Chuen Mao Yang


Affiliation: Chang Gung University
Country: Taiwan


  1. Yang C, Lee I, Hsu R, Chi P, Hsiao L. NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-α-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells. Toxicol Appl Pharmacol. 2013;272:431-42 pubmed publisher
    ..Understanding the regulation of MMP-9 expression and NADPH oxidase activation by TNF-α on H9c2 cells may provide potential therapeutic targets of chronic heart failure. ..
  2. Lin C, Hsiao L, Cho R, Yang C. CO-Releasing Molecule-2 Induces Nrf2/ARE-Dependent Heme Oxygenase-1 Expression Suppressing TNF-α-Induced Pulmonary Inflammation. J Clin Med. 2019;8: pubmed publisher
    ..Thus, the HO-1/CO system might suppress TNF-α-mediated inflammatory responses and exert a potential therapeutic strategy in pulmonary diseases. ..
  3. Yang C, Lin C, Hsiao L, Yang C. Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-κB Phosphorylation. Int J Mol Sci. 2018;19: pubmed publisher
    ..Therefore, galangin may be a potential candidate for the management of brain inflammatory diseases. ..
  4. Lee I, Lin C, Yang C, Hsiao L, Wu M, Yang C. Resveratrol Attenuates Staphylococcus Aureus-Induced Monocyte Adhesion through Downregulating PDGFR/AP-1 Activation in Human Lung Epithelial Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..Thus, resveratrol functions as a suppressor of S. aureus-induced inflammatory signaling, not only by inhibiting VCAM-1 expression but also by diminishing c-Src, PDGFR, JNK1/2, p38 MAPK, and AP-1 activation in HPAEpiCs. ..
  5. Tseng H, Lin C, Wang C, Yang C, Hsiao L, Yang C. Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts. Cell Mol Life Sci. 2018;75:4599-4617 pubmed publisher
    ..LysoPC-induced COX-2-dependent IL-6 expression provided novel insights into the therapeutic targets of the cardiac fibrotic responses. ..
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    Yang C, Chien C, Ma Y, Hsiao L, Lin C, Wu C. Bradykinin B2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells. J Biomed Sci. 2003;10:208-18 pubmed
    ..BK-mediated MAPK activation was modulated by Ca(2+), PKC, and tyrosine kinase all of which are associated with cell proliferation in rat cultured VSMCs. ..
  7. Yang C, Luo S, Wang C, Chiu C, Chien C, Lin C, et al. Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells. Br J Pharmacol. 2000;130:891-9 pubmed
    ..TNF-alpha- and IL-1beta-mediated responses were modulated by PLC, Ca(2+), PKC, and tyrosine kinase associated with cell proliferation in TSMCs. ..
  8. Yang C, Chien C, Wang C, Hsu Y, Chiu C, Lin C, et al. Interleukin-1beta enhances bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine tracheal smooth-muscle cells: involvement of the Ras/Raf/mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway. Biochem J. 2001;354:439-46 pubmed
    ..These results suggest that the augmentation of BK-induced responses produced by IL-1beta might be, at least in part, mediated through activation of the Ras/Raf/MEK/MAPK pathway in TSMCs. ..
  9. Cho R, Yang C, Lee I, Lin C, Chi P, Hsiao L, et al. Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-κB pathway in human pulmonary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L639-57 pubmed publisher

More Information


  1. Lin C, Hsieh H, Shih R, Chi P, Cheng S, Chen J, et al. NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin-induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes. Cell Commun Signal. 2012;10:35 pubmed publisher
    ..These results demonstrated that in RBA-1 cells, activation of AP-1 (c-Fos/c-Jun) by the PKC-?-mediated Nox2/ROS signals is essential for up-regulation of MMP-9 and cell migration enhanced by BK. ..
  2. Tsai C, Chen W, Hsieh H, Chi P, Hsiao L, Yang C. TNF-? induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-?B activation in osteoblast-like MC3T3-E1 cells. J Biomed Sci. 2014;21:12 pubmed publisher
    ..The interplay between MMP-9 expression and sICAM-1 release may exert an important role in the regulation of bone inflammatory diseases. ..
  3. Chien P, Lin C, Hsiao L, Yang C. Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes. Toxicol Appl Pharmacol. 2015;289:349-59 pubmed publisher
    ..These results suggested that CORM-2-induced HO-1 expression is mediated through a Pyk2/PDGFR/PI3K/Akt/FoxO1/Sp1-dependent manner and exerts a cytoprotective effect in human cardiomyocytes. ..
  4. Yang C, Lee I, Chi P, Cheng S, Hsiao L, Hsu C. TNF-? induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014;306:L543-51 pubmed publisher
    ..Taken together, these results demonstrated that TNF-?-induced cPLA2 expression and PGE2 release were mediated through a Jak2/PDGFR/PI3K/Akt/p42/p44 MAPK/Elk-1 pathway in HPAEpiCs. ..
  5. Yang C, Chen Y, Chi P, Lin C, Hsiao L. Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-?B in human rheumatoid arthritis synovial fibroblasts. Biochem Pharmacol. 2017;132:77-91 pubmed publisher
    ..Therefore, resveratrol may be a promising therapeutic intervention for treatment of inflammatory arthritis. ..
  6. Lin C, Yang C, Chen Y, Hsiao L, Yang C. Arachidonic Acid Induces ARE/Nrf2-Dependent Heme Oxygenase-1 Transcription in Rat Brain Astrocytes. Mol Neurobiol. 2018;55:3328-3343 pubmed publisher
    ..These findings suggested that AA increases formation of Nrf2 and PPARγ complex and binding with ARE1 binding site through Src, Pyk2, PI3K/Akt, and ERK1/2, which further induced HO-1 expression in RBA-1 cells. ..
  7. Lin C, Lin W, Hou W, Hsiao L, Yang C. Endothelin-1 induces VCAM-1 expression-mediated inflammation via receptor tyrosine kinases and Elk/p300 in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L211-25 pubmed publisher
  8. Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
    ..We uncover the importance of COX-2 regarding human cardiomyocyte hypertrophy that will provide a therapeutic intervention in cardiovascular diseases. ..
  9. Cho R, Lin W, Wang C, Yang C, Hsiao L, Lin C, et al. Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary inflammation. Biochem Pharmacol. 2018;148:222-237 pubmed publisher
    ..Up-regulation of HO-1 protected against the inflammatory responses triggered by LPS, at least in part, through attenuation of NF-κB. ..
  10. Yang C, Lin C, Lee I, Lin Y, Yang C, Chen W, et al. Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes. J Neuroinflammation. 2012;9:12 pubmed publisher
    ..These findings concerning JEV-induced MMP-9 expression in RBA-1 cells imply that JEV might play an important role in CNS inflammation and diseases. ..
  11. Yang C, Lin C, Chien P, Hsiao L, Yang C. Thrombin/Matrix Metalloproteinase-9-Dependent SK-N-SH Cell Migration is Mediated Through a PLC/PKC/MAPKs/NF-?B Cascade. Mol Neurobiol. 2016;53:5833-5846 pubmed publisher
    ..Our results show that thrombin stimulates a Gq/PLC/PKCs/p38 MAPK and JNK1/2 cascade, which in turn triggers NF-?B activation and ultimately induces MMP-9 expression and cell migration in SK-N-SH cells. ..
  12. Yang C, Lee I, Lin C, Yang Y, Luo S, Kou Y, et al. Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009;297:L892-902 pubmed publisher
    ..These results demonstrated that in HTSMCs, CSE-induced COX-2-dependent PGE2 generation was mediated through PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt leading to the recruitment of p300 with NF-kappaB complex. ..
  13. Yang C, Hsiao L, Yang C, Lin C. Thrombin Enhanced Matrix Metalloproteinase-9 Expression and Migration of SK-N-SH Cells via PAR-1, c-Src, PYK2, EGFR, Erk1/2 and AP-1. Mol Neurobiol. 2017;54:3476-3491 pubmed publisher
  14. Yang C, Hsieh H, Yu P, Lin C, Liu S. IL-1β Induces MMP-9-Dependent Brain Astrocytic Migration via Transactivation of PDGF Receptor/NADPH Oxidase 2-Derived Reactive Oxygen Species Signals. Mol Neurobiol. 2015;52:303-17 pubmed publisher
    ..These results demonstrated that in RBA-1 cells, activation of NF-κB and AP-1 (ATF2) by the c-Src/PDGFR/PI3K/Akt-mediated Nox2/ROS/MAPKs signals is required for upregulation of MMP-9 and cell migration enhanced by IL-1β. ..
  15. Lin C, Pan C, Wang C, Liu S, Hsiao L, Yang C. Tumor necrosis factor-alpha induces VCAM-1-mediated inflammation via c-Src-dependent transactivation of EGF receptors in human cardiac fibroblasts. J Biomed Sci. 2015;22:53 pubmed publisher
    ..Understanding the mechanisms of VCAM-1 up-regulated by TNF-α on HCFs may provide rationally therapeutic interventions for heart injury or inflammatory diseases. ..
  16. Tsai C, Chen W, Lee I, Chi P, Cheng S, Yang C. c-Src-dependent transactivation of PDGFR contributes to TNF-?-induced MMP-9 expression and functional impairment in osteoblasts. Bone. 2014;60:186-97 pubmed publisher
  17. Yang C, Hsieh H, Lin C, Shih R, Chi P, Cheng S, et al. Multiple factors from bradykinin-challenged astrocytes contribute to the neuronal apoptosis: involvement of astroglial ROS, MMP-9, and HO-1/CO system. Mol Neurobiol. 2013;47:1020-33 pubmed publisher
    ..Together, we demonstrate that BK-induced several neurotoxic factors, including ROS, MMP-9, and CO released from astrocytes, may induce neuronal death through a caspase-3-dependent apoptotic pathway. ..
  18. Yang C, Luo S, Hsieh H, Chi P, Lin C, Wu C, et al. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB. J Cell Physiol. 2010;224:516-26 pubmed publisher
    ..These results suggest that in human RASFs, activation of ERK, JNK, AP-1, and NF-kappaB are essential for IL-1beta-induced ICAM-1 expression and leukocyte adhesion. ..
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    Yang C, Lin M, Hsieh H, Sun C, Ma Y, Hsiao L. Bradykinin-induced p42/p44 MAPK phosphorylation and cell proliferation via Src, EGF receptors, and PI3-K/Akt in vascular smooth muscle cells. J Cell Physiol. 2005;203:538-46 pubmed
    ..These results suggest that, in VSMCs, the mechanism of BK-stimulated activation of p42/p44 MAPK and cell proliferation was mediated, at least in part, through activation of Src family kinases, EGFR transactivation, and PI3-K/Akt. ..
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    Yang C, Wu W, Pan S, Tsai Y, Chiu C, Wang C. P2Y(2) receptor-stimulated phosphoinositide hydrolysis and Ca(2+) mobilization in tracheal epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2000;279:L235-41 pubmed