action potential morphology and ionic currents in RVOT and LVOT cardiomyocytes. ..
  5. Huang S, Chen Y, Kao Y, Hsieh M, Lin Y, Chen S, et al. Redox and Activation of Protein Kinase A Dysregulates Calcium Homeostasis in Pulmonary Vein Cardiomyocytes of Chronic Kidney Disease. J Am Heart Assoc. 2017;6: pubmed publisher
    ..CKD increases PV arrhythmogenesis with enhanced calcium-handling abnormalities through activation of protein kinase A and ROS. ..