Pauline H Yen

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. pmc DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts
    Hsiang Ying Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan and Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Nucleic Acids Res 41:9858-69. 2013
  2. pmc Differential translation of Dazap1 transcripts during spermatogenesis
    Chi Kai Yang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 8:e60873. 2013
  3. ncbi request reprint Putative biological functions of the DAZ family
    Pauline H Yen
    Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA, USA
    Int J Androl 27:125-9. 2004
  4. pmc DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice
    Lea Chia Ling Hsu
    1Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan
    RNA 14:1814-22. 2008
  5. ncbi request reprint Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan
    Yi Wen Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Hum Mutat 28:486-94. 2007
  6. pmc Evolution of the DAZ gene and the AZFc region on primate Y chromosomes
    Yueh Hsiang Yu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    BMC Evol Biol 8:96. 2008
  7. ncbi request reprint Key apoptotic pathways for heat-induced programmed germ cell death in the testis
    Amiya P Sinha Hikim
    Division of Endocrinology, Department of Medicine, Harbor University of California Los Angeles Medical Center, Box 446, 1000 West Carson Street, Torrance, CA 90509, USA
    Endocrinology 144:3167-75. 2003
  8. ncbi request reprint Deciphering the pathways of germ cell apoptosis in the testis
    Amiya P Sinha Hikim
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Box 446, 1000W Carson Street, Torrance, CA 90509, USA
    J Steroid Biochem Mol Biol 85:175-82. 2003
  9. pmc A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein
    Yi Tzu Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    RNA 12:1486-93. 2006
  10. ncbi request reprint A two-step protocol for the detection of rearrangements at the AZFc region on the human Y chromosome
    Y W Lin
    Graduate Institute of Life Sciences, National Defense Medical Center and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Hum Reprod 12:347-51. 2006

Collaborators

Detail Information

Publications16

  1. pmc DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts
    Hsiang Ying Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan and Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Nucleic Acids Res 41:9858-69. 2013
    ..Aberrant splicing of the Pot1a gene, which encodes an essential protein that protects telomere integrity, may partially account for the growth retardation phenotype of DAZAP1-deficient mice. ..
  2. pmc Differential translation of Dazap1 transcripts during spermatogenesis
    Chi Kai Yang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 8:e60873. 2013
    ..In summary, our study shows that the translation of the two Dazap1 transcripts is differentially regulated. It also provides a new example of translational repression associated with poly(A) tail elongation during spermatogenesis...
  3. ncbi request reprint Putative biological functions of the DAZ family
    Pauline H Yen
    Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA, USA
    Int J Androl 27:125-9. 2004
    ..Their downstream RNA targets remain largely unknown, although members of the CDC25 gene family are potential candidates...
  4. pmc DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice
    Lea Chia Ling Hsu
    1Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan
    RNA 14:1814-22. 2008
    ..The phenotypes of Dazap1 mutant mice indicate that DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice...
  5. ncbi request reprint Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan
    Yi Wen Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Hum Mutat 28:486-94. 2007
    ....
  6. pmc Evolution of the DAZ gene and the AZFc region on primate Y chromosomes
    Yueh Hsiang Yu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    BMC Evol Biol 8:96. 2008
    ..We used Southern analyses to study the evolution of DAZ and AZFc amplicons on the Y chromosomes of primates...
  7. ncbi request reprint Key apoptotic pathways for heat-induced programmed germ cell death in the testis
    Amiya P Sinha Hikim
    Division of Endocrinology, Department of Medicine, Harbor University of California Los Angeles Medical Center, Box 446, 1000 West Carson Street, Torrance, CA 90509, USA
    Endocrinology 144:3167-75. 2003
    ..Taken together, these results demonstrate that the mitochondria- and possibly also endoplasmic reticulum-dependent pathways are the key apoptotic pathways for heat-induced germ cell death in the testis...
  8. ncbi request reprint Deciphering the pathways of germ cell apoptosis in the testis
    Amiya P Sinha Hikim
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Box 446, 1000W Carson Street, Torrance, CA 90509, USA
    J Steroid Biochem Mol Biol 85:175-82. 2003
    ..Taken together, these results demonstrate that the mitochondria- and possibly also ER-dependent pathways are the key apoptotic pathways for heat induced germ cell death in the testis...
  9. pmc A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein
    Yi Tzu Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    RNA 12:1486-93. 2006
    ..DAZAP1 colocalizes with hnRNP A1 and hnRNP C1 in the nucleus and is a component of the heterogeneous nuclear ribonucleoprotein particles. Our results suggest that DAZAP1 plays a key role in mRNA transport during spermatogenesis...
  10. ncbi request reprint A two-step protocol for the detection of rearrangements at the AZFc region on the human Y chromosome
    Y W Lin
    Graduate Institute of Life Sciences, National Defense Medical Center and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Hum Reprod 12:347-51. 2006
    ..It offers a simple and reliable way to screen large populations for AZFc rearrangements and study their effects on male fertility...
  11. pmc Mouse sperm acquire a new structure on the apical hook during epididymal maturation
    Yi Wen Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, China
    Asian J Androl 15:523-8. 2013
    ..Our EM images of epididymal sperm also revealed additional novel structures as well as lateral asymmetry of the sperm head, indicating that mouse sperm head has a structure more complex than previously recognized...
  12. doi request reprint Transcription-dependent nuclear localization of DAZAP1 requires an N-terminal signal
    Yi Tzu Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Biochem Biophys Res Commun 428:422-6. 2012
    ..In addition, using a yeast two-hybrid system, we have identified SLIRP as a N42-binding protein which may regulate DAZAP1 subcellular localization...
  13. doi request reprint TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP
    Yueh Hsiang Yu
    Graduate Institute of Life Sciences, National Defense Medical Center, Academia Sinica, Taipei 11529, Taiwan
    Mol Endocrinol 26:630-42. 2012
    ..The negative effect of TEX11 on cell proliferation suggests that increased expression of TEX11 in the germ cells may partially contribute to the spermatogenic defect observed in KS patients...
  14. ncbi request reprint Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation
    Yanira Vera
    Division of Medical Genetics, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California 90502 2064, USA
    J Androl 23:622-8. 2002
    ..The subcellular distribution of DAZAP1 suggests that it shuttles between the nucleus and the cytoplasm and may play a role in mRNA transport and/or localization...
  15. ncbi request reprint Polymorphisms associated with the DAZ genes on the human Y chromosome
    Yi Wen Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Genomics 86:431-8. 2005
    ..Additional polymorphisms identified within the DAZ repeat regions of the DAZ genes indicate that sister chromatid exchange plays a significant role in the genesis of deletions, duplications, and polymorphisms of the Y chromosome...
  16. pmc Restricted expression of the human DAZ protein in premeiotic germ cells
    William J Huang
    Department of Urology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Hum Reprod 23:1280-9. 2008
    ..Most men have four DAZ genes encoding protein isoforms that differ significantly in size. However, published western blots showed only a single "DAZ" band, raising the possibility that not all four DAZ genes are expressed...