Rey Huei Chen

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. ncbi Spindle checkpoint requires Mad1-bound and Mad1-free Mad2
    Eunah Chung
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 13:1501-11. 2002
  2. ncbi The spindle checkpoint in Xenopus laevis
    Rey Huei Chen
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Front Biosci 13:2231-7. 2008
  3. ncbi Dual inhibition of Cdc20 by the spindle checkpoint
    Rey Huei Chen
    Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan
    J Biomed Sci 14:475-9. 2007
  4. ncbi Cdc48 and cofactors Npl4-Ufd1 are important for G1 progression during heat stress by maintaining cell wall integrity in Saccharomyces cerevisiae
    Meng Ti Hsieh
    Molecular Cell Biology, Taiwan International Graduate Program, Institute of Molecular Biology, Academia Sinica, and National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 6:e18988. 2011
  5. ncbi Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint
    Rey Huei Chen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    EMBO J 23:3113-21. 2004
  6. ncbi The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity
    You Liang Cheng
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    J Cell Sci 123:2025-34. 2010
  7. ncbi Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae
    Jing Pan
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genes Dev 18:1439-51. 2004
  8. ncbi Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint
    Eunah Chung
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 5:748-53. 2003
  9. ncbi Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins
    Yong Zhao
    Graduate Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Curr Biol 16:1764-9. 2006
  10. ncbi BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1
    Rey Huei Chen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 158:487-96. 2002

Collaborators

  • Jing Pan
  • Eunah Chung
  • Meng Ti Hsieh
  • You Liang Cheng
  • Yong Zhao
  • Leon O Murphy
  • Sallie Smith
  • Diane C Fingar
  • John Blenis

Detail Information

Publications11

  1. ncbi Spindle checkpoint requires Mad1-bound and Mad1-free Mad2
    Eunah Chung
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 13:1501-11. 2002
    ..We propose that Mad2 may become activated and dissociated from Mad1 at kinetochores and is replenished by the pool of Mad1-free Mad2...
  2. ncbi The spindle checkpoint in Xenopus laevis
    Rey Huei Chen
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Front Biosci 13:2231-7. 2008
    ..This article reviews the progress of the spindle checkpoint studies in Xenopus laevis with a focus on the regulation by phosphorylation...
  3. ncbi Dual inhibition of Cdc20 by the spindle checkpoint
    Rey Huei Chen
    Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan
    J Biomed Sci 14:475-9. 2007
    ..This dual inhibition on Cdc20 likely ensures that the spindle checkpoint is sustained even when the cell contains only a single unattached kinetochore...
  4. ncbi Cdc48 and cofactors Npl4-Ufd1 are important for G1 progression during heat stress by maintaining cell wall integrity in Saccharomyces cerevisiae
    Meng Ti Hsieh
    Molecular Cell Biology, Taiwan International Graduate Program, Institute of Molecular Biology, Academia Sinica, and National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 6:e18988. 2011
    ..Thus, Cdc48-Npl4-Ufd1 is important for the maintenance of cell wall integrity in order for normal cell growth and division...
  5. ncbi Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint
    Rey Huei Chen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    EMBO J 23:3113-21. 2004
    ....
  6. ncbi The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity
    You Liang Cheng
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    J Cell Sci 123:2025-34. 2010
    ..Our results identify Cdc48 and Shp1 as critical components that balance the kinase and phosphatase activities at the kinetochore in order to achieve stable bipolar attachment...
  7. ncbi Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae
    Jing Pan
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genes Dev 18:1439-51. 2004
    ..Our study suggests that the spindle checkpoint reduces Cdc20p to below a certain threshold level to ensure a complete inhibition of Cdc20p before anaphase...
  8. ncbi Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint
    Eunah Chung
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 5:748-53. 2003
    ..This study demonstrates that the spindle checkpoint stops anaphase by inhibiting fully-phosphorylated Cdc20. Our results also have implications for the spindle checkpoint silencing mechanism...
  9. ncbi Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins
    Yong Zhao
    Graduate Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Curr Biol 16:1764-9. 2006
    ..In addition, our results indicate that active Mps1 must localize to kinetochores in order to execute its checkpoint function...
  10. ncbi BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1
    Rey Huei Chen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 158:487-96. 2002
    ..This paper demonstrates that BubR1 plays an important role in kinetochore association of other spindle checkpoint proteins and that Mad1 facilitates BubR1 hyperphosphorylation at kinetochores...
  11. ncbi Molecular interpretation of ERK signal duration by immediate early gene products
    Leon O Murphy
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 4:556-64. 2002
    ..Together, our data identify a general mechanism by which cells can interpret differences in ERK activation kinetics...