Ruey Hwa Chen

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. pmc PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth
    Mei Yao Lin
    Institute of Biological Chemistry, Academia Sinica, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan
    J Cell Biol 193:985-94. 2011
  2. pmc The role of PML ubiquitination in human malignancies
    Ruey Hwa Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Biomed Sci 19:81. 2012
  3. pmc Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neural Dev 3:26. 2008
  4. pmc Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin
    Hsin Yi Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cell Biol 24:10558-72. 2004
  5. ncbi request reprint K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking
    Wei Chien Yuan
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 106, Taiwan
    Mol Cell 54:586-600. 2014
  6. pmc The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
    Yu Ru Lee
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    EMBO J 29:1748-61. 2010
  7. pmc The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway
    Jean Cheng Kuo
    Institute of Molecular Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 106, Taiwan
    J Cell Biol 172:619-31. 2006
  8. ncbi request reprint A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
    Wei Chien Yuan
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Cell 20:214-28. 2011
  9. pmc Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
    Chun Hau Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    EMBO J 24:294-304. 2005
  10. doi request reprint Tumor suppressor death-associated protein kinase is required for full IL-1β production
    Ya Ting Chuang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Blood 117:960-70. 2011

Collaborators

Detail Information

Publications31

  1. pmc PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth
    Mei Yao Lin
    Institute of Biological Chemistry, Academia Sinica, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan
    J Cell Biol 193:985-94. 2011
    ..Our study identified a ubiquitin-dependent pathway that targets PDZ-RhoGEF destruction to facilitate neurite outgrowth and indicates a key role of this pathway in neurotrophin-induced neuronal morphogenesis...
  2. pmc The role of PML ubiquitination in human malignancies
    Ruey Hwa Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Biomed Sci 19:81. 2012
    ..We discuss the potential of targeting PML ubiquitination pathways for anti-cancer therapeutic strategies...
  3. pmc Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neural Dev 3:26. 2008
    ..Neuronal function of FAK has been suggested to control axonal branching; however, the underlying mechanism in this process is not clear...
  4. pmc Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin
    Hsin Yi Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cell Biol 24:10558-72. 2004
    ..Together, our findings identify novel signaling and biological roles of Brk and indicate the first potential link between Brk and metastatic malignancy...
  5. ncbi request reprint K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking
    Wei Chien Yuan
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 106, Taiwan
    Mol Cell 54:586-600. 2014
    ..Our study reveals a role of KLHL20-mediated K33-ubiquitination of Crn7 in post-Golgi transport and identifies a cellular recognition mechanism for this ubiquitin chain type. ..
  6. pmc The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
    Yu Ru Lee
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    EMBO J 29:1748-61. 2010
    ..Our findings may be relevant to the problem of IFN resistance in cancer therapy...
  7. pmc The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway
    Jean Cheng Kuo
    Institute of Molecular Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 106, Taiwan
    J Cell Biol 172:619-31. 2006
    ..Collectively, our study identifies a novel function of DAPK in regulating cell polarity during migration, which may act together with its apoptotic function to suppress tumor progression...
  8. ncbi request reprint A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
    Wei Chien Yuan
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Cell 20:214-28. 2011
    ..Our study indicates that the KLHL20-mediated PML degradation and HIF-1α autoregulation play key roles in tumor progression...
  9. pmc Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
    Chun Hau Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    EMBO J 24:294-304. 2005
    ..These results indicate that bidirectional signalings between DAPK and ERK may contribute to the apoptosis-promoting function of the death domain of DAPK...
  10. doi request reprint Tumor suppressor death-associated protein kinase is required for full IL-1β production
    Ya Ting Chuang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Blood 117:960-70. 2011
    ..In addition, DAPK knockout reduced uric acid crystal-triggered peritonitis, suggesting that DAPK may serve as a target in the treatment of IL-1β-associated autoinflammatory diseases...
  11. pmc DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals
    Won Jing Wang
    Institute of Molecular Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Cell Biol 159:169-79. 2002
    ..Our results indicate that DAP-kinase exerts apoptotic effects by suppressing integrin functions and integrin-mediated survival signals, thereby activating a p53-dependent apoptotic pathway...
  12. ncbi request reprint Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor
    Shuei Liong Lin
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Am Soc Nephrol 16:2702-13. 2005
    ..Because of the dual blockade, PTX potently attenuates the tubulointerstitial fibrosis in unilateral ureteral obstruction kidneys...
  13. doi request reprint Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation
    Che Chang Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Mol Cell 42:62-74. 2011
    ..Our findings provide structural insights into the Daxx-SIM:SUMO-1 complex, a model of SIM phosphorylation-enhanced SUMO paralog-selective modification and interaction, and phosphorylation-regulated Daxx function in apoptosis...
  14. ncbi request reprint The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR
    Won Jing Wang
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Mol Cell 27:701-16. 2007
    ..These results identify LAR and Src as a DAPK regulator through their reciprocal modification of DAPK Y491/492 residues and establish a functional link of this DAPK-regulatory circuit to tumor progression...
  15. ncbi request reprint TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase
    Chuan Wei Jang
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Nat Cell Biol 4:51-8. 2002
    ..Our findings indicate that DAP-kinase mediates TGF-beta-dependent apoptosis by linking Smads to mitochondrial-based pro-apoptotic events...
  16. ncbi request reprint Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase
    Jean Cheng Kuo
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Sci 116:4777-90. 2003
    ..Such uncoupling would lead to a perturbation of the balance between contractile and adhesion forces and subsequent cell detachment, which might contribute to its pro-apoptotic activity...
  17. ncbi request reprint Antibiotics induce apoptosis of human peritoneal mesothelial cells
    Cheng Chung Fang
    Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Nephrology (Carlton) 8:142-9. 2003
    ..In conclusion, cefotaxime and cephalothin induce apoptosis of HPMCs in vitro. Signal transduction may be through the mitochondrial pathway...
  18. ncbi request reprint The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation
    Ya Ting Chuang
    Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 180:3238-49. 2008
    ..Our results clearly demonstrate that DAPK is a novel regulator targeted to TCR-activated NF-kappaB and T cell activation...
  19. pmc C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase
    Chun Yi Huang
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e36584. 2012
    ..K. Because human eIF3k was able to partially substitute for C. elegans eif-3.K in the promotion of cell death, this WH domain-dependent EIF-3.K-mediated cell death process has potentially been conserved throughout evolution...
  20. doi request reprint Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion
    Che Hung Shen
    Institute of Molecular Medicine, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 68:7779-87. 2008
    ..Together, our findings reveal a previously unknown function of Brk in regulating both RhoA and Ras by phosphorylating p190 and provide evidence for the crucial roles of this Brk-elicited signaling pathway in promoting breast malignancy...
  21. ncbi request reprint Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4
    Che Chang Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Biol Chem 280:10164-73. 2005
    ..Together, these results indicate that Daxx suppresses Smad4-mediated transcriptional activity by direct interaction with the sumoylated Smad4 and identify a novel role of Daxx in regulating transforming growth factor beta signaling...
  22. ncbi request reprint The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
    Ruey Hwa Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 13:193-9. 2006
    ..Furthermore, a potential role of DAP-kinase to be a drug target is also discussed...
  23. pmc SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function
    Chun Hau Chen
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 73:3951-62. 2013
    ..These results not only uncover Pin1 SUMOylation on Lys6/63 as a novel mechanism to inhibit its activity and function but also identify a critical role for SENP1-mediated deSUMOylation in promoting Pin1 function during tumorigenesis...
  24. doi request reprint miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4
    Hsin Yi Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Res 72:3631-41. 2012
    ..Strategies that disrupt this regulation might be developed to block CRC metastasis...
  25. doi request reprint eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions
    Yu Min Lin
    Institute of Biochemical Sciences, National Taiwan University, Taiwan
    J Cell Sci 121:2382-93. 2008
    ....
  26. ncbi request reprint The functions and regulations of DAPK in cancer metastasis
    Hsin Yi Chen
    Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
    Apoptosis 19:364-70. 2014
    ..These effects likely all contribute to the metastasis suppressive role of DAPK. The detail molecular mechanisms of these anti-metastatic effects of DAPK are reviewed in this article. ..
  27. ncbi request reprint Pentoxifylline inhibits platelet-derived growth factor-stimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation
    Shuei Liong Lin
    Department of Internal Medicine, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, Taiwan
    Mol Pharmacol 64:811-22. 2003
    ..In conclusion, our results indicate that PTX, acting through PKA, interferes with PDGF signaling to Akt activation by blocking Akt membrane translocation, thereby inhibiting cyclin D1 expression and mesangial cell proliferation...
  28. doi request reprint Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Neurosci 32:16971-81. 2012
    ..Thus, presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 genetic disorder...
  29. doi request reprint USP11 regulates PML stability to control Notch-induced malignancy in brain tumours
    Hsin Chieh Wu
    1 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan 2 Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Nat Commun 5:3214. 2014
    ..Our study uncovers a PML degradation mechanism through Notch/Hey1-induced repression of the PML deubiquitinase USP11 and suggests an important role for this pathway in brain tumour pathogenesis. ..
  30. ncbi request reprint Regulation of inflammation by DAPK
    Ming Zong Lai
    Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan, ROC
    Apoptosis 19:357-63. 2014
    ..These results suggest the complicated role of DAPK in the regulation of inflammation that is likely dependent on cell types and environmental cues. ..
  31. doi request reprint Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line
    Chun Wei Lee
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    Virology 413:19-25. 2011
    ..DAPK roles in EBV-infected B cells remain to be identified...