Research Topics
Genomes and Genes | Deh Ming ChangSummaryCountry: Taiwan Publications
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Publications
Hormonal profiles and immunological studies of male lupus in TaiwanD M Chang
Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Clin Rheumatol 18:158-62. 1999..It was concluded that the high prolactin level and low FcgammaR distribution may play a role in the pathogenesis and prognosis of male lupus...- Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cellsDeh Ming Chang
Department of Rheumatology, Immunology and Allergy, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan
Rheumatol Int 27:1049-55. 2007..This novel finding of MMP-3 inhibition by activin A suggests a new role of activin A in cartilage remodeling. Activin A may have therapeutic potential for preventing cartilage degradation... 
Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosusD M Chang
Tri Service General Hospital, National Defense Medical Center, 325, Cheng Kung Road, Sec 2, Neihu, 114, Taipei, Taiwan, China
Ann Rheum Dis 63:1623-6. 2004..To study the effects of dehydroepiandrosterone (prasterone, DHEA) 200 mg/day on cytokine profiles in adult women with active systemic lupus erythematosus (SLE)...- Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammationDeh Ming Chang
Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325 Cheng Kung Road Section 2, Neihu 114, Taipei, Taiwan, China
Immunology 112:643-50. 2004..Our investigations indicate that this fusion protein effectively suppresses inflammatory arthritis and may initiate a trend for future clinical application to target multiple molecules at the same time... - The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritisDeh Ming Chang
Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325, Cheng Kung Road, Section 2, Neihu 114, Taipei, Taiwan, ROC
Pharmacol Res 50:371-6. 2004..The PK parameters for Chinese subjects with RA were comparable to those for non-Chinese subjects with RA. IL-1ra was well tolerated during this study, and no significant safety concerns were identified after administration... - Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trialDeh Ming Chang
Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Arthritis Rheum 46:2924-7. 2002..To evaluate the efficacy and tolerability of dehydroepiandrosterone (DHEA) at a dosage of 200 mg/day in adult women with active systemic lupus erythematosus (SLE)... 
Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cellsShyi Jou Chen
Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Mol Immunol 47:567-74. 2009..In conclusion, we demonstrate a therapeutic effect of DcR3 in EAE, suggesting its potential for treating human MS...- Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammationWan Lin Wu
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
Eur J Immunol 39:3413-22. 2009..Collectively, this study reveals not only the pathways involved in COX-2 synthesis in DV-infected DC but also the autocrine action of PGE2 on the migration of DV-infected DC... - Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cellsWan Lin Wu
Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, 350, Taiwan, Republic of China
J Clin Immunol 31:1065-78. 2011..We examined the potential immunomodulatory effects of leflunomide, a dihydroorotate dehydrogenase inhibitor commonly prescribed for arthritis, in DENV-stimulated monocyte-derived dendritic cells (mo-DCs)... - Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytesLing Jun Ho
Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
Biochem Pharmacol 70:200-8. 2005..Our results suggest that vitamin A may protect OA patients from pro-inflammatory cytokine-mediated damage of chondrocytes and their supporting matrixes... - Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases - an unrevealed role in downregulation of Th17 cellsYen Ling Wang
Graduate Institute of Life Sciences, National Defense Medical Center, Neihu, Taipei 114, Taiwan
J Autoimmun 37:160-70. 2011.... - A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeuticsFeng Cheng Liu
Graduate Institute of Medical Science, National Defense Medical Center, Neihu 114, Taipei, Taiwan, Republic of China
J Clin Immunol 31:1131-42. 2011..Using tumor necrosis factor-alpha (TNF-α)-activated porcine chondrocytes as a screening tool, we aim to synthesize and identify small-molecule inhibitors preserving immunomodulatory effects as therapeutics for osteoarthritis (OA)... - Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in miceShuk Man Ka
Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
J Am Soc Nephrol 18:2473-85. 2007.... - Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literatureFeng Cheng Liu
Division of Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Clin Rheumatol 26:1204-6. 2007..To our knowledge, this is the first reported adult-onset Still's disease patient with Purtscher's-like retinopathy as the initial presentation... - Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cellLing Jun Ho
Division of Gerontology Research, National Health Research Institute, Academia Sinica, Taipei, Taiwan
J Immunol 174:8163-72. 2005..These observations provide very useful messages with physiological significance in investigation of the pathogenesis, the defense mechanisms of human hosts and the therapeutic considerations in DV infection... - Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case reportFeng Cheng Liu
Division of Rheumatology Immunology Allergy, Department of Medicine, Tri Service General Hospital, Taipei, Taiwan, ROC
Rheumatol Int 27:489-91. 2007..Awareness of this rare presentation may be beneficial to clinicians in identifying and treating patients with both SLE and autoimmune hepatitis... - A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritisChia Pi Cheng
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
J Clin Immunol 32:762-77. 2012..7 as a screening tool; we synthesize and identify small-molecule inhibitors preserving immunomodulatory effects as therapeutics for rheumatoid arthritis... - Decoy receptor 3 attenuates collagen-induced arthritis by modulating T cell activation and B cell expansionChia Pi Cheng
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
J Rheumatol 38:2522-35. 2011..To investigate the immune-modulated effects of decoy receptor 3 (DCR3) in an experimental model of rheumatoid arthritis (RA)... - GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytesFei Lan Liu
Graduate Institute of Medical Sciences, National Defense Medical Center, Taiwan, Republic of China
Exp Mol Pathol 88:163-70. 2010.... - Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitroCheng Chung Cheng
Division of Cardiology, Department of Medicine, Tri Service General Hospital, Taiwan, ROC
Eur J Pharmacol 636:181-8. 2010..Our results suggest that through decreasing IL-1 beta-induced activation of IKK-I kappaB alpha-NF-kappaB signaling pathway, bavachin potentially protects cartilage from inflammation-mediated damage in joints of osteoarthritis patients... - Erythropoietin enhances endogenous haem oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitisShyi Jou Chen
Departments of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Clin Exp Immunol 162:210-23. 2010..Together, our data show that in EAE, EPO induction of endogenous HO-1 and modulation of adaptive immunity both centrally and peripherally may involve the repression of inflammatory responses... - TNF-α inhibitor reverse the effects of human umbilical cord-derived stem cells on experimental arthritis by increasing immunosuppressionCheng Chi Wu
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
Cell Immunol 273:30-40. 2012..Injecting both a TNF inhibitor and HUCSCs may be a potential effective therapy for ameliorating the disease... - Remitting seronegative symmetrical synovitis with pitting edema following acute intracranial hemorrhageDeng Ho Yang
Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Armed Forces Taichung General Hospital, No 348, Sec 2, Chung Shan Rd, Taiping 411 Taichung, Taiwan, Republic of China
Rheumatol Int 31:101-4. 2011..Neoplasia is the most common condition associated with RS3PE. We report a case of RS3PE that occurred following acute intracranial hemorrhage in an 80-year-old man with a 20-year history of hypertension... - Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytesFeng Cheng Liu
Graduate Institute of Medical Science, National Defense Medical Center, Neihu 114, Taipei, Taiwan, ROC
Arthritis Res Ther 12:R167. 2010..We aim to explore the potential chondroprotective effects of resveratrol on AGEs-stimulated porcine chondrocytes and cartilage explants... - Fructose-1,6-diphosphate attenuates acute lung injury induced by ischemia-reperfusion in ratsShi Jye Chu
Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Crit Care Med 30:1605-9. 2002..To determine whether fructose-1,6-diphosphate (FDP) pretreatment can attenuate acute lung injury induced by ischemia-reperfusion in our isolated lung model in rats... - Glutamine attenuates hyperoxia-induced acute lung injury in miceWann Cherng Perng
Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan, China
Clin Exp Pharmacol Physiol 37:56-61. 2010..5. The data suggest that glutamine administered to mice during hyperoxia has a protective effect against hyperoxia-induced acute lung injury and improves survival... - IL-1beta in irrigation fluid and mRNA expression in synovial tissue of the knee joint as therapeutic markers of inflammation in collagen antibody-induced arthritisWei Tso Chia
Department of Health, Taiwan Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
Dis Markers 26:1-7. 2009..This model is used to identify potential therapeutic markers for treating rheumatoid arthritis... - Increased monocyte chemoattractant protein-1 in knee joints of rats with adjuvant-induced arthritis: in vivo microdialysisShao Hsiang Liu
Graduate Institute of Life Science, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
J Rheumatol 32:2205-11. 2005..Imbalance of inflammatory and antiinflammatory cytokines plays a critical role in the pathogenesis of rheumatoid arthritis (RA). Precise determination of these cytokines would lead to better understanding of the progression of RA... - Protective role of programmed death 1 ligand 1 (PD-L1)in nonobese diabetic mice: the paradox in transgenic modelsChia Jen Wang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
Diabetes 57:1861-9. 2008..We investigated the protective potential of PD-L1 on autoimmune diabetes by transgenically overexpressing PD-L1 in pancreatic beta-cells in nonobese diabetic (NOD) mice... - Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virusYi Ting Tsai
Division of Cardiovascular Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, 114 Taipei, Taiwan
Exp Biol Med (Maywood) 236:1156-65. 2011..In conclusion, the results show that the JAK/STAT3 pathway is critical in chemokine production from DV-infected hepatocytes. Targeting this pathway may be of benefit in the therapy of DV-induced immunopathologies... - Acupuncture-associated Listeria monocytogenes arthritis in a patient with rheumatoid arthritisChiung Hsi Tien
Department of Medicine, Division of Rheumatology Immunology and Allergy, Tri Service General Hospital, National Defense Medical Center, No 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, ROC
Joint Bone Spine 75:502-3. 2008..A high index of suspicion for an infectious process is required for prompt diagnosis and treatment of acupuncture-induced joint infections in rheumatoid arthritis patients who might have additional risk factors for infection... - Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemiaFeng Cheng Liu
Division of Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Clin Rheumatol 27:463-7. 2008..Because of limited patient numbers, this tentative conclusion may need further confirmation with inclusion of more patient population... - Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cellsJun Ting Liou
Division of Cardiology, Department of Medicine, Tri Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC
Eur J Pharmacol 589:288-98. 2008..Our findings imply that triptolide and tetrandrine may attenuate dengue virus infection in human lung cells, but through distinct pathways... - Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failureDeng Ho Yang
Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Armed Forces Taichung General Hospital, No 348, Sect 2, Chung Shan Road, Taiping 411, Taichung, Taiwan, ROC
Rheumatol Int 29:95-8. 2008..After therapy with etanercept, the patient's clinical manifestations recovered and she regained normal left ventricular systolic function... - Advanced glycation end products induce T cell apoptosis: Involvement of oxidative stress, caspase and the mitochondrial pathwayLi Feng Hung
Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, Republic of China
Mech Ageing Dev 131:682-91. 2010..It is likely that AGEs-induced T cell apoptosis may play a role in T cell homeostasis in ageing... - A spontaneous intercostal artery hemorrhage in systemic lupus erythematosusChun Chi Lu
Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Road, Sec 2, Neihu 114, Taipei, Taiwan, ROC
Rheumatol Int 32:829-31. 2012..The lupus flare initiated a pathological immunological cascade and resulted in the CAPS and the vascular damage... - Formation of numerous rice bodies: an unusual finding of adult-onset Still's diseaseKang Min Lin
Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan, Republic of China
Clin Rheumatol 27:S55-7. 2008..To our knowledge, no case of formation of numerous rice bodies in AOSD has been reported thus far. We describe the case of a 28-year-old man with AOSD with rice bodies in his left shoulder joint... - Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytesLi Feng Hung
Division of Gerontology Research, National Health Research Institute, Taipei, Taiwan, ROC
Immunol Invest 37:675-93. 2008..Collectively, our results raise a therapeutic option that intra-articular administration of retinoid derivatives at 10-1000 nanomolar concentrations may be effective to suppress the progression of inflammatory OA... - Monozygotic twins concordant for idiopathic thrombocytopenic purpura and discordant for systemic lupus erythematosus and lupus nephritisWen Chin Huang
Department of Pediatrics, National Defense Medical Center, Taipei, Taiwan, Republic of China
Eur J Pediatr 166:497-500. 2007.... - Mesangial cells of lupus-prone mice are sensitive to chemokine productionShuk Man Ka
Department of Pathology, Tri Service General Hospital, National Defense Medical Center, Cheng Gung Road, Taipei 114, Taiwan, ROC
Arthritis Res Ther 9:R67. 2007..The observed abnormal molecular events provide an intrarenal pathogenic pathway involved in an accelerated type of LN, which is potentially infection triggered... - A/H1N1 influenza vaccination in patients with systemic lupus erythematosus: safety and immunityChun Chi Lu
Division of Rheumatology Immunology Allergy, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Rd, Sec 2, Neihu 114, Taipei, Taiwan, ROC
Vaccine 29:444-50. 2011..To determine the safety of and immunogenicity induced by A/H1N1 influenza vaccination in patients with systemic lupus erythematosus (SLE)... - Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosusDeng Ho Yang
Department of Internal Medicine, Division of Rheumatology Immunology Allergy, Armed Forces Taichung General Hospital, Taichung, Taiwan, Republic of China
Rheumatology (Oxford) 48:1083-7. 2009..We checked the levels of erythrocyte-bound C4d (E-C4d), an activation-derived fragment of C4 that is deposited on the erythrocytes, under different conditions of SLE in order to correlate these levels with disease activity... - Protective effect of U74500A on phorbol myristate acetate-induced acute lung injuryShi Jye Chu
Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Clin Exp Pharmacol Physiol 31:523-9. 2004..However, 6000 U/kg SOD, 50,000 U/kg catalase and 6000 U/kg SOD + 50,000 U/kg catalase had no protective effect. 4. These experimental data suggest that U74500A significantly ameliorates ALI induced by PMA in rats... - Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinonesChia Chung Lee
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
Eur J Med Chem 50:102-12. 2012..Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase targeting strategy... - Modulatory function of invariant natural killer T cells in systemic lupus erythematosusYi Ping Chuang
Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan
Clin Dev Immunol 2012:478429. 2012..Therefore, application of potential therapy for SLE using glycolipids to regulate iNKT cells should be undertaken cautiously... - Melatonin prolongs islet graft survival in diabetic NOD miceGu Jiun Lin
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
J Pineal Res 47:284-92. 2009..Our results indicate that melatonin treatment suppresses autoimmune recurrence by inhibiting the proliferation of Th1 cells in NOD mice and thus prolongs the survival of syngeneic islet grafts... - Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expressionYu Chieh Hsu
Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, 161 MinChuan E Road, Sec 6, Neihu 114, Taipei, Taiwan, Republic of China
J Rheumatol 38:1844-57. 2011..We attempted to identify the active component of P. amboinicus involved in regulation of osteoclastogenesis...