Shang Der Chen


Affiliation: Chang Gung Memorial Hospital
Country: Taiwan


  1. Chuang Y, Chen S, Hsu C, Chen S, Chen N, Jou S. Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway. Int J Mol Sci. 2019;20: pubmed publisher
    ..These results suggest that resveratrol plays a pivotal role in the mitochondrial biogenesis machinery that may provide a protective mechanism counteracting seizure-induced neuronal damage by activation of the PGC-1α signaling pathway. ..
  2. Chen S, Yang J, Hwang W, Yang D. Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond. Int J Mol Sci. 2018;19: pubmed publisher
    ..A thorough understanding of the protective mechanisms elicited by Shh may provide a rationale to design innovative therapeutic regimens for various neurodegenerative diseases. ..
  3. Yang J, Mukda S, Chen S. Diverse roles of mitochondria in ischemic stroke. Redox Biol. 2018;16:263-275 pubmed publisher
    ..A better understanding of the roles of mitochondria in ischemia-related neuronal death and protection may provide a rationale for the development of innovative therapeutic regimens for ischemic stroke and other stroke syndromes. ..
  4. Chen S, Wu C, Hwang W, Yang D. More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy. Int J Mol Sci. 2017;18: pubmed publisher
    ..Delineation of the protective signaling pathways elicited by BDNF would endow a rationale to develop novel therapeutic regimens to halt or prevent the progression of neurodegeneration. ..
  5. Yang J, Chen W, Chen S. The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders. Int J Mol Sci. 2017;18: pubmed publisher
    ..The purpose of this article is to provide new insight, from the aspect of DNA damage and repair, for studying potential treatments in neurodegenerative diseases. ..
  6. Lin T, Cheng C, Chen S, Liou C, Huang C, Chuang Y. Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats. Int J Mol Sci. 2012;13:8722-39 pubmed publisher
  7. Chen Y, Chen S, Wu C, Huang S, Yang D. Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture. Exp Neurol. 2014;253:63-71 pubmed publisher
    ..Inhibition of autophagy by bafilomycin A1 also enhanced A? neurotoxicity. Together, these results indicate that sestrin2 induced by A? plays a protective role against A? neurotoxicity through, at least in part, regulation of autophagy. ..
  8. Chen S, Lin T, Yang D, Lee S, Shaw F, Liou C, et al. Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury. Biochem Biophys Res Commun. 2015;460:397-403 pubmed publisher
    ..These findings indicated that PINK1 is an endogenous protective mediator vital for neuronal survival under ischemic insult through regulating Drp1 phosphorylation at Ser616. ..
  9. Chuang Y, Lin T, Yang D, Yang J, Liou C, Chen S. Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats. J Biomed Sci. 2016;23:44 pubmed publisher
    ..PPAR? agonist, through PPAR?-dependent mechanism and via decreasing p-Drp1(Ser616) expression, can exert anti-oxidative and anti-apoptotic effects against ischemic neuronal injury. ..

More Information


  1. Chuang Y, Yang J, Yang D, Lin T, Liou C, Chen S. Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury. Int J Mol Sci. 2015;16:26406-16 pubmed publisher
    ..Together these findings indicated that TGI-induced sestrin2 expression contributed to RpS6 phosphorylation and neuroprotection against ischemic injury in the hippocampal CA1 subfield. ..