Jong Hwei S Pang


Affiliation: Chang Gung University
Country: Taiwan


  1. Chang H, Yeh Y, Chueh H, Pang J. The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells. Phytomedicine. 2019;58:152879 pubmed publisher
    ..The anti-angiogenic effect of tryptanthrin was mediated by down-regulating apelin gene expression through suppression of promoter activity and decrease of mRNA stability in human vascular endothelial cells. ..
  2. Chiang K, Huang S, Wu R, Huang S, Yeh T, Chen M, et al. Interferon α-inducible protein 27 is an oncogene and highly expressed in cholangiocarcinoma patients with poor survival. Cancer Manag Res. 2019;11:1893-1905 pubmed publisher
    ..Clinically, higher IFI27 expression was linked to inferior overall survival of CCA patients. Our data strongly suggest that IFI27 could be deemed as a potential target for CCA treatment. ..
  3. Chuang L, Chen N, Lin S, Hu H, Kao K, Li L, et al. Monocytic C-C chemokine receptor 5 expression increases in in vitro intermittent hypoxia condition and in severe obstructive sleep apnea patients. Sleep Breath. 2019;: pubmed publisher
    ..Intermittent hypoxia, the characteristic of OSA, induced monocytic CCR5 gene expression and the enhanced RANTES-mediated chemotaxis and adhesion through p42/44 MAPK signal pathways. ..
  4. Chang C, Tsai W, Hsu Y, Pang J. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19:19066-77 pubmed publisher
    ..In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon. ..
  5. Chang H, Huang S, Yeh Y, Wang H, Wang T, Wu Y, et al. Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells. J Ethnopharmacol. 2015;174:474-81 pubmed publisher
  6. Chuang L, Chen N, Lin Y, Ko W, Pang J. Increased MCP-1 gene expression in monocytes of severe OSA patients and under intermittent hypoxia. Sleep Breath. 2016;20:425-33 pubmed publisher
    ..This is the first study to demonstrate the increase of MCP-1 gene expression in monocytes of severe OSA patients. In addition, monocytic MCP-1 gene expression can be induced under intermittent hypoxia. ..
  7. Chang C, Chu C, Wang C, Wu H, Bi K, Pang J, et al. The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-?-induced VCAM-1, ICAM-1 and CX3CL1 expression. Phytomedicine. 2014;21:207-16 pubmed publisher
  8. Hung M, Wu Y, Bamodu O, Chen X, Lin Y, HU P, et al. Activation of the monocytic α7 nicotinic acetylcholine receptor modulates oxidative stress and inflammation-associated development of coronary artery spasm via a p38 MAP-kinase signaling-dependent pathway. Free Radic Biol Med. 2018;120:266-276 pubmed publisher
    ..Our study suggests the potential role of α7-nAChR mRNA and/or protein expression as a diagnostic biomarker for CAS. ..
  9. Chiang K, Kuo S, Chen C, Ng S, Lin S, Yeh C, et al. MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential. Cancer Lett. 2015;369:76-85 pubmed publisher
    ..Since metastasis is the important cause of ATC-related death, our results strongly encourage the further in vivo study of MART-10 application against ATC. ..

More Information


  1. Tsai W, Liang F, Cheng J, Lin L, Chang S, Chen H, et al. High glucose concentration up-regulates the expression of matrix metalloproteinase-9 and -13 in tendon cells. BMC Musculoskelet Disord. 2013;14:255 pubmed publisher
    ..High glucose concentration up-regulates the expression of MMP-9 and MMP-13 in tendon cells, which may account for the molecular mechanisms underlying diabetic tendinopathy. ..
  2. Chiang K, Yeh T, Chen S, Pang J, Yeh C, Hsu J, et al. The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential. Int J Mol Sci. 2016;17: pubmed publisher
    ..Based on our result, we conclude that MART-10 could effectively inhibit TNBC cells metastatic potential and deserves further investigation as a new regimen to treat TNBC. ..
  3. Chiang K, Yeh C, Huang C, Yeh T, S Pang J, Hsu J, et al. 25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1?,25(OH)?D?. Int J Mol Sci. 2016;17: pubmed publisher
    ..Collectively, our results indicated that SNU308 cells were able to convert 25(OH)D to 1?,25(OH)?D? and 25(OH)D CYP27B1 gene therapy could be deemed as a promising therapeutic direction for CCA. ..
  4. Hsieh M, Liu H, Wang C, Huang H, Lin Y, Ko Y, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95:323-333 pubmed publisher
    ..BPC 157 up-regulates VEGFR2 expression in rats with hind limb ischemia and endothelial cell culture. BPC 157 promotes VEGFR2 internalization in association with VEGFR2-Akt-eNOS activation. ..
  5. Liu C, Bi K, Huang C, Wu H, Ho H, S Pang J, et al. Davallia bilabiata exhibits anti-angiogenic effect with modified MMP-2/TIMP-2 secretion and inhibited VEGF ligand/receptors expression in vascular endothelial cells. J Ethnopharmacol. 2017;196:213-224 pubmed publisher
    ..bilabiata. We concluded that the anti-angiogenic effect of D. bilabiata was associated with the decreased MMP-2 activity mediated by the upregulation of TIMP-2 and RECK, and the suppression of VEGF/VEGFRs expression. ..
  6. Tsai W, Yu T, Lin L, Cheng M, Chen C, Pang J. Prevention of Simvastatin-Induced Inhibition of Tendon Cell Proliferation and Cell Cycle Progression by Geranylgeranyl Pyrophosphate. Toxicol Sci. 2016;149:326-34 pubmed publisher
    ..GGPP was shown to prevent the adverse effect of simvastatin in tendon cells without interfering with its cholesterol-reducing efficacy. ..
  7. Hsueh T, Sheen J, Pang J, Bi K, Huang C, Wu H, et al. The Anti-Atherosclerotic Effect of Naringin Is Associated with Reduced Expressions of Cell Adhesion Molecules and Chemokines through NF-κB Pathway. Molecules. 2016;21: pubmed publisher
  8. Pang J, Yen J, Wu H, Huang S. Gallic Acid Inhibited Matrix Invasion and AP-1/ETS-1-Mediated MMP-1 Transcription in Human Nasopharyngeal Carcinoma Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..These findings may be useful to develop a novel chemotherapeutic agent to inhibit the metastasis of nasopharyngeal cancer. ..