Chau Ting Yeh

Summary

Affiliation: Chang Gung Memorial Hospital
Country: Taiwan

Publications

  1. pmc HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer
    Ming Ling Chang
    Liver Research Center and Department of Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 6:e26323. 2011
  2. pmc Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital Chang Gung University, College of Medicine, Taoyuan, Taiwan, Republic of China
    BMC Med Genomics 2:51. 2009
  3. doi request reprint Withdrawal of lamivudine in HBeAg-positive chronic hepatitis B patients after achieving effective maintained virological suppression
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Clin Virol 45:114-8. 2009
  4. doi request reprint Impact of the novel hepatotropic viruslike agent NV-F during chronic hepatitis C virus infection
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Infect Dis 198:1742-8. 2008
  5. ncbi request reprint Anti-sense expression of a metallopeptidase gene enhances nuclear entry of HBV-DNA
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 323:32-7. 2004
  6. ncbi request reprint Characterization of a HCV NS5A protein derived from a patient with hepatoma
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    Biochem Biophys Res Commun 327:516-22. 2005
  7. doi request reprint Expression of hepatitis B virus nuclear core antigen in young cirrhotic patients is associated with an unfavourable long-term outcome
    C T Yeh
    Department of Gastroenterology, Liver Cancer Research Centre, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Viral Hepat 15:839-48. 2008
  8. ncbi request reprint Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Biochem Biophys Res Commun 372:157-61. 2008
  9. ncbi request reprint A novel ex vivo assay of interferon-based suppression, to predict the outcome of antiviral therapy for hepatitis C
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, and Department of Surgery, Chang Gung Children s Hospital, Taipei, Taiwan
    J Infect Dis 193:1365-70. 2006
  10. ncbi request reprint Emergence and takeover of precore-stop mutant prior to exacerbation of e antigen-negative chronic hepatitis B after withdrawal of lamivudine therapy
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Med Virol 78:906-10. 2006

Collaborators

Detail Information

Publications92

  1. pmc HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer
    Ming Ling Chang
    Liver Research Center and Department of Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 6:e26323. 2011
    ..Hepatoma up-regulated protein (HURP) is a component of the chromatin-dependent pathway for spindle assembly. We examined the prognostic predictive value of HURP in human hepatocellular carcinoma (HCC)...
  2. pmc Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital Chang Gung University, College of Medicine, Taoyuan, Taiwan, Republic of China
    BMC Med Genomics 2:51. 2009
    ..These effects mediated by HCV core are reduced by administration of CD55, a regulator of the complement pathway. The model may be valuable in investigating the pathogenesis of liver inflammation in chronic hepatitis C...
  3. doi request reprint Withdrawal of lamivudine in HBeAg-positive chronic hepatitis B patients after achieving effective maintained virological suppression
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Clin Virol 45:114-8. 2009
    ..The outcome of patients following this therapeutic guideline has not been clearly investigated...
  4. doi request reprint Impact of the novel hepatotropic viruslike agent NV-F during chronic hepatitis C virus infection
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Infect Dis 198:1742-8. 2008
    ..In conclusion, coinfection of the NV-F agent in chronic HCV infection is associated with more severe hepatitis activity...
  5. ncbi request reprint Anti-sense expression of a metallopeptidase gene enhances nuclear entry of HBV-DNA
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 323:32-7. 2004
    ..Our present data suggest that in the initial stage of HBV infection, liver metallopeptidase constitutes a barrier for effective nuclear entry of HBV genomic DNA. Attenuation of metallopeptidase activity may facilitate HBV infection...
  6. ncbi request reprint Characterization of a HCV NS5A protein derived from a patient with hepatoma
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    Biochem Biophys Res Commun 327:516-22. 2005
    ..Our results suggested that other cytosolic pathways independent of Grb2-mediated mechanisms were involved in the transactivation activity of HCV NS5A...
  7. doi request reprint Expression of hepatitis B virus nuclear core antigen in young cirrhotic patients is associated with an unfavourable long-term outcome
    C T Yeh
    Department of Gastroenterology, Liver Cancer Research Centre, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Viral Hepat 15:839-48. 2008
    ..Mutations on the NLS of core protein were selected in some patients with nuclear HBcAg...
  8. ncbi request reprint Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Biochem Biophys Res Commun 372:157-61. 2008
    ..Viral passages could be achieved in these animals. The antiviral effects of interferon and sodium stibogluconate administrated as a single agent or in combination were demonstrated in this animal model...
  9. ncbi request reprint A novel ex vivo assay of interferon-based suppression, to predict the outcome of antiviral therapy for hepatitis C
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, and Department of Surgery, Chang Gung Children s Hospital, Taipei, Taiwan
    J Infect Dis 193:1365-70. 2006
    ..264-14.085]; P=.0192) were independent determinants of sustained virological response. In conclusion, this new assay serves as an independent predictor of sustained virological response in interferon-based antiviral therapy...
  10. ncbi request reprint Emergence and takeover of precore-stop mutant prior to exacerbation of e antigen-negative chronic hepatitis B after withdrawal of lamivudine therapy
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Med Virol 78:906-10. 2006
    ..The present data indicate that at least in some patients, the precore-stop mutant is the cause but not the consequence of the flare of HBeAg-negative hepatitis...
  11. ncbi request reprint Identification of NV-F virus DNA in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    J Med Virol 79:92-6. 2007
    ..In conclusion, NV-F virus DNA was identified in 15.4% of HCC tissues. HCC patients with NV-F virus infection were significantly older than those without NV-F virus infection...
  12. ncbi request reprint Identification of a novel single-stranded DNA fragment associated with human hepatitis
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    J Infect Dis 193:1089-97. 2006
    ..In conclusion, we have identified a novel single-stranded DNA fragment derived from a virus-like agent associated with human hepatitis...
  13. pmc Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses: a case report
    Ming Ling Chang
    Liver Cancer Research Center, Chang Gung Memorial Hospital, 6J Laboratory, Linko Medical Center, 199 Tung Hwa North Road, Taipei, Taiwan Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    J Med Case Reports 5:246. 2011
    ..abstract:..
  14. ncbi request reprint Inhibition of authentic hepatitis C virus replication by sodium stibogluconate
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Biochem Biophys Res Commun 310:537-41. 2003
    ..A human trial is mandatory to understand its clinical value in treating chronic hepatitis C...
  15. ncbi request reprint Antisense overexpression of BMAL2 enhances cell proliferation
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan
    Oncogene 22:5306-14. 2003
    ..In conclusion, by combining three different methods, we have obtained a panel of frequently down regulated genes in HCC, including BMAL2. Antisense overexpression of BMAL2 enhances cell proliferation...
  16. ncbi request reprint Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 18:1129-38. 2003
    ..The aim of the present study was to investigate whether spontaneous seroclearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B could be attributed to the presence of pre-S/S gene mutations...
  17. ncbi request reprint Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines
    Sheng Ming Wu
    Department of Biochemistry, School of Medicine, Chang Gung University, 259 Wen hwa 1 Road, Taoyuan, 333, Taiwan, ROC
    Cell Mol Life Sci 67:1831-43. 2010
    ..Finally, TR was downregulated in a small subset of hepatocellular carcinoma cells concomitantly reduced the expression of C/EBPalpha and MAT1A...
  18. ncbi request reprint Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4 cm
    Shi Ming Lin
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Gastroenterology 127:1714-23. 2004
    ..The aim of this study was to compare the clinical outcome of percutaneous radiofrequency (RF) ablation, conventional percutaneous ethanol injection (PEI), and higher-dose PEI in treating hepatocellular carcinoma (HCC) 4 cm or less...
  19. ncbi request reprint Liver transplantation in patients with hepatitis B virus-related hepatocellular carcinoma: the influence of viral characteristics on clinical outcome
    Ting Jung Wu
    Chang Gung Transplantation Institute, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Ann Surg Oncol 20:3582-90. 2013
    ..This study investigates the correlation between HBV relapse and HCC recurrence and it explores factors that affect patient outcomes after LT...
  20. ncbi request reprint Virus and transaminase levels determine the emergence of drug resistance during long-term lamivudine therapy in chronic hepatitis B
    Ming Ling Chang
    Liver Research Unit, Chang Gung Memorial Hospital and University, 199, Tung Hwa North Road, Taipei, Taiwan
    J Hepatol 43:72-7. 2005
    ..The aim was to evaluate the impact of viral factors, host factors, host-viral interaction and drug factor on the emergence of rtM204 I/V...
  21. ncbi request reprint Determinants for sustained HBeAg response to lamivudine therapy
    Rong Nan Chien
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Hepatology 38:1267-73. 2003
    ..In conclusion, HBV genotype, age, and additional treatment are the major determinants for the sustained HBeAg response to lamivudine therapy...
  22. ncbi request reprint Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance
    Chao Wei Hsu
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Gastroenterology 132:543-50. 2007
    ..It is generally believed to be a benevolent sign, implicating clearance of viremia. The aim of this study is to examine the authenticity of this dogma...
  23. pmc Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma
    Ya Hui Huang
    Department of Hepato Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e37188. 2012
    ..Functional analysis of a miRNA predictor, miR-155, suggested that the prognostic miRNA predictors identified under this strategy could serve as potential molecular targets for anticancer therapy...
  24. doi request reprint The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells
    Li Yuan Chang
    College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    J Immunol 189:567-74. 2012
    ..In conclusion, these results indicate that the potent in vivo suppression ability of CD103(+) Tregs is due to the tissue-migration ability through CCR5 expression...
  25. doi request reprint Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma
    Ruey Nan Chen
    Department of Biochemistry, School of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Cancer Res 68:1697-706. 2008
    ..Together, these findings indicate that PTTG1 gene expression is mediated by Sp1 and is indirectly down-regulated by T(3). Finally, overexpression of PTTG1 or SP1 in HCCs is TR-dependent and crucial in the development of HCC...
  26. ncbi request reprint Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    Scand J Gastroenterol 43:747-55. 2008
    ..The purpose of this study was to investigate the effects of core produced de novo within adult mouse hepatocytes by using a new transgenic mouse line in which expression of HCV core is regulated by tetracycline (tet-off)...
  27. pmc Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5 Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan, China
    World J Gastroenterol 13:3472-7. 2007
    ..To investigate a specific association between hepatic steatosis and hepatitis C virus (HCV) core...
  28. doi request reprint HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration
    Ming Ling Chang
    Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linko, Taiwan
    Obesity (Silver Spring) 20:1474-80. 2012
    ..024). In conclusion, HCV core-induced nonobese hepatic steatosis is associated with downregulation of the leptin gene in visceral fat and concurrent hypoadiponectinemia; however, these effects may be ameliorated by adiponectin treatment...
  29. ncbi request reprint The oncogenic potential of hepatitis B virus rtA181T/ surface truncation mutant
    Ming Wei Lai
    Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Antivir Ther 13:875-9. 2008
    ..Surprisingly, this patient has never received lamivudine or adefovir antiviral therapy. Here, we aimed to evaluate the oncogenic potential of HBV rtA181T/surface truncation mutant...
  30. ncbi request reprint Radiofrequency ablation for hepatocellular carcinoma: a prospective comparison of four radiofrequency devices
    Shi Ming Lin
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199 Tung Hwa North Road, Taipei, Taiwan
    J Vasc Interv Radiol 18:1118-25. 2007
    ..To compare the effectiveness of ablation techniques for hepatocellular carcinoma (HCC) with the use of four radiofrequency (RF) devices...
  31. ncbi request reprint Pneumoperitoneum following percutaneous radiofrequency ablation of hepatocellular carcinoma unrelated to bowel injury: a case report
    Wei Ting Chen
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Hepatogastroenterology 54:2365-7. 2007
    ..The pneumoperitoneum without peritoneal sign after RF ablation is previously unreported. A case is reported here of localized pneumoperitoneum unrelated to bowel injury following RF ablation for hepatocellular carcinoma...
  32. pmc An occult hepatitis B-derived hepatoma cell line carrying persistent nuclear viral DNA and permissive for exogenous hepatitis B virus infection
    Chih Lang Lin
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Keelung, Taiwan
    PLoS ONE 8:e65456. 2013
    ..Additionally, Hep-Y2 cells carried persistent extrachromosomal HBV DNA in the nuclei. This cell line could serve as a useful tool to establish the molecular and virological basis of occult HBV infection...
  33. ncbi request reprint Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Hum Gene Ther 19:391-5. 2008
    ....
  34. ncbi request reprint Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
    Yao Shih Hsu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Hepatology 35:1522-7. 2002
    ..005). In conclusion, the results suggest that spontaneous HBeAg seroconversion confers favorable long-term outcomes. However, active hepatitis still may develop and lead to cirrhosis and HCC...
  35. pmc Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma
    Ya Hui Huang
    Department of Hepato Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e40738. 2012
    ..In conclusion, furin overexpression inhibited HCC tumor growth in a subcutaneous xenograft model and predicted a better postoperative DFS in clinical analysis...
  36. doi request reprint Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells
    Chen Hsin Liao
    Department of Biochemistry, School of Medicine, Chang Gung University, Taoyuan, Taiwan
    Hepatology 55:910-20. 2012
    ..J7-DKK4 and J7-TRα1 overexpressing mice, which displayed growth arrest, lower lung colony formation index, and smaller tumor size than in control mice, supporting an inhibitory role of DKK4 in tumor progression...
  37. pmc Large fragment pre-S deletion and high viral load independently predict hepatitis B relapse after liver transplantation
    Ting Jung Wu
    Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e32189. 2012
    ..In conclusion, besides high viral load, LFpreSDel mutation is an important independent predictor for hepatitis B relapse after LT. More aggressive preventive strategies should be applied for patients carrying these risk factors...
  38. ncbi request reprint Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatology 52:1922-33. 2010
    ..005) and overall (P = 0.020) survival. A hot deletion region located between codons 107 and 141 of the pre-S sequence was identified for the short stretch pre-S deletion mutants...
  39. pmc Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines
    Ruey Nan Chen
    Department of Biochemistry, Chang Gung University, 259 Wen hwa 1 Road, Taoyuan 333, Taiwan, Republic of China
    Endocrinology 149:3817-31. 2008
    ..Thus, T(3) regulates furin gene expression via a novel mechanism or in cooperation with TGF-beta to enhance tumor metastasis in vitro and in vivo...
  40. pmc Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan
    BMC Genomics 9:109. 2008
    ..Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis...
  41. ncbi request reprint Fine-needle aspiration cytology to distinguish dysplasia from hepatocellular carcinoma with different grades
    Chen Chun Lin
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    J Gastroenterol Hepatol 23:e146-52. 2008
    ..The aim of this study was to diagnose HCC and the distinction of liver cell dysplasia from HCC with different grades by interpreting and scoring the cyto-morphological features...
  42. doi request reprint A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Unit, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Int J Cancer 134:1214-24. 2014
    ..Combining GALNT14 genotype and clinical parameters, a subgroup of patients with excellent outcome was identified. ..
  43. pmc Quantitative assessment of serum NV-F virus DNA concentrations in samples from patients coinfected with hepatitis B or C virus
    Chao Wei Hsu
    Liver Research Unit, Chang Gung Medical Center, 199, Tung Hwa North Road, Taipei, Taiwan
    J Clin Microbiol 44:3130-3. 2006
    ..A reciprocal relationship was found between NV-F-DNA and HBV DNA concentrations in HBVCI patients, indicating the presence of viral interference between these two DNA viruses...
  44. doi request reprint Increased seroprevalence of HBV DNA with mutations in the s gene among individuals greater than 18 years old after complete vaccination
    Ming Wei Lai
    Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Gastroenterology 143:400-7. 2012
    ..We investigated the seroepidemiology and genotypic characteristic of HBV for long periods after neonatal vaccination...
  45. pmc Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    BMC Cancer 11:398. 2011
    ..Recent studies demonstrated an increased oncogenic potential of this mutant in NIH3T3 cells. In this study, we aimed to investigate the clinical significance of this finding...
  46. doi request reprint Hydrodynamics-based transfection of the combination of betacellulin and neurogenic differentiation 1 DNA ameliorates hyperglycemia in mice with streptozotocin-induced diabetes
    Chang Mu Sung
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Diabetes Technol Ther 13:519-25. 2011
    ..We aimed to evaluate the feasibility of hydrodynamics-based transfection (HBT) with Neurod1 and Btc in improving hyperglycemia...
  47. ncbi request reprint Prospective randomized controlled study of interferon-alpha in preventing hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors
    Shi Ming Lin
    Liver Research Unit, Chang Gung Memorial Hospitaland Chang Gung University, 199 Tung Hwa North Road, Taipei, Taiwan
    Cancer 100:376-82. 2004
    ..Hepatocellular carcinoma (HCC) recurrence after ablation therapy for primary tumors is common...
  48. ncbi request reprint Impact of acute hepatitis C virus superinfection in patients with chronic hepatitis B virus infection
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Gastroenterology 126:1024-9. 2004
    ..The natural course following acute hepatitis C virus (HCV) superinfection has not been well studied. The aim of this study was to investigate the impact of acute HCV superinfection...
  49. ncbi request reprint Identification of nonsense mutations in hepatitis B virus S gene in patients with hepatocellular carcinoma developed after lamivudine therapy
    Ming Wei Lai
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    Antivir Ther 14:249-61. 2009
    ..The significance of such mutations in hepatocarcinogenesis remains elusive. Here, we aimed to understand the oncogenicity of HBV pre-S/S nonsense mutations identified in patients with HCC that developed after lamivudine therapy...
  50. pmc CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection
    Chau Ting Yeh
    Liver Research Unit, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    BMC Cancer 9:324. 2009
    ..The aim of this study was to investigate the significance of CD133 expression in HCC in an area endemic for hepatitis B virus (HBV) infection to gain insights on this issue...
  51. ncbi request reprint Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabetic mice
    Tsung Hsing Chen
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Kuei Shan, Taoyuan, Taiwan
    Endocr J 56:783-90. 2009
    ..In studies on the short-term biological effects of Pdx1 in vivo, HBT is a potential alternative to viral delivery of Pdx1 to the murine liver...
  52. ncbi request reprint Dense packing of portal lymphocytes predicts favorable treatment outcome in hepatitis C
    Ming Ling Chang
    Liver Research Unit, Chang Gung Medical Center, 199, Tung Hwa North Road, Taipei, Taiwan
    Hepatogastroenterology 55:1716-20. 2008
    ..To identify pre-therapeutic predictors of sustained virological response (SVR) in Taiwanese patients with chronic hepatitis C...
  53. pmc Inhibition of hepatitis C virus replication by arsenic trioxide
    Der Ren Hwang
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taipei, Taiwan
    Antimicrob Agents Chemother 48:2876-82. 2004
    ..The study highlights the indications for use of a novel class of anti-HCV agent. Further elucidation of the exact antiviral mechanism of As2O3 may lead to the development of agents with potent activities against HCV or related viruses...
  54. doi request reprint The various impacts of the hepatitis C virus core protein upon hepatic oxidative stress after common bile duct ligation and partial hepatectomy
    Ming Yu Chang
    Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Redox Rep 13:172-8. 2008
    ....
  55. ncbi request reprint Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization
    Mei Ling Tsao
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Biochem Biophys Res Commun 348:271-7. 2006
    ..Since HCV replication requires intact microtubule and actin polymerization, HCV F protein may serve as a modulator to prevent high level of HCV replication and thus contributes to viral persistence in chronic HCV infection...
  56. ncbi request reprint Evaluation of serum matrix metalloproteinase (MMP)-9 to MMP-2 ratio as a biomarker in hepatocellular carcinoma
    Huei Chung Yeh
    Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatogastroenterology 57:98-102. 2010
    ..In this study, we evaluate the clinical usefulness of this ratio as a biomarker in hepatitis B virus-related hepatocellular carcinoma (HCC)...
  57. doi request reprint Emergence of hepatitis B virus S gene mutants in patients experiencing hepatitis B surface antigen seroconversion after peginterferon therapy
    Chao Wei Hsu
    Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatology 54:101-8. 2011
    ..A phenotypic study of Huh-7 cells showed a complete loss of antigenicity. Patient 2 subsequently experienced an episode of hepatitis relapse 7 months after the end of treatment and was negative for HBsAg throughout the hepatitis flare...
  58. ncbi request reprint Treatment of hepatocellular carcinoma using internally cooled electrodes. A prospective comparison of modified automated vs. manual pulsed radiofrequency algorithms
    Ian Homer Y Cua
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Oncology 72:76-82. 2007
    ..To compare the effectiveness of modified automated and manual pulsed radiofrequency (RF) algorithms using internally cooled electrodes for hepatocellular carcinoma (HCC)...
  59. doi request reprint GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC
    Kung Hao Liang
    Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pharmacogenomics 12:1061-73. 2011
    ..We aimed to identify germline SNP markers in order to predict the objective response of combination chemotherapy using 5-fluorouracil, mitoxantrone and cisplatin (FMP)...
  60. doi request reprint Segregation of signaling proteins as prognostic predictors for local recurrence and distant metastasis in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei 105, Taiwan, R O C
    Int J Oncol 44:491-504. 2014
    ..004) were associated with EHM-free survival. These factors were further examined in the verification cohort. In conclusion, postoperative LR and EHM in HCC were associated with separable sets of clinical and molecular predictors. ..
  61. ncbi request reprint Genetic alterations of INK4alpha/ARF locus and p53 in human hepatocellular carcinoma
    Cheng Yuan Peng
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
    Anticancer Res 22:1265-71. 2002
    ..results suggest that p14(ARF), p16(INK4a) and p53 are differentially disrupted through distinct molecular mechanisms at different stages in HCC and that p14(ARF) and p53 appear to function in the same tumor suppression pathway in HCC..
  62. pmc Peritumoral small ephrinA5 isoform level predicts the postoperative survival in hepatocellular carcinoma
    Tong Hong Wang
    Tissue Bank, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    PLoS ONE 7:e41749. 2012
    ..However, the role of ephrinA5S in hepato-carcinogenesis remains unclear. In this study, we evaluate the role of ephrinA5 isoforms in human hepatocellular carcinomas (HCC)...
  63. doi request reprint Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy
    Chih Lang Lin
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Keelung, Taiwan
    J Antimicrob Chemother 67:39-48. 2012
    ..The aim of this study was to search for previously unrecognized compensatory mutations following development of lamivudine-resistant mutants...
  64. pmc Development of a non-invasive fibrosis test for chronic hepatitis B patients and comparison with other unpatented scores
    Chao Wei Hsu
    Chang Gung Memorial Hospital, Taipei, Taiwan
    BMC Res Notes 6:212. 2013
    ..Such inadequacy is largely caused by requirement of biochemical parameters rarely performed in routine clinical tests. We developed a novel fibrosis HB-F score using commonly performed tests for HBV infected patients...
  65. doi request reprint Network analysis and proteomic identification of vimentin as a key regulator associated with invasion and metastasis in human hepatocellular carcinoma cells
    Tai Long Pan
    School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan
    J Proteomics 75:4676-92. 2012
    ..This article is part of a Special Issue entitled: Translational Proteomics...
  66. ncbi request reprint Emergence of mutation clusters in the HCV genome during sequential viral passages in Sip-L expressing cells
    Der Ren Hwang
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taipei, Taiwan
    J Virol Methods 129:170-7. 2005
    ..The mutant HCV can be used as an infection source to study the molecular mechanism of HCV replication...
  67. ncbi request reprint Expression of the HCRP1 mRNA in HCC as an independent predictor of disease-free survival after surgical resection
    Ming Wei Lai
    Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatol Res 39:164-76. 2009
    ..852; 95% CI, 1.131-3.032; P = 0.014) were included as independent predictors for disease-free survival. Conclusion: Expression of HCRP1 mRNA served as an independent predictor for postoperative disease-free survival in HCC patients...
  68. pmc Distinct Patterns of the Lipid Alterations between Genotype 1 and 2 Chronic Hepatitis C Patients after Viral Clearance
    Ming Ling Chang
    Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 9:e104783. 2014
    ..The hepatitis C virus (HCV) genotype-specific impacts on the host metabolic alterations remained inconclusive...
  69. doi request reprint Overexpression of cyclin-dependent kinase-associated protein phosphatase enhances cell proliferation in renal cancer cells
    Ming Wei Lai
    Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Urol Oncol 30:871-8. 2012
    ..The aim of this study was to understand the role of cyclin-dependent kinase-associated protein phosphatase (KAP) in renal cancer cell growth...
  70. pmc Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    J Clin Microbiol 40:16-21. 2002
    ..Precore mutant ratios tended to correlate with ALT levels and anti-HBe seroconversion, but high precore mutant ratios were associated with persistent hepatitis after anti-HBe seroconversion and increased risk of cirrhosis...
  71. ncbi request reprint No benefit to continue lamivudine therapy after emergence of YMDD mutations
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Antivir Ther 9:257-62. 2004
    ..In addition, experiments have shown that the defective replication competency of rt M 204 I/V restores upon addition of lamivudine...
  72. doi request reprint Tumor-derived chemokine CCL5 enhances TGF-β-mediated killing of CD8(+) T cells in colon cancer by T-regulatory cells
    Li Yuan Chang
    Graduate Institute of Biomedical Sciences, Chang Gung University, Taiwan
    Cancer Res 72:1092-102. 2012
    ..Together, our findings establish that CCL5/CCR5 signaling recruits T(reg) to tumors and enhances their ability to kill antitumor CD8(+) T cells, thereby defining a novel mechanism of immune escape in colorectal cancer...
  73. ncbi request reprint Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine
    Wei Ping Lee
    Department of Internal Medicine and Cancer Center, Taipei Veterans General Hospital, 201 Shi Pai Road Section 2, Taipei, Taiwan
    Cancer Res 63:6229-36. 2003
    ..Further study showed that both NF-kappaB and PARP played protective roles in the prevention of E1A+gemcitabine-induced apoptosis...
  74. ncbi request reprint Overexpression of kappa-actin alters growth properties of hepatoma cells and predicts poor postoperative prognosis
    Kuei Wen Chang
    Department of Pediatric Gastroenterology, Chang Gung Children s Hospital, and Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC
    Anticancer Res 31:2037-44. 2011
    ..Here, we investigated the function of a novel class of actins, named κ-actins, in hepatocellular carcinoma (HCC)...
  75. ncbi request reprint Development of HBV S gene mutants in chronic hepatitis B patients receiving nucleotide/nucleoside analogue therapy
    Chau Ting Yeh
    Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan
    Antivir Ther 15:471-5. 2010
    ..The clinical consequences of infection by these S gene mutants demand further clarification. Judicious selection of the antiviral agents and vigilant monitoring of viral mutants during the course of therapy are advised...
  76. ncbi request reprint Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, China
    World J Gastroenterol 11:4167-72. 2005
    ..To build up the research models of hepatic fibrosis in mice...
  77. ncbi request reprint Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, 199, Tung Hwa North Road, Taipei 105, Taiwan
    Biochem Biophys Res Commun 305:311-4. 2003
    ..In conclusion, a previously unidentified KAP-Cdk2 interaction domain was discovered. Truncated KAP mutants containing this domain interfered with the wild-type KAP-Cdk2 interaction...
  78. pmc Identification of a two-layer regulatory network of proliferation-related microRNAs in hepatoma cells
    Yi Huang
    Graduate Institute of Biomedical Science, Department of Biomedical Science, School of Medicine, Molecular Medicine Research Center, Chang Gung University, Tao Yuan 33302, Taiwan
    Nucleic Acids Res 40:10478-93. 2012
    ....
  79. doi request reprint Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    J Med Virol 81:467-72. 2009
    ..This may account at least partially for the strong association between HCV-related hepatocarcinogenesis and hepatic inflammation/ fibrosis...
  80. doi request reprint SLC25A13 gene mutations in Taiwanese patients with non-viral hepatocellular carcinoma
    Kuei Wen Chang
    Department of Pediatrics, Chang Gung Memorial Hospital, Taipei, Taiwan
    Mol Genet Metab 103:293-6. 2011
    ..No significant differences in patient characteristics were observed. Further analyses of patients with SLC25A13 gene mutations may elucidate the relationship between the citrin gene and susceptibility of HCC...
  81. ncbi request reprint Identification of a novel actin isoform in hepatocellular carcinoma
    Kuei Wen Chang
    Department of Pediatric Gastroenterology, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Hepatol Res 36:33-9. 2006
    ..Altered actin isoform expression occurs in some pathological conditions including muscular malignancies. This study was to investigate whether a similar event occurs in hepatocellular carcinoma...
  82. ncbi request reprint Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy-dye labeling combined with three-dimensional fractionation
    Chih Ching Wu
    Proteomics Core Laboratory, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    Proteomics 8:3605-20. 2008
    ..In conclusion, Cy dye labeling combined with three-dimensional fractionation is a feasible strategy for identifying differentially expressed serum proteins in an NPC xenograft model, and Prx-II may represent a potential NPC biomarker...
  83. pmc New enzyme-linked immunosorbent assay for detection of antibodies against hepatitis delta virus using a hepatitis delta antigen derived from a Taiwanese clone and comparison to the Abbott radioimmunoassay
    Yung Bin Kuo
    Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Clin Vaccine Immunol 19:817-9. 2012
    ..The detection efficiency of this assay was comparable to that of the commercially available Abbott anti-HD radioimmunoassay (RIA) and could be useful in routine laboratory diagnoses of HDV infection...
  84. doi request reprint Regulation of AKR1B1 by thyroid hormone and its receptors
    Chen Shin Liao
    Department of Biochemistry, Chang Gung University, Taoyuan, Taiwan, ROC
    Mol Cell Endocrinol 307:109-17. 2009
    ..Thus, T(3) regulates AKR1B1 gene expression via a TRE-dependant mechanism and associates liver cancer...
  85. pmc Retrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma
    Chau Ting Yeh
    Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    BMC Cancer 11:117. 2011
    ..Chemotherapy given in a split-dose manner was associated with reduced toxicities. In this retrospective study, we compared the efficacies and side effects between a regular and a split-dose FMP protocol approved in our medical center...
  86. ncbi request reprint Primary biliary cirrhosis in antimitochondrial antibody-negative patients: Chang Gung Memorial Hospital experience
    Yung Kuan Tsou
    Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei
    Chang Gung Med J 26:323-9. 2003
    ..In Asian countries, clinical information regarding AMA-negative PBC is still limited. In this report, we reviewed our patients with AMA-negative PBC in order to further understand this disease...
  87. pmc Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199, Tung Hwa North Road, Taipei, 105, Taiwan
    Hepatol Int 1:267-73. 2007
    ..To elucidate the long-term natural course following the onset of cirrhosis in patients with chronic hepatitis B...
  88. ncbi request reprint Power rolloff during interactive radiofrequency ablation can enhance necrosis when treating hepatocellular carcinoma
    Shi Ming Lin
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199, Tung Hwa North Rd, Taipei, 105 Taiwan
    AJR Am J Roentgenol 180:151-7. 2003
    ..The purpose of this study was to compare the efficacy between standard and interactive radiofrequency ablation for treatment of hepatocellular carcinoma...
  89. ncbi request reprint Cytologic changes in small hepatocellular carcinomas after radiofrequency ablation
    Shi Ming Lin
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Acta Cytol 46:490-4. 2002
    ..To illustrate the cytologic changes in hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA)...
  90. doi request reprint Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity
    Yung Chang Lin
    School of Medicine, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    J Immunol 182:6095-104. 2009
    ..Taken together, data suggest that effector/memory Treg cells are responsible for the loss of concomitant tumor immunity associated with tumor progression...
  91. pmc Infection with hepatitis B virus carrying novel pre-S/S gene mutations in female siblings vaccinated at birth: two case reports
    Ming Wei Lai
    Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taoyuan, Taiwan
    J Med Case Reports 4:190. 2010
    ..Here, we report two female siblings in whom the infection occurred in their adolescence. This report raises the question of whether a booster for hepatitis B vaccination is needed...
  92. ncbi request reprint Telbivudine versus lamivudine in patients with chronic hepatitis B
    Ching Lung Lai
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    N Engl J Med 357:2576-88. 2007
    ..Reducing hepatitis B virus (HBV) replication to minimal levels is emerging as a key therapeutic goal for chronic hepatitis B...