Horng Heng Juang


Affiliation: Chang Gung University
Country: Taiwan


  1. Tsui K, Hou C, Chang K, Lin Y, Feng T, Chen C, et al. Metallothionein 3 Is a Hypoxia-Upregulated Oncogene Enhancing Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher
    ..The experiments indicated that MT3 is an arsenic- and hypoxia-upregulated oncogene that promotes cell growth and invasion of bladder carcinoma cells via downregulation of NDRG1, NDRG2, and MASPIN expressions. ..
  2. Chiang K, Yeh C, Hsu J, Jan Y, Chen L, Kuo S, et al. The vitamin D analog, MART-10, represses metastasis potential via downregulation of epithelial-mesenchymal transition in pancreatic cancer cells. Cancer Lett. 2014;354:235-44 pubmed publisher
    ..Both 1α,25(OH)2D3 and MART-10 decreased MMP-2 and -9 secretion in BxPC-3 cells as determined by western blot and zymography. Collectively, MART-10 should be deemed as a promising regimen against PDA. ..
  3. Lee J, Chung L, Chen Y, Feng T, Chen W, Juang H. Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells. Cancer Lett. 2015;360:310-8 pubmed publisher
    ..Our results indicate that EGCG attenuates cell proliferation of OSCC cells by upregulating BTG2 expression via p38 and ERK pathways. ..
  4. Chiang K, Yen C, Yeh C, Hsu J, Chen L, Kuo S, et al. Hepatocellular carcinoma cells express 25(OH)D-1?-hydroxylase and are able to convert 25(OH)D to 1?,25(OH)?D, leading to the 25(OH)D-induced growth inhibition. J Steroid Biochem Mol Biol. 2015;154:47-52 pubmed publisher
    ..Our data justifies the application of 25(OH)D and CYP27B1 gene transfection therapy in further HCC treatment studies. ..
  5. Shen C, Juang H, Chen H, Yang C, Wu C, Lee M, et al. The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma. Int J Mol Sci. 2015;16:27371-7 pubmed publisher
    ..Such obtained results contribute to the basis of developing a promising therapeutic strategy for asthma by silencing AMCase expression. ..
  6. Chiang K, Yeh T, Chen S, Pang J, Yeh C, Hsu J, et al. The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential. Int J Mol Sci. 2016;17: pubmed publisher
    ..Based on our result, we conclude that MART-10 could effectively inhibit TNBC cells metastatic potential and deserves further investigation as a new regimen to treat TNBC. ..
  7. Chiang K, Yeh C, Huang C, Yeh T, S Pang J, Hsu J, et al. 25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1?,25(OH)?D?. Int J Mol Sci. 2016;17: pubmed publisher
    ..Collectively, our results indicated that SNU308 cells were able to convert 25(OH)D to 1?,25(OH)?D? and 25(OH)D CYP27B1 gene therapy could be deemed as a promising therapeutic direction for CCA. ..
  8. Lee J, Chiang K, Feng T, Chen Y, Chuang S, Tsui K, et al. The Iron Chelator, Dp44mT, Effectively Inhibits Human Oral Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo. Int J Mol Sci. 2016;17: pubmed publisher
    ..NDRG3 knockdown enhanced the growth of OECM-1 cells in vitro and in vivo. Our results indicated that NDRG3 is a tumor suppressor gene in OSCC cells, and Dp44mT could be a promising therapeutic agent for OSCC treatment. ..
  9. request reprint
    Juang H. Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells. Mol Genet Metab. 2004;81:244-52 pubmed
    ..Our study demonstrated the key role of the mACON in the cellular bioenergy and cell proliferation of human prostate carcinoma cells. ..

More Information


  1. Lee J, Chung L, Chen Y, Feng T, Juang H. N-myc downstream-regulated gene 1 downregulates cell proliferation, invasiveness, and tumorigenesis in human oral squamous cell carcinoma. Cancer Lett. 2014;355:242-52 pubmed publisher
    ..The downregulation of EMT, MMP-2, and MMP-9 may explain the role of anti-invasion of NDRG1 in human OSCC cells. The experiments recognize that NDRG1 is an antitumor gene in OSCC cells. ..
  2. Tsui K, Lin Y, Chung L, Chuang S, Feng T, Chiang K, et al. Prostate-derived ets factor represses tumorigenesis and modulates epithelial-to-mesenchymal transition in bladder carcinoma cells. Cancer Lett. 2016;375:142-151 pubmed publisher
    ..The induction of BTG2, NDRG1, MASPIN, and KAI1 gene expressions by PDEF may explain the inhibitory functions of PDEF on the proliferation, invasion, and tumorigenesis in bladder carcinoma cells. ..