Research Topics
| Pao Hsien ChuSummaryAffiliation: Chang Gung Memorial Hospital Country: Taiwan Publications
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Detail Information
Publications
Gene-engineered models for genetic manipulation and functional analysis of the cardiovascular system in micePao Hsien Chu
First Cardiovascular Department, Internal Medicine, Chang Gung Memorial Hospital, Taipei
Chang Gung Med J 26:868-78. 2003..In conclusion, the gene-engineered mouse model is one of the most important tools developed in recent basic and clinical research...- The novel roles of four and a half LIM proteins 1 and 2 in the cardiovascular systemPao Hsien Chu
Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
Chang Gung Med J 34:127-34. 2011..This article reviews recent advances in the characterization of FHL1 and FHL2, their biological roles, LIM domain binding proteins, and functions in the cardiovascular system... 
Deletion of the FHL2 gene attenuates the formation of atherosclerotic lesions after a cholesterol-enriched dietPao Hsien Chu
The Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Life Sci 86:365-71. 2010..FHL2, a member of the four and a half LIM domain (FHL) family of proteins, may play an important role in the circulatory system and in particular atherosclerosis...- MUC1, MUC2 and MUC5AC expressions in cardiac myxomaPao Hsien Chu
The First Cardiovascular Division, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, 199 Tun Hwa North Road, 105 Taipei, Taiwan
Virchows Arch 446:52-5. 2005..An abundant mucopolysaccharidic matrix exists, including mucin, within cardiac myxoma. This investigation first reports the expressions of mucin genes in cardiac myxoma... - Survivin expression in cardiac myxomaYu Sheng Lin
Division of Cardiology, Chang Gung Memorial Hospital at Chiayi, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
Chang Gung Med J 34:360-6. 2011..Survivin, an antiapoptosis protein, may play an important role in the causes of cardiac myxoma. This investigation will report the expression pattern of survivin in cardiac myxomas... - Deep venous thrombosis: comparison of indirect multidetector CT venography and sonography of lower extremities in 26 patientsKun Eng Lim
Department of Radiology, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC
Clin Imaging 28:439-44. 2004.... - The Fas-mediated apoptotic pathway in cardiac myxomaCheng Chung Liu
Chang Gung University, Taipei, Taiwan
Int J Surg Pathol 18:493-8. 2010..The extrinsic Fas/FasL-dependent apoptosis pathways in cardiac myxomas were proved by both RNA and protein levels... - Irregular connexin43 expressed in a rare cardiac hamartoma containing adipose tissue in the crista terminalisPao Hsien Chu
The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University, 199 Tun Hwa North Road, 105 Taipei, Taiwan
Virchows Arch 444:383-6. 2004..Microscopically, this hamartoma comprised dense collagen and adipose tissue, mixed with hypertrophy, but with disarrayed cardiomyocytes. An irregular gap junction, connexin43, was demonstrated in this cardiac hamartoma... - Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein-Barr virusPao Hsien Chu
The Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
Mod Pathol 18:822-7. 2005..In conclusion, no viral genomes of HPV or EBV were detected in these 15 patients. This study demonstrates that caspase-3-dependent apoptosis in cardiac myxoma is not dependent on concurrence of previous HPV and/or EBV infection... - MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasisYu Sheng Lin
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan Taiwan
Mol Med Report 2:291-4. 2009..005). In conclusion, the expression of mucins, especially MUC1, confirms the malignant nature of hepatocellular carcinoma with cardiac metastasis. It is recommended that such patients receive aggressive therapy... - Impact of acute kidney injury on one-year survival after surgery for aortic dissectionHsing Shan Tsai
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Ann Thorac Surg 94:1407-12. 2012..Acute kidney injury (AKI) influences the disease course after surgery. Our hypothesis was that AKI should be an important prognostic factor for aortic dissection after surgical treatment... - Peripheral vascular endothelial dysfunction in glaucomatocyclitic crisis: a preliminary studySu Chin Shen
Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Invest Ophthalmol Vis Sci 51:272-6. 2010.... - Early prediction of acute kidney injury in patients with acute myocardial injuryPing Gune Hsiao
The Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 105, Taiwan
J Crit Care 27:525.e1-7. 2012..The dynamic changes in renal function during AMI are strongly related to long-term mortality and heart failure... 
Polycythemia vera as a presentation of renal angiomyolipoma: a case reportMing Shyan Lin
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
J Med Case Reports 3:90. 2009..This report describes a rare case of a woman diagnosed with renal angiomyolipoma and polycythemia vera. The report discusses the differential diagnosis using erythropoietin, erythropoietin-receptor and Janus kinase 2...- TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced deathI Shing Yu
Graduate Institute of Medical Technology, Department of Pathology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
Blood 104:135-42. 2004..The TXAS-deleted mice will be valuable for investigating the roles of arachidonate metabolic shunt in various pathophysiologic processes... - MUC5AC in juvenile conjunctival nevusHsin Chiung Lin
Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fu Hsing St, Kweishan, 333, Taoyuan, Taiwan
Jpn J Ophthalmol 56:107-12. 2012..To evaluate the possible role of cysts with mucins and inflammatory cells in rapid-growing juvenile conjunctival nevus... - Deletion of the FHL2 gene attenuating neovascularization after corneal injuryPao Hsien Chu
First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Invest Ophthalmol Vis Sci 49:5314-8. 2008..Although FHL2 is expressed in the cornea, its role in angiogenesis is unclear. The aim of this study was to investigate the role of the FHL2 gene in corneal angiogenesis after chemical injury... - Expression of caspase-3-dependent apoptosis in mural thrombi leukocytesPao Hsien Chu
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan
APMIS 116:995-9. 2008..4 mg/dL). Thrombi were characterized by apoptosis (32%) in a caspase-dependent pathway in all types of leukocytes. Thrombi in arteriovenous access failure demonstrate apoptosis by means of the caspase-3 pathway in white blood cells... - Persistence of transplanted oral mucosal epithelial cells in human corneaHung Chi Jesse Chen
Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Invest Ophthalmol Vis Sci 50:4660-8. 2009..To determine the expression of differentiation and progenitor cell markers in corneal tissues that previously underwent autologous cultivated oral mucosal epithelial transplantation (COMET)... - Hyperacute rejection from a donor who died of carbamate intoxication--a case reportYi Hsin Chan
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Am J Emerg Med 30:1661.e1-4. 2012..This report reviews the cardiac manifestations of acute carbamate intoxication and the possibility of heart transplantations from donors who died of carbamate intoxication... - Association between peripheral vascular endothelial dysfunction and livedoid vasculopathyChih Hsun Yang
Department of Dermatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
J Am Acad Dermatol 67:107-12. 2012..Many researchers suggest that a hypercoagulable status is the pathogenetic factor for LV. However, the cause of LV remains elusive... - Right ventricular dysfunction secondary to acute massive pulmonary embolism detected by helical computed tomography pulmonary angiographyKun Eng Lim
Department of Radiology, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC
Clin Imaging 29:16-21. 2005..The study compared the accuracy of helical computed tomographic (CT) scans with echocardiography in the detecting of RVD in patients with acute massive pulmonary embolism... - Neisseria elongata endocarditis complicated by brain embolism and abscessJu Feng Hsiao
Division of Cardiology, Department of Internal Medicine, Chang Gung University College of Medicine, Taipei, Taiwan, ROC
J Med Microbiol 57:376-81. 2008..elongata endocarditis, including ours, this will remind physicians that invasive N. elongata infections should be managed and followed up cautiously, as surgical intervention is often required... - Hepatoma with cardiac metastasis: an advanced cancer requiring advanced treatmentYu Sheng Lin
The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei 105, Taiwan, China
World J Gastroenterol 13:3513-6. 2007..To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis... - Effect of pre-eclampsia-eclampsia on major cardiovascular events among peripartum women in TaiwanYu Sheng Lin
Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Am J Cardiol 107:325-30. 2011..Our results suggest that women with pre-eclampsia/eclampsia should be closely monitored during pregnancy and for up to ≥3 years postpartum... - Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infectionShih-Ming Jung
Department of Pathology, Chang Gung University, Taipei, Taiwan
Virchows Arch 448:301-5. 2006..This investigation then showed that the expression of cell cycles in SCC was associated with key tumor clinicopathological features. This approach can help distinguish the potential roles of cell cycle in the development of SCC... - Lumican expression in diaphragm induced by mechanical ventilationLi Fu Li
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
PLoS ONE 6:e24692. 2011..We hypothesized that diaphragmatic damage by short duration of mechanical stretch caused up-regulation of lumican that modulated TGF-β1 signaling... - Laparoscopic cholecystectomy for gallbladder disease in patients with severe cardiovascular diseaseYu Yin Liu
Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5, Fu Hsing Street, Kwei Shan, Taoyuan, Taiwan
World J Surg 33:1720-6. 2009..This study aims to assess the suitability of LC for the treatment of gallbladder disease in CVD patients... - Clinical role of recurrently elevated macro creatine kinase type 1Ju Feng Hsiao
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
J Clin Lab Anal 22:186-91. 2008..Good linear correlation is documented between total CK and recurrent macro CK type 1. In conclusion, the macro CK type I isoenzyme recurred primarily in patients with myopathy... - Pulmonary embolism in a patient with multiple myeloma receiving thalidomide-dexamethasone therapyWen Juei Jeng
The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa North Road, Taipei, 105, Taiwan
Int J Hematol 87:542-4. 2008..After heparinization and warfarin therapy, the patient's condition improved. This is the first report of a patient with a rare complication of pulmonary embolism from thalidomide-treated multiple myeloma... - Expression of thyroid transcription factor-1 in brain metastases: a useful indicator of pulmonary originWen Yu Chuang
Department of Pathology, Chang Gung Memorial Hospital and Chang Gung Children s Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
J Clin Neurosci 15:643-6. 2008..Overall, TTF-1 positivity is a useful indicator of pulmonary origin in brain metastases, with a very high positive predictive value (95%) and a moderate negative predictive value (67%)... - Cadmium excretion predicting hospital mortality and illness severity of critically ill medical patientsJa Liang Lin
Division of Nephrology and Clinical Toxicology, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung University and School of Medicine, Taipei, Taiwan, ROC
Crit Care Med 37:957-62. 2009..To determine the prognostic value of day 1 urine excretion of cadmium (1st DUE-Cd) for predicting outcomes in intensive care unit (ICU) patients... - Diagnostic value of the helical CT scan for traumatic aortic injury: correlation with mortality and early ruptureChip-Jin Ng
Department of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
J Emerg Med 30:277-82. 2006..TAI patients with > or = 3 direct signs, including periaortic contrast material extravasation, may not require aortography before immediate surgery... - Unusual cardiac papillary fibroelastoma in the right ventricular outflow tractYu-Sheng Chang
Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Chang Gung University, 199 Tun-Hwa North Road, Taipei 105, Taiwan
Cardiovasc Pathol 14:104-6. 2005..The unique chondroid metaplasia of fibrous tissue in this CPF has never been reported. This work is the first to present an unusual CPF at the RVOT with reactive process of fibrous connective tissue... - Simultaneous biplane single-beat assessment of left ventricular systolic function in patients with atrial fibrillationChun-Li Wang
Department of Cardiology, Chang Gung Memorial Hospital, Taipei, Taiwan
Am J Cardiol 94:942-4. 2004..Bland-Altman analysis showed excellent correlation and agreement between the systolic parameters of a single beat with identical RR1 and RR2 intervals and the measured average value over all cardiac cycles... - Acute myocardial infarction in a young man complicated with left ventricular thrombiChia-Pin Lin
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei 105, Taiwan
Jpn Heart J 45:1029-35. 2004..This work reviews the pathophysiology and natural history of coronary artery disease in a case of very young myocardial infarction... - Use of a B-type natriuretic peptide in evaluating the treatment response of a relapsed lymphoma with cardiac involvementYu-Sheng Lin
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
Int J Hematol 83:44-6. 2006..This article is the first to report the use of BNP monitoring before and after chemotherapy to evaluate a patient with an unusual relapsed lymphoma with cardiac involvement... - ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscleXiangdong Xu
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 120:59-72. 2005..Our results validate ASF/SF2 as a fundamental splicing regulator in the reprogramming pathway and reveal the central contribution of ASF/SF2-regulated CaMKIIdelta alternative splicing to functional remodeling in developing heart... - Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heartJian Hua Ding
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
EMBO J 23:885-96. 2004..These studies raise a new paradigm for the etiology of certain human heart diseases of genetic or environmental origin that may be triggered by dysfunction in RNA processing...