Jui Yang Lai

Summary

Affiliation: Chang Gung University
Country: Taiwan

Publications

  1. doi request reprint Functional assessment of cross-linked porous gelatin hydrogels for bioengineered cell sheet carriers
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomacromolecules 11:1387-97. 2010
  2. doi request reprint Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Electronic address
    Carbohydr Polym 101:203-12. 2014
  3. doi request reprint Effect of chemical composition on corneal tissue response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Electronic address
    Mater Sci Eng C Mater Biol Appl 34:334-40. 2014
  4. ncbi request reprint Effect of matrix nanostructure on the functionality of carbodiimide cross-linked amniotic membranes as limbal epithelial cell scaffolds
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    J Biomed Nanotechnol 9:2048-62. 2013
  5. pmc The role of bloom index of gelatin on the interaction with retinal pigment epithelial cells
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan
    Int J Mol Sci 10:3442-56. 2009
  6. doi request reprint Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, 33302 Taiwan, Republic of China
    J Mater Sci Mater Med 24:2201-10. 2013
  7. doi request reprint Effect of chemical composition on corneal cellular response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
    Mater Sci Eng C Mater Biol Appl 33:3704-10. 2013
  8. pmc Characterization of cross-linked porous gelatin carriers and their interaction with corneal endothelium: biopolymer concentration effect
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    PLoS ONE 8:e54058. 2013
  9. pmc Corneal Stromal Cell Growth on Gelatin/Chondroitin Sulfate Scaffolds Modified at Different NHS/EDC Molar Ratios
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
    Int J Mol Sci 14:2036-55. 2013
  10. doi request reprint Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC
    Acta Biomater 8:1068-79. 2012

Collaborators

  • Ko Hua Chen
  • Ging Ho Hsiue
  • Jan Kan Chen
  • Grace Chang
  • Chen Chi Tsai
  • Shan Yang Lin
  • Pao Hsien Chu
  • David Hui Kang Ma
  • Feng Yi Chou
  • Shingjiang Jessie Lue
  • Hung Chi Jesse Chen
  • Chao Ming Shih
  • Chi Chin Sun
  • Wen Yen Chiu
  • Hsiao Lei Lei
  • Ken Kuo Lin
  • Su Fang Wang
  • Chao Kung Lu
  • Wen Ming Hsu
  • Yen Shien Li
  • Jinn Jong Hwu
  • Meng Chao Tsai
  • Bo Wei Chen
  • Yi Ju Ho
  • Lung Kung Yeh
  • Szu Tzu Yu
  • Jia ye Liu
  • Unique Yang
  • Ming Hui Sun
  • Wan Chen Ku
  • Lung Kun Yeh
  • Hsiao Yun Cheng
  • Hsiang Ling Chen
  • Ming Tse Kuo
  • Chih Chun Chen
  • Yueh Ju Tsai
  • Shui Mei Lee

Detail Information

Publications31

  1. doi request reprint Functional assessment of cross-linked porous gelatin hydrogels for bioengineered cell sheet carriers
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomacromolecules 11:1387-97. 2010
    ..Our findings suggest that the gelatin discs with enlarged pore structure have potential as cell sheet carriers for intraocular delivery and corneal tissue engineering...
  2. doi request reprint Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Electronic address
    Carbohydr Polym 101:203-12. 2014
    ..The cell viability, pro-inflammatory gene and cytokine expression, and glutamate uptake were suggested to be indicative of cytocompatibility and found to be strongly dependent on the cross-linker concentration. ..
  3. doi request reprint Effect of chemical composition on corneal tissue response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan, ROC Electronic address
    Mater Sci Eng C Mater Biol Appl 34:334-40. 2014
    ..e., -38.6 to -56.5mV) may lead to abnormal transmembrane transport. It is concluded that the chemical composition of HEMA/AAc has an important influence on the corneal tissue responses to polymeric biomaterials. ..
  4. ncbi request reprint Effect of matrix nanostructure on the functionality of carbodiimide cross-linked amniotic membranes as limbal epithelial cell scaffolds
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    J Biomed Nanotechnol 9:2048-62. 2013
    ..In summary, the findings reported in this paper suggest that a specific limbal epithelial stem cell-biomaterial interaction may occur in response to biophysical cue such as nanostructure of carbodiimide cross-linked AM matrix...
  5. pmc The role of bloom index of gelatin on the interaction with retinal pigment epithelial cells
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan
    Int J Mol Sci 10:3442-56. 2009
    ..These findings suggest that the Bloom index gives influence on cellular responses to gelatin materials...
  6. doi request reprint Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, 33302 Taiwan, Republic of China
    J Mater Sci Mater Med 24:2201-10. 2013
    ..It is concluded that, except for cell viability and pro-inflammatory cytokine expression, the retinal sheet delivery performance strongly depends on the solvent composition for EDC cross-linking of gelatin molecules. ..
  7. doi request reprint Effect of chemical composition on corneal cellular response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
    Mater Sci Eng C Mater Biol Appl 33:3704-10. 2013
    ..It is concluded that the chemical composition of HEMA/AAc has an important influence on the corneal stromal and endothelial cell responses to polymeric biomaterials...
  8. pmc Characterization of cross-linked porous gelatin carriers and their interaction with corneal endothelium: biopolymer concentration effect
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    PLoS ONE 8:e54058. 2013
    ..It is concluded that the characteristics of cross-linked porous gelatin hydrogel carriers and their triggered biological responses are in relation to biopolymer concentration effects...
  9. pmc Corneal Stromal Cell Growth on Gelatin/Chondroitin Sulfate Scaffolds Modified at Different NHS/EDC Molar Ratios
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
    Int J Mol Sci 14:2036-55. 2013
    ..These findings suggest that a positive correlation is noticed between the NHS to EDC molar ratio and the CS content in the biopolymer matrices, thereby greatly affecting the corneal stromal cell growth...
  10. doi request reprint Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC
    Acta Biomater 8:1068-79. 2012
    ..It is concluded that the cultured RCKs on surfaces coated with HA of different MWs can sense ECM cues, and the multicellular spheroids may potentially be used for corneal stromal tissue engineering applications...
  11. pmc Biocompatibility of genipin and glutaraldehyde cross-linked chitosan materials in the anterior chamber of the eye
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan E Mail Tel 886 3 211 8800 ext 3598 Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan
    Int J Mol Sci 13:10970-85. 2012
    ..In summary, the intracameral tissue response to the chemically modified chitosan materials strongly depends on the selection of cross-linking agents...
  12. pmc Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Int J Nanomedicine 7:1101-14. 2012
    ..Porous membranes with a CS content of 0.112 ± 0.003 nmol per 10 mg scaffold may hold potential for use in corneal stromal tissue engineering...
  13. doi request reprint A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomaterials 33:2372-87. 2012
    ..e., miosis and IOP lowering effect and preservation of corneal endothelial cell density)...
  14. doi request reprint Low Bloom strength gelatin as a carrier for potential use in retinal sheet encapsulation and transplantation
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomacromolecules 10:310-9. 2009
    ....
  15. doi request reprint Ocular biocompatibility of carbodiimide cross-linked hyaluronic acid hydrogels for cell sheet delivery carriers
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    J Biomater Sci Polym Ed 21:359-76. 2010
    ..It is concluded that the cross-linking agent type gives influence on ocular biocompatibility of cell carriers and the EDC-HA hydrogel is an ideal candidate for use as an implantable material in cell sheet delivery applications...
  16. doi request reprint Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, 33302, Taoyuan, Taiwan, Republic of China
    J Mater Sci Mater Med 21:1899-911. 2010
    ..In comparison to GTA treatment, the EDC cross-linking is more suitable for preparation of chemically modified gelatin hydrogels for ophthalmic use...
  17. ncbi request reprint Micron- and nano-sized poly(N-isopropylacrylamide-co-acrylic acid) latex syntheses and their applications for controlled drug release
    Shingjiang Jessie Lue
    Department of Chemical and Materials Engineering, Chang Gung University, Kwei Shan, Taoyuan 333, Taiwan
    J Nanosci Nanotechnol 13:5305-15. 2013
    ..The smaller or AAc-rich hydrogel particles provided sustainable drug release property and have potential use in biomedical applications...
  18. doi request reprint Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells
    David Hui Kang Ma
    Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan, ROC
    Biomaterials 31:6647-58. 2010
    ..It is concluded that the AM cross-linked with 0.05 mmol EDC/mg AM may be a potential biomaterial for regenerative medicine...
  19. ncbi request reprint A novel strategy for corneal endothelial reconstruction with a bioengineered cell sheet
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
    Transplantation 81:473-6. 2006
    ..These data indicate the feasibility of the proposed procedure in cell therapy for corneal endothelial cell loss...
  20. ncbi request reprint Tissue-engineered human corneal endothelial cell sheet transplantation in a rabbit model using functional biomaterials
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, ROC
    Transplantation 84:1222-32. 2007
    ..This study was performed to investigate whether transplantation of bioengineered human corneal endothelial cell (HCEC) sheet grafts into corneas denuded of endothelium could restore corneal function and clarity in a rabbit model...
  21. doi request reprint In vitro biocompatibility of magnetic thermo-responsive nanohydrogel particles of poly(N-isopropylacrylamide-co-acrylic acid) with Fe3O4 cores: effect of particle size and chemical composition
    Feng Yi Chou
    Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, 333, Taiwan
    Colloids Surf B Biointerfaces 104:66-74. 2013
    ..Overall, the in vitro biocompatibilities of the nanoparticles depend on the chemical composition and size of the Fe(3)O(4)/P(NIPAAm-co-AAc) particles...
  22. doi request reprint Up-regulation of heat shock protein 70-1 (Hsp70-1) in human limbo-corneal epithelial cells cultivated on amniotic membrane: A proteomic study
    David Hui Kang Ma
    Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Cell Physiol 227:2030-9. 2012
    ..Thus, deltaNp63α-associated Hsp70-1 over-expression may promote HLE progenitor cell survival on IAM, possibly through the cytoprotective and anti-apoptotic effect of Hsp70-1...
  23. ncbi request reprint Ocular hypersensitivitiy to topical vancomycin in a case of chronic endophthalmitis
    Jinn Jong Hwu
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Cornea 24:754-6. 2005
    ..To report a case of ocular allergy to topical vancomycin eye drops...
  24. doi request reprint Persistence of transplanted oral mucosal epithelial cells in human cornea
    Hung Chi Jesse Chen
    Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Invest Ophthalmol Vis Sci 50:4660-8. 2009
    ..To determine the expression of differentiation and progenitor cell markers in corneal tissues that previously underwent autologous cultivated oral mucosal epithelial transplantation (COMET)...
  25. ncbi request reprint Matrix revolution: molecular mechanism for inflammatory corneal neovascularization and restoration of corneal avascularity by epithelial stem cell transplantation
    David Hui Kang Ma
    Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Ocul Surf 7:128-44. 2009
    ..Taken together, the merits of enhanced anti-angiogenic activity and the preservation of corneal epithelial stem cells encourage further application of this tissue engineering technique for ocular surface reconstruction...
  26. ncbi request reprint Time-resolved polymer propagation for acrylic acid-mediated nanolatexes containing magnetic Fe3O4 cores
    Feng Yi Chou
    Chemical and Materials Engineering, Chang Gung University, Tao Yuan, Taiwan 333, ROC
    J Nanosci Nanotechnol 13:2147-52. 2013
    ..This declining AAc concentration is beneficial for profound thermal responses in the synthesized nanoparticle...
  27. ncbi request reprint Multiple elements in the deposits of opacified Hydroview intraocular lens
    Jui Yang Lai
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
    Am J Ophthalmol 139:1123-5. 2005
    ..To report the ultrastructural and elemental features of two opacified intraocular lenses (IOLs)...
  28. pmc Glutaraldehyde cross-linking of amniotic membranes affects their nanofibrous structures and limbal epithelial cell culture characteristics
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan Biomedical Engineering Research Center, Chang Gung University, Taoyuan, Taiwan Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Int J Nanomedicine 8:4157-68. 2013
    ..The AM treated with GTA for 6 hours holds promise for use as a niche for the expansion and transplantation of limbal epithelial progenitor cells. ..
  29. ncbi request reprint Herpes simplex keratitis following excimer laser application
    Chao Kung Lu
    Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan, ROC
    J Refract Surg 22:509-11. 2006
    ..To report two cases of herpes simplex keratitis following excimer laser application...
  30. pmc Cyclosporine a eye drop-induced elongated eyelashes: a case report
    Hsiao Lei Lei
    Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC
    Case Report Ophthalmol 2:398-400. 2011
    ..Here, we report a specific side effect of CsA, namely eye drop-induced eyelash elongation in a patient with refractory giant papillary conjunctivitis...
  31. pmc In vitro response of retinal pigment epithelial cells exposed to chitosan materials prepared with different cross-linkers
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan
    Int J Mol Sci 11:5256-72. 2010
    ..In terms of material safety, the GP cross-linked chitosan may be compatible with human RPE cells and may have a potential application as delivery carriers in the treatment of posterior segment diseases...