Chi Huey Wong
Affiliation: Academia Sinica
Shie J, Liu Y, Hsiao J, Fang J, Wong C. A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells. Chem Commun (Camb). 2017;53:1490-1493 pubmed publisher
..This probe is cell-permeable and generates fluorescence after triazole formation, thus minimizing the background signal and enabling the real-time intracellular imaging of glycoconjugate trafficking. ..
Tseng Y, Wu C, Liu M, Chen T, Chiang W, Yu Y, et al
. Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
..This study provides a simple and practical procedure to enhance the cross-strain protection of influenza vaccine by removing the outer part of glycans from the virus surface through modifications of the current egg-based process. ..
Lin C, Tsai M, Li S, Tsai T, Chu K, Liu Y, et al
. A common glycan structure on immunoglobulin G for enhancement of effector functions. Proc Natl Acad Sci U S A. 2015;112:10611-6 pubmed publisher
Chen J, Chen C, Ku K, Hsiao M, Chiang C, Hsu T, et al
. Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response. Proc Natl Acad Sci U S A. 2015;112:13057-62 pubmed publisher
Chuang P, Hsiao M, Hsu T, Chang C, Wu C, Chen B, et al
. Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer. Proc Natl Acad Sci U S A. 2019;116:3518-3523 pubmed publisher
Cheng C, Zhou Y, Pan W, Dey S, Wu C, Hsu W, et al
. Hierarchical and programmable one-pot synthesis of oligosaccharides. Nat Commun. 2018;9:5202 pubmed publisher
..This advanced programmable one-pot method provides potential synthetic solutions for complex glycans with four successful examples demonstrated in this work. ..
Wang S, Liao H, Zhang J, Cheng T, Wong C. Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris. Virology. 2019;526:125-137 pubmed publisher
Wang X, Krasnova L, Wu K, Wu W, Cheng T, Wong C. Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor. Bioorg Med Chem Lett. 2018;28:2708-2712 pubmed publisher
..Compound 2b showed 70% inhibition of transglycosylase from Acinetobacter baumannii, providing a basis for further improvement. ..
Lo P, Shie J, Chen C, Wu C, Hsu T, Wong C. O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2. Proc Natl Acad Sci U S A. 2018;115:7302-7307 pubmed publisher
..Our results show the effect of individual O-GlcNAcylation sites on the function of EZH2 and suggest an alternative approach to tumor suppression through selective inhibition of EZH2 O-GlcNAcylation. ..