Tse Ching Chen

Summary

Affiliation: Chang Gung University
Country: Taiwan

Publications

  1. ncbi Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan
    Cancer Lett 134:23-8. 1998
  2. ncbi p16INK4 gene mutation and allelic loss of chromosome 9p21-22 in Taiwanese hepatocellular carcinoma
    T C Chen
    Department of Pathology, Chang Gung University, Tao Yuan, Taiwan
    Anticancer Res 20:1621-6. 2000
  3. ncbi Follicular dendritic cell tumor of the liver: a clinicopathologic and Epstein-Barr virus study of two cases
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    Mod Pathol 14:354-60. 2001
  4. ncbi Intrahepatic cholangiocarcinoma with lymphoepithelioma-like component
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    Mod Pathol 14:527-32. 2001
  5. ncbi Hepatocellular carcinoma associated with focal nodular hyperplasia. Report of a case with clonal analysis
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, 5 Fu Shin Street, Kwei San, Tao Yuan, Taiwan
    Virchows Arch 438:408-11. 2001
  6. ncbi Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions
    Ta Sen Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Hepatology 42:657-64. 2005
  7. ncbi Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma
    Ta Sen Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Arch Surg 140:1184-90. 2005
  8. ncbi Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling
    Ing Tsung Hsiao
    Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan
    J Hepatol 52:540-9. 2010
  9. ncbi Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma
    Ya Hui Huang
    Department of Hepato Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e37188. 2012
  10. ncbi Large fragment pre-S deletion and high viral load independently predict hepatitis B relapse after liver transplantation
    Ting Jung Wu
    Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e32189. 2012

Collaborators

Detail Information

Publications38

  1. ncbi Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan
    Cancer Lett 134:23-8. 1998
    ..None of the cases showed a loss of heterozygosity at the APC and MCC gene loci. The results suggested that the possibility of APC and MCC as the gene defect in the genesis of human hepatocellular carcinoma may be very rare...
  2. ncbi p16INK4 gene mutation and allelic loss of chromosome 9p21-22 in Taiwanese hepatocellular carcinoma
    T C Chen
    Department of Pathology, Chang Gung University, Tao Yuan, Taiwan
    Anticancer Res 20:1621-6. 2000
    ..The p16INK4 (MTS1/CDNK2A) gene, located on chromosome 9p21, is an inhibitor of cyclin-dependent kinase 4. Various data have shown that it is frequently inactivated in several types of cell lines and primary human cancers...
  3. ncbi Follicular dendritic cell tumor of the liver: a clinicopathologic and Epstein-Barr virus study of two cases
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    Mod Pathol 14:354-60. 2001
    ..The unique clinicopathological features of our cases have not been reported for FDC tumors before. The clinical significance of the 30-bp deletion in Exon 3 of the LMP-1 gene in FDC tumor of the liver warrants further investigation...
  4. ncbi Intrahepatic cholangiocarcinoma with lymphoepithelioma-like component
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    Mod Pathol 14:527-32. 2001
    ..The clinical significance of 30-bp deletion in Exon 3 of the LMP-1 gene in lymphoepithelioma-like carcinoma of the liver warrants further investigation...
  5. ncbi Hepatocellular carcinoma associated with focal nodular hyperplasia. Report of a case with clonal analysis
    T C Chen
    Department of Pathology, Chang Gung Memorial Hospital, 5 Fu Shin Street, Kwei San, Tao Yuan, Taiwan
    Virchows Arch 438:408-11. 2001
    ..Therefore, the focal nodular hyperplasia and hepatocellular carcinoma probably derived from the clonal expansion of two different clones...
  6. ncbi Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions
    Ta Sen Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Hepatology 42:657-64. 2005
    ..Expression of CDX2 and MUC2 are helpful in differentiating IPNL and non-IG-ICC. Significant differences in survival associated with the various lesions studied warrants a more aggressive surgical strategy in their management...
  7. ncbi Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma
    Ta Sen Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Arch Surg 140:1184-90. 2005
    ..Pancreatic cystic neoplasms and ductal adenocarcinoma manifest diverse clinical features and prognoses, which might be related to cellular distribution of ezrin modulated through various trophic molecules...
  8. ncbi Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling
    Ing Tsung Hsiao
    Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan
    J Hepatol 52:540-9. 2010
    ..The efficacy of PVL on subjects with non-alcohol fatty liver disease (NAFLD) is largely unknown...
  9. ncbi Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma
    Ya Hui Huang
    Department of Hepato Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e37188. 2012
    ..Functional analysis of a miRNA predictor, miR-155, suggested that the prognostic miRNA predictors identified under this strategy could serve as potential molecular targets for anticancer therapy...
  10. ncbi Large fragment pre-S deletion and high viral load independently predict hepatitis B relapse after liver transplantation
    Ting Jung Wu
    Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e32189. 2012
    ..In conclusion, besides high viral load, LFpreSDel mutation is an important independent predictor for hepatitis B relapse after LT. More aggressive preventive strategies should be applied for patients carrying these risk factors...
  11. ncbi Aberrant expression of cdx2 homeobox gene in intraductal papillary-mucinous neoplasm of the pancreas but not in pancreatic ductal adenocarcinoma
    Ta Sen Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Pancreas 30:233-8. 2005
    ..The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma...
  12. ncbi The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells
    Li Yuan Chang
    College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    J Immunol 189:567-74. 2012
    ..In conclusion, these results indicate that the potent in vivo suppression ability of CD103(+) Tregs is due to the tissue-migration ability through CCR5 expression...
  13. ncbi Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatology 52:1922-33. 2010
    ..A short stretch pre-S deletion located between codons 107 and 141 was strongly associated with a poorer postoperative prognosis...
  14. ncbi Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts
    Ta Sen Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Ann Surg 244:248-53. 2006
    ..To propose a cholangiographic classification for intraductal growth type intrahepatic cholangiocarcinoma (IG-ICC) and its precursor, collectively termed intraductal papillary mucinous neoplasm of the bile ducts (IPMN-B)...
  15. ncbi Comparison of genomic signatures of non-small cell lung cancer recurrence between two microarray platforms
    John Wen Cheng Chang
    Division of Hematoloy Oncology, Genomic Medicine Research Core Lab, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC
    Anticancer Res 32:1259-65. 2012
    ..We compared the differential gene expression in non-small cell lung cancer (NSCLC) between two platforms in order to find the most relevant genomic signatures of tumor recurrence...
  16. ncbi Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    BMC Cancer 11:398. 2011
    ..Recent studies demonstrated an increased oncogenic potential of this mutant in NIH3T3 cells. In this study, we aimed to investigate the clinical significance of this finding...
  17. ncbi Genetic alterations of INK4alpha/ARF locus and p53 in human hepatocellular carcinoma
    Cheng Yuan Peng
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
    Anticancer Res 22:1265-71. 2002
    ..results suggest that p14(ARF), p16(INK4a) and p53 are differentially disrupted through distinct molecular mechanisms at different stages in HCC and that p14(ARF) and p53 appear to function in the same tumor suppression pathway in HCC..
  18. ncbi Peritumoral small ephrinA5 isoform level predicts the postoperative survival in hepatocellular carcinoma
    Tong Hong Wang
    Tissue Bank, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    PLoS ONE 7:e41749. 2012
    ..However, the role of ephrinA5S in hepato-carcinogenesis remains unclear. In this study, we evaluate the role of ephrinA5 isoforms in human hepatocellular carcinomas (HCC)...
  19. ncbi Expression of the HCRP1 mRNA in HCC as an independent predictor of disease-free survival after surgical resection
    Ming Wei Lai
    Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatol Res 39:164-76. 2009
    ..852; 95% CI, 1.131-3.032; P = 0.014) were included as independent predictors for disease-free survival. Conclusion: Expression of HCRP1 mRNA served as an independent predictor for postoperative disease-free survival in HCC patients...
  20. ncbi Overexpression of kappa-actin alters growth properties of hepatoma cells and predicts poor postoperative prognosis
    Kuei Wen Chang
    Department of Pediatric Gastroenterology, Chang Gung Children s Hospital, and Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC
    Anticancer Res 31:2037-44. 2011
    ..Here, we investigated the function of a novel class of actins, named κ-actins, in hepatocellular carcinoma (HCC)...
  21. ncbi Clinicopathological analysis of β-catenin and Axin-1 in solid pseudopapillary neoplasms of the pancreas
    Shih Chiang Huang
    Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan
    Ann Surg Oncol 19:S438-46. 2012
    ..In this study, we investigated the status of Axin-1, the spectrum of mutations in the CTNNB1 gene, and the clinicopathological features of SPNs...
  22. ncbi Encapsulation is a significant prognostic factor for better outcome in large hepatocellular carcinoma
    Tsung Han Wu
    Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University Medical School, Taoyuan, Taiwan
    J Surg Oncol 105:85-90. 2012
    ..The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival...
  23. ncbi Modified endoscopic submucosal dissection with enucleation for treatment of gastric subepithelial tumors originating from the muscularis propria layer
    Yin Yi Chu
    Department of Internal Medicine, Chang Gung University, Taoyuan, Taiwan
    BMC Gastroenterol 12:124. 2012
    ..The aim of this study is to demonstrate the feasibility of a modified ESD technique with enucleation for removal of gastric subepithelial tumors originating from the muscularis propria layer, and to evaluate its efficacy and safety...
  24. ncbi Hepatoid microcarcinoma of the pancreas: a case report and review of the literature
    Shih Chiang Huang
    Department of Pathology, Division of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 35:285-91. 2012
    ..The clinicopathological features of pancreatic hepatoid carcinomas and their histogenesis are discussed...
  25. ncbi Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin
    Ming Chin Yu
    Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan
    Ann Surg Oncol 19:S455-63. 2012
    ..Furthermore, the study for small HBV-HCC was limited. Therefore, the aim of this study was to explore the potential genetic signature for HBV-related small HCC as novel prognostic factors...
  26. ncbi Predictive factors for lymph node metastasis in early gastric cancer
    Chang Mu Sung
    Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China
    World J Gastroenterol 16:5252-6. 2010
    ..To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC)...
  27. ncbi Overexpression of cyclin-dependent kinase-associated protein phosphatase enhances cell proliferation in renal cancer cells
    Ming Wei Lai
    Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Urol Oncol 30:871-8. 2012
    ..The aim of this study was to understand the role of cyclin-dependent kinase-associated protein phosphatase (KAP) in renal cancer cell growth...
  28. ncbi K-ras mutation is strongly associated with perineural invasion and represents an independent prognostic factor of intrahepatic cholangiocarcinoma after hepatectomy
    Tse Ching Chen
    Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan
    Ann Surg Oncol 19:S675-81. 2012
    ..This study was designed to determine the prevalence of k-ras mutation and its clinical significance in ICC, as well as to pave the reference for future application of TKIs...
  29. ncbi EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability
    Tong Hong Wang
    Tissue Bank, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    FEBS J 279:251-63. 2012
    ..In conclusion, ephrinA5 inhibited colon cancer progression by promoting c-Cbl-mediated EGFR degradation. Our findings identify a novel mechanism that could be utilized to improve the therapeutic efficiency of EGFR-targeting strategies...
  30. ncbi A useful model to audit liver resolution from cirrhosis in rats using functional proteomics
    Erh Hao Liu
    Department of Surgery, Chang Gung Memorial Hospital, School of Traditional Chinese Medicine, Taipei, Taiwan
    J Surg Res 138:214-23. 2007
    ..We conducted a rat cirrhosis and recovery model, on the basis of which proteomics was used to audit liver resolution from cirrhosis...
  31. ncbi Secretome-based identification of ULBP2 as a novel serum marker for pancreatic cancer detection
    Ya Ting Chang
    Graduate Institute of Biomedical Sciences, Chang Gung University, Tao Yuan, Taiwan
    PLoS ONE 6:e20029. 2011
    ..UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues...
  32. ncbi Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung
    Chih Wei Wang
    Department of Anatomic Pathology, Chang Gung Memorial Hospital, 5, Fu Shin St, Kwei Shan, Tao Yuan 333, Taiwan
    Am J Clin Pathol 131:715-22. 2009
    ..p16 is a useful marker for the discrimination between cervical and pulmonary SCCs. The performance of p16 staining at different cutoff values was also compared...
  33. ncbi CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection
    Chau Ting Yeh
    Liver Research Unit, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    BMC Cancer 9:324. 2009
    ..The aim of this study was to investigate the significance of CD133 expression in HCC in an area endemic for hepatitis B virus (HBV) infection to gain insights on this issue...
  34. ncbi SLC25A13 gene mutations in Taiwanese patients with non-viral hepatocellular carcinoma
    Kuei Wen Chang
    Department of Pediatrics, Chang Gung Memorial Hospital, Taipei, Taiwan
    Mol Genet Metab 103:293-6. 2011
    ..No significant differences in patient characteristics were observed. Further analyses of patients with SLC25A13 gene mutations may elucidate the relationship between the citrin gene and susceptibility of HCC...
  35. ncbi Direct peroral cholangioscopy and pancreatoscopy for diagnosis of a pancreatobiliary fistula caused by an intraductal papillary mucinous neoplasm of the pancreas: a case report
    Kai Feng Sung
    Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    Dig Endosc 23:247-50. 2011
    ..In conclusion, direct peroral cholangioscopy and pancreatoscopy using the ultra-slim endoscope is an efficient tool for diagnosis of PB fistula and pancreatic IPMN...
  36. ncbi Tumor-derived chemokine CCL5 enhances TGF-β-mediated killing of CD8(+) T cells in colon cancer by T-regulatory cells
    Li Yuan Chang
    Graduate Institute of Biomedical Sciences, Chang Gung University, Taiwan
    Cancer Res 72:1092-102. 2012
    ..Together, our findings establish that CCL5/CCR5 signaling recruits T(reg) to tumors and enhances their ability to kill antitumor CD8(+) T cells, thereby defining a novel mechanism of immune escape in colorectal cancer...
  37. ncbi Improved hepatocyte function of future liver remnant of cirrhotic rats after portal vein ligation: a bonus other than volume shifting
    Kun Ju Lin
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Surgery 145:202-11. 2009
    ..However, the alterations of histologic architecture and hepatocyte function of future liver remnant (FLR) remain unexplored...
  38. ncbi New sarcomatoid cancer cell line SAR-HCV established from a hepatitis C virus-related liver tumour lesion
    Dar In Tai
    Liver Unit, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC
    Anticancer Res 31:129-37. 2011
    ..This cell line will be useful in further studying hepato-sarcomatoid carcinoma cells and in understanding carcinogenesis and epithelial-mesenchymal transition in hepatitis C virus-related liver tumour...