Research Topics
| Cheng Hsun ChiuSummaryAffiliation: Chang Gung Memorial Hospital Country: Taiwan Publications
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Detail Information
Publications
Differential genomic variation between short- and long-term bacterial evolution revealed by ultradeep sequencingYe Feng
Genomics Research Center, Harbin Medical University, People s Republic of China
Genome Biol Evol 5:572-7. 2013..These findings suggest that the genomic differences between closely related bacterial strains have already undergone selection and are therefore not representative of spontaneous mutation...
Clonal dissemination of the multi-drug resistant Salmonella enterica serovar Braenderup, but not the serovar Bareilly, of prevalent serogroup C1 Salmonella from TaiwanChien Shun Chiou
The Central Region Laboratory, Center of Research and Diagnostics, Centers for Disease Control, No 30, Wenxin S 3rd Rd, Nantun Dist, Taichung, 40856, Taiwan
BMC Microbiol 9:264. 2009..Bareilly) and Braenderup (S. Braenderup) were compared, and multi-drug resistance (MDR) plasmids were characterized...
Characterization of 13 multi-drug resistant Salmonella serovars from different broiler chickens associated with those of human isolatesLan Ho Chiu
Department of Microbiology and Immunology, National Chiayi University, No 300, University Rd, Chiayi, 60004, Taiwan
BMC Microbiol 10:86. 2010..To understand the possible serovar and H antigens for transmission between chicken and human, serovars and their H antigens of 164 chicken and 5314 human isolates were compared...
Survey of childhood empyema in Asia: implications for detecting the unmeasured burden of culture-negative bacterial diseaseBatmunkh Nyambat
Division of Translational Research, International Vaccine Institute, Seoul, South Korea
BMC Infect Dis 8:90. 2008..Parapneumonic empyema continues to be a disease of significant morbidity and mortality among children despite recent advances in medical management. To date, only a limited number of studies have assessed the burden of empyema in Asia...
Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14Feng Ding
The CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China
BMC Genomics 10:158. 2009..Multiple serotype 14 clinical isolates were also genotyped by multilocus sequence typing (MLST)...
Liver abscess caused by Klebsiella pneumoniae in siblingsC H Chiu
Divisions of Pediatric Infectious Diseases, Department of Medicine, Chang Gung Children s Hospital, 5 Fu Hsin Street, Kweishan 333, Taoyuan, Taiwan
J Clin Microbiol 39:2351-3. 2001..pneumoniae isolates from two siblings with liver abscess, their family members, and the environment suggest a possibility of cross infection of liver abscess by the fecal-oral route within diabetic patients...
Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatmentCheng Hsun Chiu
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
Clin Microbiol Rev 17:311-22. 2004..The availability, in the near future, of the genome sequence of serotype Cholearesuis will facilitate the development of effective vaccines as well as the discovery of new targets for novel antimicrobial agents...
Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003Cheng Hsun Chiu
Chang Gung Children s Hospital, Taoyuan, Taiwan
Emerg Infect Dis 10:1674-6. 2004..Surveillance in Taiwan showed that fluoroquinolone resistance in S. Choleraesuis markedly increased from 2000 to 2003, reaching approximately 70% in 2003...
The impact of constipation on growth in childrenHsun Chin Chao
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan 33305, Taiwan
Pediatr Res 64:308-11. 2008..We conclude that chronic constipation may retard growth status in children, and a long-term medication for constipation in children appears beneficial to their growth status...
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogenCheng Hsun Chiu
Department of Pediatrics, Chang Gung Children s Hospital Taoyuan, Taiwan
Nucleic Acids Res 33:1690-8. 2005..Our findings suggest that the formation of pseudogenes may provide a simple evolutionary pathway that complements gene acquisition to enhance virulence and antimicrobial resistance in S. Choleraesuis...
Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71Cheng Hsun Chiu
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan 333, Taiwan
Microbes Infect 8:1671-8. 2006..Our data indicated that Salmonella-based VP1 subunit vaccines are a promising vaccine strategy in the prevention of EV71 infection...
Salmonella enterica serotype Choleraesuis infections in pediatric patientsCheng Hsun Chiu
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, Taoyuan, Taiwan
Pediatrics 117:e1193-6. 2006..The objective of this study was to delineate the clinical and microbiologic features of pediatric patients with Salmonella Choleraesuis infections...
Prevalence and antimicrobial susceptibility of serogroup D nontyphoidal Salmonella in a university hospital in TaiwanCheng Hsun Chiu
Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan 333, Taiwan
J Clin Microbiol 42:415-7. 2004..Furthermore, the first identification of ciprofloxacin and ceftriaxone resistance in serogroup D Salmonella in our hospital is also than they did to other antimicrobial agents cause for concern...
The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuisCheng Hsun Chiu
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
N Engl J Med 346:413-9. 2002..Because fluoroquinolones are the drug of choice for the treatment of severe salmonella infections, the emergence and dissemination of fluoroquinolone-resistant S. enterica serotype choleraesuis have clinical consequences...
Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in TaiwanCheng Hsun Chiu
Department of Pediatrics, Chang Gung Children s Hospital, 5 Fu Hsin Street, Kweishan 333, Taoyuan, Taiwan
Antimicrob Agents Chemother 51:3404-6. 2007..Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance...
Safety and immunogenicity of a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4, and 6 months of ageTzou Yien Lin
Division of Pediatric Infectious Diseases, Chang Gung Children s Hospital, Taipei
Chang Gung Med J 26:315-22. 2003....
CMY-2 beta-lactamase-carrying community-acquired urinary tract Escherichia coli: genetic correlation with Salmonella enterica serotypes Choleraesuis and TyphimuriumTsu Lan Wu
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Int J Antimicrob Agents 29:410-6. 2007..Awareness of this mobile resistance element is required to prevent introduction into hospitals and to reduce the spread of this emerging resistance within the community...
Distribution of a transposon-like element carrying bla(CMY-2) among Salmonella and other EnterobacteriaceaeLin Hui Su
Department of Clinical Pathology, Chang Gung Memorial Hospital, 5 Fu Hsin Street, Kweishan, Taoyuan 333, Taiwan
J Antimicrob Chemother 57:424-9. 2006..The dissemination of cephamycin resistance in Enterobacteriaceae and its correlation with a transposon-like DNA element consisting of a specific tnpA-bla(CMY-2)-blc-sugE structure were investigated...
Wide spread of Tn2006 in an AbaR4-type resistance island among carbapenem-resistant Acinetobacter baumannii clinical isolates in TaiwanHao Yuan Lee
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
Int J Antimicrob Agents 40:163-7. 2012..009 and 0.027, respectively). Tn2006 is currently the most common imipenem resistance determinant, which showed a higher ability to spread among A. baumannii and was associated with a higher mortality in IRAB-infected patients...
Functional and molecular characterization of pSE34 encoding a type IV secretion system in Salmonella enterica serotype Enteritidis phage type 34Chyi Liang Chen
Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
FEMS Immunol Med Microbiol 57:274-83. 2009..The presence of conjugative pSE34 in PT4 caused the conversion of phage type from PT4 to PT34, suggesting that the emergence of PT34 was a result of the introduction of the conjugative pSE34 into its common progenitor PT4...
Clinical features and molecular characteristics of invasive community-acquired methicillin-resistant Staphylococcus aureus infections in Taiwanese childrenChih Jung Chen
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan 333, Taiwan
Diagn Microbiol Infect Dis 59:287-93. 2007..Surgical interventions were often required, and a prolonged course of antibiotic therapy was needed. A multiresistant CA-MRSA clone characterized as ST59 was identified from these children in Taiwan...
Mechanisms of resistance to ciprofloxacin, ampicillin/sulbactam and imipenem in Acinetobacter baumannii clinical isolates in TaiwanCheng Hsun Chiu
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
Int J Antimicrob Agents 35:382-6. 2010..The major metallo-beta-lactamase contributing to imipenem resistance in A. baumannii in Taiwan was bla(IMP-1), which was carried by the class 1 integron. The class 1 integron was associated with the MDR phenotype in A. baumannii...
Molecular epidemiology and clinical manifestations of viral gastroenteritis in hospitalized pediatric patients in Northern TaiwanShih Yen Chen
Division of Pediatric Gastroenterology, Chang Gung University College of Medicine, Kweishan 333, Taoyuan, Taiwan
J Clin Microbiol 45:2054-7. 2007..Higher disease severity was found for AGE caused by multiple viruses and by rotavirus alone. The majority of rotaviruses isolated from 2004 to 2006 belonged to genotypes G1 (20.4%), G2 (16.5%), G3 (27.2%), and G9 (21.4%)...
Experience with linezolid therapy in children with osteoarticular infectionsChih Jung Chen
Division of Pediatric Infectious Diseases, Department of Pediatrics Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Pediatr Infect Dis J 26:985-8. 2007..The clinical efficacy of this drug has not been previously evaluated for Gram-positive osteoarticular infections in children...
The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for Streptococcus pneumoniae carriage in childrenYu Chia Hsieh
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
Pediatr Infect Dis J 31:e163-8. 2012..The aim of the study was to investigate whether the 7-valent pneumococcal conjugate vaccine (PCV7) alters common risk factors of nasopharyngeal carriage by Streptococcus pneumoniae in children...
Antigenemia and cytokine expression in rotavirus gastroenteritis in childrenTsung Han Yu
Divisions of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
J Microbiol Immunol Infect 45:265-70. 2012..The aim of this study was to evaluate the association of antigenemia with clinical manifestations and cytokine profiles in children infected by rotavirus...
Nontyphoidal Salmonella bacteremia in previously healthy children: analysis of 199 episodesMing Han Tsai
Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan
Pediatr Infect Dis J 26:909-13. 2007..Nontyphoidal Salmonella (NTS) bacteremia is not rare in otherwise healthy children in Taiwan. Few studies described the clinical manifestations and outcomes of NTS bacteremia in previously healthy children...
Probiotics have clinical, microbiologic, and immunologic efficacy in acute infectious diarrheaChien Chang Chen
Division of Gastroenterology, Department of Pediatrics, Chang Gung Children s Hospital, Taiwan
Pediatr Infect Dis J 29:135-8. 2010..Acute infectious diarrhea is a major cause of childhood morbidity and economic burden for families. We evaluate the clinical, microbiologic, and immunologic effects of probiotics in acute infectious diarrhea...
Comparison of clinical features between coxsackievirus A2 and enterovirus 71 during the enterovirus outbreak in Taiwan, 2008: a children's hospital experienceShih Perng Chen
Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children s Medical Center, Taoyuan, Taiwan
J Microbiol Immunol Infect 43:99-104. 2010..In this study, we compared Cox A2 with enterovirus 71 (EV71) in terms of clinical manifestation and epidemiology during the 2008 enterovirus outbreak in Taiwan...
Salmonella enterica serotype Choleraesuis infection in a medical center in northern TaiwanShun Chiu
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, 5 Fu Hsin Street, Kweishan, Taoyuan, Taiwan 333, ROC
J Microbiol Immunol Infect 37:99-102. 2004..In view of the emergence of fluoroquinolone resistance, the third-generation cephalosporins appear to be the best choice for treatment of invasive infections caused by this organism...
Recognition of mechanisms involved in bile resistance important to halting antimicrobial resistance in nontyphoidal SalmonellaMing Han Tsai
Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan
Int J Antimicrob Agents 40:151-7. 2012..Addition of an efflux pump inhibitor to fluoroquinolones may be an effective strategy to deal with the increasing resistance in NTS...
Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implicationsHao Yuan Lee
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
Int J Antimicrob Agents 37:302-8. 2011..Physicians should weigh the benefits and risks of each carbapenem-based treatment in managing carbapenem-susceptible MDR-AB infection...
Sequence types and antimicrobial susceptibility of invasive streptococcus pneumoniae isolates from a region with high antibiotic selective pressure and suboptimal vaccine coverageRajendra Prasad Janapatla
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
Pediatr Infect Dis J 29:467-9. 2010..Antimicrobial nonsusceptibility was common in the predominant STs of serotypes 14, 19A, 19F, and 23F...
Host and microbiologic factors associated with mortality in Taiwanese children with invasive pneumococcal diseases, 2001 to 2006Chih Jung Chen
Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan
Diagn Microbiol Infect Dis 63:194-200. 2009..1; 95% CI, 1.4-47.3), which are the independent predictors for fatality. This finding highlighted the importance of immunization of disadvantaged children, targeting drug-resistant pneumococci...
Renal abscess in children: a 10-year clinical and radiologic experience in a tertiary medical centerChi Hui Cheng
Division of Pediatric Nephrology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taiwan
Pediatr Infect Dis J 27:1025-7. 2008..Experiences gained from this 10-year study on patients with CT-proved diagnosis include the varied clinical presentations and use of sonographic-marked nephromegaly and focal mass as indications for further CT diagnosis...
Outbreak of dysentery associated with ceftriaxone-resistant Shigella sonnei: First report of plasmid-mediated CMY-2-type AmpC beta-lactamase resistance in S. sonneiI Fei Huang
Department of Pediatrics, Veterans General Hospital Kaohsiung, 386, Ta Chung 1st Road, Kaohsiung, Taiwan
J Clin Microbiol 43:2608-12. 2005..This is the first report of plasmid-mediated CMY-2-type AmpC beta-lactamase in S. sonnei. Ampicillin-resistant isolates can develop during the course of antibiotic treatment...
Group B streptococcal disease in nonpregnant patients: emergence of highly resistant strains of serotype Ib in Taiwan in 2006 to 2008Ying Hsiang Wang
Department of Pediatrics, Chang Gung Memorial Hospital, Chiayi, Taiwan
J Clin Microbiol 48:2571-4. 2010..Serotype Ib isolates (24.6%) were the second most prevalent serotype, next to serotype V (29.4%), and showed the highest resistance rates to erythromycin (91.0%) and clindamycin (82.1%)...
Nasopharyngeal carriage of Streptococcus pneumoniae in Taiwan before and after the introduction of a conjugate vaccineChen Yen Kuo
Department of Pediatrics, Chang Gung Children s Hospital, College of Medicine, Chang Gung University, 5 Fu Hsin Street, Kwei Shan Hsiang, Taoyuan, Taiwan
Vaccine 29:5171-7. 2011..To evaluate the effect of the vaccination, we conducted an active, prospective, large-scale, long-term, and multicenter study to assess the prevalence of nasopharyngeal Streptococcus pneumoniae carriage in Taiwanese children...
Antimicrobial susceptibility of Streptococcus pneumoniae at a university hospital in Taiwan, 2000-07: impact of modified non-meningeal penicillin breakpoints in CLSI M100-S18Lin Hui Su
Department of Laboratory Medicine, Chang Gung Memorial Hospital, 5 Fu Hsin Street, Kweishan, Taoyuan 333, Taiwan
J Antimicrob Chemother 64:336-42. 2009..In 2008, a new set of penicillin breakpoints was published in the CLSI revised guideline, M100-S18, to define the susceptibility of non-meningeal isolates of Streptococcus pneumoniae. The impact of the change is studied and discussed...
Complete nucleotide sequence of a virulence plasmid of Salmonella enterica serovar Dublin and its phylogenetic relationship to the virulence plasmids of serovars Choleraesuis, Enteritidis and TyphimuriumSeau Feng Hong
Department of Microbiology and Immunology, Chang Gung University College of Medicine, Taoyuan, Taiwan
FEMS Microbiol Lett 282:39-43. 2008....
Immunogenicity and safety of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) co-administered with routine childhood vaccines in TaiwanTzou Yien Lin
Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taiwan
J Formos Med Assoc 111:495-503. 2012..The immunogenicity and safety of the 10-valent pneumococcal nontypeable Haemophilus influenzae (H. Influenzae) protein D conjugate vaccine (PHiD-CV), co-administered with routine childhood vaccines, were assessed in Taiwanese infants...
Etiology of community-acquired pneumonia in hospitalized children in northern TaiwanChih Jung Chen
Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, Taiwan
Pediatr Infect Dis J 31:e196-201. 2012..There has been no comprehensive study of the etiology of childhood community-acquired pneumonia (CAP), either in the pre- or postpneumococcal conjugate vaccine era, in Taiwan...
Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomesShih Cheng Chang
Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan
J Med Virol 84:931-9. 2012..Further studies of EV71 pathogenesis should examine the significance of genomic diversity and the effects of multiple mutations in a viral population...
Seroprevalence of human papillomavirus types 16 and 18 in the general population in Taiwan: implication for optimal age of human papillomavirus vaccinationChih Jung Chen
Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu Shin Street, Kweishan 333, Taoyuan, Taiwan
J Clin Virol 38:126-30. 2007..The optimal age for administration of recently approved prophylactic human papillomavirus (HPV) vaccines remains undetermined...
Prolonged fecal shedding of CTX-M-15-producing Escherichia coli and recurrent sepsis in a patient after cord blood stem-cell transplantationKuan Ying Huang
Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang GongChildren s Hospital, Taiwan
Scand J Infect Dis 41:224-7. 2009..The bla(CTX-M-15) is carried by a large plasmid of approximately 130 kb in size. The prolonged shedding of the highly resistant E. coli posed a great challenge to infection control and public health...
Molecular epidemiology and antimicrobial susceptibility of Salmonella enterica serotype Stanley isolates in TaiwanKuan Ying Huang
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
J Microbiol Immunol Infect 40:411-8. 2007..The present study was conducted to gain further understanding of the epidemiology and antimicrobial suseptibility of S. Stanley...
One-year post-primary antibody persistence and booster immune response to a fully liquid five-component acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccineTzou Yien Lin
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University Medicine, Taoyuan, Taipei, Taiwan
Int J Infect Dis 11:488-95. 2007....
Change in the molecular epidemiology of methicillin-resistant Staphylococcus aureus bloodstream infections in TaiwanChih Jung Chen
Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, 333, Taoyuan, Taiwan
Diagn Microbiol Infect Dis 65:199-201. 2009..Multiresistance might be one of the characteristics that could have contributed to its quick adaptation to hospital environments...
Translocation of coagulase-negative bacterial staphylococci in rats following intestinal ischemia-reperfusion injuryChih Cheng Luo
Departments of Pediatric Surgery and Pediatrics, Chang Gung Children s Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
Biol Neonate 85:151-4. 2004..Intact mucosa integrity readily prevented bacterial translocation; however, bacterial translocation could occur in rats following mild IRI in the presence of a higher number of CoNS in the gut...
Clinical manifestations, antibiotic susceptibility and molecular analysis of Mycobacterium kansasii isolates from a university hospital in TaiwanTing Shu Wu
Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Gueishan Shiang 33305, Taoyuan, Taiwan
J Antimicrob Chemother 64:511-4. 2009..The purpose of this study was to establish a relationship between the clinical treatment outcomes of M. kansasii infections and bacterial drug susceptibility, and their clonality...
Pseudogene recoding revealed from proteomic analysis of salmonella serovarsYe Feng
Genomics Research Center, Harbin Medical University, Harbin, PR China
J Proteome Res 11:1715-9. 2012..We believe that the phenomena of recoding are not rare in bacteria. More studies are required for a better understanding of bacterial translation and the implication of pseudogene recoding in Salmonella serovars...
Cutoff volume of dietary fiber to ameliorate constipation in childrenHsun Chin Chao
Division of Gastroenterology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
J Pediatr 153:45-9. 2008..To evaluate the proper ingested volume of dietary fiber for relieving constipation in children...
Genotyping and antimicrobial susceptibility of Salmonella enterica serotype Panama isolated in TaiwanHao Yuan Lee
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
J Microbiol Immunol Infect 41:507-12. 2008..The present study was undertaken to gain more understanding of the molecular epidemiology and antimicrobial resistance of Salmonella Panama...
Enterovirus 71 in Taiwan, 2004-2006: epidemiological and virological featuresKuan Ying Huang
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
Scand J Infect Dis 40:571-4. 2008..No obvious phylogenetically distinct clones or clusters were found related to varying degrees of disease severity or clinical manifestations...
Clinical features of echovirus 6 and 9 infections in childrenHao Yuan Lee
Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
J Clin Virol 49:175-9. 2010..Clinical features of echovirus 6 and 9 infections in children have not been comprehensively evaluated, particularly for sporadic cases...
The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and managementTzou Yien Lin
Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
Clin Infect Dis 34:S52-7. 2002..After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it...
Waning population immunity to measles in TaiwanChih Jung Chen
Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan
Vaccine 30:6721-7. 2012..The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older...
Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985-2010Wen I Lee
Primary Immunodeficiency Care and Research PICAR Institute, Chang Gung University College of Medicine and Chang Gung Memorial Hospital, Taoyuan, Taiwan
Immunobiology 216:1286-94. 2011..Awareness of under-diagnosis among physicians rather than pediatricians is vital for timely diagnosis and consequently adequate treatment...
High rate of reduced susceptibility to ciprofloxacin and ceftriaxone among nontyphoid Salmonella clinical isolates in AsiaHao Yuan Lee
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
Antimicrob Agents Chemother 53:2696-9. 2009..8%) and S. Virchow (75.0%) from all countries. Reduced susceptibility to ceftriaxone (MIC, 2 to 8 microg/ml) remained uncommon in Asia, except in Taiwan (38.0%) or in S. Typhimurium (25.0%) from all countries...
Seroprevalence and severity of 2009 pandemic influenza A H1N1 in TaiwanChih Jung Chen
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan
PLoS ONE 6:e24440. 2011..This study is to determine the seroprevalence of the pandemic influenza A H1N1 virus (pH1N1) in Taiwan before and after the 2009 pandemic, and to estimate the relative severity of pH1N1 infections among different age groups...
A multiplex polymerase chain reaction method for rapid identification of Citrobacter freundii and Salmonella species, including Salmonella TyphiChia Ling Lin
Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
J Microbiol Immunol Infect 40:222-6. 2007..We devised a polymerase chain reaction (PCR) method that simultaneously uses three pairs of specific primers to detect inv, spv, and via genes of Salmonella...
Seroprevalence of SARS Coronavirus Among Residents Near a Hospital with a Nosocomial OutbreakMing Han Tsai
Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taiwan
J Formos Med Assoc 107:885-91. 2008....
Antibiotic resistance patterns of community-acquired urinary tract infections in children with vesicoureteral reflux receiving prophylactic antibiotic therapyChi Hui Cheng
Department of Pediatrics, Chang Gung Children s Hospital, and Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Pediatrics 122:1212-7. 2008..The goal was to examine bacterial antimicrobial resistance of recurrent urinary tract infections in children receiving antibiotic prophylaxis because of primary vesicoureteral reflux...
Norovirus infection as a cause of diarrhea-associated benign infantile seizuresShih Yen Chen
Divisions of 1Pediatric Gastroenterology, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
Clin Infect Dis 48:849-55. 2009..Norovirus is a major cause of acute gastroenteritis in children. This study identified norovirus as an emerging agent causing convulsive disorder in children, particularly in young infants. Long-term neurological sequelae are uncommon...
Antimicrobial susceptibility of Shigella isolates in eight Asian countries, 2001-2004Chen Yen Kuo
Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
J Microbiol Immunol Infect 41:107-11. 2008..Because of increasing trends towards drug resistance, this study was undertaken to monitor local resistance patterns of Shigella isolates from 8 Asian countries...
National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: emergence of serotype 19A with high invasive potentialYu Chia Hsieh
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
Vaccine 27:5513-8. 2009..7% of cases in children aged <2 years. Among patients aged >or=65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed...
Nucleotide and amino acid sequences of oriT-traM-traJ-traY-traA-traL regions and mobilization of virulence plasmids of Salmonella enterica serovars enteritidis, gallinarum-pullorum, and typhimuriumChishih Chu
Department of Microbiology and Immunology, Chang Gung University College of Medicine, Taiwan
J Bacteriol 184:2857-62. 2002....
Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009Shih Hsuan Lo
Department of Pediatrics, Children s Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
J Microbiol Immunol Infect 44:252-7. 2011..This study is to define clinical manifestations and laboratory findings of Cox A6 infection in children...
Biofilm production, use of intravascular indwelling catheters and inappropriate antimicrobial therapy as predictors of fatality in Chryseobacterium meningosepticum bacteraemiaPen Yi Lin
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
Int J Antimicrob Agents 36:436-40. 2010..The outcome of patients with biofilm-forming C. meningosepticum infection was adversely affected by the choice of inappropriate antimicrobial therapy and the use of long-term indwelling intravascular catheters...
Implementation and outcomes of a hospital-wide computerised antimicrobial stewardship programme in a large medical centre in TaiwanYuk Ying Chan
Department of Pharmacy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
Int J Antimicrob Agents 38:486-92. 2011..HCAAS is a sustainable system for providing antibiotic stewardship and exerts a positive impact on the hospital by reducing antimicrobial consumption and expenditure whilst not compromising healthcare quality...
2009 Pandemic influenza H1N1: paediatric perspectivesHao Yuan Lee
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
Ann Acad Med Singapore 39:333-3. 2010..This paper reviews the underlying medical conditions associated with death or complications of pandemic H1N1 infection in children...
An epidemic of plasmids? Dissemination of extended-spectrum cephalosporinases among Salmonella and other EnterobacteriaceaeLin Hui Su
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
FEMS Immunol Med Microbiol 52:155-68. 2008....
Clinical analysis of computed tomography-staged orbital cellulitis in childrenChen Fang Ho
Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan
J Microbiol Immunol Infect 40:518-24. 2007..This study sought to delineate the clinical, bacteriological and radiological findings, management and outcome of orbital cellulitis...
A cluster of adenovirus serotype 3 infections in children in northern Taiwan: clinical features and laboratory findingsChien Hui Lin
Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Kweishan, Taoyuan, Taiwan
J Microbiol Immunol Infect 40:302-9. 2007..To define clinical manifestations and laboratory findings of adenovirus serotype 3 infections in children...
Multidrug resistant Acinetobacter baumannii: risk factors for appearance of imipenem resistant strains on patients formerly with susceptible strainsJung Jr Ye
Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taoyuan, Taiwan
PLoS ONE 5:e9947. 2010..The study was designed to identify the risk factors for appearance of IR-MDRAB on patients formerly with imipenem susceptible MDRAB (IS-MDRAB) and the impact on clinical outcomes...
Fulminant Clostridium septicum infection mimicking appendicitis in a healthy childYi Jung Chang
Division of Paediatric Critical Care and Emergency Medicine, Department of Paediatics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tauyuan, Taiwan
Ann Trop Paediatr 27:91-4. 2007..On the day after admission, shock, neutropenia and pneumoperitoneum prompted a laparotomy. Gangrene of the ileum and colon was identified, associated with a fatal Clostridium septicum infection...
Detection of multidrug-resistant Salmonella enterica serovar typhimurium phage types DT102, DT104, and U302 by multiplex PCRCheng-Hsun Chiu
Department of Pediatrics, Chang Gung Children's Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
J Clin Microbiol 44:2354-8. 2006..Nevertheless, the multiplex PCR devised in the present study appears to be efficient and useful in the rapid identification of ACSSuT-type serovar Typhimurium with SGI1, irrespective of their phage types...
Influenza-associated central nervous system dysfunction in Taiwanese children: clinical characteristics and outcomes with and without administration of oseltamivirYhu Chering Huang
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung Memorial Hospital, Kweishan, Taoyan, Taiwan
Pediatr Infect Dis J 28:647-8. 2009..Seventeen children received oseltamivir therapy after admission and no significant difference between administration of oseltamivir and outcome was observed (P = 0.1512 by Fisher exact test)...
Clinical and microbiological analysis of Elizabethkingia meningoseptica bacteremia in adult patients in TaiwanYi Tsung Lin
Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Scand J Infect Dis 41:628-34. 2009..meningoseptica bacteremia face poor prognoses, with shock and use of inappropriate antibiotics as the main risk factors for mortality. Further clinical study is needed to establish the optimal therapy for E. meningoseptica bacteremia...
In vivo acquisition of ceftriaxone resistance in Salmonella enterica serotype anatumLin-Hui Su
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Antimicrob Agents Chemother 47:563-7. 2003..The emergence of resistance to ceftriaxone in S. enterica serotype Anatum was due to the in vivo acquisition of a plasmid containing the bla(CTX-M-3) gene and was the cause for treatment failure in this patient...
Molecular epidemiology of Salmonella enterica serovar Enteritidis isolated in TaiwanLin-Hui Su
Department of Clinical Pathology, Chang Gung Memorial Hospital, Kweishan, 333, Taoyuan, Taiwan
Microbiol Immunol 46:833-40. 2002..Between the two, the latter, though less discriminatory than PFGE, seems the method of choice, since it is simpler, less time-consuming and above all easy to perform...
Increasing ceftriaxone resistance in Salmonella isolates from a university hospital in TaiwanLin-Hui Su
Department of Clinical Pathology, Lin-Kou Medical Center, Chang Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan
J Antimicrob Chemother 55:846-52. 2005..CONCLUSIONS: Increasing ceftriaxone resistance in non-typhoid Salmonella appears to link to the spread of plasmid-mediated ampC or ESBL genes. Effective measures should be taken to prevent the problem worsening...
Booster vaccination at 6-8 years of age with a reduced antigen content dTpa-IPV vaccine is immunogenic and safe after priming with whole-cell pertussis vaccineTzou Yien Lin
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
Hum Vaccin 4:50-3. 2008....
Reduced apoptosis in newborn compared to adult rat intestine after ischemia-reperfusion injuryChih Cheng Luo
Department of Pediatric Surgery, Chang Gung Children s Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan
Biol Neonate 85:90-3. 2004..We demonstrated that the activation of apoptosis occurred after intestinal I/R injury, especially during the reperfusion phase. The newborn intestine was more resistant to I/R injury and thus may have significant clinical application...
The role of Helicobacter pylori infection in children with acute immune thrombocytopenic purpuraTang Her Jaing
Division of Hematology Oncology, Chang Gung Children s Hospital, Taoyuan, Taiwan
Pediatr Blood Cancer 47:215-7. 2006..Our prospective cohort studies found no statistically significant relation between H. pylori infection and acute ITP. There is therefore no indication to screen children with presumed acute ITP for H. pylori infection...
Cutaneous lymphocytic vasculitis as the presenting feature of acute lymphoblastic leukemiaTang Her Jaing
Division of Hematology and Oncology, Chang Gung Children s Hospital, Taoyuan, Taiwan
J Pediatr Hematol Oncol 24:555-7. 2002..Lymphocytic vasculitis may also reflect a new manifestation of host-leukemia interaction...
Necrotizing pneumococcal pneumonia with bronchopleural fistula among children in TaiwanYu Chia Hsieh
Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
Pediatr Infect Dis J 30:740-4. 2011..Histopathologic features of children receiving surgical resections of the lung because of BPF were analyzed to explore the pathogenesis of destructive lung disease caused by Streptococcus pneumoniae...
Successful unrelated cord blood transplantation in a girl with malignant infantile osteopetrosisTang-Her Jaing
Divisions of Hematology/Oncology, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan, China
Chin Med J (Engl) 121:1245-6. 2008
Antimicrobial resistance in nontyphoid Salmonella serotypes: a global challengeLin-Hui Su
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Clin Infect Dis 39:546-51. 2004..Continued surveillance of antimicrobial resistance and use of antimicrobial agents in food animals is also indispensable...
Clinical features and genotyping analysis of community-acquired methicillin-resistant Staphylococcus aureus infections in Taiwanese childrenChih-Jung Chen
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang-Gung Children's Hospital, 5 Fu-Shin Street, 333, Taoyuan, Taiwan
Pediatr Infect Dis J 24:40-5. 2005..aureus infection, even community-acquired, a glycopeptide-containing regimen should be considered for initial empirical therapy in the case of serious infection...
Resistance to fluoroquinolones linked to gyrA and par C mutations and overexpression of acr AB efflux pump in Salmonella enterica serotype CholeraesuisChishih Chu
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan
Microb Drug Resist 11:248-53. 2005..Fluoroquinolone resistance in S. Choleraesuis appears to be the combination effect of multiple mutations in various target genes and overexpression of the Acr AB-TolC efflux pump...
Chlamydial pneumonia in children requiring hospitalization: effect of mixed infection on clinical outcomeMing Han Tsai
Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, Taoyuan, Taiwan
J Microbiol Immunol Infect 38:117-22. 2005..8%) among these patients. The clinical course of chlamydial pneumonia was not serious in most patients, but alertness is needed to the possibility of developing severe pneumonia in cases with bacterial coinfection...
Invasive pediatric Neisseria meningitidis infectionsPao Lan Tuan
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
J Microbiol Immunol Infect 42:427-32. 2009..However, the number of infections increased in 2001 and 2002. This study was performed to ascertain the epidemiology and clinical manifestations of infections caused by meningococcus in a pediatric population...
Characterization of a laboratory-derived, high-level ampicillin-resistant Salmonella enterica serovar Typhimurium strain that caused meningitis in an infantCheng-Hsun Chiu
Department of Pediatrics, Chang Gung Children's Hospital, Kweishan 333, Taoyuan, Taiwan
Antimicrob Agents Chemother 46:1604-6. 2002..This 3.2-kb plasmid was further characterized to be a nonconjugative pGEM series cloning vector containing a foreign insert. The strain was likely laboratory derived and contaminated the environment before it caused the infection...
Invasion of murine respiratory tract epithelial cells by Chryseobacterium meningosepticum and identification of genes present specifically in an invasive strainPen-Yi Lin
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan
New Microbiol 29:55-62. 2006..In most cases, the identities between the references and the amino acid sequences deduced were low, suggesting that the functions of these sequences remain unknown...
Hemolytic uremic syndrome associated with pneumococcal pneumonia in TaiwanYu-Hsuan Huang
Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, College of Medicine, 5, Fu Hsin Street, Taoyuan, Taiwan
Eur J Pediatr 165:332-5. 2006..The long-term prognosis for recovery of renal function appears to be good in these patients in northern Taiwan...
Dissemination of extended-spectrum beta-lactamase-producing Enterobacteriaceae in pediatric intensive care unitsTsu-Lan Wu
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
J Clin Microbiol 41:4836-8. 2003....
Neonatal enterovirus infections: emphasis on risk factors of severe and fatal infectionsTzou-Yien Lin
Division of Pediatric Infecti=ious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan
Pediatr Infect Dis J 22:889-94. 2003....
Duration of antimicrobial therapy for non-typhoid Salmonella bacteremia in healthy childrenMeng-Hsin Yen
Department of Pediatric Infectious Disease, Chang Gung Children's Hospital, Taoyuan, Taiwan, ROC
J Microbiol Immunol Infect 35:94-8. 2002....
Multidrug-resistant non-typhoid Salmonella infections in a medical centerChien-Yu Lee
Department of Pediatrics, Provincial Tao-Yuan Hospital, Taiwan, ROC
J Microbiol Immunol Infect 35:78-84. 2002..choleraesuis found in this study indicate the importance of judicious use of antimicrobial agents in both humans and animals to reduce the selection and spread of resistant strains...
Dissemination of extended-spectrum beta-lactamase-producing Enterobacteriaceae in intensive care units of a medical center in TaiwanTsu-Lan Wu
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Microb Drug Resist 12:203-9. 2006....
