Huang H, Chang H, Tsai M, Chen J, Wang M. 6-Mercaptopurine attenuates tumor necrosis factor-? production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation. J Neuroinflammation. 2016;13:78 pubmed publisher
..These results suggest that 6-MP might have a therapeutic potential in neuroinflammation-related neurodegenerative disorders through downregulation of microglia-mediated inflammatory processes. ..
Wang M, Lin S, Kuo J, Huang H, Tzeng S, Liao C, et al. Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation. J Immunol. 2007;179:6204-14 pubmed
..These results suggest that endogenous UCN and its receptors might be involved in a complex network of paracrine interaction between dopaminergic neurons and glia. ..
Wang M, Huang H, Chen W, Chang H, Kuo J. Glycogen synthase kinase-3? inactivation inhibits tumor necrosis factor-? production in microglia by modulating nuclear factor ?B and MLK3/JNK signaling cascades. J Neuroinflammation. 2010;7:99 pubmed publisher
..These results suggest that inactivation of GSK-3? might represent a potential strategy to downregulate microglia-mediated inflammatory processes. ..