Wen Neng Chang


Country: Taiwan


  1. Tsai W, Lien C, Lee J, Hsiao W, Huang C, Tsai N, et al. The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: a hospital-based study. BMC Geriatr. 2019;19:91 pubmed publisher
    ..This study is limited by the small number of patients, and further large-scale studies are needed to better delineate this specific infectious syndrome. ..
  2. Lee J, Tsai M, Lien C, Huang Y, Chang W. Intra-family phenotype variations in familial neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2019;30:57-62 pubmed publisher
    ..For better delineation of the intra-familial phenotype variations in familial NMO spectrum disorder, further large-scale studies are needed. ..
  3. Tsai W, Lien C, Lee J, Lin W, Hsu C, Huang C, et al. The prognostic factors of HIV-negative adult cryptococcal meningitis with a focus on cranial MRI-based neuroimaging findings. J Clin Neurosci. 2018;55:57-61 pubmed publisher
  4. Lien C, Lee J, Chien C, Huang C, Lu C, Chang W. Clinical characteristics of Citrobacter meningitis in adults: High incidence in patients with a postneurosurgical state and strains not susceptible to third-generation cephalosporins. J Clin Neurosci. 2018;54:83-87 pubmed publisher
    ..3% (2/6) and 66.7% (4/6) were not susceptible to ceftazidime or ceftriaxone, respectively, but they were all susceptible to carbapenem. The therapeutic results showed a mortality rate of 21.4% (3/14). ..
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    Chang W, Lu C, Chang H, Lui C, Tsai N, Huang C, et al. Time course of cerebral hemodynamics in cryptococcal meningitis in HIV-negative adults. Eur J Neurol. 2007;14:770-6 pubmed
    ..However, because of the limited case numbers for this study, further large-scale studies are needed to delineate the clinical characteristics and therapeutic influence of cerebrovascular insults in HIV-negative CM patients. ..
  6. Chang W, Lu C, Huang C, Chuang Y, Tsai N, Chen S, et al. Cerebrospinal fluid 14-3-3-gamma protein level in eight HIV-negative cryptococcal meningitis adults. Eur J Neurol. 2008;15:428-30 pubmed publisher
    ..Significant neurologic deficits were shown in 60% (3/5) of the survivors. This study revealed that HIV-negative CM patients have elevated CSF 14-3-3-gamma protein levels, and that this level is not changed with a short-term treatment. ..
  7. Tsai T, Lu C, Wallace C, Chang W, Chen S, Huang C, et al. Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial. Crit Care. 2015;19:49 pubmed publisher
    ..04). EPO therapy significantly improved long-term neurological outcomes in patients after IS. ISRCTN71371114 . Registered 10 October 2008. ..
  8. Chang W, Lu C, Huang C, Tsai N, Chuang Y, Chang C, et al. Changing epidemiology of adult bacterial meningitis in southern taiwan: a hospital-based study. Infection. 2008;36:15-22 pubmed publisher
    ..Clinicians should pay greater attention to these changes, which may affect their management of ABM. ..
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    Chang W, Lu C, Huang C, Chuang Y, Tsai N, Chen S, et al. Epidemiology of adult staphylococcal meningitis in southern Taiwan: a clinical comparison of Staphylococcus aureus infection and coagulase-negative staphylococcal infection. Jpn J Infect Dis. 2007;60:262-6 pubmed
    ..This study revealed an increase of methicillin-resistant, postneurosurgical staphylococcal infection in ABM. Patients with CoNS infection had a younger age at onset and a lower mortality rate. ..

More Information


  1. Lien C, Huang C, Tsai W, Hsu C, Tsai N, Chang C, et al. Epidemiologic trend of adult bacterial meningitis in southern Taiwan (2006-2015). J Clin Neurosci. 2017;42:59-65 pubmed publisher
    ..This study revealed a change in the epidemiologic trend of ABM and the study results may offer important information for clinicians managing patients with ABM. ..
  2. Huang C, Lien C, Tsai W, Lai W, Hsu C, Tsai N, et al. The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: A clinical comparison with Ps. aeruginosa meningitis. Kaohsiung J Med Sci. 2018;34:49-55 pubmed publisher
    ..Even though the cases with NPAP ABM had better therapeutic results than those with Ps. aeruginosa ABM, further large-scale studies are needed to better delineate this specific group of ABM. ..
  3. Lee J, Lien C, Chien C, Huang C, Tsai N, Chang C, et al. Anaerobic bacterial meningitis in adults. J Clin Neurosci. 2018;50:45-50 pubmed publisher
    ..These results may offer a preliminary view of the clinical characteristics of anaerobic ABM. ..
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    Chang W, Lu C. Diagnosis and management of adult bacterial meningitis. Acta Neurol Taiwan. 2009;18:3-13 pubmed
    ..This review may help first-line, primary-care neurologists have a better view on handling this critical central nervous system infection...
  5. Su Y, Cheng T, Chen C, Chang W, Tsai N, Kung C, et al. Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic Lupus erythematosus. J Transl Med. 2014;12:303 pubmed publisher
    ..05). The disease activity of SLE is positively associated with APO2.7 level of CD19+ cells but negatively associated with MAVS and caspase-9 levels, which all point to a mitochondrial pathway. ..