Hsien Yuan Lane

Summary

Affiliation: Chang Gung Memorial Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Schizophr Res 67:63-70. 2004
  2. ncbi request reprint Pharmacogenetic studies of response to risperidone and other newer atypical antipsychotics
    Hsien Yuan Lane
    China Medical University and Hospital, Department of Psychiatry, No 2, Yuh Der Road, Taichung, 404 Taiwan
    Pharmacogenomics 6:139-49. 2005
  3. ncbi request reprint Dopamine D3 receptor Ser9Gly polymorphism and risperidone response
    Hsien Yuan Lane
    Department of Psychiatry and Medical Research, China Medical University Hospital, Taichung, Taiwan
    J Clin Psychopharmacol 25:6-11. 2005
  4. ncbi request reprint Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan, ROC
    Int J Neuropsychopharmacol 7:461-70. 2004
  5. ncbi request reprint Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Arch Gen Psychiatry 62:1196-204. 2005
  6. ncbi request reprint Risperidone-related weight gain: genetic and nongenetic predictors
    Hsien Yuan Lane
    Department of Psychiatry and Institute of Medical Sciences, China Medical University, Taichung, Taiwan
    J Clin Psychopharmacol 26:128-34. 2006
  7. doi request reprint Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Schizophr Res 146:231-7. 2013
  8. ncbi request reprint Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Biol Psychiatry 60:645-9. 2006
  9. ncbi request reprint Effects of patient demographics, risperidone dosage, and clinical outcome on body weight in acutely exacerbated schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical College and Hospital, Taichung, Taiwan
    J Clin Psychiatry 64:316-20. 2003
  10. ncbi request reprint Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene
    Hsien Yuan Lane
    Department of Psychiatry, Tzu Chi General Hospital, Institute of Neuroscience, Tzu Chi University, Hualien City, Taiwan
    Am J Psychiatry 159:1593-5. 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Schizophr Res 67:63-70. 2004
    ..In conclusion, the 5HT6 receptor gene variant can affect risperidone response to positive symptoms and general psychopathology (but not negative symptoms) after control for nongenetic factors...
  2. ncbi request reprint Pharmacogenetic studies of response to risperidone and other newer atypical antipsychotics
    Hsien Yuan Lane
    China Medical University and Hospital, Department of Psychiatry, No 2, Yuh Der Road, Taichung, 404 Taiwan
    Pharmacogenomics 6:139-49. 2005
    ....
  3. ncbi request reprint Dopamine D3 receptor Ser9Gly polymorphism and risperidone response
    Hsien Yuan Lane
    Department of Psychiatry and Medical Research, China Medical University Hospital, Taichung, Taiwan
    J Clin Psychopharmacol 25:6-11. 2005
    ..These data suggest that the DRD3 Ser9Gly polymorphism or, alternatively, another genetic variation that is in linkage disequilibrium, may influence response to risperidone in negative symptoms and social functioning...
  4. ncbi request reprint Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan, ROC
    Int J Neuropsychopharmacol 7:461-70. 2004
    ..Several clinical factors may also contribute to inter-individual differences in risperidone treatment response...
  5. ncbi request reprint Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Arch Gen Psychiatry 62:1196-204. 2005
    ....
  6. ncbi request reprint Risperidone-related weight gain: genetic and nongenetic predictors
    Hsien Yuan Lane
    Department of Psychiatry and Institute of Medical Sciences, China Medical University, Taichung, Taiwan
    J Clin Psychopharmacol 26:128-34. 2006
    ..This study aimed to simultaneously explore the effects of multiple candidate genes and environment factors on body weight of schizophrenia patients who received risperidone, a commonly used atypical antipsychotic agent...
  7. doi request reprint Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Schizophr Res 146:231-7. 2013
    ..The current study employed structural equation modeling (SEM) to examine whether clinical symptoms mediate the relationship between cognitive function and functional outcome in a large cohort of patients with schizophrenia...
  8. ncbi request reprint Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Biol Psychiatry 60:645-9. 2006
    ..The present study aims to determine the effects of sarcosine adjuvant therapy for schizophrenic patients receiving clozapine treatment...
  9. ncbi request reprint Effects of patient demographics, risperidone dosage, and clinical outcome on body weight in acutely exacerbated schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical College and Hospital, Taichung, Taiwan
    J Clin Psychiatry 64:316-20. 2003
    ..Predictors for risperidone-related weight gain remain unclear. This study aimed to identify clinical factors influencing body weight in risperidone-treated patients...
  10. ncbi request reprint Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene
    Hsien Yuan Lane
    Department of Psychiatry, Tzu Chi General Hospital, Institute of Neuroscience, Tzu Chi University, Hualien City, Taiwan
    Am J Psychiatry 159:1593-5. 2002
    ..This study investigated the effect of the 102-T/C polymorphism in the 5-HT(2A) receptor gene on risperidone efficacy...
  11. ncbi request reprint Significant association of caveolin-1 (CAV1) genotypes with breast cancer in Taiwan
    Liang Chih Liu
    Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R O C
    Anticancer Res 31:3511-5. 2011
    ..The aim of this study was to evaluate the association of six polymorphic genotypes of CAV1, which is reported to be overexpressed in tumors, with breast cancer within a Taiwanese population...
  12. doi request reprint RGS4 polymorphisms predict clinical manifestations and responses to risperidone treatment in patients with schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    J Clin Psychopharmacol 28:64-8. 2008
    ....
  13. pmc Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults
    Hsien Yuan Lane
    Department of Psychiatry, Institute of Clinical Medical Science, China Medical University and Hospital, Taichung, Taiwan
    J Psychiatry Neurosci 33:47-53. 2008
    ..The current study's objective was to investigate whether executive function varies with these genetic variations...
  14. doi request reprint The risk of temporomandibular disorder in patients with depression: a population-based cohort study
    Chun Hui Liao
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Community Dent Oral Epidemiol 39:525-31. 2011
    ..This study used a population-based retrospective cohort design to examine whether depression is a risk factor of temporomandibular disorder (TMD)...
  15. ncbi request reprint Fine-tuning risperidone dosage for acutely exacerbated schizophrenia: clinical determinants
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, No 2 Yuh Der Road, 404 Taichung, Taiwan
    Psychopharmacology (Berl) 172:393-9. 2004
    ..Risperidone doses for acute schizophrenia were rather high in most recent studies...
  16. doi request reprint A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Int J Neuropsychopharmacol 13:451-60. 2010
    ..These findings suggest that the GlyT-1 inhibitor is more efficacious than the NMDA/glycine site agonist in treatment for schizophrenia, including life quality and global function, at the dosages tested...
  17. ncbi request reprint Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Biol Psychiatry 63:9-12. 2008
    ..However, the efficacy of these agents as a primary antipsychotic agent has not yet been demonstrated...
  18. ncbi request reprint Shifting from haloperidol to risperidone for behavioral disturbances in dementia: safety, response predictors, and mood effects
    Hsien Yuan Lane
    Department of Psychiatry, Tzu Chi General Hospital and Tzu Chi University School of Medicine, Hualien City, Taiwan
    J Clin Psychopharmacol 22:4-10. 2002
    ..In contrast to the dose (1 mg/day) recommended for most white individuals, 0.5 mg/day could be tried at first in Chinese patients. Because of the design's limitations, further controlled studies are warranted...
  19. doi request reprint Clozapine protects bone mineral density in female patients with schizophrenia
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Int J Neuropsychopharmacol 15:897-906. 2012
    ..007) were associated with LBMD. This study suggests that clozapine treatment is beneficial for BMD compared to PR antipsychotic treatment in women with chronic schizophrenia, and clozapine's bone-density protecting effect is dose-related...
  20. pmc Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone
    Chin Chuan Hung
    Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    PLoS ONE 8:e59419. 2013
    ....
  21. ncbi request reprint Significant association of caveolin-1 single nucleotide polymorphisms with childhood leukemia in Taiwan
    Chung Hsing Wang
    Terry Fox Cancer Research Lab, Department of Medical Genetics, China Medical University Hospital, and Graduate Institute of Clinical Medical Science, China Medical University, 2 Yuh Der Road, Taichung, 404 Taiwan, ROC
    Cancer Genomics Proteomics 10:75-9. 2013
    ....
  22. doi request reprint Add-on Treatment of Benzoate for Schizophrenia: A Randomized, Double-blind, Placebo-Controlled Trial of d-Amino Acid Oxidase Inhibitor
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan2Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    JAMA Psychiatry 70:1267-75. 2013
    ..The preliminary results show promise for d-amino acid oxidase inhibition as a novel approach for new drug development for schizophrenia. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00960219. ..
  23. ncbi request reprint Influences of patient-related variables on risperidone efficacy for acutely exacerbated schizophrenia: analyses with rigorous statistics
    Hsien Yuan Lane
    Department of Psychiatry, Tzu Chi General Hospital and Tzu Chi University, Taichung, Taiwan
    J Clin Psychopharmacol 22:353-8. 2002
    ..Further studies with longer observation and larger samples in not only acutely ill patients but also other populations (e.g., first-episode patients) are warranted...
  24. doi request reprint A model testing factors that influence physical activity for Taiwanese adults with anxiety
    Wei Fen Ma
    School of Nursing and Nursing Department, China Medical University and Hospital, 91, Hsueh Shih Road, Taichung 40402, Taiwan
    Res Nurs Health 31:476-89. 2008
    ..The results suggest that these variables should be addressed in designing treatment physical activity programs for Taiwanese individuals with anxiety...
  25. ncbi request reprint Adjunctive fluvoxamine inhibits clozapine-related weight gain and metabolic disturbances
    Mong Liang Lu
    Department of Psychiatry, Taipei Medical University Wan Fang Hospital, Taiwan
    J Clin Psychiatry 65:766-71. 2004
    ..This study aimed to demonstrate the effects of fluvoxamine on clozapine-related weight gain, hyperglycemia, and lipid abnormalities...
  26. doi request reprint Inverse association between cancer risks and age in schizophrenic patients: a 12-year nationwide cohort study
    Chun Yuan Lin
    Institute of Clinical Medical Science, Medical College, China Medical University, Taichung, Taiwan
    Cancer Sci 104:383-90. 2013
    ..Higher cancer comorbidity in young schizophrenic patients deserves more attention...
  27. pmc MET and AKT genetic influence on facial emotion perception
    Ming Teng Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    PLoS ONE 7:e36143. 2012
    ..The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. This study explores the possible role of MET/AKT cascade in facial emotion perception...
  28. doi request reprint Gender-specific differences in susceptibility to low-dose methadone-associated QTc prolongation in patients with heroin dependence
    Kuan Cheng Chang
    Division of Cardiology, Department of Medicine, China Medical University Hospital, Taichung, Taiwan
    J Cardiovasc Electrophysiol 23:527-33. 2012
    ..We sought to investigate whether there is a gender-based difference in susceptibility to methadone-associated QTc prolongation in heroin-dependent patients receiving a low-dose treatment regimen...
  29. doi request reprint Synergistic effects of COMT and TPH2 on social cognition
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Psychiatry 76:273-94. 2013
    ..The findings suggest that genetic variations of COMT and TPH2 have synergistic effects on social cognition in the general population. ..
  30. doi request reprint Sarcosine therapy for obsessive compulsive disorder: a prospective, open-label study
    Po Lun Wu
    Department of Psychiatry, China Medical University Hospital, Taichung, Taipei, Taiwan
    J Clin Psychopharmacol 31:369-74. 2011
    ..In this 10-week open-label trial, we examined the potential benefit of sarcosine treatment in OCD patients...
  31. doi request reprint Mental disorder as a risk factor for dog bites and post-bite cellulitis
    Chun Chieh Yeh
    Trauma and Emergency Center, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
    Injury 43:1903-7. 2012
    ..No study has evaluated the association between mental disorders and the injury of dog bite. We conducted case-control studies to investigate whether people with mental disorders are at elevated risks of dog bite and post-bite cellulitis...
  32. ncbi request reprint The carcinoembryonic antigen as a potential prognostic marker for neuroendocrine carcinoma of the breast
    Chen Hsien Su
    Department of Surgery, China Medical University Hospital, Taichung, Taiwan, ROC
    Anticancer Res 32:183-8. 2012
    ..We aim at reporting a case and providing a marker useful for prognosis and prediction of tumor recurrence for patients with PNCB...
  33. doi request reprint Schizophrenia patients at higher risk of diabetes, hypertension and hyperlipidemia: a population-based study
    Chun Hui Liao
    Department of Psychiatry, China Medical University and Hospital, Taichung 404, Taiwan
    Schizophr Res 126:110-6. 2011
    ..This study investigates risks of developing diabetes mellitus (DM), hypertension, and hyperlipidemia in treating schizophrenia with first- and second-generation antipsychotics (FGA and SGA, respectively)...
  34. doi request reprint Inhibition of glycine transporter-I as a novel mechanism for the treatment of depression
    Chih Chia Huang
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Biol Psychiatry 74:734-41. 2013
    ..Glutamatergic neurotransmission is involved in depression. However, it is unclear whether enhancement of the N-methyl-D-aspartate (NMDA) subtype glutamate receptor can be a treatment for depression...
  35. pmc NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease
    Yu Jhen Huang
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
    Curr Neuropharmacol 10:272-85. 2012
    ..Prospective study using NMDA enhancers in patients with Alzheimer's disease and associated behavioral disturbance is needed to verify this hypothesis...
  36. doi request reprint Assessing gene-gene interactions in pharmacogenomics
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
    Mol Diagn Ther 16:15-27. 2012
    ....
  37. doi request reprint Electroconvulsive therapy improves clinical manifestation with plasma BDNF levels unchanged in treatment-resistant depression patients
    Ching Hua Lin
    Kaohsiung Municipal Kai Syuan Psychiatric Hospital, Fooyin University, Kaohsiung, Taiwan, ROC
    Neuropsychobiology 68:110-5. 2013
    ..188, p = 0.169). Our results do not support the hypothesis that improvements in treatment-resistant depression patients after ECT are due to changes in BDNF levels. ..
  38. doi request reprint Sensitivity and specificity of the Chinese version of the Schizotypal Personality Questionnaire-Brief for identifying undergraduate students susceptible to psychosis
    Wei Fen Ma
    School of Nursing, China Medical University and Hospital, 91, Hsueh Shih Road, Taichung 40402, Taiwan
    Int J Nurs Stud 47:1535-44. 2010
    ..However, no suitable instruments are available to screen individuals in the Taiwanese population for evidence of early psychotic symptoms...
  39. doi request reprint Association between plasma endothelin-1 and severity of different types of glaucoma
    Hsin Yi Chen
    Graduate Institute of Clinical Medical Science, China Medical University
    J Glaucoma 22:117-22. 2013
    ....
  40. doi request reprint Optimizing the early prediction model for symptomatic remission with short-term treatment for schizophrenia
    Ching Hua Lin
    Kai Syuan Psychiatric Hospital, China
    J Clin Psychopharmacol 32:773-7. 2012
    ..Whether the finding can be extrapolated to other validated assessment scales and other antipsychotics require further studies...
  41. doi request reprint Glutamate signaling in the pathophysiology and therapy of schizophrenia
    Chieh Hsin Lin
    Department of Psychiatry, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Pharmacol Biochem Behav 100:665-77. 2012
    ....
  42. doi request reprint Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients
    Chin Chuan Hung
    Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    Pharmacogenomics 12:1525-33. 2011
    ..The present study explored the integrative effect of genes encoding methadone pharmacokinetic and pharmacodynamic pathways on methadone maintenance doses in Han Chinese Patients...
  43. ncbi request reprint Association of Alpha B-Crystallin (CRYAB) genotypes with breast cancer susceptibility in Taiwan
    Chen Hsien Su
    Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan
    Cancer Genomics Proteomics 8:251-4. 2011
    ..However, the association of genomic variation of CRYAB and breast cancer is not well studied. The aim of this study was to evaluate the association of polymorphic genotypes of CRYAB with breast cancer within a Taiwanese population...
  44. doi request reprint Roles of state and trait anxiety in physical activity participation for adults with anxiety disorders
    Wei Fen Ma
    School of Nursing and Nursing Department, China Medical University and Hospital, Taichung 404, Taiwan
    J Formos Med Assoc 108:481-92. 2009
    ..Here, we aimed to clarify the roles of state and trait anxiety in physical activity participation by examining relationships among seven major study variables in Taiwanese adults with anxiety disorders...
  45. ncbi request reprint The study of electroacupuncture on cerebral blood flow in rats with and without cerebral ischemia
    Ching Liang Hsieh
    Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan
    Am J Chin Med 34:351-61. 2006
    ..We concluded that both 2 and 15 Hz EA at both Zusanli acupoints induced the increase of CBF in rats with and without CI. Whether the effect of EA is related to NO or CGRP will be investigated in a future study...
  46. doi request reprint Antipsychotic combination using low-dose antipsychotics is as efficacious and safe as, but cheaper, than optimal-dose monotherapy in the treatment of schizophrenia: a randomized, double-blind study
    Ching Hua Lin
    Department of Adult Psychiatry, Kaohsiung Municipal Kai Syuan Psychiatric Hospital, Kaohsiung, Taiwan
    Int Clin Psychopharmacol 28:267-74. 2013
    ..The current study suggests that an antipsychotic combination of low-dose antipsychotics is as efficacious and safe as, but cheaper than, optimal-dose monotherapy in the treatment of schizophrenia. ..
  47. doi request reprint Correlation in retinal nerve fiber layer thickness between two OCT units
    Hsin Yi Chen
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Optom Vis Sci 88:1326-32. 2011
    ....