Lee Yung Shih

Summary

Affiliation: Chang Gung Memorial Hospital
Country: Taiwan

Publications

  1. pmc Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations
    Tung Liang Lin
    Haematologica 99:28-36. 2014
  2. doi request reprint Emerging kinetics of BCR-ABL1 mutations and their effect on disease outcomes in chronic myeloid leukemia patients with imatinib failure
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
    Leuk Res 37:43-9. 2013
  3. ncbi request reprint Clonality analysis using X-chromosome inactivation patterns by HUMARA-PCR assay in female controls and patients with idiopathic thrombocytosis in Taiwan
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Exp Hematol 29:202-8. 2001
  4. ncbi request reprint Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia
    L Y Shih
    Department of Internal Medicine, Division of Hematology Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Leukemia 18:466-75. 2004
  5. ncbi request reprint Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples
    Lee Yung Shih
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, and Chang Gung University, Taoyuan, Taiwan
    Clin Cancer Res 10:1326-32. 2004
  6. ncbi request reprint Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Cancer 101:989-98. 2004
  7. ncbi request reprint Heterogeneous patterns of CEBPalpha mutation status in the progression of myelodysplastic syndrome and chronic myelomonocytic leukemia to acute myelogenous leukemia
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Clin Cancer Res 11:1821-6. 2005
  8. ncbi request reprint Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Leukemia 20:218-23. 2006
  9. ncbi request reprint AML patients with CEBPalpha mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Leukemia 20:604-9. 2006
  10. ncbi request reprint Internal tandem duplication and Asp835 mutations of the FMS-like tyrosine kinase 3 (FLT3) gene in acute promyelocytic leukemia
    Lee Yung Shih
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Cancer 98:1206-16. 2003

Collaborators

Detail Information

Publications58

  1. pmc Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations
    Tung Liang Lin
    Haematologica 99:28-36. 2014
    ..Our findings provide a novel insight into the role of TET2/IDH mutation in the pathogenesis of myelodysplastic syndrome and subsequent progression to acute myeloid leukemia. ..
  2. doi request reprint Emerging kinetics of BCR-ABL1 mutations and their effect on disease outcomes in chronic myeloid leukemia patients with imatinib failure
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
    Leuk Res 37:43-9. 2013
    ..006). Our study demonstrates kinetics of different BCR-ABL1 mutant emergence and an association between BCR-ABL1 mutations and disease progression...
  3. ncbi request reprint Clonality analysis using X-chromosome inactivation patterns by HUMARA-PCR assay in female controls and patients with idiopathic thrombocytosis in Taiwan
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Exp Hematol 29:202-8. 2001
    ....
  4. ncbi request reprint Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia
    L Y Shih
    Department of Internal Medicine, Division of Hematology Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Leukemia 18:466-75. 2004
    ..N-ras mutations had no prognostic impact either at the MDS or AML stage. Our results show that one-third of MDS patients acquire activating mutations of FLT3 or N-ras gene during AML evolution and FLT3/ITD predicts a poor outcome in MDS...
  5. ncbi request reprint Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples
    Lee Yung Shih
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, and Chang Gung University, Taoyuan, Taiwan
    Clin Cancer Res 10:1326-32. 2004
    ..We analyzed Asp(835) mutations of FLT3 on paired marrow samples at diagnosis and relapse from 120 adult patients with de novo acute myeloid leukemia (AML) to determine the role of FLT3 Asp(835) mutation in the relapse of AML...
  6. ncbi request reprint Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Cancer 101:989-98. 2004
    ..In the current study, the authors sought to assess the value of FLT3/ITD mutation status as a prognostic genetic marker for patients with MDS...
  7. ncbi request reprint Heterogeneous patterns of CEBPalpha mutation status in the progression of myelodysplastic syndrome and chronic myelomonocytic leukemia to acute myelogenous leukemia
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Clin Cancer Res 11:1821-6. 2005
    ..We aimed to assess the role of CEBPalpha mutations in the progression of myelodysplastic syndrome (MDS) to acute myelogenous leukemia (AML) and their cooperating mutations...
  8. ncbi request reprint Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Leukemia 20:218-23. 2006
    ..The present study showed that cDNA panhandle PCR can identify all rare or novel MLL partner genes. MLL-PTD was rare in childhood AML. MLL(+) adults had a poor outcome with no difference in survival between MLL-PTD and MLL/t11q23 groups...
  9. ncbi request reprint AML patients with CEBPalpha mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Leukemia 20:604-9. 2006
    ..Our study showed that 91% of de novo AML harboring CEBPalpha mutations at diagnosis retained the identical mutant patterns but frequently changed in the allelic distribution at relapse...
  10. ncbi request reprint Internal tandem duplication and Asp835 mutations of the FMS-like tyrosine kinase 3 (FLT3) gene in acute promyelocytic leukemia
    Lee Yung Shih
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Cancer 98:1206-16. 2003
    ....
  11. ncbi request reprint Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia
    L Y Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Genes Chromosomes Cancer 30:402-6. 2001
    ..Our results suggest that BCL10 is not involved in the oncogenesis of plasma cell dyscrasias...
  12. ncbi request reprint Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan
    Blood 100:2387-92. 2002
    ..Our results suggest that FLT3/ITD may contribute as the initial transforming event in AML, and relapse can reflect the selection and outgrowth of a mutant clone or evolution of a new clone harboring this mutation...
  13. ncbi request reprint Predictive values of X-chromosome inactivation patterns and clinicohematologic parameters for vascular complications in female patients with essential thrombocythemia
    Lee Yung Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Blood 100:1596-601. 2002
    ..083) and hypertension (P =.073) tended to predict thrombosis. Our results suggest that older patients who have clonal XCIPs or hypertension are at increased risk for thrombosis and should be monitored closely for this complication...
  14. doi request reprint Clinical and laboratory significance of defective P2Y(12) pathway function in patients with myeloproliferative neoplasms: a pilot study
    Hung Chang
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taiwan, China
    Acta Haematol 130:181-7. 2013
    ....
  15. doi request reprint Value of surveillance computed tomography in the follow-up of diffuse large B-cell and follicular lymphomas
    Tung Liang Lin
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Rd, Taipei, Taiwan
    Ann Hematol 91:1741-5. 2012
    ....
  16. doi request reprint Primary colonic lymphoma: an analysis of 74 cases with localized large-cell lymphoma
    Tzung Chih Tang
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Eur J Haematol 87:28-36. 2011
    ..To further explore the optimal therapeutic approach in different clinical scenarios, we reviewed cases with localized large-cell lymphoma and analyzed the factors related to the outcomes...
  17. pmc A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia
    Hsiao Wen Kao
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Neoplasia 13:1035-42. 2011
    ..8% of patients during sAML transformation. The findings suggest that C-CBL mutations play a role at least in part in a subset of MDS patients during sAML transformation...
  18. ncbi request reprint K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements
    Der Cherng Liang
    Division of Pediatric Hematology Oncology, Mackay Memorial Hospital, Taipei, Taiwan
    Cancer 106:950-6. 2006
    ....
  19. doi request reprint The impact of age, Charlson comorbidity index, and performance status on treatment of elderly patients with diffuse large B cell lymphoma
    Tung Liang Lin
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, via Tun Hwa North Rd, Taipei, Taiwan
    Ann Hematol 91:1383-91. 2012
    ..The treatment regimen was not different between patients with lower and higher CCI. Rituximab-containing regimens improved the outcome of elderly patients with DLBCL...
  20. doi request reprint Primary bone marrow diffuse large B cell lymphoma: a case series and review
    Hung Chang
    Division of Hematology Oncology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Ann Hematol 90:791-6. 2011
    ..We concluded that primary bone marrow DLBCL is a rare but distinctive subtype of lymphoma. The prognosis for this entity is poor but rituximab-based treatment is promising for improving its outcomes...
  21. ncbi request reprint Acute promyelocytic leukemia-associated thrombosis
    Hung Chang
    Division of Hematology Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Acta Haematol 130:1-6. 2013
    ..Ischemic stroke and catheter-related thrombosis were the most common events in our Taiwanese cohort. Such a thrombosis pattern is unique and worth further investigation. ..
  22. doi request reprint Clinical bleeding events and laboratory coagulation profiles in acute promyelocytic leukemia
    Hung Chang
    Division of Hematology Oncology, Chang Gung Memorial Hospital, and School of Medicine, Chang Gung University, Taipei, Taiwan
    Eur J Haematol 88:321-8. 2012
    ..The benefit of fresh frozen plasma transfusion is unproven. Using laboratory profiles to predict bleeding is important guidance for the determination of transfusion policies in the treatment of APL...
  23. doi request reprint Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A
    Der Cherng Liang
    Division of Pediatric Hematology Oncology, Mackay Memorial Hospital, Taipei, Taiwan
    Blood 121:2988-95. 2013
    ..We conclude that mutated epigenetic regulators were much less than those in adult AML but with frequent cooperating mutations. ASXL1, TET2, and IDH1 mutations were associated with specific genetic subtypes...
  24. ncbi request reprint Frequencies of ETV6-RUNX1 fusion and hyperdiploidy in pediatric acute lymphoblastic leukemia are lower in far east than west
    Der Cherng Liang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    Pediatr Blood Cancer 55:430-3. 2010
    ..Both ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) in transformed lymphoblasts are favorable genetic features in childhood acute lymphoblastic leukemia (ALL)...
  25. ncbi request reprint Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia
    Der Cherng Liang
    Division of Pediatric Hematology Oncology, Mackay Memorial Hospital, Taipei, Taiwan
    Cancer 94:3292-8. 2002
    ..However, there are few studies on FLT3/ITD in childhood AML, and the clinical significance of FLT3/ITD is thus unclear...
  26. ncbi request reprint Primary salivary gland lymphoma: a clinicopathologic study of 23 cases in Taiwan
    Po Dunn
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Acta Haematol 112:203-8. 2004
    ..Overall, only 2 patients succumbed. The overall survival and relapse-free survival rates at 5 years were 94.7 and 51.4%, respectively. Thus, salivary gland lymphoma proved to be an indolent disease...
  27. ncbi request reprint Retinoic acid syndrome in patients following the treatment of acute promyelocytic leukemia with all-trans retinoic acid
    Yung Cheng Su
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:535-42. 2009
    ..The incidence and risk factors have been shown to vary in different series. In this study we want to establish the incidence of RAS in our hospital and try to elucidate factors that increase its risk...
  28. doi request reprint Clinical features, molecular diagnosis, and treatment outcome of infants with leukemia in Taiwan
    Shih Hsiang Chen
    Division of Hematology Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pediatr Blood Cancer 55:1264-71. 2010
    ..The clinical features and molecular analyses for the fusion transcripts of mixed lineage leukemia (MLL) gene rearrangement in infant leukemia have not been well documented in the Chinese population...
  29. ncbi request reprint Primary gastric diffuse large B-cell lymphoma
    Yu Shin Hung
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R O C
    Chang Gung Med J 31:159-66. 2008
    ..The optimal treatment of primary gastric large-cell non-Hodgkin's lymphoma (PGL) has not been defined. Recent studies have suggested that organ-preserving treatment produces the same results as surgical treatment...
  30. ncbi request reprint Molecular analysis of t(X;11)(q24;q23) in an infant with AML-M4
    Jen Fen Fu
    Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genes Chromosomes Cancer 38:253-9. 2003
    ..The presence of deletions, duplications, and non-template DNA sequence at the break junctions suggested that the DNA damage-repair machinery is likely to be involved in the translocation events...
  31. ncbi request reprint Gene mutation patterns in patients with minimally differentiated acute myeloid leukemia
    Hsiao Wen Kao
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan Chang Gung University, Taoyuan, Taiwan
    Neoplasia 16:481-8. 2014
    ....
  32. ncbi request reprint Clinical features of testicular lymphoma
    Hsuan Jen Shih
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC
    Acta Haematol 131:187-92. 2014
    ..3 and 36.3 months, respectively. A good response to treatment was a favorable prognostic factor. Because of the high relapse rate, the outcome is poor for testicular lymphoma. Therefore, long-term follow-up is strongly recommended...
  33. doi request reprint Classical hairy cell leukemia and its variant: a 17-year retrospective survey in Taiwan Chinese
    Hsiao Wen Kao
    Division of Hematology Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Acta Haematol 126:186-93. 2011
    ..Classical hairy cell leukemia (HCL-C) and its variant (HCL-V) are rare chronic B-cell lymphoproliferative disorders. Only a few reports in Chinese patients are available...
  34. doi request reprint Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: a cross-laboratory study
    Hsi Che Liu
    Division of Pediatric Hematology Oncology, Mackay Memorial Hospital, Taipei, Taiwan
    Cancer Genet 204:252-9. 2011
    ..Another contribution of this study is to demonstrate that using public data from other studies enriches samples for analysis and yields more conclusive results...
  35. ncbi request reprint Cancer in infants: a review of 82 cases
    Chao Ping Yang
    Division of Hematology Oncology, Chang Gung Children s Hospital at Linkou, Taoyuan, Taiwan
    Pediatr Hematol Oncol 22:463-81. 2005
    ..The prognosis is poor for infant leukemia and rhabdoid tumor, while it is good for embryonal tumors and germ cell tumors occurring in infancy...
  36. ncbi request reprint Neuroblastoma with expression of erythropoietin resulting in erythrocytosis
    Lin Yen Wang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Pediatr Hematol Oncol 25:649-50. 2003
    ..RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production...
  37. ncbi request reprint Extramedullary relapse in the left proximal femur with Philadelphia chromosome positive acute lymphoblastic leukemia after allogeneic bone marrow transplantation
    Tang Her Jaing
    Divisions of Hematology Oncology, Department of Pediatrics, Chang Gung Children s Hospital, Taipei, Taiwan
    J Pediatr Hematol Oncol 25:65-8. 2003
    ..Overt bone marrow relapse was identified 14 months later. Reestablishment of normal donor hematopoiesis was achieved with reinduction chemotherapy...
  38. doi request reprint Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model
    Jen Fen Fu
    Department of Medical Research, Chang Gung Memorial Hospital, and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
    Int J Cancer 133:1792-802. 2013
    ..Our results indicated that upregulation of Gpr125 by cooperating MLL/AF10(OM-LZ) and KRASG12C promoted cell adhesion and contributed to the MS formation...
  39. ncbi request reprint Recombinant urate oxidase (rasburicase) for the prevention and treatment of tumor lysis syndrome in patients with hematologic malignancies
    Lin Yen Wang
    Division of Hematology Oncology, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    Acta Haematol 115:35-8. 2006
    ..Rasburicase was very well tolerated, with only 1 adult having grade 1 vomiting. We conclude that rasburicase is safe and highly effective for preventing the complications of tumor lysis syndrome in patients with hematologic malignancies...
  40. ncbi request reprint Analysis of acute leukemias with MLL/ENL fusion transcripts: identification of two novel breakpoints in ENL
    Jen Fen Fu
    Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Am J Clin Pathol 127:24-30. 2007
    ....
  41. doi request reprint Clinical impact of in vitro cellular drug resistance on childhood acute lymphoblastic leukemia in Taiwan
    Shih Hsiang Chen
    Division of Hematology Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Leuk Lymphoma 53:1536-42. 2012
    ..009). From the present case series, the demonstrated in vitro resistance to chemotherapeutic agents may have a prognostic value in children with ALL before comprehensive minimal residual disease measurement is available...
  42. ncbi request reprint Imatinib-induced tumor lysis syndrome: report of a case and review of the literature
    Hung Chang
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 31:510-4. 2008
    ....
  43. ncbi request reprint Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia
    Jen Fen Fu
    Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genes Chromosomes Cancer 37:214-9. 2003
    ..CBL is the second gene at 11q23.3 found to fuse with MLL...
  44. ncbi request reprint MLL is fused to EB1 (MAPRE1), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemia
    Jen Fen Fu
    Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genes Chromosomes Cancer 43:206-10. 2005
    ..Immunofluorescence staining demonstrated that the MLL-EB1 fusion proteins were localized in the nuclei...
  45. doi request reprint MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model
    Jen Fen Fu
    Department of Medical Research, Chang Gung Memorial Hospital, and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
    Int J Cancer 126:1621-9. 2010
    ..Our results showed that the MLL/AF10(OM-LZ)-immortalized cells could induce host cell proliferation in the transplanted mice, probably through stimulation by CSFs or cytokines produced by the donor cells...
  46. ncbi request reprint Multiplex RT-PCR assay for the detection of major fusion transcripts in Taiwanese children with B-lineage acute lymphoblastic leukemia
    Der Cherng Liang
    Division of Pediatric Hematology Oncology, Mackay Memorial Hospital, Taipei, Taiwan
    Med Pediatr Oncol 39:12-7. 2002
    ..In general, fusion transcripts are determined individually, a process which is labor intensive in order to detect all major fusion transcripts...
  47. ncbi request reprint Hematopoietic progenitor cells increase remarkably in the peripheral blood of children with infection
    Ting Chi Yeh
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    Acta Paediatr Taiwan 48:10-4. 2007
    ..The authors sought to investigate the hematopoietic changes in children with infection...
  48. doi request reprint Cross-generation and cross-laboratory predictions of Affymetrix microarrays by rank-based methods
    Hsi Che Liu
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Biomed Inform 41:570-9. 2008
    ..In addition, we discuss some pitfalls in evaluating cross-generation/laboratory predictions. To use data from various sources one must be cautious on some important but easily neglected steps...
  49. ncbi request reprint Use of a B-type natriuretic peptide in evaluating the treatment response of a relapsed lymphoma with cardiac involvement
    Yu Sheng Lin
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int J Hematol 83:44-6. 2006
    ..This article is the first to report the use of BNP monitoring before and after chemotherapy to evaluate a patient with an unusual relapsed lymphoma with cardiac involvement...
  50. ncbi request reprint Ultrasound-guided core needle biopsy of cervical lymphadenopathy in patients with lymphoma: the clinical efficacy and factors associated with unsuccessful diagnosis
    Pei Ching Huang
    Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan
    Ultrasound Med Biol 36:1431-6. 2010
    ..001), nodal necrosis or infarct (p = 0.001) and insufficiency or fragmentation of the specimens (p < 0.001). UGCNB is a safe and efficient procedure in subclassifying lymphoma. It may obviate surgical biopsy in 89.7% of cases...
  51. ncbi request reprint The synergistic effect of thrombopoietin in erythropoiesis with erythropoietin and/or IL-3 and myelopoiesis with G-CSF or IL-3 from umbilical cord blood cells of premature neonates
    Der Cherng Liang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    Pediatr Hematol Oncol 19:399-405. 2002
    ..000) also. TPO synergizes myelopoiesis from cord blood of premature neonates. Thus, TPO has synergistic effects on both erythropoiesis and myelopoiesis from cord blood of premature neonates...
  52. ncbi request reprint Simultaneous occurrence of gastric adenocarcinoma and low-grade gastric lymphoma of mucosa-associated lymphoid tissue
    Chung Chih Tang
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei Taiwan, ROC
    Chang Gung Med J 25:115-21. 2002
    ..pylori) was detected once in the repeated endoscopic gastric biopsies. The occurrence of both gastric MALT lymphoma and gastric adenocarcinoma was reviewed and the association of H. pylori infection with both malignancies is discussed...
  53. pmc Polycythemia vera as a presentation of renal angiomyolipoma: a case report
    Ming Shyan Lin
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Med Case Reports 3:90. 2009
    ..This report describes a rare case of a woman diagnosed with renal angiomyolipoma and polycythemia vera. The report discusses the differential diagnosis using erythropoietin, erythropoietin-receptor and Janus kinase 2...
  54. ncbi request reprint Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome
    Ming Horng Tsai
    Division of Pediatric Hematology Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Pediatr Hematol Oncol 31:980-2. 2009
    ..She died soon after second-course chemotherapy. To our knowledge, this is the first reported case of childhood acute myeloid leukemia presenting with mediastinal granulocytic sarcoma causing pericardium invasion and SVC syndrome...
  55. ncbi request reprint Imaging findings of retroperitoneal lymphangiomyomatosis in a patient with lymphoma
    Yung Liang Wan
    Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, 5 Fushing Road, Kweishan, Taoyuan 333, Taiwan
    Clin Imaging 30:218-20. 2006
    ..It was managed conservatively and remained stable on 2-year follow-up study. LAM should be considered in the differential diagnoses in cases of a retroperitoneal solid mass with cystic components...
  56. doi request reprint Pulmonary embolism in a patient with multiple myeloma receiving thalidomide-dexamethasone therapy
    Wen Juei Jeng
    The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa North Road, Taipei, 105, Taiwan
    Int J Hematol 87:542-4. 2008
    ..After heparinization and warfarin therapy, the patient's condition improved. This is the first report of a patient with a rare complication of pulmonary embolism from thalidomide-treated multiple myeloma...
  57. doi request reprint Granulomatous Pneumocystis jiroveci pneumonia in a patient with diffuse large B-cell lymphoma: case report and review of the literature
    Hung Chang
    Division of Hematology Oncology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, 5 Fu Shing Street, Kweishan, Taoyuan, Taiwan ROC
    Acta Haematol 123:30-3. 2010
    ..In addition to our report, only one case had previously presented with an SPN. Our experience suggests that granulomatous PJP should be considered a possible etiology when immunocompromised patients develop fever and SPNs...
  58. ncbi request reprint Thymic hyperplasia following successful chemotherapy for Hodgkin's lymphoma: report of a case
    Tung Liang Lin
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Chang Gung Med J 32:98-103. 2009
    ..It is impossible to delineate radiologically benign from malignant lesions. Resection of the tumor for tissue diagnosis is mandatory to establish an accurate diagnosis and thus avoid further harmful therapy...