Hung Li Wang

Summary

Affiliation: Chang Gung University
Country: Taiwan

Publications

  1. ncbi request reprint A cluster of Ser/Thr residues at the C-terminus of mu-opioid receptor is required for G protein-coupled receptor kinase 2-mediated desensitization
    H L Wang
    Department of Physiology, Chang Gung University School of Medicine, Tao Yuan, Taiwan
    Neuropharmacology 39:353-63. 2000
  2. doi request reprint Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Tao Yuan, Taiwan, ROC
    Exp Neurol 224:486-94. 2010
  3. doi request reprint PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons
    Hung Li Wang
    Department of Physiology and Pharmacology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Biochim Biophys Acta 1812:674-84. 2011
  4. doi request reprint Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons
    Chung Yu Huang
    Department of Physiology and Pharmacology, School of Medicine, Chang Gung University, 259 Wen hwa 1 Road, Kwei San, Tao Yuan 333, Taiwan
    J Neuroinflammation 11:7. 2014
  5. doi request reprint H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse
    Hung Li Wang
    Department of Physiology and Pharmacology, Chang Gung University School of Medicine, 259 Wen hwa 1 Road, Kwei San, Tao Yuan, Taiwan, ROC
    Neuropharmacology 70:1-11. 2013
  6. doi request reprint XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Taiwan, Republic of China
    Biochim Biophys Acta 1832:585-93. 2013
  7. ncbi request reprint PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Neurobiol Dis 28:216-26. 2007
  8. ncbi request reprint Polyglutamine-expanded ataxin-7 decreases nuclear translocation of NF-kappaB p65 and impairs NF-kappaB activity by inhibiting proteasome activity of cerebellar neurons
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Taiwan, ROC
    Cell Signal 19:573-81. 2007
  9. ncbi request reprint Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine Kwei San, Tao Yuan, Taiwan, ROC
    Cell Signal 18:670-8. 2006
  10. ncbi request reprint Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-x(L)
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Cell Signal 18:541-52. 2006

Collaborators

Detail Information

Publications28

  1. ncbi request reprint A cluster of Ser/Thr residues at the C-terminus of mu-opioid receptor is required for G protein-coupled receptor kinase 2-mediated desensitization
    H L Wang
    Department of Physiology, Chang Gung University School of Medicine, Tao Yuan, Taiwan
    Neuropharmacology 39:353-63. 2000
    ....
  2. doi request reprint Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Tao Yuan, Taiwan, ROC
    Exp Neurol 224:486-94. 2010
    ..Our study provides the evidence that polyglutamine-expanded ataxin-7 upregulates the expression of Bax and Puma and causes apoptotic neuronal death by enhancing phosphorylation and transcriptional activity of p53...
  3. doi request reprint PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons
    Hung Li Wang
    Department of Physiology and Pharmacology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Biochim Biophys Acta 1812:674-84. 2011
    ..Our study also provides the evidence that PARK6 mutant (G309D), (E417G) or (CΔ145) PINK1 is defective in regulating mitochondrial functions and attenuating ROS production of SN dopaminergic cells...
  4. doi request reprint Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons
    Chung Yu Huang
    Department of Physiology and Pharmacology, School of Medicine, Chang Gung University, 259 Wen hwa 1 Road, Kwei San, Tao Yuan 333, Taiwan
    J Neuroinflammation 11:7. 2014
    ....
  5. doi request reprint H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse
    Hung Li Wang
    Department of Physiology and Pharmacology, Chang Gung University School of Medicine, 259 Wen hwa 1 Road, Kwei San, Tao Yuan, Taiwan, ROC
    Neuropharmacology 70:1-11. 2013
    ..H1152 also ameliorated pontine neuronal death and neurological phenotype of SCA3 transgenic mice. Our results suggest that H1152 might be an effective therapeutic agent for SCA3 or SCA7...
  6. doi request reprint XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Taiwan, Republic of China
    Biochim Biophys Acta 1832:585-93. 2013
    ..Our results suggest that XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons...
  7. ncbi request reprint PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Neurobiol Dis 28:216-26. 2007
    ..These results suggest that PINK1 exerts anti-apoptotic effect by inhibiting the opening of mPTP and that PARK6 mutant PINK1 loses its ability to prevent mPTP opening and cytochrome c release...
  8. ncbi request reprint Polyglutamine-expanded ataxin-7 decreases nuclear translocation of NF-kappaB p65 and impairs NF-kappaB activity by inhibiting proteasome activity of cerebellar neurons
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Taiwan, ROC
    Cell Signal 19:573-81. 2007
    ..Our study provides the evidence that polyglutamine-expanded ataxin-7-Q75 decreases nuclear translocation of NF-kappaB p65 and impairs NF-kappaB activity by inhibiting proteasome activity of cerebellar neurons...
  9. ncbi request reprint Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine Kwei San, Tao Yuan, Taiwan, ROC
    Cell Signal 18:670-8. 2006
    ..These results suggest that two C-terminal serine residues, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of ORL1...
  10. ncbi request reprint Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-x(L)
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Cell Signal 18:541-52. 2006
    ....
  11. ncbi request reprint Point mutation associated with X-linked dominant Charcot-Marie-Tooth disease impairs the P2 promoter activity of human connexin-32 gene
    H L Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Brain Res Mol Brain Res 78:146-53. 2000
    ..These findings propose that a reduced expression of connexin-32 mRNA and protein in the myelin sheath could be responsible for the development of X-linked dominant Charcot-Marie-Tooth neuropathy...
  12. ncbi request reprint Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Tao Yuan, Taiwan, ROC
    Biochem Pharmacol 64:257-66. 2002
    ..These results suggest that two C-terminal amino acids, Ser(355) and Thr(357), are required for short-term homologous desensitization and agonist-induced phosphorylation of mu-opioid receptors expressed in HEK 293 cells...
  13. ncbi request reprint Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    J Neurochem 92:1285-94. 2005
    ..These results provide the evidence that ORL1/muR heterodimerization and the resulting impairment of mu receptor-activated signaling pathways may contribute to ORL1-mediated antiopioid effects in the brain...
  14. ncbi request reprint Functional analysis of connexin-26 mutants associated with hereditary recessive deafness
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, Republic of China
    J Neurochem 84:735-42. 2003
    ....
  15. ncbi request reprint Functional analysis of connexin-32 mutants associated with X-linked dominant Charcot-Marie-Tooth disease
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Tao Yuan, Taiwan, ROC
    Neurobiol Dis 15:361-70. 2004
    ..However, further studies are required to elucidate the exact mechanism by which CMTX mutant Cx32 proteins, which retain the ability to form homotypic junctional channels, damage Schwann cells and cause demyelinating neuropathy...
  16. ncbi request reprint Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL
    An Hsun Chou
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taiwan, ROC
    Neurobiol Dis 21:333-45. 2006
    ..Our results suggest that polyglutamine-expanded ataxin-3-Q79 activates mitochondrial apoptotic pathway and induces neuronal death by upregulating Bax expression and downregulating Bcl-xL expression...
  17. doi request reprint Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation
    An Hsun Chou
    Department of Anesthesiology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Neurochem Int 56:329-39. 2010
    ..Our study suggests that polyglutamine-expanded ataxin-7-induced transcriptional dysregulation causes cerebellar dysfunction and ataxia...
  18. doi request reprint Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation
    An Hsun Chou
    Department of Anesthesiology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Neurobiol Dis 31:89-101. 2008
    ..Our study suggests that polyglutamine-expanded ataxin-3 causes cerebellar dysfunction and ataxia by disrupting the normal pattern of gene transcriptions...
  19. ncbi request reprint Global ischemia downregulates the function of metabotropic glutamate receptor subtype 5 in hippocampal CA1 pyramidal neurons
    Tu Hsueh Yeh
    Department of Neurology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Mol Cell Neurosci 29:484-92. 2005
    ....
  20. doi request reprint p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons
    An Hsun Chou
    Department of Anesthesiology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Neurochem Int 58:145-52. 2011
    ..Our results suggest that polyglutamine-expanded ataxin-3 upregulates mRNA expression of Bax and PUMA and causes apoptotic death of affected neurons by enhancing phosphorylation and transcriptional activity of p53...
  21. doi request reprint HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3
    An Hsun Chou
    Department of Anesthesiology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Neurobiol Dis 41:481-8. 2011
    ..Our results suggest that sodium butyrate might be a promising therapeutic agent for SCA3...
  22. doi request reprint Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons
    Ying Ling Chen
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan, ROC
    Mol Cell Neurosci 40:76-88. 2009
    ..Our study provides the evidence that the molecular and cellular basis for opposite effects of N/OFQ and NST on supraspinal pain regulation is their opposing effects on the excitability of peptidergic CeA(M)-PAG neurons...
  23. ncbi request reprint Clinical and electrophysiological studies of a family with probable X-linked dominant Charcot-Marie-Tooth neuropathy and ptosis
    Tony Wu
    First Section, Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Chang Gung Med J 27:489-500. 2004
    ..Clinical and genetic features of CMTX have not previously been reported in Taiwanese...
  24. ncbi request reprint Glutamate transporter function of rat hippocampal astrocytes is impaired following the global ischemia
    Tu Hsueh Yeh
    Department of Neurology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Neurobiol Dis 18:476-83. 2005
    ..The present study provides the evidence that transient global ischemia downregulates glutamate transporter function of hippocampal CA1 astrocytes by decreasing mRNA and protein levels of GLT-1...
  25. pmc CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons
    Der Jang Kao
    Department of Physiology and Pharmacology, Chang Gung University School of Medicine, Kwei San, Tao Yuan 333, Taiwan
    J Neuroinflammation 9:189. 2012
    ..We therefore tested the hypothesis that CCL2 causes peripheral sensitization of nociceptive DRG neurons by upregulating the function and expression of TRPV1 and Nav1.8 channels...
  26. ncbi request reprint Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress
    Tsung I Peng
    Department of Neurology, Lin Kou Medical Center, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Biochim Biophys Acta 1762:241-55. 2006
    ....
  27. ncbi request reprint Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia
    Jin Chung Chen
    Department of Pharmacology, Chang Gung University, 259 Wen Hwa 1st Road, Tao Yuan, Kwei Shan, Taiwan, ROC
    Neuropharmacology 49:703-14. 2005
    ..The current findings pinpoint the significance of GLT-1 during ischemia/reperfusion and suggest a potential application of group III metabotropic glutamate receptor antagonist against ischemic/hypoxic neuronal damage...
  28. pmc Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study
    Ya Tin Lin
    Department of Physiology and Pharmacology, Chang Gung University, Taiwan, Republic of China
    J Neuroinflammation 8:126. 2011
    ..The aim of this study was to investigate whether and how BDNF-trkB signaling in the DRG is involved in the process of inflammatory pain...