Jong Shyan Wang

Summary

Affiliation: Chang Gung University
Country: Taiwan

Publications

  1. doi request reprint Exercise affects platelet-promoted tumor cell adhesion and invasion to endothelium
    Yu Wen Chen
    Graduate Institute of Basic Medical Sciences, Chang Gung University, Tao Yuan, Taiwan
    Eur J Appl Physiol 105:393-401. 2009
  2. ncbi request reprint Exercise prescription and thrombogenesis
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan, 333, Taiwan
    J Biomed Sci 13:753-61. 2006
  3. pmc Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men
    Tzu Pin Weng
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan Department of Rehabilitation Science, Jen Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
    PLoS ONE 8:e80248. 2013
  4. doi request reprint Hypoxic exercise training improves cardiac/muscular hemodynamics and is associated with modulated circulating progenitor cells in sedentary men
    Jong Shyan Wang
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan Heart Failure Center, Chang Gung Memorial Hospital, Keeling, Taiwan Electronic address
    Int J Cardiol 170:315-23. 2014
  5. ncbi request reprint Effect of aerobic interval training on erythrocyte rheological and hemodynamic functions in heart failure patients with anemia
    Jong Shyan Wang
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan Electronic address
    Int J Cardiol 168:1243-50. 2013
  6. doi request reprint Exertional periodic breathing potentiates erythrocyte rheological dysfunction by elevating pro-inflammatory status in patients with anemic heart failure
    Jong Shyan Wang
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan
    Int J Cardiol 167:1289-97. 2013
  7. ncbi request reprint Systemic vascular resistance is increased and associated with accelerated arterial stiffening change in patients with chronic cervical spinal cord injury
    S C Huang
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Eur J Phys Rehabil Med 49:41-9. 2013
  8. doi request reprint Systemic hypoxia enhances bactericidal activities of human polymorphonuclear leuocytes
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Healthy Aging Research, Chang Gung University, Tao Yuan, Taiwan
    Clin Sci (Lond) 116:805-17. 2009
  9. doi request reprint Hypoxic exercise training promotes antitumour cytotoxicity of natural killer cells in young men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan
    Clin Sci (Lond) 121:343-53. 2011
  10. doi request reprint Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Healthy Aging Research, Chang Gung University, Tao Yuan, Taiwan
    J Appl Physiol (1985) 107:1817-24. 2009

Collaborators

Detail Information

Publications63

  1. doi request reprint Exercise affects platelet-promoted tumor cell adhesion and invasion to endothelium
    Yu Wen Chen
    Graduate Institute of Basic Medical Sciences, Chang Gung University, Tao Yuan, Taiwan
    Eur J Appl Physiol 105:393-401. 2009
    ..We conclude that SE, but not ME, enhances the capacity of PNA to adhere to ECs, withstand flowing blood, and facilitate the invasion of NPCs toward ECs...
  2. ncbi request reprint Exercise prescription and thrombogenesis
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan, 333, Taiwan
    J Biomed Sci 13:753-61. 2006
    ..These findings can aid in determining appropriate exercise regimes to prevent early thrombotic events and further hinder the cardiovascular disease progression...
  3. pmc Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men
    Tzu Pin Weng
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan Department of Rehabilitation Science, Jen Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
    PLoS ONE 8:e80248. 2013
    ..Moreover, either HIT or MCT effectively depresses apoptosis and promotes autophagy in CD4 lymphocytes and is accompanied by increased interleukin-4/interferon-γ ratio and decreased peroxide production during HE...
  4. doi request reprint Hypoxic exercise training improves cardiac/muscular hemodynamics and is associated with modulated circulating progenitor cells in sedentary men
    Jong Shyan Wang
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan Heart Failure Center, Chang Gung Memorial Hospital, Keeling, Taiwan Electronic address
    Int J Cardiol 170:315-23. 2014
    ..This study investigates whether exercise regimens with/without hypoxia affect cardiac and muscular hemodynamics by modulating CPCs and angiogenic factors...
  5. ncbi request reprint Effect of aerobic interval training on erythrocyte rheological and hemodynamic functions in heart failure patients with anemia
    Jong Shyan Wang
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan Electronic address
    Int J Cardiol 168:1243-50. 2013
    ..This study investigated whether AIT influences functional capacity by modulating hemorheological/hemodynamic functions in HF patients with/without anemia...
  6. doi request reprint Exertional periodic breathing potentiates erythrocyte rheological dysfunction by elevating pro-inflammatory status in patients with anemic heart failure
    Jong Shyan Wang
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan
    Int J Cardiol 167:1289-97. 2013
    ..The disturbed rheological properties of erythrocytes may contribute to circulatory disorders. This study investigated whether EPB with/without anemia influences rheological/hemodynamic functions in patients with HF...
  7. ncbi request reprint Systemic vascular resistance is increased and associated with accelerated arterial stiffening change in patients with chronic cervical spinal cord injury
    S C Huang
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Eur J Phys Rehabil Med 49:41-9. 2013
    ..Despite of stiffening change of conduit arteries, how total peripheral resistance (TPR) is adapted to chronic spinal cord injury (SCI) remains unclear...
  8. doi request reprint Systemic hypoxia enhances bactericidal activities of human polymorphonuclear leuocytes
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Healthy Aging Research, Chang Gung University, Tao Yuan, Taiwan
    Clin Sci (Lond) 116:805-17. 2009
    ..However, this hypoxic effect on PMN bactericidal activity is ameliorated by pretreatment with vitamin E...
  9. doi request reprint Hypoxic exercise training promotes antitumour cytotoxicity of natural killer cells in young men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan
    Clin Sci (Lond) 121:343-53. 2011
    ..These findings could help to determine effective hypoxic exercise regimens for improving individual aerobic capacity and simultaneously promoting the natural cytotoxicity of NKs...
  10. doi request reprint Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Healthy Aging Research, Chang Gung University, Tao Yuan, Taiwan
    J Appl Physiol (1985) 107:1817-24. 2009
    ..Moreover, exposure to 12% O(2) promotes the NK cytotoxicity with mobilizing the replicative senescent/inhibitory NKs into the bloodstream during ME...
  11. ncbi request reprint Chronic intermittent hypoxia modulates eosinophil- and neutrophil-platelet aggregation and inflammatory cytokine secretion caused by strenuous exercise in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, Kwei Shan, Tao Yuan 333, Taiwan
    J Appl Physiol (1985) 103:305-14. 2007
    ..Furthermore, SIH simultaneously increases circulatory anti-inflammatory IL-6 and IL-10 concentrations. These findings can help to develop effective IH regimens that improve aerobic fitness and minimize risk of thromboinflammation...
  12. ncbi request reprint Exercise modulates platelet-nasopharyngeal carcinoma cell aggregation and subsequent tissue factor and matrix metalloproteinase activities
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, 259 Wen Hwa 1st Rd, Kwei Shan, Tao Yuan 333, Taiwan
    J Appl Physiol (1985) 103:763-70. 2007
    ..These effects on HIE diminish after WUE. However, MIE minimizes the risk of thrombosis induced by platelet-NPC interactions...
  13. doi request reprint Vitamin E suppresses enhancement of factor VIII-dependent thrombin generation by systemic hypoxia
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, Kwei Shan, Tao Yuan, Taiwan
    Stroke 40:656-9. 2009
    ..Increased thrombin activity is an essential component of hemostatic reactions. This study elucidates how various hypoxic interventions impact endogenous thrombin generation (TG) after treatment with/without lipophilic antioxidant vitamin E...
  14. doi request reprint Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan, Taiwan
    Med Sci Sports Exerc 41:115-22. 2009
    ..This investigation explores how various exercise regimens influence platelet-impeded cytotoxicity of NK to nasopharyngeal carcinoma cells (NPC)...
  15. ncbi request reprint Systemic hypoxia enhances exercise-mediated bactericidal and subsequent apoptotic responses in human neutrophils
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung Univ, 259 Wen Hwa 1st Rd, Kwei Shan, Tao Yuan 333, Taiwan
    J Appl Physiol (1985) 107:1213-22. 2009
    ..Therefore, we conclude that ME at 12-15% O2 enhances bactericidal capacity and facilitates the subsequent apoptosis of neutrophils...
  16. doi request reprint Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Center for Healthy Aging Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan, 333, Taiwan
    Eur J Appl Physiol 108:371-82. 2010
    ....
  17. doi request reprint Effects of normoxic and hypoxic exercise regimens on cardiac, muscular, and cerebral hemodynamics suppressed by severe hypoxia in humans
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, 259 Wen Hwa 1st Rd, Kwei Shan, Tao Yuan 333, Taiwan
    J Appl Physiol (1985) 109:219-29. 2010
    ....
  18. doi request reprint Hypoxic exercise training reduces senescent T-lymphocyte subsets in blood
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan 333, Taiwan
    Brain Behav Immun 25:270-8. 2011
    ..These findings can help to determine an effective hypoxic exercise regimen to minimize immune dysfunction by retarding T-lymphocyte senescence...
  19. ncbi request reprint Warm-up exercise suppresses platelet-eosinophil/neutrophil aggregation and platelet-promoted release of eosinophil/neutrophil oxidant products enhanced by severe exercise in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan
    Thromb Haemost 95:490-8. 2006
    ..However, LIE minimizes the risk of thromboinflammation...
  20. ncbi request reprint Effects of moderate and severe intermittent hypoxia on vascular endothelial function and haemodynamic control in sedentary men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan, 333, Taiwan
    Eur J Appl Physiol 100:127-35. 2007
    ..However, SIH but not MIH decreases anti-oxidative capacity and increases lipid peroxidation in circulation, leading to suppression of vascular endothelial function, causing impairment of vascular haemodynamics...
  21. ncbi request reprint Exercise paradoxically modulates oxidized low density lipoprotein-induced adhesion molecules expression and trans-endothelial migration of monocyte in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, Tao Yuan, Taiwan
    Thromb Haemost 94:846-52. 2005
    ..These findings provide a new insight into the may aid the development of suitable exercise intensity enable people to prevent early atherogenesis...
  22. ncbi request reprint Intense exercise increases shear-induced platelet aggregation in men through enhancement of von Willbrand factor binding, glycoprotein IIb/IIIa activation, and P-selectin expression on platelets
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, 333 Tao Yuan, Taiwan
    Eur J Appl Physiol 91:741-7. 2004
    ....
  23. ncbi request reprint Strenuous, acute exercise affects reciprocal modulation of platelet and polymorphonuclear leukocyte activities under shear flow in men
    J S Wang
    Graduate Institute of Rehabilitation Science and Graduate Institute of Basic Medical Science, Chang Gung University, Taoyuan, Taiwan
    J Thromb Haemost 1:2031-7. 2003
    ..However, strenuous exercise can also simultaneously enhance the antiplatelet effect of PMNs. The finding provides a new insight into the negative feedback of PMNs against exercise-evoked platelet-related thrombotic risk...
  24. ncbi request reprint Tai Chi Chuan training is associated with enhanced endothelium-dependent dilation in skin vasculature of healthy older men
    Jong Shyan Wang
    Department of Physical Therapy Chang Gung University, 259 Wen Haw 1st Road, Kwei Shan, Tao Yuan 333, Taiwan, ROC
    J Am Geriatr Soc 50:1024-30. 2002
    ..Endothelium-dependent vasodilation declines with age. This study investigated whether Tai Chi Chuan (TCC) training could enhance endothelial function in the skin vasculature of older men...
  25. ncbi request reprint Suppressed cutaneous endothelial vascular control and hemodynamic changes in paretic extremities with edema in the extremities of patients with hemiplegia
    Jong Shyan Wang
    Department of Physical Therapy, Gung University, Tao Yuan, Taiwan
    Arch Phys Med Rehabil 83:1017-23. 2002
    ..To investigate peripheral circulatory function and its underlying mechanisms in the paretic upper extremity after a stroke...
  26. ncbi request reprint Effect of strenuous arm crank exercise on platelet function in patients with spinal cord injury
    Jong Shyan Wang
    Department of Physical Therapy, Chang Gung University, Kwei Shan, Tao Yuan, Taiwan, ROC
    Arch Phys Med Rehabil 83:210-6. 2002
    ..To investigate the effects of arm crank exercise on various platelet functions and prostacyclin in individuals with spinal cord injury (SCI)...
  27. ncbi request reprint Tai Chi Chuan training to enhance microcirculatory function in healthy elderly men
    J S Wang
    Department of Physical Therapy, Chang Gung University, Taipei, Taiwan
    Arch Phys Med Rehabil 82:1176-80. 2001
    ..To evaluate cutaneous microcirculatory function in geriatric Tai Chi Chuan (TCC) practitioners...
  28. ncbi request reprint Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury
    J S Wang
    Department of Physical Therapy, Chang Gung University, Taoyun, Tawan
    Thromb Haemost 84:118-23. 2000
    ..Therefore, supplementation therapy with antioxidants may be needed for patients with SCI, especially in a strenuous arm exercise period...
  29. ncbi request reprint Role of chronic exercise in decreasing oxidized LDL-potentiated platelet activation by enhancing platelet-derived no release and bioactivity in rats
    J S Wang
    Department of Physical Therapy, Chang Gung University, Taoyuan, Taiwan
    Life Sci 66:1937-48. 2000
    ..Moreover, exercise training decreases Ox-LDL-potentiated platelet activation most likely by enhancing platelet-derived NO release and bioactivity...
  30. ncbi request reprint Moderate-intensity exercise suppresses platelet activation and polymorphonuclear leukocyte interaction with surface-adherent platelets under shear flow in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan, 333, Taiwan
    Thromb Haemost 91:587-94. 2004
    ....
  31. ncbi request reprint Effect of exercise training on oxidized LDL-mediated platelet function in rats
    J S Wang
    Department of Physical Therapy, Chang Gung University, Taoyuan, Taiwan ROC
    Thromb Haemost 83:503-8. 2000
    ..Results in this study demonstrate that exercise training decreases Ox-LDL-potentiated platelet activation most likely by enhancing platelet-derived NO release...
  32. ncbi request reprint Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Center for Gerontological Research, Chang Gung University, Taoyuan, Taiwan
    Arterioscler Thromb Vasc Biol 25:454-60. 2005
    ..This study investigated how exercise training and deconditioning influence alternating shear-induced platelet aggregation (ASIPA) and clarify the mechanisms underlying ASIPA...
  33. ncbi request reprint Strenuous, acute exercise suppresses polymorphonuclear leukocyte respiratory burst under adherence to surface-adherent platelets in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science, Chang Gung University, Kwei Shan, Tao Yuan 333, Taiwan
    Thromb Haemost 92:1076-85. 2004
    ....
  34. ncbi request reprint Effects of exercise training and detraining on oxidized low-density lipoprotein-potentiated platelet function in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Department of Physiology, Chang Gung University, Taoyuan, Taiwan
    Arch Phys Med Rehabil 85:1531-7. 2004
    ..To investigate how exercise training and detraining affect oxidized low-density lipoprotein (Ox-LDL)-potentiated platelet function in men...
  35. ncbi request reprint Effects of exercise intensity on lymphocyte apoptosis induced by oxidative stress in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, 333, Tao Yuan, Taiwan
    Eur J Appl Physiol 95:290-7. 2005
    ..However, moderate exercise attenuates lymphocyte apoptosis induced by oxidative stress, possibly by improving intracellular anti-oxidative capacity...
  36. ncbi request reprint Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation
    Chiang Wen Lee
    Department of Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 207:174-86. 2006
    ..These results suggest that in HTSMCs, activation of MAPK pathways, NF-kappaB, and p300 is essential for TNF-alpha-induced VCAM-1 expression...
  37. ncbi request reprint Involvement of p42/p44 MAPK, p38 MAPK, JNK, and NF-kappaB in IL-1beta-induced VCAM-1 expression in human tracheal smooth muscle cells
    Chien Chun Wang
    Graduate Institute of Natural Products, Department of Pharmacology, 259 Wen Hwa 1st Road, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Am J Physiol Lung Cell Mol Physiol 288:L227-37. 2005
    ..These results provide new insight into the mechanisms of IL-1beta action that cytokines may promote inflammatory responses in airway disease...
  38. doi request reprint Strenuous exercise promotes shear-induced thrombin generation by increasing the shedding of procoagulant microparticles from platelets
    Yu Wen Chen
    Graduate Institute of Biomedical Sciences, Chang Gung University, Tao Yuan, Taiwan
    Thromb Haemost 104:293-301. 2010
    ..Therefore, we conclude that strenuous exercise modestly contributes to the acceleration of shear-induced TG by increasing the release of procoagulant microparticles from platelets...
  39. ncbi request reprint Neuromuscular electric stimulation enhances endothelial vascular control and hemodynamic function in paretic upper extremities of patients with stroke
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Sciences and Center for Gerontological Research, Chang Gung University, Tao Yuan, Taipei, Taiwan 10016
    Arch Phys Med Rehabil 85:1112-6. 2004
    ..To investigate the effects of neuromuscular electric stimulation (NMES) on endothelial vascular control and hemodynamic function in patients in rehabilitation after acute stroke...
  40. pmc Suppression of cerebral hemodynamics is associated with reduced functional capacity in patients with heart failure
    Tieh Cheng Fu
    Department of Physical Medicine and Rehabilitation, Gung Memorial Hospital, Keelung, Taiwan
    Am J Physiol Heart Circ Physiol 300:H1545-55. 2011
    ..We concluded that the suppression of cerebral/muscle hemodynamics during exercise is associated with ventilatory abnormality, which reduces functional capacity in patients with HF...
  41. doi request reprint Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts
    Shue Fen Luo
    Chang Gung University, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan
    Arthritis Rheum 62:105-16. 2010
    ..To investigate the roles of MAPKs and NF-kappaB in tumor necrosis factor alpha (TNFalpha)-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human rheumatoid arthritis synovial fibroblasts (RASFs)...
  42. ncbi request reprint Role of exercise intensities in oxidized low-density lipoprotein-mediated redox status of monocyte in men
    Jong Shyan Wang
    Institute of Coaching Science, National College of Physical Education and Sports, Tao Yuan, Taiwan
    J Appl Physiol (1985) 101:740-4. 2006
    ..However, mild and moderate exercise likely protects individuals against suppression of anti-oxidative capacity of monocyte by ox-LDL...
  43. ncbi request reprint Resveratrol protects vascular endothelial cell from ox-LDL-induced reduction in antithrombogenic activity
    Ying Jen Chen
    Department of General Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Chin J Physiol 50:22-8. 2007
    ..The effect of ox-LDL on the NOS protein content was abrogated by pretreating EC with RSV. The results suggest that ox-LDL acts via reducing the endothelial NOS activity to suppress the antithrombogenic activity of the EC...
  44. doi request reprint Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure
    Tieh Cheng Fu
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan
    Int J Cardiol 167:41-50. 2013
    ..This study investigates how interval and continuous exercise regimens influence functional capacity by modulating ventilatory efficiency and hemodynamic function in HF patients...
  45. doi request reprint Systemic hypoxia affects cardiac autonomic activity and vascular hemodynamic control modulated by physical stimulation
    Shu Chun Huang
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Eur J Appl Physiol 106:31-40. 2009
    ..Moreover, the BP and cardiac autonomic responses to 12% O(2), but not 15% O(2), exposure are depressed while performing posture change and the Valsalva maneuver...
  46. doi request reprint Negative pressure accelerated monolayer keratinocyte healing involves Cdc42 mediated cell podia formation
    Chih Chin Hsu
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, No 222 Maijin Road, Keelung, Taiwan
    J Dermatol Sci 70:196-203. 2013
    ..Negative-pressure wound therapy (NPWT) is developed to facilitate wound healing at controlled subatmospheric pressures in modern medicine. Molecular mechanism for this therapy is still undefined...
  47. ncbi request reprint Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells
    Wei Ning Lin
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Cell Signal 19:1258-67. 2007
    ..These results provide new insight into the mechanisms of LPS action that bacterial toxins may promote inflammatory responses in the airway disease...
  48. ncbi request reprint Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages
    Shu Er Chow
    Center for General Studies, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    J Appl Physiol 102:1520-7. 2007
    ..In addition, ANG II-induced NOX activation is also attenuated. These results suggest that RSV or AST protects EC from oxLDL-induced oxidative stress by both direct ROS scavenging and inhibition of NOX activity...
  49. doi request reprint ATP stimulates PGE(2)/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation
    I Ta Lee
    Department of Anesthetics, Chang Gung Memorial Hospital at Linkuo and Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Biochem Pharmacol 85:954-64. 2013
    ..These results suggested that ATPγS-induced cPLA2/COX-2 expression and PGE2 secretion is mediated through a PKC/NADPH oxidase/ROS/STAT3-dependent pathway in VSMCs...
  50. ncbi request reprint Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Sciences and Center for Gerontological Research, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, 333 Tao Yuan, Taiwan
    Eur J Appl Physiol 93:429-34. 2005
    ..The results suggest that endothelium-dependent dilation in skin vasculature is enhanced by moderate exercise training and reversed to the pretraining state with detraining...
  51. ncbi request reprint Non-invasive cardiac index monitoring during cardiopulmonary functional testing provides additional prognostic value in patients after acute heart failure
    Ming Feng Lee
    Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taiwan
    Int Heart J 53:364-9. 2012
    ..02) were significant independent predictors. In conclusion, NICOM during the CPET was demonstrated to provide prognostic information in addition to traditional risk factors, biomarkers, and other well-established CPET parameters...
  52. doi request reprint Absolute hypoxic exercise training enhances in vitro thrombin generation by increasing procoagulant platelet-derived microparticles under high shear stress in sedentary men
    Yu Wen Chen
    Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Chang Gung University, Tao Yuan, Taiwan
    Clin Sci (Lond) 124:639-49. 2013
    ..These findings provide new insights into how exercise training under a hypoxic condition influences the risk of thrombosis associated with stenotic arteries...
  53. ncbi request reprint Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system
    Chao Hung Wang
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, 222, Mai Chin Road, Keelung, Taiwan
    Am J Physiol Regul Integr Comp Physiol 294:R811-8. 2008
    ..In summary, CsA manipulates the mobilization of EPCs into the circulation via the CD26/DPP IV system. Short-term CsA treatment has beneficial effects on angiogenesis of ischemic tissues...
  54. ncbi request reprint VE-Cadherin(low)α-smooth muscle actin+ component of vascular progenitor cells correlates with the coronary artery Gensini score
    Chao Hung Wang
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
    Circ J 76:477-84. 2012
    ..This study sought to determine whether the level of this subpopulation correlated with the coronary Gensini score...
  55. doi request reprint Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells
    Shu Er Chow
    Center for General Studies, Chang Gung University, Taoyuan, Taiwan
    J Cell Biochem 113:3476-85. 2012
    ..This study indicated wogonin-induced both autophagy and apoptosis through a variety of Akt pathways and suggested modulation of autophagy might provide profoundly the potential therapeutic effect...
  56. ncbi request reprint Hypoxic exercise training causes erythrocyte senescence and rheological dysfunction by depressed Gardos channel activity
    Tso Yen Mao
    Graduate Institute of Physical Education, National Taiwan Sport University, Taiwan
    J Appl Physiol (1985) 111:382-91. 2011
    ..Simultaneously, this intervention depresses Gardos channel-modulated erythrocyte rheological functions. Results of this study provide further insight into erythrocyte senescence induced by HE...
  57. doi request reprint Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells
    Shu Er Chow
    Department of Nature Science Center for General Studies, Chang Gung University, Taoyuan, Taiwan
    Apoptosis 19:527-41. 2014
    ..Targeting the different status of ER stress may provide a possible strategy for cancer treatments. ..
  58. doi request reprint Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63
    Shu Er Chow
    Center for General Studies, Chang Gung University, Taoyuan, Taiwan
    Cancer Chemother Pharmacol 68:835-45. 2011
    ..Dysregulation of GSK-3β has been implicated in tumorigenesis and cancer progression. In this study, we investigated the antitumor activity and the mechanistic action of wogonin in human nasopharyngeal carcinoma (NPC) cells...
  59. ncbi request reprint Effects of negative pressures on epithelial tight junctions and migration in wound healing
    Chih Chin Hsu
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan
    Am J Physiol Cell Physiol 299:C528-34. 2010
    ..Negative pressure of 125 mmHg can help disassemble the cell junction to enhance epithelial migration and subsequently result in quick wound closure...
  60. doi request reprint Downregulation of p57kip² promotes cell invasion via LIMK/cofilin pathway in human nasopharyngeal carcinoma cells
    Shu Er Chow
    Center for General Studies, Chang Gung University, Taoyuan, Taiwan
    J Cell Biochem 112:3459-68. 2011
    ....
  61. doi request reprint Accuracy of body mass index to determine obesity in women with breast cancer: an observational study of Taiwanese sample
    Li Ni Liu
    Graduate Institute of Clinical Medical Sciences, Chang Gung University, and Department of Surgery, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Int J Nurs Stud 47:994-1000. 2010
    ..Excessive body fat accumulation has been associated with a worse prognosis. However, the most popular clinical indicator of obesity is not fat itself, but body mass index (BMI)...
  62. ncbi request reprint Effects of Acute Systematic Hypoxia on Human Urinary Metabolites Using LC-MS-Based Metabolomics
    Bih Show Lou
    1 Chemistry Division, Center for General Education, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    High Alt Med Biol 15:192-202. 2014
    ..The increase of free carnitine and acetyl carnitines, on the other hand, signals a change in the pathway of energy, or lipid, metabolism. ..
  63. doi request reprint A computational modeling and analysis in cell biological dynamics using electric cell-substrate impedance sensing (ECIS)
    Szi Wen Chen
    Department of Electronic Engineering, Chang Gung University, Tao Yuan 333, Taiwan
    Biosens Bioelectron 33:196-203. 2012
    ..Our analyses indicated that the proposed study on ECIS time series could provide a hopeful start and great potentials in both modeling and elucidating the complex mechanisms of cell biological systems...