Genomes and Genes


Hsin Shih Wang


Affiliation: Chang Gung Memorial Hospital
Country: Taiwan


  1. Wu H, Wang H, Huang H, Lai C, Lee C, Soong Y, et al. Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2. BMC Cancer. 2013;13:300 pubmed publisher
    ..In mammals, expression of GnRH-II is higher than GnRH-I in reproductive tissues. Here, we examined the effect of a GnRH-II agonist on the motility of endometrial cancer cells and its mechanism of action in endometrial cancer therapy...
  2. Wu H, Huang H, Lee C, Soong Y, Leung P, Wang H. Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the motility of human decidual endometrial stromal cells: possible effect on embryo implantation and pregnancy. Biol Reprod. 2015;92:98 pubmed publisher
    ..Our findings represent a new concept regarding the mechanisms of GnRH-II-promoted cell motility, suggesting that GnRH-II agonist has strong effects on embryo implantation and decidual programming of human pregnancy. ..