Benjamin Yat Ming Yung

Summary

Affiliation: Chang Gung University
Country: Taiwan

Publications

  1. pmc Involvement of nucleophosmin/B23 in TPA-induced megakaryocytic differentiation of K562 cells
    C Y Hsu
    Graduate Institute of Pharmacology, National Yang Ming University, Taiwan, Republic of China
    Br J Cancer 89:1320-6. 2003
  2. ncbi Oncogenic role of nucleophosmin/B23
    Benjamin Yat Ming Yung
    Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Chang Gung Med J 30:285-93. 2007
  3. ncbi c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells
    Benjamin Y M Yung
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung Genomics Research Center, Chang Gung University, Tao Yuan 333, Taiwan, Republic of China
    FEBS Lett 578:211-6. 2004
  4. pmc Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair
    Chiao Yun Lin
    Department of Pharmacology, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan
    Mol Biol Cell 21:4409-17. 2010
  5. ncbi Searching cell-secreted proteomes for potential urinary bladder tumor markers
    Chiao Yun Lin
    Department of Pharmacology, College of Medicine, Chang Gung University, Tao Yuan, Taiwan, ROC
    Proteomics 6:4381-9. 2006
  6. ncbi Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells
    Chun Wei Yeh
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, R O C
    Mol Pharmacol 70:1443-53. 2006
  7. pmc Epigeneitc silencing of ribosomal RNA genes by Mybbp1a
    Bertrand Chin Ming Tan
    Graduate Institute of Biomedical Sciences and Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan 333, Taiwan
    J Biomed Sci 19:57. 2012
  8. doi Bikunin loss in urine as useful marker for bladder carcinoma
    Ke Hung Tsui
    Department of Urology, Chang Gung Memorial Hospital, Chang Gung Bioinformatics Center, Taiwan, Republic of China
    J Urol 183:339-44. 2010
  9. ncbi Association of nucleophosmin/B23 mRNA expression with clinical outcome in patients with bladder carcinoma
    Ke Hung Tsui
    Chang Gung Genomics Research Center, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    Urology 64:839-44. 2004
  10. pmc Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
    Hsuan Liu
    Cancer Biochemistry Laboratory, Department of Pharmacology, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, Republic of China
    EMBO Rep 8:394-400. 2007

Collaborators

  • Bertrand Chin Ming Tan
  • Petrus Tang
  • Sheng Chung Lee
  • Shu Jen Chen
  • Ann Joy Cheng
  • Tai Long Pan
  • Sen Yung Hsieh
  • Tzu Hao Wang
  • Yi Huang
  • Chiao Yun Lin
  • Ke Hung Tsui
  • Hsuan Liu
  • Ming H Wu
  • Chun Wei Yeh
  • Phei Lang Chang
  • Shao Jung Lo
  • Chang Ching Yang
  • Chien lun Chen
  • Hui Jia Chan
  • Jing J Weng
  • C Y Hsu
  • Jei H Chang
  • Tse Chin Chen
  • Li Ching Fan
  • Shiu Fen Huang
  • Hsiao Ling Huang
  • Kuo Yang Lin
  • Yow Fu Tsai
  • Yu Jr Lin
  • Chee Jen Chang
  • Hua Chien Chen
  • Chia Ling Hsieh
  • Bertrand Chin-Ming Tan
  • Kun Yi Chien
  • Chih Li Lin
  • Chih Hao Chang
  • Chii Jiun Shih
  • Kwang Den Chen
  • Kai Hung Tseng
  • Ching Ping Chuang
  • Ru Ping Lee
  • Yu Chun Liang
  • Chih Chia Yu
  • Sheng Shun Huang
  • Jing Jei Weng
  • Ph ei Lang Chang
  • Chih C Chou

Detail Information

Publications19

  1. pmc Involvement of nucleophosmin/B23 in TPA-induced megakaryocytic differentiation of K562 cells
    C Y Hsu
    Graduate Institute of Pharmacology, National Yang Ming University, Taiwan, Republic of China
    Br J Cancer 89:1320-6. 2003
    ....
  2. ncbi Oncogenic role of nucleophosmin/B23
    Benjamin Yat Ming Yung
    Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Chang Gung Med J 30:285-93. 2007
    ..In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis...
  3. ncbi c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells
    Benjamin Y M Yung
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung Genomics Research Center, Chang Gung University, Tao Yuan 333, Taiwan, Republic of China
    FEBS Lett 578:211-6. 2004
    ..These results provide evidence for a novel mechanism of transcriptional downregulation of nucleophosmin/B23 and the functional role of c-Myc in RA-induced differentiation...
  4. pmc Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair
    Chiao Yun Lin
    Department of Pharmacology, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan
    Mol Biol Cell 21:4409-17. 2010
    ..Thus, this study unveils a key phosphatase of NPM and highlights a novel mechanism by which the PP1β-NPM pathway contributes to cellular DNA damage response...
  5. ncbi Searching cell-secreted proteomes for potential urinary bladder tumor markers
    Chiao Yun Lin
    Department of Pharmacology, College of Medicine, Chang Gung University, Tao Yuan, Taiwan, ROC
    Proteomics 6:4381-9. 2006
    ..Our work also has identified the loss of pro-u-PA in urine as potential marker of more advanced bladder carcinoma...
  6. ncbi Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells
    Chun Wei Yeh
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, R O C
    Mol Pharmacol 70:1443-53. 2006
    ....
  7. pmc Epigeneitc silencing of ribosomal RNA genes by Mybbp1a
    Bertrand Chin Ming Tan
    Graduate Institute of Biomedical Sciences and Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan 333, Taiwan
    J Biomed Sci 19:57. 2012
    ....
  8. doi Bikunin loss in urine as useful marker for bladder carcinoma
    Ke Hung Tsui
    Department of Urology, Chang Gung Memorial Hospital, Chang Gung Bioinformatics Center, Taiwan, Republic of China
    J Urol 183:339-44. 2010
    ..We searched for bladder tumor markers by analyzing urine samples from patients with bladder cancer and normal individuals...
  9. ncbi Association of nucleophosmin/B23 mRNA expression with clinical outcome in patients with bladder carcinoma
    Ke Hung Tsui
    Chang Gung Genomics Research Center, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    Urology 64:839-44. 2004
    ..To determine whether nucleophosmin/B23 mRNA expression in bladder carcinoma predicts recurrence, progression, and survival...
  10. pmc Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
    Hsuan Liu
    Cancer Biochemistry Laboratory, Department of Pharmacology, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, Republic of China
    EMBO Rep 8:394-400. 2007
    ..This study unveils a hitherto unrecognized transcriptional corepressor function of the NPM protein, and highlights a novel mechanism by which NPM regulates cell growth and differentiation...
  11. ncbi Nucleophosmin/B23 regulates transcriptional activation of E2F1 via modulating the promoter binding of NF-kappaB, E2F1 and pRB
    Chiao Yun Lin
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, R O C
    Cell Signal 18:2041-8. 2006
    ..The results demonstrate a novel mechanism for transcriptional regulation of E2F1 and identify the functional role of nucleophosmin/B23 in modulating the binding of NF-kappaB, E2F1 and pRB to activate E2F1 promoter...
  12. pmc Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis
    Chang Ching Yang
    Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan, ROC
    EMBO J 31:1739-51. 2012
    ....
  13. doi A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells
    Shao Jung Lo
    Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Hepatology 57:1893-905. 2013
    ..Our findings are of clinical significance because NPM up-regulation and p53 mutations are usually found in advanced human cancers, including HCC...
  14. ncbi Can probability of genetic mutation be an indicator of clinical relevance?
    Chien lun Chen
    Department of Urology, Chang Gung Memorial Hospital, Chang Gung Bioinformatics Center, Kwei Shan, Tao Yuan 333, Taiwan, ROC
    Genomics 90:746-50. 2007
    ..These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy...
  15. ncbi UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA
    Ming H Wu
    Graduate Institute of Pharmacology, National Yang Ming University, Taipei 112, Taiwan, Republic of China
    J Biol Chem 277:48234-40. 2002
    ..Our results thus provide important evidence for an involvement of NPM/B23 in the acute response of mammalian cells to environmental stress...
  16. ncbi Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation
    Ming H Wu
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, Republic of China
    Int J Cancer 97:297-305. 2002
    ..Our results indicate that nucleophosmin/B23 correlates with PCNA and DNA repair capacity in cellular sensitivity to UV...
  17. ncbi Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression
    Ming H Wu
    Graduate Institute of Pharmacology, National Yang Ming University, Taiwan, Republic of China
    Carcinogenesis 23:93-100. 2002
    ..The effect of PCNA up-regulation may be one of the reasons that nucleophosmin/B23 over-expression made cells resistant to UV-induced growth inhibition and cell-killing...
  18. ncbi Nucleophosmin/B23-binding peptide inhibits tumor growth and up-regulates transcriptional activity of p53
    Hui Jia Chan
    Chang Gung Genomics Research Center and Department of Pharmacology, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan, ROC
    Biochem Biophys Res Commun 333:396-403. 2005
    ..Peptides having high affinity of binding to molecular targets such as nucleophosmin/B23 represent a potentially useful approach to anti-cancer biotherapeutics...
  19. ncbi Nucleophosmin/B23 regulates PCNA promoter through YY1
    Jing J Weng
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, ROC
    Biochem Biophys Res Commun 335:826-31. 2005
    ..We have demonstrated that nucleophosmin/B23 plays an important role in the regulation of PCNA through YY1...