K D Yang

Summary

Affiliation: Chang Gung Memorial Hospital
Country: Taiwan

Publications

  1. pmc Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children
    Chung Chen Li
    Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan and Chang Gung University College of Medicine, Kaohsiung
    Emerg Infect Dis 16:1265-72. 2010
  2. pmc Sialylated glycans as receptor and inhibitor of enterovirus 71 infection to DLD-1 intestinal cells
    Betsy Yang
    Kaohsiung American School, Taiwan, Republic of China
    Virol J 6:141. 2009
  3. pmc Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
    Yun Shien Lee
    Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    BMC Genomics 6:132. 2005
  4. ncbi Altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in Taiwan
    K D Yang
    Chang Gung Children s Hospital, Niau Sung, Kaohsiung 833, Taiwan
    J Infect Dis 183:850-6. 2001
  5. ncbi Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases
    K D Yang
    Departments of Medical Research and Obstetrics, Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
    Clin Exp Allergy 34:32-7. 2004
  6. ncbi Implication of cord blood myeloperoxidase but not of soluble p-selectin levels in preterm deliveries
    Kuender D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital at Kaohsiung, Taiwan
    J Perinat Med 32:49-52. 2004
  7. ncbi Asthma management issues in infancy and childhood
    Kuender D Yang
    Department 4 Medical Research, Chang Gung Children s Hospital at Kaohsiung, 123 Ta Pei Road, Niao Sung, Kaohsiung 833, Taiwan
    Treat Respir Med 4:9-20. 2005
  8. ncbi Current understanding and therapy of asthma workshop summary
    Kuender D Yang
    Chang Gung Children Hospital at Kaohsiung, Taiwan, ROC
    Cell Mol Immunol 1:436-9. 2004
  9. ncbi Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production
    K D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Clin Exp Allergy 37:680-7. 2007
  10. doi MicroRNA-21 expression in neonatal blood associated with antenatal immunoglobulin E production and development of allergic rhinitis
    R F Chen
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Clin Exp Allergy 40:1482-90. 2010

Collaborators

Detail Information

Publications96

  1. pmc Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children
    Chung Chen Li
    Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan and Chang Gung University College of Medicine, Kaohsiung
    Emerg Infect Dis 16:1265-72. 2010
    ..7 days). These results suggest that younger children may require a longer isolation period and that patients with pneumonia may require treatment that is more aggressive than standard therapy for pandemic (H1N1) 2009 virus...
  2. pmc Sialylated glycans as receptor and inhibitor of enterovirus 71 infection to DLD-1 intestinal cells
    Betsy Yang
    Kaohsiung American School, Taiwan, Republic of China
    Virol J 6:141. 2009
    ..Using DLD-1 intestinal cells, this study investigated whether SA-linked glycan on DLD-1 intestinal cells was a receptor for EV71, and whether natural SA-linked sugars from human milk could block EV71 infection...
  3. pmc Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
    Yun Shien Lee
    Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    BMC Genomics 6:132. 2005
    ..6% mortality rate. Although immunopathological damages may account for the severity of respiratory distress, little is known about how the genome-wide gene expression of the host changes under the attack of SARS-CoV...
  4. ncbi Altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in Taiwan
    K D Yang
    Chang Gung Children s Hospital, Niau Sung, Kaohsiung 833, Taiwan
    J Infect Dis 183:850-6. 2001
    ..Results from this study suggest that younger children with a certain CTLA-4 polymorphism and altered cellular but not humoral response may be linked to EV 71 meningoencephalitis...
  5. ncbi Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases
    K D Yang
    Departments of Medical Research and Obstetrics, Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
    Clin Exp Allergy 34:32-7. 2004
    ..A variety of genes are related to allergic disorders in different ethnic populations. The genetic basis for the gender discrepancy of allergic diseases remains to be determined...
  6. ncbi Implication of cord blood myeloperoxidase but not of soluble p-selectin levels in preterm deliveries
    Kuender D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital at Kaohsiung, Taiwan
    J Perinat Med 32:49-52. 2004
    ..This suggests that fetal phagocyte activation may be implicated in preterm delivery, and subsequently in prematurity-related inflammatory insults...
  7. ncbi Asthma management issues in infancy and childhood
    Kuender D Yang
    Department 4 Medical Research, Chang Gung Children s Hospital at Kaohsiung, 123 Ta Pei Road, Niao Sung, Kaohsiung 833, Taiwan
    Treat Respir Med 4:9-20. 2005
    ..Moreover, recent advances in pharmacogenetics and pharmacogenomics may provide better individualized care for early pharmacological prevention of childhood asthma via selective modulation of airway remodeling...
  8. ncbi Current understanding and therapy of asthma workshop summary
    Kuender D Yang
    Chang Gung Children Hospital at Kaohsiung, Taiwan, ROC
    Cell Mol Immunol 1:436-9. 2004
    ..This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population...
  9. ncbi Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production
    K D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Clin Exp Allergy 37:680-7. 2007
    ..This study investigated the interaction of CTLA-4 polymorphism with prenatal factors on the elevation of cord blood IgE (CBIgE)...
  10. doi MicroRNA-21 expression in neonatal blood associated with antenatal immunoglobulin E production and development of allergic rhinitis
    R F Chen
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Clin Exp Allergy 40:1482-90. 2010
    ..The prevalence of allergic diseases has increased in the past decades. It is unknown whether expression of certain microRNAs (miRNAs) in neonatal leucocytes is correlated to IgE production and/or allergic diseases...
  11. ncbi Gene-gene and gene-environment interactions on IgE production in prenatal stage
    K D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, No 123 Ta pei Road, Kaohsiung, Taiwan
    Allergy 65:731-9. 2010
    ..Allergy sensitization may occur in fetal life. This study investigated whether gene-gene and gene-environment interactions affected cord blood IgE (CBIgE) levels...
  12. doi Prenatal and postnatal probiotics reduces maternal but not childhood allergic diseases: a randomized, double-blind, placebo-controlled trial
    C Y Ou
    Department of Obstetrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Clin Exp Allergy 42:1386-96. 2012
    ..This study evaluated the effectiveness of prenatal and postnatal probiotics in the prevention of early childhood and maternal allergic diseases...
  13. ncbi A single dose of nebulized budesonide decreases exhaled nitric oxide in children with acute asthma
    Y G Tsai
    Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Pediatr 139:433-7. 2001
    ..A single dose of nebulized budesonide, but not nebulized terbutaline, rapidly decreased eNO levels in 6 hours. The decrease in eNO levels induced by nebulized budesonide was correlated to an increase in peak expiratory flow rate...
  14. pmc A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells
    E Y Huang
    Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Cell Death Dis 3:e251. 2012
    ..These findings suggest that galectin-1 mediates radioresistance through the H-Ras-dependent pathway involved in DNA damage repair...
  15. ncbi Physical shock wave mediates membrane hyperpolarization and Ras activation for osteogenesis in human bone marrow stromal cells
    F S Wang
    Department of Medical Research, Chang Gung University, Kaohsiung, Taiwan, Republic of China
    Biochem Biophys Res Commun 287:648-55. 2001
    ....
  16. ncbi Antibody-dependent enhancement of heterotypic dengue infections involved in suppression of IFNgamma production
    K D Yang
    Chang Gung Children s Hospital at Kaohsiung, Chang Gung University, Kaohsiung, Taiwan
    J Med Virol 63:150-7. 2001
    ..Better regulation of Th1/Th2 reactions may be useful for prevention of heterotypic immune enhancement of dengue infections...
  17. doi Regular Tai Chi Chuan exercise improves T cell helper function of patients with type 2 diabetes mellitus with an increase in T-bet transcription factor and IL-12 production
    S H Yeh
    Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University, Kaohsiung 833, Taiwan
    Br J Sports Med 43:845-50. 2009
    ..Exercise has been shown to be beneficial in the treatment of type 2 diabetes mellitus (DM); its benefit to immune function, however, remains to be determined...
  18. ncbi Severe acute respiratory syndrome: prognostic implications of chest radiographic findings in 52 patients
    Sheung Fat Ko
    Department of Radiology, Chang Gung University, Chang Gung Memorial Hospital at Kaouhsiung, 123 Ta Pei Rd, Niao Sung Hsiang, Kaohsiung Hsien 833, Taiwan
    Radiology 233:173-81. 2004
    ..To retrospectively assess prognostic implications of radiographic findings in severe acute respiratory syndrome (SARS)...
  19. ncbi Long-term results of extracorporeal shockwave treatment for plantar fasciitis
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Kaohsiung, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan 833
    Am J Sports Med 34:592-6. 2006
    ..Extracorporeal shockwave treatment has shown mixed short-term results for plantar fasciitis. However, the long-term results are not available...
  20. ncbi Treatment of osteonecrosis of the hip: comparison of extracorporeal shockwave with shockwave and alendronate
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University School of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan
    Arch Orthop Trauma Surg 128:901-8. 2008
    ..We hypothesized that joint effects of ESWT and alendronate may produce superior results. This prospective study compared the results of ESWT and alendronate with that of ESWT without alendronate in early ONFH...
  21. ncbi Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting
    Ching Jen Wang
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital Medical Center, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung 833, Taiwan
    J Bone Joint Surg Am 87:2380-7. 2005
    ..We compared the results of noninvasive treatment with extracorporeal shock waves with those of core decompression and bone-grafting in similar groups of patients...
  22. doi Extracorporeal shockwave treatment for chronic diabetic foot ulcers
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    J Surg Res 152:96-103. 2009
    ..This prospective study compared extracorporeal shockwave treatment (ESWT) with hyperbaric oxygen therapy (HBO) in chronic diabetic foot ulcers...
  23. ncbi Correlation of augmented IL-8 production to premature chronic lung disease: implication of posttranscriptional regulation
    Hsin Chun Huang
    Department of Pediatrics, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Science, Chang Gung University at Kaohsiung, Kaohsiung 833, Taiwan
    Pediatr Res 58:216-21. 2005
    ..Thus, an appropriate modulation of initial IL-8 production in premature infants might be beneficial for the prevention of the development of CLD...
  24. ncbi Platelet glycoprotein IIb/IIIa receptor antagonist (abciximab) inhibited platelet activation and promoted skin flap survival after ischemia/reperfusion injury
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Kaohsiung, Taiwan
    J Surg Res 107:50-5. 2002
    ....
  25. ncbi Association of cord blood cytokines with prematurity and cerebral palsy
    Hsin Chun Huang
    Department of Pediatrics, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Science, Chang Gung University at Kaohsiung, No 123 Ta pei Road, Niau Sung Hsiang, Kaohsiung 833, Taiwan
    Early Hum Dev 77:29-36. 2004
    ..Many studies have shown that certain cytokines in amniotic fluids are correlated to premature labor and neonatal brain insults...
  26. doi Biological effects of extracorporeal shockwave in bone healing: a study in rabbits
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung 833, Taiwan
    Arch Orthop Trauma Surg 128:879-84. 2008
    ..This study is an investigation of the biological effects of extracorporeal shockwave treatment (ESWT) on bone healing in a rabbit model...
  27. ncbi Implications of dynamic changes among tumor necrosis factor-alpha (TNF-alpha), membrane TNF receptor, and soluble TNF receptor levels in regard to the severity of dengue infection
    Lin Wang
    Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China
    Am J Trop Med Hyg 77:297-302. 2007
    ..This finding suggests that a lower level of mTNFR1 expression in response to a higher plasma TNF-alpha level may be a pathogenic marker for early detection of DHF...
  28. ncbi Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Kaohsiung, 123 Ta Pei Road, Niao Sung Hsiang, 833 Kaohsiung, Taiwan
    J Orthop Res 21:984-9. 2003
    ..The neovascularization may play a role to improve blood supply and tissue regeneration at the tendon-bone junction...
  29. ncbi Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease
    Chih Lu Wang
    Division of Allergy and Immunology, Chang Gung Children s Hospital at Kaohsiung, Chang Gung University, Niau Sung, Kaohsiung, Taiwan
    Pediatrics 111:E140-7. 2003
    ..Kawasaki disease (KD) is an acute febrile vasculitic syndrome in children. CD40 ligand (CD40L) has been implicated in certain types of vasculitis. We proposed that CD40L expression might be correlated with coronary artery lesions in KD...
  30. ncbi Coronary artery fistula associated with Kawasaki disease
    Chi Di Liang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Am Heart J 157:584-8. 2009
    ..The aim of this study was to investigate the rate, risks factors, and clinical impact of coronary artery fistula (CAF) in Kawasaki disease (KD)...
  31. doi Extracorporeal shockwave for hip necrosis in systemic lupus erythematosus
    C J Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Lupus 18:1082-6. 2009
    ..86 vs. 0.89; P = 0.467) and function scores (89% vs. 91%; P = 0.194) between patients with SLE and controls. SLE response to ESWT for ONFH is comparable with ONFH in patients without SLE...
  32. ncbi Increased IL-17A secreting CD4+ T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity
    J W Chien
    Department of Pediatrics, Changhua Christian Hospital, Changhua, Taiwan
    Clin Exp Allergy 43:1018-26. 2013
    ..IL-17 plays an important role in T cell-dependent inflammatory response that occurs in allergic asthma, it could act as a potent activator of inducible nitric oxide synthase (iNOS) to amplify FeNO levels...
  33. ncbi Childhood asthma: aspects of global environment, genetics and management
    K D Yang
    Department of Pediatric, Chang Gung Children Hospital, 123 Ta Pei Road, Niaosung, Kaohsiung, Taiwan, R O C
    Chang Gung Med J 23:641-61. 2000
    ..As progress in therapeutic gene vaccines as well as genetic immunoregulation continues, we expect early environmental avoidance and genetic vaccines may prevent childhood asthma in the near future...
  34. ncbi Cord blood myeloperoxidase in preterm infants with periventricular hyperechogenicity
    Chien An Wang
    Department of Pediatrics, Chang Gung Children s Hospital, Kaoshiung, Taiwan
    Chang Gung Med J 27:337-43. 2004
    ....
  35. doi Prevalence of haematuria positively associated with urine albumin excretion in Type 2 diabetes
    F C Shen
    Division of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Diabet Med 29:1178-83. 2012
    ..This study examined the justification of excluding haematuria in interpreting urinary albumin excretion in patients with Type 2 diabetes and its associations with other diabetes-related variables...
  36. ncbi Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections: implications for early recognition and therapy
    T Y Lin
    Department of Pediatrics, Chang Gung Children s Hospital, Linkou, Taiwan
    Acta Paediatr 91:632-5. 2002
    ..The mechanism of pulmonary oedema, a life-threatening manifestation of enterovirus 71 (EV71) encephalitis, is unclear. Our aim was to assess the relationship of proinflammatory cytokines to EV71-related pulmonary oedema...
  37. ncbi Evaluation of different nebulized bronchodilators on clinical efficacy and hypokalemia in asthmatic children
    C H Hung
    Department of Pediatrics, Tri-Service General Hospital, 40, Sec. 3, Ting-Chow Road, Taipei 100, Taiwan
    Acta Paediatr Taiwan 42:287-90. 2001
    ....
  38. ncbi Chronic granulomatous disease: a case report
    C H Hung
    Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Formos Med Assoc 100:281-4. 2001
    ..A definite absence of superoxide activity in the patient's granulocytes detected by chemiluminescence and nitroblue tetrazolium dye test confirmed this diagnosis...
  39. doi Extracorporeal shock wave treatment modulates skin fibroblast recruitment and leukocyte infiltration for enhancing extended skin-flap survival
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Wound Repair Regen 17:80-7. 2009
    ..The mechanisms of action of ESWs involve modulation of oxygen radicals, attenuation of leukocyte infiltration, decrease in tissue apoptosis, and recruitment of skin fibroblasts, which results in increased flap tissue survival...
  40. ncbi Persistent monocytosis after intravenous immunoglobulin therapy correlated with the development of coronary artery lesions in patients with Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 40:395-400. 2007
    ..This study was conducted to investigate whether changes in the complete blood count (CBC)/differential count (DC) and C-reactive protein (CRP) were correlated to Kawasaki disease (KD) with coronary artery lesions (CALs)...
  41. ncbi Reactive thrombocytosis without endothelial damage does not affect the microvascular anastomotic patency
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Kaohsiung, Taiwan
    Ann Plast Surg 50:57-63. 2003
    ..Meticulous microvascular anastomosis without triggering platelet activation is the most important factor to prevent thrombosed vessels in microsurgical anastomosis...
  42. ncbi Nitrosoglutathione modulation of platelet activation and nitric oxide synthase expression in promotion of flap survival after ischemia/reperfusion injury
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    J Surg Res 119:92-9. 2004
    ....
  43. ncbi Prediction of elevated cord blood IgE levels by maternal IgE levels, and the neonate's gender and gestational age
    Chieh An Liu
    Department of Pediatrics, Chang Gung Children s Hospital, Kaoshiung, Taiwan, ROC
    Chang Gung Med J 26:561-9. 2003
    ..In an effort to catch such problems at an earlier time, we sought to identify the impact of parental atopy as well as gestational age, the baby's gender, and the season of delivery on cord blood IgE levels...
  44. ncbi Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever
    Wen Ting Yeh
    Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University College of Medicine, Niau Sung, Kaohsiung, Taiwan
    FEMS Immunol Med Microbiol 48:84-90. 2006
    ..7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load...
  45. ncbi Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome
    Chen Hsiang Lee
    Department of Internal Medicine, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niau Sung, Kaohsiung 833, Taiwan
    J Immunol 172:7841-7. 2004
    ..These results suggest that regulation of TGF-beta and PGE(2) production and MAPKs activation in different leukocytes may be considered while developing therapeutics for the SARS treatment...
  46. ncbi Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels
    Jen Chieh Chang
    Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 15:506-12. 2004
    ..Association of the CTLA-4 (+49) polymorphism with elevated CB IgE levels was found only in female infants. Newborn infants with the (+49, GG and -318, CC) genotype tended to have a low rate of elevated CB IgE...
  47. ncbi Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect
    F S Wang
    Department of Medical Research, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Bone 32:387-96. 2003
    ..BMP-7 expression was evident on osteoblasts located at endochondral ossification junction. Our findings suggest that BMP play an important role in signaling ESW-activated cell proliferation and bone regeneration of segmental defect...
  48. ncbi Granulocyte function disorders: aspects of development, genetics and management
    K D Yang
    Chang Gung Children s Hospital at Kaohsiung, Chang Gung University, Kaohsiung 833, Taiwan
    Pediatr Infect Dis J 20:889-900. 2001
    ..Carrier detection and prenatal diagnosis employing with chain reaction techniques or direct nucleotide sequencing in fetal blood have made these diseases potentially preventable or treatable in utero or shortly after birth...
  49. ncbi TLR2 agonists enhance CD8+Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy
    Yi Giien Tsai
    Department of Pediatrics, Changhua Christian Hospital and Institute of Clinical Medicine, National Ynag Ming University, Taipei, Taiwan, Republic of China
    J Immunol 184:7229-37. 2010
    ..Our results provide direct evidence that Pam3CSK4 induces an immunomodulatory effect by inducing CD8+ Treg cells; therefore, it may be a good adjuvant for the treatment of mite allergies...
  50. ncbi Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment
    Chih Hsing Hung
    Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University, Taiwan, ROC
    Pulm Pharmacol Ther 20:233-9. 2007
    ....
  51. ncbi Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass
    Feng Sheng Wang
    Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Niao Sung, Kaohsiung 833, Taiwan
    Endocrinology 146:2415-23. 2005
    ..These findings suggest that SFRP1 modulates glucocorticoid-induced bone loss. Regulation of Wnt/SFRP signal transduction can be used in the future as an alternative strategy for the prevention of glucocorticoid-induced osteoporosis...
  52. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
    ..Post-IVIG treatment eosinophilia has an inverse correlation to KD patients with IVIG-resistance and may indicate IVIG-responsive. This may be a valuable factor to survey for the necessity of a second dose IVIG treatment...
  53. ncbi Effects of leukotriene receptor antagonists on monocyte chemotaxis, p38 and cytoplasmic calcium
    Chih Hsing Hung
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, and Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University, Taiwan, Republic of China
    Pediatr Allergy Immunol 17:250-8. 2006
    ..These data demonstrate that montelukast is effective in down-regulating human monocyte chemotaxis induced by MCP-1. This effect may involve the down-regulation of MCP-1-induced [Ca2+]i and p38 MAPK expression...
  54. doi Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 20:266-72. 2009
    ..An increase of eosinophils and IL-5, but not ECP levels after IVIG treatment, was inversely correlated with CAL formation in KD...
  55. ncbi Shock wave treatment shows dose-dependent enhancement of bone mass and bone strength after fracture of the femur
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Kaohsiung, Taiwan
    Bone 34:225-30. 2004
    ..015) and modulus of elasticity (P = 0.011) than the low-energy and control groups. Overall, the effect of shock wave treatment on bone mass and bone strength appears to be dose dependent in acute fracture healing in rabbits...
  56. ncbi Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS)
    Rong Fu Chen
    Department of Medical Research 12F12L, Chang Gung Memorial Hospital at Kaohsiung, 123 Ta Pei Road, Niau Sung, Kaohsiung 833, Taiwan, ROC
    Microbes Infect 8:122-7. 2006
    ..However, lymphopenia may be due to enhanced cell death. Inhibition of cell adhesion and caspase-3 activation could, therefore, have prevented SARS patients from developing thrombocytopenia and lymphopenia...
  57. doi Comparison of the Global Initiative for Asthma guideline-based Asthma Control Measure and the Childhood Asthma Control Test in evaluating asthma control in children
    Hong Ren Yu
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Pediatr neonatol 51:273-8. 2010
    ....
  58. ncbi A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease
    Hong Ren Yu
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taiwan
    Pediatr Allergy Immunol 20:699-707. 2009
    ....
  59. ncbi Hyperfibrinogenemia alone does not affect the patency of microvascular anastomosis: clinical experience and animal study
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kaohsiung, Taiwan
    Ann Plast Surg 54:435-41. 2005
    ..This experimental data can lend support to the idea that microvascular anastomosis could be safely performed in patients with hyperfibrinogenemia alone without untoward thrombotic complications...
  60. ncbi Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression
    Hong Ren Yu
    Division of Clinical Immunology and Allergy, Chang Gung Children s Hospital, Chang Gung University, Kaohsiung, Taiwan, ROC
    J Leukoc Biol 74:952-8. 2003
    ..These results suggest that different antigens trigger various Th1/Th2 reactions in PBMC and CBMC resulting from kinetic changes of T-bet/GATA-3 expression...
  61. doi Seroprevalence of SARS Coronavirus Among Residents Near a Hospital with a Nosocomial Outbreak
    Ming Han Tsai
    Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taiwan
    J Formos Med Assoc 107:885-91. 2008
    ....
  62. ncbi Hyposensitization therapy reduced exhaled nitric oxide in asthmatic children with corticosteroid dependency
    Chih Hsing Hung
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Acta Paediatr Taiwan 45:89-93. 2004
    ..84+/-1.22 vs 5.80+/-0.67, p<0.05). Hyposensitization with extracts of Der p and Der f appears to improve clinical symptoms and reduce airway inflammation as determined by FeNO concentrations in children with mite allergy asthma...
  63. ncbi Shockwave stimulates oxygen radical-mediated osteogenesis of the mesenchymal cells from human umbilical cord blood
    Feng Sheng Wang
    Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University, Niau Sung, Kaohsiung, Taiwan
    J Bone Miner Res 19:973-82. 2004
    ..Transplantation of shockwave-treated HUCB mesenchymal progenitor cells enhanced healing of segmental femoral defect in severe combined immunodeficiency disease (SCID) mice...
  64. doi Association of acute urticaria with Mycoplasma pneumoniae infection in hospitalized children
    Chih Chiang Wu
    Division of Pediatric Allergy and Immunology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
    Ann Allergy Asthma Immunol 103:134-9. 2009
    ..Acute urticaria is a common and disturbing disorder in children and has a versatile etiology...
  65. ncbi Prolonged acquired neutropenia in children
    Jiunn Ming Sheen
    Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Blood Cancer 53:1284-8. 2009
    ..Acquired neutropenia is not uncommon in childhood. This study investigated the risk factors associated with developing prolonged acquired neutropenia...
  66. ncbi Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study
    Kuender D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
    J Allergy Clin Immunol 120:842-8. 2007
    ..Wheezing episodes are common in young infants. However, the molecular mechanism of wheezing is unclear, and very few therapeutic regimens are effective...
  67. ncbi Epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory syndrome in a medical center in Kaohsiung, Taiwan
    Jien Wei Liu
    Committee of Infection Control and Division of Infectious Diseases, Chang Gung Memorial Hospital, Kaohsiung Medical Center, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien 833, Taiwan
    Infect Control Hosp Epidemiol 27:466-72. 2006
    ....
  68. ncbi Kawasaki disease: infection, immunity and genetics
    Chih Lu Wang
    Division of Pediatric Immunology, Chang Gung Children s Hospital at Kaohsiung, 123 Ta Pei Road, Niau Sung, Kaohsiung 833, Taiwan
    Pediatr Infect Dis J 24:998-1004. 2005
    ....
  69. ncbi Comparison of the effects of nebulized terbutaline with or without intravenous betamethasone on exhaled nitric oxide in children with acute asthma attack
    Ming Yung Lee
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Microbiol Immunol Infect 39:33-8. 2006
    ....
  70. ncbi Outcomes of continuing education in the care of children with asthma for pediatric healthcare providers
    Yu Fen Cheng
    Department of Nursing, Chang Gung Memorial Hospital, Kohsiung, Taiwan
    J Contin Educ Nurs 38:122-31. 2007
    ..Results from this study suggest that continuing education can improve the knowledge of asthma care among pediatric healthcare providers...
  71. ncbi Montelukast decreased exhaled nitric oxide in children with perennial allergic rhinitis
    Chih Hsing Hung
    Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Pediatr Int 49:322-7. 2007
    ....
  72. ncbi Effects of montelukast on symptoms and eNO in children with mild to moderate asthma
    Ming Yung Lee
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Pediatr Int 47:622-6. 2005
    ..This study was conducted to investigate whether montelukast, a leukotriene receptor antagonist, could be used for the management of asthma and how fast the montelukast sodium decreased airway inflammation as demonstrated by eNO levels...
  73. ncbi Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma
    Chih Hsing Hung
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Pediatr Allergy Immunol 16:306-9. 2005
    ..05), macrophage-derived chemokine (355.11 +/- 174.30 vs. 169.19 +/- 62.42, p < 0.05) levels. In conclusion, different oral non-steroidal anti-inflammatory drugs revealed faster or slower treatment responses due to different mechanisms...
  74. ncbi It is time to call for perinatal prevention of allergy diseases
    Kuender D Yang
    Acta Paediatr Taiwan 46:257-9. 2005
  75. ncbi Implications of blood soluble and cell surface tumor necrosis factor receptors in childhood nephrotic syndrome
    You Lin Tain
    Division of Pediatric Nephrology, Chang Gung Children s Hospital, Kaohsiung, Taiwan
    Pediatr Nephrol 17:926-32. 2002
    ..TNFR may play a pathophysiological role in childhood NS...
  76. ncbi Prenatal prediction of infant atopy by maternal but not paternal total IgE levels
    Chieh An Liu
    Chang Gung Children s Hospital at Kaohsiung, Taiwan
    J Allergy Clin Immunol 112:899-904. 2003
    ..However, bias from questionnaires of allergic history are also frequently suspected, because a large number of vasomotor rhinitis, intrinsic asthma, and seborrheic dermatitis cases are probably misinterpreted to be atopic diseases...
  77. ncbi Higher spontaneous and TNFalpha-induced apoptosis of neonatal blood granulocytes
    Chieh An Liu
    Departments of Neonatology and Clinical Immunology, Chang Gung Children Hospital at Kaohsiung, Institute of Clinical Medical Sciences, Chang Gung University, Kaohsiung, Taiwan 833
    Pediatr Res 58:132-7. 2005
    ..Results from this study suggest that higher plasma death ligands associated with lower anti-apoptotic molecules in granulocytes may act an important role in triggering neonatal granulocyte apoptosis...
  78. ncbi Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever
    Rong Fu Chen
    Department of Biological Sciences, National Sun Yat Sen University, Kaohsiung, Taiwan
    FEMS Immunol Med Microbiol 44:43-50. 2005
    ..In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever...
  79. ncbi Shock wave therapy for calcific tendinitis of the shoulder: a prospective clinical study with two-year follow-up
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Am J Sports Med 31:425-30. 2003
    ..Shock wave therapy is a new modality that has shown efficacy in the treatment of various orthopaedic disorders...
  80. ncbi Extracorporeal shockwave treatment of osteonecrosis of the femoral head in systemic lupus erythematosis
    Po Chun Lin
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Kaohsiung Taiwan
    J Arthroplasty 21:911-5. 2006
    ..It appeared that ESWT might have the potential to curtail the progression of the disease and to delay the need for total hip arthroplasty in the very young patients contracted with SLE...
  81. ncbi Implication of serum IgE in childhood nephrotic syndrome
    You Lin Tain
    Division of Pediatric Nephrology, Chang Gung Children s Hospital, Kaohsiung, Taiwan
    Pediatr Nephrol 18:1211-5. 2003
    ..Our results suggest that regulation of total IgE production correlates with the disease activity and outcome of NS, although the presence of common specific IgE may not be linked to the pathogenesis...
  82. ncbi Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats
    Yeung Jen Chen
    Department of Orthopedic Surgery, Chang Gung University, Linkou, Taiwan
    Bone 34:466-77. 2004
    ..ERK phosphorylation is active throughout the period of ESW-induced bone regeneration. p38 activation most likely plays an important role in signaling cartilage formation in callus...
  83. ncbi Reactive thrombocytosis alone does not affect the patency of microvascular anastomosis in the splenectomy rat
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital Kaohsiung, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    Plast Reconstr Surg 110:812-7. 2002
    ..561). In conclusion, this study demonstrates that microvascular anastomosis can be performed safely in patients with reactive thrombocytosis without platelet activation...
  84. ncbi Reversible phosphatidylserine expression on blood granulocytes related to membrane perturbation but not DNA strand breaks
    Ming Yu Yang
    Chang Gung Children s Hospital at Kaohsiung, Chang Gung University, Taiwan
    J Leukoc Biol 71:231-7. 2002
    ....
  85. ncbi Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan, Republic of China
    Am J Trop Med Hyg 72:221-6. 2005
    ..07, P = 0.017) were independent risk factors for dual infection. Clinicians should be alert to the potential for concurrent bacteremia when treating patients with DHF/DSS who are at risk for dual infection and manage them accordingly...
  86. ncbi Dengue hemorrhagic fever patients with acute abdomen: clinical experience of 14 cases
    Boon Siang Khor
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China
    Am J Trop Med Hyg 74:901-4. 2006
    ..015). To avoid unnecessary invasive procedure-related morbidity and mortality, this report underscores the importance of a careful differential diagnosis in patients with acute abdomen in a dengue-endemic setting...
  87. ncbi Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency
    Rong Fu Chen
    Department of Biological Sciences, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Trans R Soc Trop Med Hyg 101:1106-13. 2007
    ..DF involves a Th1 reaction and DF w/B involves an altered Th2 reaction, whereas DHF involves an altered Th2 reaction and augmented vascular insult...
  88. ncbi Methylprednisolone pulse therapy for massive lymphadenopathy in a child with intravenous immunoglobulin-resistant Kawasaki disease
    Hsin Hsu Chen
    Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung Children s Hospital, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 38:149-52. 2005
    ..High-dose pulse steroid may be an alternative therapeutic option in KD which presents with possible life-threatening complications or failure to respond to high-dose IVIG infusion...
  89. ncbi Hyperlipasemia/pancreatitis in adults with dengue hemorrhagic fever
    Ing Kit Lee
    Pancreas 35:381-2. 2007
  90. doi Patient characteristics and intravenous immunoglobulin product may affect eosinophils in Kawasaki disease
    Ho Chang Kuo
    Pediatr Allergy Immunol 19:184-5. 2008
  91. ncbi Similarities of immune reactions between hepatitis C and severe acute respiratory syndrome-associated coronavirus infections
    Wu Shiung Huang
    J Gastroenterol Hepatol 20:1625-6. 2005
  92. ncbi The effect of shock wave treatment at the tendon-bone interface-an histomorphological and biomechanical study in rabbits
    Ching Jen Wang
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital Medical Center, Kaohsiung, Taiwan
    J Orthop Res 23:274-80. 2005
    ..This study was performed to investigate the effect of shock wave treatment on the healing at tendon-bone interface in rabbits...
  93. ncbi Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 79:149-53. 2008
    ..001) was found in the elderly counterparts that died. Multivariate analysis showed that only DSS (odd ratio = 77.33, P = 0.001) was an independent risk factor for fatality in elderly patients...
  94. ncbi Suppression of plasma matrix metalloproteinase-9 following montelukast treatment in childhood asthma
    Shih Sung Chuang
    Department of Pathology, Chi Mei Medical Center and Taipei Medical University, Taipei, Taiwan
    Pediatr Int 49:918-22. 2007
    ..Montelukast and ketotifen are commonly prescribed anti-inflammatory medications used in the treatment of childhood asthma...
  95. ncbi Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression
    Yeung Jen Chen
    Department of Orthopaedic Trauma, Chang Gung University, Linkou, Taiwan
    J Orthop Res 22:854-61. 2004
    ..Together, low-energy shock wave effectively promoted tendon healing. TGF-beta1 and IGF-I played important roles in mediating ESW-stimulated cell proliferation and tissue regeneration of tendon...
  96. ncbi Recruitment of mesenchymal stem cells and expression of TGF-beta 1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats
    Yeung Jen Chen
    Department of Orthopedic Surgery, Chang Gung University, Linkou, Taiwan
    J Orthop Res 22:526-34. 2004
    ..TGF-beta 1 and VEGF-A are proposed to play a chemotactic and mitogenic role in recruitment and differentiation of mesenchymal stem cells...