Woan Yuh Tarn

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. ncbi request reprint RBM4 promotes neuronal differentiation and neurite outgrowth via modulating Numb isoform expression
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Biol Cell . 2016
  2. pmc Alternative splicing and bioinformatic analysis of human U12-type introns
    Wen Cheng Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan
    Nucleic Acids Res 35:1833-41. 2007
  3. ncbi request reprint The current understanding of Ded1p/DDX3 homologs from yeast to human
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
    RNA Biol 6:17-20. 2009
  4. pmc Translational control of cyclins
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei 11529, Taiwan
    Cell Div 6:5. 2011
  5. ncbi request reprint Cellular signals modulate alternative splicing
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei, 11529, Taiwan
    J Biomed Sci 14:517-22. 2007
  6. pmc A novel splicing regulator shares a nuclear import pathway with SR proteins
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    EMBO J 22:1359-69. 2003
  7. ncbi request reprint Phosphorylation of Y14 modulates its interaction with proteins involved in mRNA metabolism and influences its methylation
    Ia Wen Hsu
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 280:34507-12. 2005
  8. ncbi request reprint Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 279:31745-9. 2004
  9. pmc Phylogenetic and molecular characterization of the splicing factor RBM4
    Chia Chen Lu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    PLoS ONE 8:e59092. 2013
  10. pmc Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1
    Chin Li
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Cell Biol 23:7363-76. 2003

Collaborators

Detail Information

Publications40

  1. ncbi request reprint RBM4 promotes neuronal differentiation and neurite outgrowth via modulating Numb isoform expression
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Biol Cell . 2016
    ..Therefore, our findings indicate that RBM4 modulates exon selection ofNumbto generate isoforms that promote neuronal cell differentiation and neurite outgrowth...
  2. pmc Alternative splicing and bioinformatic analysis of human U12-type introns
    Wen Cheng Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan
    Nucleic Acids Res 35:1833-41. 2007
    ..We finally discuss the potential effects of splicing of a U12-type intron with genetic defects or within a set of genes encoding RNA processing factors on global gene expression...
  3. ncbi request reprint The current understanding of Ded1p/DDX3 homologs from yeast to human
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
    RNA Biol 6:17-20. 2009
    ..Here, we review these findings and particularly discuss the functional aspects of Ded1p/DDX3 in translation control...
  4. pmc Translational control of cyclins
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei 11529, Taiwan
    Cell Div 6:5. 2011
    ..This review will summarize translational control of cyclins and its influence on cell cycle progression...
  5. ncbi request reprint Cellular signals modulate alternative splicing
    Woan Yuh Tarn
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei, 11529, Taiwan
    J Biomed Sci 14:517-22. 2007
    ..Nevertheless, further intensive investigation will be needed to fully understand the intricacies of signal-mediated alternative splicing control...
  6. pmc A novel splicing regulator shares a nuclear import pathway with SR proteins
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    EMBO J 22:1359-69. 2003
    ..Thus, a novel splicing regulator with opposite activities to SR proteins shares an identical import pathway with SR proteins to the nucleus...
  7. ncbi request reprint Phosphorylation of Y14 modulates its interaction with proteins involved in mRNA metabolism and influences its methylation
    Ia Wen Hsu
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 280:34507-12. 2005
    ..This study reveals antagonistic post-translational modifications of Y14 that may be involved in the remodeling of Y14-containing mRNPs...
  8. ncbi request reprint Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 279:31745-9. 2004
    ..Thus, the phosphorylation state of RS domains may modulate the function of mammalian shuttling SR proteins during mRNA maturation or export...
  9. pmc Phylogenetic and molecular characterization of the splicing factor RBM4
    Chia Chen Lu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    PLoS ONE 8:e59092. 2013
    ..This study offers a first clue to functional evolution of a splicing factor...
  10. pmc Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1
    Chin Li
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Cell Biol 23:7363-76. 2003
    ..Therefore, Pnn may participate, via its interaction with RNPS1, in mRNA metabolism in the nucleus, including mRNA splicing and export...
  11. pmc The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo
    Kai Ti Lin
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Rd, Section 2, Nankang, Taipei 11529, Taiwan
    Mol Cell Biol 24:9176-85. 2004
    ..Our results suggest an essential role of WW/FF domain-containing factors in pre-mRNA splicing that likely occurs in concert with transcription in vivo...
  12. pmc The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation
    Tzu Wei Chuang
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan
    Mol Biol Cell 24:1-13. 2013
    ....
  13. pmc Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei 11529, Taiwan
    Mol Cell Biol 25:10111-21. 2005
    ..This study suggests a possible mechanism underlying the regulated alternative splicing of alpha-TM by the antagonistic splicing regulators RBM4 and PTB...
  14. pmc RBM4 promotes pancreas cell differentiation and insulin expression
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Cell Biol 33:319-27. 2013
    ..These results suggest that RBM4 may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation...
  15. pmc TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation
    Kuo Ming Lee
    Institute of Biomedical Sciences, Academia Sinica, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nucleic Acids Res 38:3340-50. 2010
    ..Moreover, TRAP150 activates pre-mRNA splicing and induces mRNA degradation by its separable functional domains. Therefore, TRAP150 represents a multi-functional protein involved in nuclear mRNA metabolism...
  16. pmc RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan
    J Cell Biol 193:509-20. 2011
    ....
  17. pmc TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing
    Jayarama Krishnan Bose
    Institute of Molecular Medicine, National Taiwan University, Taipei 106, Taiwan
    J Biol Chem 283:28852-9. 2008
    ..Our data further evidence TDP-43 as a multifunctional RNA-binding protein for a diverse set of cellular activities...
  18. pmc RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:34658-65. 2009
    ..Altogether, our results suggest that RBM4 translocates to the cytoplasm and participates in translation suppression during muscle cell differentiation...
  19. pmc BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing
    Po Han Chen
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    RNA 19:208-18. 2013
    ..In summary, Drosophila and human BCAS2 share a similar function in RNA splicing, which affects cell viability...
  20. pmc The exon junction complex component Y14 modulates the activity of the methylosome in biogenesis of spliceosomal small nuclear ribonucleoproteins
    Tzu Wei Chuang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 286:8722-8. 2011
    ..We hypothesize that Y14 provides a regulatory link between pre-mRNA splicing and snRNP biogenesis...
  21. pmc Differential effects of hyperphosphorylation on splicing factor SRp55
    Ming Chih Lai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Biochem J 371:937-45. 2003
    ..We report for the first time that SRp55 can be hyperphosphorylated under different circumstances whereby its fate is differentially influenced...
  22. pmc DDX3 regulates cell growth through translational control of cyclin E1
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei 11529, Taiwan
    Mol Cell Biol 30:5444-53. 2010
    ..Taken together, our results indicate that DDX3 is critical for translation of cyclin E1 mRNA, which provides an alternative mechanism for regulating cyclin E1 expression during the cell cycle...
  23. pmc Alanine repeats influence protein localization in splicing speckles and paraspeckles
    Shuo Hsiu Chang
    Program in Molecular Medicine, National Yang Ming University and Academia Sinica, Taipei, Taiwan Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
    Nucleic Acids Res 42:13788-98. 2014
    ..Our results indicate that the alanine-rich CAD, in conjunction with its conjoined RNA-binding domain(s), differentially influences the subnuclear localization and biogenesis of RBM4 and CoAZ. ..
  24. pmc hnRNP Q regulates Cdc42-mediated neuronal morphogenesis
    Hung Hsi Chen
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Cell Biol 32:2224-38. 2012
    ..Together, our results suggest that hnRNP Q1 may participate in localization of mRNAs encoding Cdc42 signaling factors in neurites, and thereby may regulate actin dynamics and control neuronal morphogenesis...
  25. ncbi request reprint Alternative splicing of U12-type introns
    Wen Cheng Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Front Biosci 13:1681-90. 2008
    ..Moreover, we propose possible roles for U12-type introns in a wide range of gene regulation through splicing regulation...
  26. doi request reprint Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization
    Tsui Yi Peng
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
    FEBS J 275:4152-63. 2008
    ..Taken together, phosphorylation of the severe acute respiratory syndrome-CoV nucleocapsid protein modulates its activity in translation control and also interferes with its oligomerization and aggregation in stress granules...
  27. pmc Wobble splicing reveals the role of the branch point sequence-to-NAGNAG region in 3' tandem splice site selection
    Kuo Wang Tsai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Mol Cell Biol 27:5835-48. 2007
    ..We conclude that the NAGNAG motif and its upstream region to the branch point sequence are required for 3' tandem splice site selection...
  28. pmc Cell stress modulates the function of splicing regulatory protein RBM4 in translation control
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Proc Natl Acad Sci U S A 104:2235-40. 2007
    ....
  29. ncbi request reprint Multiple roles of RBM4 in muscle cell differentiation
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
    Front Biosci (Schol Ed) 4:181-9. 2012
    ..Overexpression of RBM4 promotes muscle cell differentiation, suggesting that RBM4 acts as a positive myogenic regulator. In this review, we discuss recent data regarding how RBM4...
  30. ncbi request reprint A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement
    Tzu Wei Chuang
    Academia Sinica, Taiwan
    J Biol Chem . 2016
    ..These results reveal a residue of Y14 that confers cap-binding activity and is essential for Y14-mediated enhancement of translation. Finally, we demonstrated that Y14 may selectively and differentially modulate protein biosynthesis...
  31. pmc The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Mol Biol Cell 19:3847-58. 2008
    ..Given that the DDX3 RNA helicase activity is essential for its involvement in translation, we suggest that DDX3 facilitates translation by resolving secondary structures of the 5'-untranslated region in mRNAs during ribosome scanning...
  32. doi request reprint Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation
    Ming Chih Lai
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    FEBS J 276:1517-26. 2009
    ..We review our current understanding of the interplay between virus and host in post-transcriptional regulation of gene expression via RS domain-containing proteins...
  33. pmc Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events
    Jung Chun Lin
    School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 110, Taipei, Taiwan
    RNA 20:1621-31. 2014
    ..These findings suggest that the splicing events regulated by the SRPK1-RMB4 network may contribute to tumorigenesis through altered sensitivity to apoptotic signals in breast cancer cells. ..
  34. pmc miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans
    Pai Sheng Chen
    Laboratory of Molecular and Cellular Toxicology, Institute of Toxicology, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Invest 121:3442-55. 2011
    ..Altogether, we have identified an oncogenic role for miR-107 and provide evidence of a transregulational interaction among miRNAs in human cancer development...
  35. pmc Function and pathological implications of exon junction complex factor Y14
    Tzu Wei Chuang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Biomolecules 5:343-55. 2015
    ..Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles. ..
  36. pmc TRAP150 activates splicing in composite terminal exons
    Kuo Ming Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Nucleic Acids Res 42:12822-32. 2014
    ..Together, these results indicate that TRAP150 provides an additional layer of PCPA regulation, through which it may increase the diversity of abortive RNA transcripts under conditions of compromised gene expression. ..
  37. pmc The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene
    Hung Hsi Chen
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road Section 2, Nankang, Taipei 11529, Taiwan
    Mol Cell Biol 28:6929-38. 2008
    ..Here, we demonstrate that hnRNP Q is a splicing modulator of SMN, further underscoring the potential of hnRNP Q as a therapeutic target for SMA...
  38. pmc A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay
    Wei Lun Chang
    Graduate Institute of Life Sciences, National Defense Medical Center and Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan
    Nucleic Acids Res 37:6600-12. 2009
    ..Therefore, our data together suggest that TRN plays a role in trafficking of TTP between the cytoplasmic granules and whereby modulates the stability of ARE-containing mRNAs...
  39. doi request reprint Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice
    Nagham George Abd Al Ahad Sabbagha
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Pediatr Res 70:31-6. 2011
    ..This mouse model of isobutyryl-CoA dehydrogenase deficiency could provide us a better understanding of the possible role of IBD deficiency in mitochondriopathy and fatty liver...
  40. pmc RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion
    Amar Kar
    Department of Neurology, Lurie Comprehensive Cancer Center, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611
    J Biol Chem 281:24479-88. 2006
    ..Our work also suggests that down-regulating tau exon 10 splicing activators, such as RBM4, may be of therapeutic potential in tauopathies involving excessive tau exon 10 inclusion...