Deh Ming Chang

Summary

Country: Taiwan

Publications

  1. doi request reprint TACE-dependent amphiregulin release is induced by IL-1β and promotes cell invasion in fibroblast-like synoviocytes in rheumatoid arthritis
    Fei Lan Liu
    Rheumatology Immunology Allergy, Tri Service General Hospital, 325 Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
    Rheumatology (Oxford) 53:260-9. 2014
  2. ncbi request reprint Hormonal profiles and immunological studies of male lupus in Taiwan
    D M Chang
    Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Clin Rheumatol 18:158-62. 1999
  3. pmc Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation
    Deh Ming Chang
    Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road Section 2, Neihu 114, Taipei, Taiwan, China
    Immunology 112:643-50. 2004
  4. ncbi request reprint The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritis
    Deh Ming Chang
    Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325, Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan, ROC
    Pharmacol Res 50:371-6. 2004
  5. pmc Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus
    D M Chang
    Tri Service General Hospital, National Defense Medical Center, 325, Cheng Kung Road, Sec 2, Neihu, 114, Taipei, Taiwan, China
    Ann Rheum Dis 63:1623-6. 2004
  6. ncbi request reprint Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial
    Deh Ming Chang
    Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Arthritis Rheum 46:2924-7. 2002
  7. ncbi request reprint Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells
    Deh Ming Chang
    Department of Rheumatology, Immunology and Allergy, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan
    Rheumatol Int 27:1049-55. 2007
  8. pmc Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1
    Shu Meng Cheng
    Division of Cardiology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, ROC
    Br J Pharmacol 142:933-42. 2004
  9. ncbi request reprint Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity
    Shih Ping Yang
    Cardiology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Cardiovasc Res 59:776-87. 2003
  10. pmc Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell
    Ling Jun Ho
    Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
    Br J Pharmacol 143:919-27. 2004

Collaborators

Detail Information

Publications67

  1. doi request reprint TACE-dependent amphiregulin release is induced by IL-1β and promotes cell invasion in fibroblast-like synoviocytes in rheumatoid arthritis
    Fei Lan Liu
    Rheumatology Immunology Allergy, Tri Service General Hospital, 325 Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
    Rheumatology (Oxford) 53:260-9. 2014
    ....
  2. ncbi request reprint Hormonal profiles and immunological studies of male lupus in Taiwan
    D M Chang
    Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Clin Rheumatol 18:158-62. 1999
    ..It was concluded that the high prolactin level and low FcgammaR distribution may play a role in the pathogenesis and prognosis of male lupus...
  3. pmc Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation
    Deh Ming Chang
    Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road Section 2, Neihu 114, Taipei, Taiwan, China
    Immunology 112:643-50. 2004
    ..Our investigations indicate that this fusion protein effectively suppresses inflammatory arthritis and may initiate a trend for future clinical application to target multiple molecules at the same time...
  4. ncbi request reprint The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritis
    Deh Ming Chang
    Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325, Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan, ROC
    Pharmacol Res 50:371-6. 2004
    ..The PK parameters for Chinese subjects with RA were comparable to those for non-Chinese subjects with RA. IL-1ra was well tolerated during this study, and no significant safety concerns were identified after administration...
  5. pmc Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus
    D M Chang
    Tri Service General Hospital, National Defense Medical Center, 325, Cheng Kung Road, Sec 2, Neihu, 114, Taipei, Taiwan, China
    Ann Rheum Dis 63:1623-6. 2004
    ..To study the effects of dehydroepiandrosterone (prasterone, DHEA) 200 mg/day on cytokine profiles in adult women with active systemic lupus erythematosus (SLE)...
  6. ncbi request reprint Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial
    Deh Ming Chang
    Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Arthritis Rheum 46:2924-7. 2002
    ..To evaluate the efficacy and tolerability of dehydroepiandrosterone (DHEA) at a dosage of 200 mg/day in adult women with active systemic lupus erythematosus (SLE)...
  7. ncbi request reprint Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells
    Deh Ming Chang
    Department of Rheumatology, Immunology and Allergy, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan
    Rheumatol Int 27:1049-55. 2007
    ..This novel finding of MMP-3 inhibition by activin A suggests a new role of activin A in cartilage remodeling. Activin A may have therapeutic potential for preventing cartilage degradation...
  8. pmc Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1
    Shu Meng Cheng
    Division of Cardiology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, ROC
    Br J Pharmacol 142:933-42. 2004
    ..4 Our studies show that irbesartan may modulate inflammation-based atherosclerotic diseases through a cell-mediated mechanism involving suppression of human T-lymphocytes activation via downregulation of AP-1 activity...
  9. ncbi request reprint Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity
    Shih Ping Yang
    Cardiology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Cardiovasc Res 59:776-87. 2003
    ..The activation of T lymphocytes contributes to the inflammatory process of atherosclerosis. Here we examined the effects of carvedilol, a new beta-blocker containing an antioxidative property, on the activation of T cells...
  10. pmc Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell
    Ling Jun Ho
    Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
    Br J Pharmacol 143:919-27. 2004
    ..Our results provide the molecular basis of immunomodulation of Tet for being a potential disease-modifying antirheumatic drug in the therapy of autoimmune disorders like rheumatoid arthritis...
  11. ncbi request reprint Carvedilol differentially regulates cytokine production from activated human peripheral blood mononuclear cells
    Shih Ping Yang
    Cardiology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Cardiovasc Drugs Ther 18:183-8. 2004
    ..We concluded that carvedilol might mediate its therapeutic effects through differentially regulating cytokine production from activated mononuclear cells, including at least monocytes and macrophages...
  12. doi request reprint Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation
    Wan Lin Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Eur J Immunol 39:3413-22. 2009
    ..Collectively, this study reveals not only the pathways involved in COX-2 synthesis in DV-infected DC but also the autocrine action of PGE2 on the migration of DV-infected DC...
  13. doi request reprint Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cells
    Shyi Jou Chen
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    Mol Immunol 47:567-74. 2009
    ..In conclusion, we demonstrate a therapeutic effect of DcR3 in EAE, suggesting its potential for treating human MS...
  14. ncbi request reprint Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells
    Shu Meng Cheng
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Biochem Pharmacol 66:679-89. 2003
    ..The inhibition of AP-1 signaling pathway in T cells by EGb provides a support for its efficacy in cardiovascular and cerebrovascular diseases and raises a therapeutic potential for this drug in activated T cell-mediated pathologies...
  15. doi request reprint Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology
    Chun Liang Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Eur J Med Chem 60:29-41. 2013
    ..Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase and polypharmacological targeting strategy...
  16. doi request reprint Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells
    Wan Lin Wu
    Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, 350, Taiwan, Republic of China
    J Clin Immunol 31:1065-78. 2011
    ..We examined the potential immunomodulatory effects of leflunomide, a dihydroorotate dehydrogenase inhibitor commonly prescribed for arthritis, in DENV-stimulated monocyte-derived dendritic cells (mo-DCs)...
  17. ncbi request reprint Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes
    Ling Jun Ho
    Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
    Biochem Pharmacol 70:200-8. 2005
    ..Our results suggest that vitamin A may protect OA patients from pro-inflammatory cytokine-mediated damage of chondrocytes and their supporting matrixes...
  18. ncbi request reprint Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature
    Hsiang Cheng Chen
    Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng Kung Road, 114 Neihu, Taipei, Taiwan
    Rheumatol Int 25:303-6. 2005
    ..Our patient was successfully treated with intravenous pulse methylprednisolone, anticoagulation with heparin, oral hydroxychloroquine, azathioprine, and low-dose aspirin...
  19. ncbi request reprint Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines
    Ling Jun Ho
    Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
    Immunol Invest 33:423-37. 2004
    ..Our results provide a basic support for clinical observations and may be of help in understanding the pathogenesis of DV infection...
  20. doi request reprint Decoy receptor 3 suppresses RANKL-induced osteoclastogenesis via down-regulating NFATc1 and enhancing cell apoptosis
    Chia Pi Cheng
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Rheumatology (Oxford) 52:609-22. 2013
    ..Decoy receptor 3 (DCR3) has been known to modulate immune functions of monocyte or macrophage. In the present study, we investigated the mechanism and the effect of DCR3 on RANK ligand (RANKL)-induced osteoclastogenesis...
  21. doi request reprint Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases - an unrevealed role in downregulation of Th17 cells
    Yen Ling Wang
    Graduate Institute of Life Sciences, National Defense Medical Center, Neihu, Taipei 114, Taiwan
    J Autoimmun 37:160-70. 2011
    ....
  22. doi request reprint A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeutics
    Feng Cheng Liu
    Graduate Institute of Medical Science, National Defense Medical Center, Neihu 114, Taipei, Taiwan, Republic of China
    J Clin Immunol 31:1131-42. 2011
    ..Using tumor necrosis factor-alpha (TNF-α)-activated porcine chondrocytes as a screening tool, we aim to synthesize and identify small-molecule inhibitors preserving immunomodulatory effects as therapeutics for osteoarthritis (OA)...
  23. doi request reprint GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes
    Fei Lan Liu
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taiwan, Republic of China
    Exp Mol Pathol 88:163-70. 2010
    ....
  24. doi request reprint Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro
    Cheng Chung Cheng
    Division of Cardiology, Department of Medicine, Tri Service General Hospital, Taiwan, ROC
    Eur J Pharmacol 636:181-8. 2010
    ..Our results suggest that through decreasing IL-1 beta-induced activation of IKK-I kappaB alpha-NF-kappaB signaling pathway, bavachin potentially protects cartilage from inflammation-mediated damage in joints of osteoarthritis patients...
  25. doi request reprint TNF-α inhibitor reverse the effects of human umbilical cord-derived stem cells on experimental arthritis by increasing immunosuppression
    Cheng Chi Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Cell Immunol 273:30-40. 2012
    ..Injecting both a TNF inhibitor and HUCSCs may be a potential effective therapy for ameliorating the disease...
  26. ncbi request reprint Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell
    Ling Jun Ho
    Division of Gerontology Research, National Health Research Institute, Academia Sinica, Taipei, Taiwan
    J Immunol 174:8163-72. 2005
    ..These observations provide very useful messages with physiological significance in investigation of the pathogenesis, the defense mechanisms of human hosts and the therapeutic considerations in DV infection...
  27. ncbi request reprint Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report
    Feng Cheng Liu
    Division of Rheumatology Immunology Allergy, Department of Medicine, Tri Service General Hospital, Taipei, Taiwan, ROC
    Rheumatol Int 27:489-91. 2007
    ..Awareness of this rare presentation may be beneficial to clinicians in identifying and treating patients with both SLE and autoimmune hepatitis...
  28. ncbi request reprint Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in mice
    Shuk Man Ka
    Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
    J Am Soc Nephrol 18:2473-85. 2007
    ....
  29. ncbi request reprint Carvedilol modulates in-vitro granulocyte-macrophage colony-stimulating factor-induced interleukin-10 production in U937 cells and human monocytes
    Shu Meng Cheng
    Division of Cardiology, Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan, ROC
    Immunol Invest 32:43-58. 2003
    ..Our observations that carvedilol modulated GM-CSF-induced IL-10 production may have some implication in understanding the broad-spectrum effects of carvedilol in regulating inflammatory reactions...
  30. doi request reprint A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis
    Chia Pi Cheng
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Clin Immunol 32:762-77. 2012
    ..7 as a screening tool; we synthesize and identify small-molecule inhibitors preserving immunomodulatory effects as therapeutics for rheumatoid arthritis...
  31. doi request reprint Decoy receptor 3 attenuates collagen-induced arthritis by modulating T cell activation and B cell expansion
    Chia Pi Cheng
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Rheumatol 38:2522-35. 2011
    ..To investigate the immune-modulated effects of decoy receptor 3 (DCR3) in an experimental model of rheumatoid arthritis (RA)...
  32. pmc Erythropoietin enhances endogenous haem oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis
    Shyi Jou Chen
    Departments of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Clin Exp Immunol 162:210-23. 2010
    ..Together, our data show that in EAE, EPO induction of endogenous HO-1 and modulation of adaptive immunity both centrally and peripherally may involve the repression of inflammatory responses...
  33. doi request reprint Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice
    Li Tzu Yeh
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan
    J Immunol 191:594-607. 2013
    ..Taken together, our results demonstrate that Pep overexpression in T cells attenuates autoimmune diabetes in NOD mice by preferentially modulating TCR signaling-mediated functions in diabetogenic T cells but not in T(regs)...
  34. pmc Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes
    Feng Cheng Liu
    Graduate Institute of Medical Science, National Defense Medical Center, Neihu 114, Taipei, Taiwan, ROC
    Arthritis Res Ther 12:R167. 2010
    ..We aim to explore the potential chondroprotective effects of resveratrol on AGEs-stimulated porcine chondrocytes and cartilage explants...
  35. doi request reprint Remitting seronegative symmetrical synovitis with pitting edema following acute intracranial hemorrhage
    Deng Ho Yang
    Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Armed Forces Taichung General Hospital, No 348, Sec 2, Chung Shan Rd, Taiping 411 Taichung, Taiwan, Republic of China
    Rheumatol Int 31:101-4. 2011
    ..Neoplasia is the most common condition associated with RS3PE. We report a case of RS3PE that occurred following acute intracranial hemorrhage in an 80-year-old man with a 20-year history of hypertension...
  36. doi request reprint Glutamine attenuates hyperoxia-induced acute lung injury in mice
    Wann Cherng Perng
    Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan, China
    Clin Exp Pharmacol Physiol 37:56-61. 2010
    ..5. The data suggest that glutamine administered to mice during hyperoxia has a protective effect against hyperoxia-induced acute lung injury and improves survival...
  37. doi request reprint Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties
    Chia Chung Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan
    Bioorg Med Chem 21:7125-33. 2013
    ..Furthermore, 3c attenuated topoisomerase I-mediated DNA relaxation at low micromolar concentrations. These results indicated that fluorenones have potential to be further developed into anticancer drugs...
  38. ncbi request reprint Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus
    Hsiang Cheng Chen
    Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Am J Med Sci 327:105-8. 2004
    ..The possibility of SLE should be kept in mind in women presenting with paraplegia with no apparent cause...
  39. ncbi request reprint Effects of various body temperatures after lipopolysaccharide-induced lung injury in rats
    Shi Jye Chu
    Department of Emergency Medicine, Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, 161 Ming Chuan East Rd, Section 6, Neihu 114, Taipei, Taiwan, Republic of China
    Chest 128:327-36. 2005
    ..In this study, we determined the effects of various body temperatures (BTs) after initiation of lipopolysaccharide (LPS)-induced lung injury...
  40. pmc Protective role of programmed death 1 ligand 1 (PD-L1)in nonobese diabetic mice: the paradox in transgenic models
    Chia Jen Wang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Diabetes 57:1861-9. 2008
    ..We investigated the protective potential of PD-L1 on autoimmune diabetes by transgenically overexpressing PD-L1 in pancreatic beta-cells in nonobese diabetic (NOD) mice...
  41. ncbi request reprint Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature
    Feng Cheng Liu
    Division of Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Clin Rheumatol 26:1204-6. 2007
    ..To our knowledge, this is the first reported adult-onset Still's disease patient with Purtscher's-like retinopathy as the initial presentation...
  42. pmc IL-1beta in irrigation fluid and mRNA expression in synovial tissue of the knee joint as therapeutic markers of inflammation in collagen antibody-induced arthritis
    Wei Tso Chia
    Department of Health, Taiwan Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Dis Markers 26:1-7. 2009
    ..This model is used to identify potential therapeutic markers for treating rheumatoid arthritis...
  43. ncbi request reprint Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia
    Feng Cheng Liu
    Division of Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Clin Rheumatol 27:463-7. 2008
    ..Because of limited patient numbers, this tentative conclusion may need further confirmation with inclusion of more patient population...
  44. ncbi request reprint Fructose-1,6-diphosphate attenuates acute lung injury induced by ischemia-reperfusion in rats
    Shi Jye Chu
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Crit Care Med 30:1605-9. 2002
    ..To determine whether fructose-1,6-diphosphate (FDP) pretreatment can attenuate acute lung injury induced by ischemia-reperfusion in our isolated lung model in rats...
  45. doi request reprint Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells
    Jun Ting Liou
    Division of Cardiology, Department of Medicine, Tri Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC
    Eur J Pharmacol 589:288-98. 2008
    ..Our findings imply that triptolide and tetrandrine may attenuate dengue virus infection in human lung cells, but through distinct pathways...
  46. pmc Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases
    Gu Jiun Lin
    Department of Biology and Anatomy, National Defense Medical Center, No 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan
    Int J Mol Sci 14:11742-66. 2013
    ....
  47. doi request reprint Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus
    Yi Ting Tsai
    Division of Cardiovascular Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, 114 Taipei, Taiwan
    Exp Biol Med (Maywood) 236:1156-65. 2011
    ..In conclusion, the results show that the JAK/STAT3 pathway is critical in chemokine production from DV-infected hepatocytes. Targeting this pathway may be of benefit in the therapy of DV-induced immunopathologies...
  48. doi request reprint Overexpression of galectin-9 in islets prolongs grafts survival via downregulation of Th1 responses
    Feng Cheng Chou
    Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan
    Cell Transplant 22:2135-45. 2013
    ....
  49. ncbi request reprint Pleural effusion as a manifestation of Lyme disease
    Hsiang Cheng Chen
    Division of Rheumatology Immunology Allergy, Tri Service General Hospital, Taipei, Taiwan, Republic of China
    J Rheumatol 31:811-3. 2004
    ..Lyme disease was confirmed by seroreactivities against Borrelia burgdorferi spirochetes. The unique clinical findings reveal a rare manifestation with a possible association between B. burgdorferi infection and pleural effusion...
  50. ncbi request reprint An unrecognized cause of oedema in a patient with lupus nephritis: protein losing enteropathy
    Chia Chao Wu
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, Taipei, Taiwan, ROC
    Nephrol Dial Transplant 19:2149-50. 2004
  51. pmc Mesangial cells of lupus-prone mice are sensitive to chemokine production
    Shuk Man Ka
    Department of Pathology, Tri Service General Hospital, National Defense Medical Center, Cheng Gung Road, Taipei 114, Taiwan, ROC
    Arthritis Res Ther 9:R67. 2007
    ..The observed abnormal molecular events provide an intrarenal pathogenic pathway involved in an accelerated type of LN, which is potentially infection triggered...
  52. ncbi request reprint Increased monocyte chemoattractant protein-1 in knee joints of rats with adjuvant-induced arthritis: in vivo microdialysis
    Shao Hsiang Liu
    Graduate Institute of Life Science, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Rheumatol 32:2205-11. 2005
    ..Imbalance of inflammatory and antiinflammatory cytokines plays a critical role in the pathogenesis of rheumatoid arthritis (RA). Precise determination of these cytokines would lead to better understanding of the progression of RA...
  53. doi request reprint Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure
    Deng Ho Yang
    Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Armed Forces Taichung General Hospital, No 348, Sect 2, Chung Shan Road, Taiping 411, Taichung, Taiwan, ROC
    Rheumatol Int 29:95-8. 2008
    ..After therapy with etanercept, the patient's clinical manifestations recovered and she regained normal left ventricular systolic function...
  54. doi request reprint Advanced glycation end products induce T cell apoptosis: Involvement of oxidative stress, caspase and the mitochondrial pathway
    Li Feng Hung
    Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, Republic of China
    Mech Ageing Dev 131:682-91. 2010
    ..It is likely that AGEs-induced T cell apoptosis may play a role in T cell homeostasis in ageing...
  55. doi request reprint Acupuncture-associated Listeria monocytogenes arthritis in a patient with rheumatoid arthritis
    Chiung Hsi Tien
    Department of Medicine, Division of Rheumatology Immunology and Allergy, Tri Service General Hospital, National Defense Medical Center, No 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, ROC
    Joint Bone Spine 75:502-3. 2008
    ..A high index of suspicion for an infectious process is required for prompt diagnosis and treatment of acupuncture-induced joint infections in rheumatoid arthritis patients who might have additional risk factors for infection...
  56. ncbi request reprint A spontaneous intercostal artery hemorrhage in systemic lupus erythematosus
    Chun Chi Lu
    Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Road, Sec 2, Neihu 114, Taipei, Taiwan, ROC
    Rheumatol Int 32:829-31. 2012
    ..The lupus flare initiated a pathological immunological cascade and resulted in the CAPS and the vascular damage...
  57. doi request reprint Formation of numerous rice bodies: an unusual finding of adult-onset Still's disease
    Kang Min Lin
    Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, Republic of China
    Clin Rheumatol 27:S55-7. 2008
    ..To our knowledge, no case of formation of numerous rice bodies in AOSD has been reported thus far. We describe the case of a 28-year-old man with AOSD with rice bodies in his left shoulder joint...
  58. doi request reprint Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes
    Li Feng Hung
    Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
    Immunol Invest 37:675-93. 2008
    ..Collectively, our results raise a therapeutic option that intra-articular administration of retinoid derivatives at 10-1000 nanomolar concentrations may be effective to suppress the progression of inflammatory OA...
  59. ncbi request reprint Monozygotic twins concordant for idiopathic thrombocytopenic purpura and discordant for systemic lupus erythematosus and lupus nephritis
    Wen Chin Huang
    Department of Pediatrics, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Eur J Pediatr 166:497-500. 2007
    ....
  60. ncbi request reprint Acute gouty inflammation of a cystic tophaceous lesion of a leg muscle associated with "urate milk"
    Guo Shu Huang
    Department of Radiology, Tri Service General Hospital, Taipei, Taiwan
    J Rheumatol 32:2443-4. 2005
  61. doi request reprint Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus
    Deng Ho Yang
    Department of Internal Medicine, Division of Rheumatology Immunology Allergy, Armed Forces Taichung General Hospital, Taichung, Taiwan, Republic of China
    Rheumatology (Oxford) 48:1083-7. 2009
    ..We checked the levels of erythrocyte-bound C4d (E-C4d), an activation-derived fragment of C4 that is deposited on the erythrocytes, under different conditions of SLE in order to correlate these levels with disease activity...
  62. doi request reprint A/H1N1 influenza vaccination in patients with systemic lupus erythematosus: safety and immunity
    Chun Chi Lu
    Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Rd, Sec 2, Neihu 114, Taipei, Taiwan, ROC
    Vaccine 29:444-50. 2011
    ..To determine the safety of and immunogenicity induced by A/H1N1 influenza vaccination in patients with systemic lupus erythematosus (SLE)...
  63. ncbi request reprint Protective effect of U74500A on phorbol myristate acetate-induced acute lung injury
    Shi Jye Chu
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Clin Exp Pharmacol Physiol 31:523-9. 2004
    ..However, 6000 U/kg SOD, 50,000 U/kg catalase and 6000 U/kg SOD + 50,000 U/kg catalase had no protective effect. 4. These experimental data suggest that U74500A significantly ameliorates ALI induced by PMA in rats...
  64. doi request reprint Melatonin prolongs islet graft survival in diabetic NOD mice
    Gu Jiun Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Pineal Res 47:284-92. 2009
    ..Our results indicate that melatonin treatment suppresses autoimmune recurrence by inhibiting the proliferation of Th1 cells in NOD mice and thus prolongs the survival of syngeneic islet grafts...
  65. pmc Modulatory function of invariant natural killer T cells in systemic lupus erythematosus
    Yi Ping Chuang
    Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan
    Clin Dev Immunol 2012:478429. 2012
    ..Therefore, application of potential therapy for SLE using glycolipids to regulate iNKT cells should be undertaken cautiously...
  66. doi request reprint Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones
    Chia Chung Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Eur J Med Chem 50:102-12. 2012
    ..Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase targeting strategy...
  67. doi request reprint Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expression
    Yu Chieh Hsu
    Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, 161 MinChuan E Road, Sec 6, Neihu 114, Taipei, Taiwan, Republic of China
    J Rheumatol 38:1844-57. 2011
    ..We attempted to identify the active component of P. amboinicus involved in regulation of osteoclastogenesis...