Hung Li Wang
Affiliation: Chang Gung University
Wang H, Chou A, Lin A, Chen S, Weng Y, Yeh T. Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons. Exp Neurol. 2010;224:486-94 pubmed publisher
..Our study provides the evidence that polyglutamine-expanded ataxin-7 upregulates the expression of Bax and Puma and causes apoptotic neuronal death by enhancing phosphorylation and transcriptional activity of p53. ..
Chiu C, Lu C, Weng Y, Chen Y, Huang Y, Chen R, et al
. PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Mol Neurobiol. 2018;: pubmed publisher
..Our results suggest that PARK14 (D331Y) PLA2G6 mutation causes degeneration of SNpc dopaminergic neurons by causing mitochondrial dysfunction, elevated ER stress, mitophagy impairment, and transcriptional abnormality. ..
Wang H, Hu S, Chou A, Wang S, Weng Y, Yeh T. H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse. Neuropharmacology. 2013;70:1-11 pubmed publisher
..H1152 also ameliorated pontine neuronal death and neurological phenotype of SCA3 transgenic mice. Our results suggest that H1152 might be an effective therapeutic agent for SCA3 or SCA7. ..
Weng Y, Chen C, Lin K, Chen Y, Yeh T, Hsiao I, et al
. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Exp Neurol. 2016;275 Pt 1:104-15 pubmed publisher
..Our results suggest that altered expression of these genes involved in regulating neuronal survival may contribute to the pathogenesis of (R1441C) LRRK2-induced PD. ..
Chiu C, Yeh T, Lai S, Wu Chou Y, Chen C, Mochly Rosen D, et al
. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Exp Neurol. 2015;263:244-53 pubmed publisher
..These results indicate that ALDH2 activation could be a neuroprotective therapy for PD. ..
Chou A, Chen Y, Chiu C, Yuan S, Weng Y, Yeh T, et al
. T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse. Neuropharmacology. 2015;99:308-17 pubmed publisher
Wang H, Kuo Y, Hsu C, Huang P, Li A, Chou A, et al
. Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors. Cell Signal. 2006;18:670-8 pubmed
..These results suggest that two C-terminal serine residues, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of ORL1. ..
Wang H, Chou A, Yeh T, Li A, Chen Y, Kuo Y, et al
. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. Neurobiol Dis. 2007;28:216-26 pubmed
..These results suggest that PINK1 exerts anti-apoptotic effect by inhibiting the opening of mPTP and that PARK6 mutant PINK1 loses its ability to prevent mPTP opening and cytochrome c release. ..
Wang H, Chang N, Weng Y, Yeh T. XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. Biochim Biophys Acta. 2013;1832:585-93 pubmed publisher
..Our results suggest that XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. ..