Chia Ming Chu

Summary

Affiliation: Chang Gung Memorial Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Precore stop mutant in anti-HBe-positive phases of chronic hepatitis B virus infection
    Chia Ming Chu
    Am J Gastroenterol 97:2138-9; author reply 2139-40. 2002
  2. ncbi request reprint Hepatitis B virus-related cirrhosis: natural history and treatment
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Semin Liver Dis 26:142-52. 2006
  3. ncbi request reprint Epidemiological characteristics, risk factors, and clinical manifestations of acute non-A-E hepatitis
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    J Med Virol 65:296-300. 2001
  4. ncbi request reprint Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan
    Am J Med 116:829-34. 2004
  5. ncbi request reprint Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Scand J Gastroenterol 39:778-82. 2004
  6. ncbi request reprint Increased incidence of fulminant hepatic failure in previously unrecognized HBsAg carriers with acute hepatitis independent of etiology
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Infection 33:136-9. 2005
  7. ncbi request reprint Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at bas
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University Taipei, 199, Tung Hwa North Road, Taipei 105, Taiwan, ROC
    J Hepatol 43:411-7. 2005
  8. ncbi request reprint Sequential changes of hepatitis C virus antibody profiles during treatment of chronic hepatitis C of genotype 1b: pretreatment antibody response to E2/NS1 correlated sustained response
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Infection 32:153-6. 2004
  9. pmc Acute hepatitis C virus (HCV) infection in chronic carriers of hepatitis B virus (HBV): the impact of underlying active HBV replication on persistence of HCV infection and antibody responses to HCV
    C M Chu
    Liver Research Unit, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Gut 51:95-9. 2002
  10. pmc Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    J Clin Microbiol 40:16-21. 2002

Detail Information

Publications41

  1. ncbi request reprint Precore stop mutant in anti-HBe-positive phases of chronic hepatitis B virus infection
    Chia Ming Chu
    Am J Gastroenterol 97:2138-9; author reply 2139-40. 2002
  2. ncbi request reprint Hepatitis B virus-related cirrhosis: natural history and treatment
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Semin Liver Dis 26:142-52. 2006
    ..Adefovir or entecavir is preferred in patients with decompensated cirrhosis who require long duration of treatment, due to the lower rate of development of resistance...
  3. ncbi request reprint Epidemiological characteristics, risk factors, and clinical manifestations of acute non-A-E hepatitis
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    J Med Virol 65:296-300. 2001
    ..In conclusion, there is no obvious parenteral risk factor identified in acute non-A-E hepatitis. Clinical severity is similar to that of hepatitis C at least in hospitalized patients, but the rate of chronic evolution is much lower...
  4. ncbi request reprint Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan
    Am J Med 116:829-34. 2004
    ..Follow-up of patients beginning at the early phase of infection might provide data with less referral bias than in previous studies...
  5. ncbi request reprint Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Scand J Gastroenterol 39:778-82. 2004
    ..The aim of this study was to investigate the effect of concurrent HBV infection on serum titers of HCV RNA and HCV antibody profiles in chronic HCV infection...
  6. ncbi request reprint Increased incidence of fulminant hepatic failure in previously unrecognized HBsAg carriers with acute hepatitis independent of etiology
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Infection 33:136-9. 2005
    ..The etiology of acute hepatitis in HBsAg carriers was heterogeneous. This study aimed to correlate the incidence of fulminant hepatitis with the etiology in HBsAg carriers with acute hepatitis...
  7. ncbi request reprint Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at bas
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University Taipei, 199, Tung Hwa North Road, Taipei 105, Taiwan, ROC
    J Hepatol 43:411-7. 2005
    ..Longitudinal studies on the relationship between hepatitis B virus (HBV) genotypes and reactivation of hepatitis B and progression to cirrhosis were very rare...
  8. ncbi request reprint Sequential changes of hepatitis C virus antibody profiles during treatment of chronic hepatitis C of genotype 1b: pretreatment antibody response to E2/NS1 correlated sustained response
    C M Chu
    Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Infection 32:153-6. 2004
    ..This study aimed to investigate the relation between hepatitis C virus (HCV) antibody profiles and response to therapy of chronic HCV infection of genotype 1b...
  9. pmc Acute hepatitis C virus (HCV) infection in chronic carriers of hepatitis B virus (HBV): the impact of underlying active HBV replication on persistence of HCV infection and antibody responses to HCV
    C M Chu
    Liver Research Unit, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Gut 51:95-9. 2002
    ..The aim of this study was to assess whether underlying chronic hepatitis B virus (HBV) infection interferes with persistence of hepatitis C virus (HCV) infection and humoral immune responses to HCV in acute HCV infection...
  10. pmc Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    J Clin Microbiol 40:16-21. 2002
    ..Precore mutant ratios tended to correlate with ALT levels and anti-HBe seroconversion, but high precore mutant ratios were associated with persistent hepatitis after anti-HBe seroconversion and increased risk of cirrhosis...
  11. doi request reprint Relative roles of HBsAg seroclearance and mortality in the decline of HBsAg prevalence with increasing age
    Dar In Tai
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Gastroenterol 105:1102-9. 2010
    ..Their relative roles in the decline of HBsAg prevalence with increasing age are unknown...
  12. ncbi request reprint Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
    Yao Shih Hsu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Hepatology 35:1522-7. 2002
    ..005). In conclusion, the results suggest that spontaneous HBeAg seroconversion confers favorable long-term outcomes. However, active hepatitis still may develop and lead to cirrhosis and HCC...
  13. doi request reprint Viral load, genotypes, and mutants in hepatitis B virus-related hepatocellular carcinoma: special emphasis on patients with early hepatocellular carcinoma
    Chia Ming Chu
    Department of Gastroenterology and Hepatology, Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tung Hwa North Road, Taipei 10591, Taiwan
    Dig Dis Sci 57:232-8. 2012
    ..A case-control study including patients with early HCC and HBsAg carriers who are presumed to be at the minimal potential of HCC as controls might better identify factors significantly associated with HCC development...
  14. doi request reprint Off-therapy durability of response to entecavir therapy in hepatitis B e antigen-negative chronic hepatitis B patients
    Wen Juei Jeng
    Liver Research Unit, Linkou Medical Center, Chang Gung Memorial Hospital, Taipei, Taiwan College of Medicine, Chang Gung University, Taipei, Taiwan
    Hepatology 58:1888-96. 2013
    ..027). For the latter, consolidation therapy >64 weeks reduced the relapse rate to 33.3% in patients without cirrhosis...
  15. ncbi request reprint Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma
    Shi Ming Lin
    Liver Research Unit, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan
    J Hepatol 46:45-52. 2007
    ..The long-term outcomes of interferon-alpha (IFN-alpha) therapy in hepatitis B e antigen (HBeAg) seropositive patients remain controversial. This study was conducted to address this issue...
  16. ncbi request reprint Impact of acute hepatitis C virus superinfection in patients with chronic hepatitis B virus infection
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Gastroenterology 126:1024-9. 2004
    ..The natural course following acute hepatitis C virus (HCV) superinfection has not been well studied. The aim of this study was to investigate the impact of acute HCV superinfection...
  17. ncbi request reprint Level of hepatitis B virus DNA in inactive carriers with persistently normal levels of alanine aminotransferase
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Gastroenterol Hepatol 8:535-40. 2010
    ..We investigated HBV DNA levels in inactive carriers and identified factors that correlated with this state among anti-HBe-positive carriers with HBV DNA levels of 10(4) copies/mL or greater (5.26 copies/mL = 1 IU/mL)...
  18. ncbi request reprint Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 18:1129-38. 2003
    ..The aim of the present study was to investigate whether spontaneous seroclearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B could be attributed to the presence of pre-S/S gene mutations...
  19. ncbi request reprint Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Gastroenterology 123:1084-9. 2002
    ..The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients...
  20. ncbi request reprint Incidence and risk factors of progression to cirrhosis in inactive carriers of hepatitis B virus
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Am J Gastroenterol 104:1693-9. 2009
    ....
  21. ncbi request reprint Determinants for sustained HBeAg response to lamivudine therapy
    Rong Nan Chien
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Hepatology 38:1267-73. 2003
    ..In conclusion, HBV genotype, age, and additional treatment are the major determinants for the sustained HBeAg response to lamivudine therapy...
  22. ncbi request reprint Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Gastroenterology 133:1458-65. 2007
    ..Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study...
  23. doi request reprint Hepatitis B virus infection
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Lancet 373:582-92. 2009
    ..However, hepatitis B virus is rarely eliminated, and drug resistance is a major drawback during long term therapy. The development of new drugs and strategies is needed to improve treatment outcomes...
  24. doi request reprint Immunopathology on hepatocyte expression of HBV surface, core, and x antigens in chronic hepatitis B: clinical and virological correlation
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 199 Tung Hwa North Road, Taipei 10591, Taiwan
    Dig Dis Sci 55:446-51. 2010
    ..Hepatocyte expression of HBV surface, core, and x antigens (HBsAg, HBcAg and HBxAg), semi-quantitated by immunopathology, were correlated with clinical and virological data in 80 patients with chronic hepatitis B...
  25. ncbi request reprint Hepatitis C virus infection facilitates gallstone formation
    Te Sheng Chang
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 20:1416-21. 2005
    ..The purpose of the present study was to examine the relationship between biliary diseases and hepatitis C virus infection...
  26. doi request reprint Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time
    Dar In Tai
    Liver Research Unit, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, Taipei, Taiwan
    Hepatology 49:1859-67. 2009
    ....
  27. ncbi request reprint HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Hepatology 45:1187-92. 2007
    ..In multivariate analysis, the probability of HBsAg seroclearance correlated positively with age at entry (P<0.0001) and sustained remission of hepatitis (P<0.0001) and marginally significantly with male sex (P=0.053)...
  28. doi request reprint Clinical and virological characteristics post HBsAg seroclearance in hepatitis B virus carriers with hepatic steatosis versus those without
    Chia Ming Chu
    Liver Research Unit, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199, Tung Hwa North Road, Taipei, 10591, Taiwan
    Dig Dis Sci 58:275-81. 2013
    ..Further studies are needed to compare clinical and virological characteristics post HBsAg seroclearance between subjects with hepatic steatosis and those without...
  29. doi request reprint Prevalence of and risk factors for hepatitis B viremia after spontaneous hepatitis B surface antigen seroclearance in hepatitis B carriers
    Chia Ming Chu
    Liver Research Unit, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Infect Dis 54:88-90. 2012
    ..The frequency of HBV viremia was significantly (P = .002) lower in patients with anti-HBsAg seroconversion (6 of 69 [8.7%]) than in those without seroconversion (15 of 49 [30.6%])...
  30. doi request reprint Hepatitis B surface antigen seroclearance during chronic HBV infection
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Antivir Ther 15:133-43. 2010
    ..Studies to assess the effects of antiviral therapy, and in particular interferon treatment, are also discussed together with virological, biochemical and histological profiles following HBsAg seroclearance and the long-term outcomes...
  31. doi request reprint Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Hepatology 51:435-44. 2010
    ..7% [P < 0.0001], 42.9% [P <0.0001], and 7.7% [P = 0.29], respectively). The hazard ratio of HBeAg-negative hepatitis, cirrhosis, and HCC was 2.95, 17.6, and 5.22, respectively, in group C compared with group A...
  32. doi request reprint Decreasing levels of HBsAg predict HBsAg seroclearance in patients with inactive chronic hepatitis B virus infection
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Gastroenterol Hepatol 10:297-302. 2012
    ..Serum levels of hepatitis B surface antigen (HBsAg) decrease gradually during chronic hepatitis B virus infection. We investigated the association between levels of HBsAg and HBsAg seroclearance...
  33. ncbi request reprint Genetic alterations of INK4alpha/ARF locus and p53 in human hepatocellular carcinoma
    Cheng Yuan Peng
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
    Anticancer Res 22:1265-71. 2002
    ..results suggest that p14(ARF), p16(INK4a) and p53 are differentially disrupted through distinct molecular mechanisms at different stages in HCC and that p14(ARF) and p53 appear to function in the same tumor suppression pathway in HCC..
  34. ncbi request reprint Comparative studies on expression of alpha-smooth muscle actin in hepatic stellate cells in chronic hepatitis B and C
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan
    Dig Dis Sci 53:1364-9. 2008
    ..We performed a comparative study on the expression of alpha-smooth muscle actin (alpha-SMA) in hepatic stellate cells (HSCs), a marker of HSC activation, in patients with chronic hepatitis B and hepatitis C...
  35. pmc Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan
    BMC Genomics 9:109. 2008
    ..Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis...
  36. ncbi request reprint Replication of hepatitis B in HBsAg-positive siblings
    Dar In Tai
    Liver Unit, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Hong Kong, Institute for International Health, Faculty of Medicine, University of Sydney, Australia
    J Viral Hepat 9:272-9. 2002
    ..A significant number of younger siblings appeared to have a shorter HBV replication phase than their older siblings. The possible role of this in maternal-fetal transmission is discussed...
  37. pmc Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study
    Yi Cheng Chen
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199, Tung Hwa North Road, Taipei, 105, Taiwan
    Hepatol Int 1:267-73. 2007
    ..To elucidate the long-term natural course following the onset of cirrhosis in patients with chronic hepatitis B...
  38. ncbi request reprint Diagnostic laparoscopy in ascites of unknown origin: Chang Gung Memorial Hospital 20-year experience
    Chien Min Han
    Division of Gynecologic Endoscopy, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 31:378-83. 2008
    ..The aim of this study was to assess the diagnostic accuracy of laparoscopy in patients with ascites of unknown origin, and evaluate the role of laparoscopy in this population after the advent of ultrasonography and computed tomography...
  39. ncbi request reprint Secondary prevention of hepatitis C virus-related hepatocellular carcinoma
    Shi Ming Lin
    J Gastroenterol Hepatol 20:1475-7. 2005
  40. ncbi request reprint Percutaneous tumor ablation or surgical resection for small hepatocellular carcinoma?
    Shi Ming Lin
    J Gastroenterol Hepatol 22:1561-4. 2007
  41. ncbi request reprint Immunoglobulin class M anti-hepatitis B core antigen for serodiagnosis of acute hepatitis: pitfalls and recommendations
    Chia Ming Chu
    J Gastroenterol Hepatol 21:789-91. 2006