Ruey Hwa Chen

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. pmc The role of PML ubiquitination in human malignancies
    Ruey Hwa Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Biomed Sci 19:81. 2012
  2. pmc Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neural Dev 3:26. 2008
  3. pmc Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin
    Hsin Yi Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cell Biol 24:10558-72. 2004
  4. doi request reprint A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
    Wei Chien Yuan
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Cell 20:214-28. 2011
  5. pmc DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals
    Won Jing Wang
    Institute of Molecular Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Cell Biol 159:169-79. 2002
  6. doi request reprint Tumor suppressor death-associated protein kinase is required for full IL-1β production
    Ya Ting Chuang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Blood 117:960-70. 2011
  7. pmc Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
    Chun Hau Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    EMBO J 24:294-304. 2005
  8. pmc The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
    Yu Ru Lee
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    EMBO J 29:1748-61. 2010
  9. doi request reprint Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation
    Che Chang Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Mol Cell 42:62-74. 2011
  10. pmc PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth
    Mei Yao Lin
    Institute of Biological Chemistry, Academia Sinica, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan
    J Cell Biol 193:985-94. 2011

Collaborators

  • Ming Zong Lai
  • Kun Ping Lu
  • Zee Fen Chang
  • Jin Tung Liang
  • John Y J Shyy
  • Wei Chi Wang
  • Yeong Shiau Pu
  • Kuang Hui Sun
  • Pei I Tsai
  • Chun Hau Chen
  • Hsin Yi Chen
  • Hsiu Ming Shih
  • Che Chang Chang
  • Ya Ting Chuang
  • Yu Min Lin
  • Wei Chien Yuan
  • Yu Ru Lee
  • Che Hung Shen
  • Chun Yi Huang
  • Pei Hsin Liao
  • Hsiang Ching Chung
  • Ruei Ying Tzeng
  • Mei Yao Lin
  • Chun Wei Lee
  • Manli Luo
  • Pengyu Huang
  • Tae Ho Lee
  • Xiao Zhen Zhou
  • Shuo Wei
  • Fu An Li
  • Zhen Chen
  • Yu Feng Wu
  • Ching Jung Lin
  • John Huang
  • Chieh Hsiang Tan
  • Jia Yun Chen
  • Yi Chun Wu
  • Pei Ju Lu
  • Feng Mao Lin
  • Yaw Dong Lang
  • Shu Chun Wu
  • Hsien Da Huang
  • Hong Yi Kuo
  • Nandita M Naik
  • Chun Kai Lai
  • Pei Wen Hsiao
  • Ting Fang Chou
  • Sheng Fan Wang
  • Yung Lin Hsieh
  • Yu Chuan Lin
  • Shu Chun Tsai
  • Yen Sung Huang
  • Jen Chong Jeng
  • De Leung Gu
  • Camy C H Kung
  • Shu Yu Lin
  • Li Ting Lu
  • Tai Huang Huang
  • Nai Jia Huang
  • Kuan Hung Lin
  • Tzu Yin Chen
  • Pei Rung Wu
  • Hsiang Hao Chuang
  • Jason C Huang
  • Wen Chih Kuo
  • Mandar T Naik
  • Kai Ting Yang
  • Shiu Feng Huang
  • Kun Sang Chang
  • Chiou Hong Lin
  • Yuh Shan Jou
  • Adi Kimchi
  • Te Chan Kao
  • Chin Hsien Tsai
  • Cheng Ta Chiang
  • Shr Jeng Jim Leu
  • Chun Chen Ho
  • Hsuan Chung Ho
  • Ming Hsien Lin-Feng
  • Li Wen Fang
  • Jeffrey Settleman
  • Cheng Chi Chang
  • Min Liang Kuo
  • Fang Yen Li
  • Ming Shien Lin
  • Hsin I Fang
  • Hsiao Chien Tsai
  • Jean Cheng Kuo
  • Jia Ren Lin
  • Ding Yen Lin

Detail Information

Publications20

  1. pmc The role of PML ubiquitination in human malignancies
    Ruey Hwa Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Biomed Sci 19:81. 2012
    ..We discuss the potential of targeting PML ubiquitination pathways for anti-cancer therapeutic strategies...
  2. pmc Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neural Dev 3:26. 2008
    ..Neuronal function of FAK has been suggested to control axonal branching; however, the underlying mechanism in this process is not clear...
  3. pmc Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin
    Hsin Yi Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cell Biol 24:10558-72. 2004
    ..Together, our findings identify novel signaling and biological roles of Brk and indicate the first potential link between Brk and metastatic malignancy...
  4. doi request reprint A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
    Wei Chien Yuan
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Cell 20:214-28. 2011
    ..Our study indicates that the KLHL20-mediated PML degradation and HIF-1α autoregulation play key roles in tumor progression...
  5. pmc DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals
    Won Jing Wang
    Institute of Molecular Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Cell Biol 159:169-79. 2002
    ..Our results indicate that DAP-kinase exerts apoptotic effects by suppressing integrin functions and integrin-mediated survival signals, thereby activating a p53-dependent apoptotic pathway...
  6. doi request reprint Tumor suppressor death-associated protein kinase is required for full IL-1β production
    Ya Ting Chuang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Blood 117:960-70. 2011
    ..In addition, DAPK knockout reduced uric acid crystal-triggered peritonitis, suggesting that DAPK may serve as a target in the treatment of IL-1β-associated autoinflammatory diseases...
  7. pmc Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
    Chun Hau Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    EMBO J 24:294-304. 2005
    ..These results indicate that bidirectional signalings between DAPK and ERK may contribute to the apoptosis-promoting function of the death domain of DAPK...
  8. pmc The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
    Yu Ru Lee
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    EMBO J 29:1748-61. 2010
    ..Our findings may be relevant to the problem of IFN resistance in cancer therapy...
  9. doi request reprint Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation
    Che Chang Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Mol Cell 42:62-74. 2011
    ..Our findings provide structural insights into the Daxx-SIM:SUMO-1 complex, a model of SIM phosphorylation-enhanced SUMO paralog-selective modification and interaction, and phosphorylation-regulated Daxx function in apoptosis...
  10. pmc PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth
    Mei Yao Lin
    Institute of Biological Chemistry, Academia Sinica, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan
    J Cell Biol 193:985-94. 2011
    ..Our study identified a ubiquitin-dependent pathway that targets PDZ-RhoGEF destruction to facilitate neurite outgrowth and indicates a key role of this pathway in neurotrophin-induced neuronal morphogenesis...
  11. ncbi request reprint The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR
    Won Jing Wang
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Mol Cell 27:701-16. 2007
    ..These results identify LAR and Src as a DAPK regulator through their reciprocal modification of DAPK Y491/492 residues and establish a functional link of this DAPK-regulatory circuit to tumor progression...
  12. ncbi request reprint The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
    Ruey Hwa Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 13:193-9. 2006
    ..Furthermore, a potential role of DAP-kinase to be a drug target is also discussed...
  13. doi request reprint SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function
    Chun Hau Chen
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 73:3951-62. 2013
    ..These results not only uncover Pin1 SUMOylation on Lys6/63 as a novel mechanism to inhibit its activity and function but also identify a critical role for SENP1-mediated deSUMOylation in promoting Pin1 function during tumorigenesis...
  14. pmc C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase
    Chun Yi Huang
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e36584. 2012
    ..K. Because human eIF3k was able to partially substitute for C. elegans eif-3.K in the promotion of cell death, this WH domain-dependent EIF-3.K-mediated cell death process has potentially been conserved throughout evolution...
  15. doi request reprint miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4
    Hsin Yi Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cancer Res 72:3631-41. 2012
    ..Strategies that disrupt this regulation might be developed to block CRC metastasis...
  16. ncbi request reprint The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation
    Ya Ting Chuang
    Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 180:3238-49. 2008
    ..Our results clearly demonstrate that DAPK is a novel regulator targeted to TCR-activated NF-kappaB and T cell activation...
  17. doi request reprint Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Neurosci 32:16971-81. 2012
    ..Thus, presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 genetic disorder...
  18. ncbi request reprint Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4
    Che Chang Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Biol Chem 280:10164-73. 2005
    ..Together, these results indicate that Daxx suppresses Smad4-mediated transcriptional activity by direct interaction with the sumoylated Smad4 and identify a novel role of Daxx in regulating transforming growth factor beta signaling...
  19. doi request reprint Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion
    Che Hung Shen
    Institute of Molecular Medicine, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 68:7779-87. 2008
    ..Together, our findings reveal a previously unknown function of Brk in regulating both RhoA and Ras by phosphorylating p190 and provide evidence for the crucial roles of this Brk-elicited signaling pathway in promoting breast malignancy...
  20. doi request reprint Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line
    Chun Wei Lee
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    Virology 413:19-25. 2011
    ..DAPK roles in EBV-infected B cells remain to be identified...