Jyh Yih Chen


Affiliation: Academia Sinica
Country: Taiwan


  1. Su B, Pan C, Chen J. Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant p53 Glioblastoma Cells. Cancers (Basel). 2019;11: pubmed publisher
    ..Based on these data, we conclude that TP4 induces necrosis in both WT and mutant p53 glioblastoma cells through a mitochondrial ROS-dependent pathway. ..
  2. Ting C, Lee K, Wu S, Feng P, Chan Y, Chen Y, et al. FOSB⁻PCDHB13 Axis Disrupts the Microtubule Network in Non-Small Cell Lung Cancer. Cancers (Basel). 2019;11: pubmed publisher
    ..Importantly, downregulation of both FOSB and PCDHB13 was observed in NSCLC patients and was negatively correlated with pathological grade. These findings introduce the FOSB⁻PCDHB13 axis as a novel tumor suppressive pathway in NSCLC. ..
  3. Huang H, Chuang C, Chen J, Chieh Yu P. Epinecidin-1: A marine fish antimicrobial peptide with therapeutic potential against Trichomonas vaginalis infection in mice. Peptides. 2019;112:139-148 pubmed publisher
    ..Taken together, our results demonstrate that Epi-1 is a strong candidate for development as an alternative therapeutic for T. vaginalis infection. ..
  4. Ting C, Chen J. Nile Tilapia Derived TP4 Shows Broad Cytotoxicity Toward to Non-Small-Cell Lung Cancer Cells. Mar Drugs. 2018;16: pubmed publisher
    ..This work provides novel insights into potential NSCLC treatments, which may utilize antimicrobial peptide TP4 as monotherapy or in combination with EGFR-TKIs. ..
  5. Ting C, Liu Y, Lyu P, Chen J. Nile Tilapia Derived Antimicrobial Peptide TP4 Exerts Antineoplastic Activity Through Microtubule Disruption. Mar Drugs. 2018;16: pubmed publisher
    ..Importantly, the TP4 mutants also showed decreased cytotoxicity in A549 cells, suggesting that microtubule disruption is a major mechanistic component of TP4-mediated death in lung carcinoma cells. ..
  6. Ting C, Chen Y, Chen J. Nile tilapia fry fed on antimicrobial peptide Epinecidin-1-expressing Artemia cyst exhibit enhanced immunity against acute bacterial infection. Fish Shellfish Immunol. 2018;81:37-48 pubmed publisher
    ..Epi-1 transgenic cysts should therefore be considered as a potential functional feed for larval aquaculture. ..
  7. Lakshmaiah Narayana J, Chen J. Antimicrobial peptides: Possible anti-infective agents. Peptides. 2015;72:88-94 pubmed publisher
    ..Moreover, we also consider current production methods and delivery tools for AMPs, which must be improved for the effective use of these agents. ..
  8. Narayana J, Huang H, Wu C, Chen J. Epinecidin-1 antimicrobial activity: In vitro membrane lysis and In vivo efficacy against Helicobacter pylori infection in a mouse model. Biomaterials. 2015;61:41-51 pubmed publisher
    ..Collectively, our results suggest that Epi-1 may be a promising, effective, and safe monotherapeutic agent for the treatment of multi-drug resistant H. pylori infection. ..
  9. Huang H, Chan Y, Wu C, Chen J. Tilapia Piscidin 4 (TP4) Stimulates Cell Proliferation and Wound Closure in MRSA-Infected Wounds in Mice. Mar Drugs. 2015;13:2813-33 pubmed publisher
    ..Overall, these results suggest that TP4 may be suitable for development as a novel topical agent for wound dressing. ..

More Information


  1. Chen W, Huang S, Liao C, Sung C, Chen J, Wen Z. The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials. 2015;53:1-11 pubmed publisher
    ..Taken together, the present findings demonstrate that the marine antimicrobial peptide PCD-1 has anti-nociceptive effects, and thus may have potential for development as an alternative pain-alleviating agent. ..
  2. Huang H, Pan C, Chen J. Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro. Peptides. 2018;106:91-95 pubmed publisher
    ..Taken together, our data show that Epi-1 may be a promising candidate for development as an anti-FMDV agent. ..
  3. Ting C, Huang H, Huang T, Wu C, Chen J. The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS. Biomaterials. 2014;35:3627-40 pubmed publisher
    ..Importantly, pardaxin treatment or c-FOS overexpression induced cell death in diverse cancer cell lines, indicating that pardaxin and c-FOS may possess therapeutic potential for use in cancer treatment. ..
  4. Pan C, Chen J, Chen T, Wu J, Hui C, Chen J. Piscidin is highly active against carbapenem-resistant Acinetobacter baumannii and NDM-1-producing Klebsiella pneumonia in a systemic Septicaemia infection mouse model. Mar Drugs. 2015;13:2287-305 pubmed publisher
  5. Wang Y, Rajanbabu V, Chen J. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. Fish Shellfish Immunol. 2015;42:121-31 pubmed publisher
    ..These observations demonstrate that epinecidin-1 and TH1-5 modulate NNV-induced host signaling mechanisms, thereby preventing viral multiplication in host organisms. ..
  6. Su B, Lin W, Chen J. Recombinant Epinephelus lanceolatus serum amyloid A as a feed additive: Effects on immune gene expression and resistance to Vibrio alginolyticus infection in Epinephelus lanceolatus. Fish Shellfish Immunol. 2018;76:233-239 pubmed publisher
    ..Together, our results demonstrate that rElSAA is a promising candidate as a feed additive for giant grouper, which may effectively enhance disease resistance after being administered for several weeks. ..
  7. Huang H, Rajanbabu V, Pan C, Chan Y, Chen J, Wu C. Enhanced Control of Bladder-Associated Tumors Using Shrimp Anti-Lipopolysaccharide Factor (SALF) Antimicrobial Peptide as a Cancer Vaccine Adjuvant in Mice. Mar Drugs. 2015;13:3241-58 pubmed publisher
    ..Recruitment of macrophages, T-helper cells, and NK cells was enhanced, but levels of VEGF were decreased in immunized mice. This report provides empirical evidence that our SALF as vaccine adjuvant enhances antitumor immunity in mice. ..
  8. Wang Y, Huang S, Chou H, Liao W, Gong H, Chen J. Transcriptome analysis of the effect of Vibrio alginolyticus infection on the innate immunity-related complement pathway in Epinephelus coioides. BMC Genomics. 2014;15:1102 pubmed publisher
    ..alginolyticus infection at early developmental stages, enhancing our understanding of the mechanisms underlying the immune response to Vibrio infection in Epinephelus coioides. ..
  9. Wang Y, Wang Y, Hui C, Chen J. Transcriptome analysis of the effect of Vibrio alginolyticus infection on the innate immunity-related TLR5-mediated induction of cytokines in Epinephelus lanceolatus. Fish Shellfish Immunol. 2016;52:31-43 pubmed publisher
    ..These results may be applied by examining the immune effects of feeding E. lanceolatus larvae on a recombinant protein mixture based on the up-regulated genes. ..
  10. Su B, Lai Y, Chen J, Pan C. Transgenic expression of tilapia piscidin 3 (TP3) in zebrafish confers resistance to Streptococcus agalactiae. Fish Shellfish Immunol. 2018;74:235-241 pubmed publisher
    ..Together, these actions are conducive to the resolution of inflammation and bacterial clearance. We further postulate that TP3 may exert its anti-inflammatory effects by enhancing TLR4a-mediated negative regulation of NF-?B. ..
  11. Chen J, Lin W, Lin T. A fish antimicrobial peptide, tilapia hepcidin TH2-3, shows potent antitumor activity against human fibrosarcoma cells. Peptides. 2009;30:1636-42 pubmed publisher
    ..These findings suggest a mechanism of cytotoxic action of TH2-3 and indicate that TH2-3 may be a promising chemotherapeutic agent against human fibrosarcoma cells. ..
  12. Su B, Chen J. Antimicrobial Peptide Epinecidin-1 Modulates MyD88 Protein Levels via the Proteasome Degradation Pathway. Mar Drugs. 2017;15: pubmed publisher
    ..Thus, our data suggest that epinecidin-1 directly inhibits MyD88 via induction of the Smurf E3 ligase proteasome pathway. ..
  13. Ken C, Chen C, Ting C, Pan C, Chen J. Transcriptome analysis of hybrid tilapia (Oreochromis spp.) with Streptococcus agalactiae infection identifies Toll-like receptor pathway-mediated induction of NADPH oxidase complex and piscidins as primary immune-related responses. Fish Shellfish Immunol. 2017;70:106-120 pubmed publisher
  14. Su B, Lin W, Huang H, Chen J. Recombinant expression of Epinephelus lanceolatus serum amyloid A (ElSAA) and analysis of its macrophage modulatory activities. Fish Shellfish Immunol. 2017;64:276-286 pubmed publisher
    ..lanceolatus and have demonstrated that rElSAA promotes inflammatory cytokine production and macrophage differentiation. In addition, rElSAA enhances phagocytosis of bacteria by macrophages via an opsonization-independent mechanism. ..
  15. Pan C, Liu Y, Gong H, Chen J. Transcriptome analysis of the effect of polyunsaturated fatty acids against Vibrio vulnificus infection in Oreochromis niloticus. Fish Shellfish Immunol. 2017;62:153-163 pubmed publisher
    ..In summary, the results of the present study demonstrated that DHA and EPA reduce the severity of Vibrio vulnificus infection and increase the survival rate of Oreochromis niloticus. ..
  16. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  17. Wang Y, Peng K, Wu J, Chen J. Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish Shellfish Immunol. 2014;39:223-30 pubmed publisher
    ..Overall, these results identify delta-5 and delta-6 desaturase as novel candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production. ..
  18. Chen J, Chiou M. Molecular cloning and functional analysis of the zebrafish luteinizing hormone beta subunit (LH<beta>) promoter. Fish Physiol Biochem. 2010;36:1253-62 pubmed publisher
    ..These results suggest that the LH plays important roles in reproduction and general embryonic development in zebrafish. ..
  19. Chen J, Chiou M, Chen L, Wu J. Molecular cloning and functional analysis of the zebrafish follicle-stimulating hormone (FSH)beta promoter. Comp Biochem Physiol B Biochem Mol Biol. 2010;155:155-63 pubmed publisher
    ..Morphological studies of transgenic zebrafish indicated that the FSHbeta promoter-driven GFP transcripts appeared in the heart, skin, and vertebrae. ..
  20. Chen L, Wu J, Shiau C, Chen J. Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter. Fish Physiol Biochem. 2010;36:511-521 pubmed publisher
    ..7 cells, and LPS-treated zfl cells. These results reveal that the zebrafish CXC-64 chemokine gene promoter region can be induced by LPS in both human and fish cell lines, which suggests that it plays an important role in regulating LPS. ..
  21. Su B, Huang H, Lin T, Hsiao C, Chen J. Epinecidin-1 protects mice from LPS-induced endotoxemia and cecal ligation and puncture-induced polymicrobial sepsis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3028-3037 pubmed publisher
    ..Overall, our results demonstrate that Epi is a promising therapeutic agent for endotoxemia and polymicrobial sepsis. ..
  22. Lin W, Chang H, Chen J. Electrotransfer of the tilapia piscidin 3 and tilapia piscidin 4 genes into skeletal muscle enhances the antibacterial and immunomodulatory functions of Oreochromis niloticus. Fish Shellfish Immunol. 2016;50:200-9 pubmed publisher
    ..These data suggest that TP3 and TP4 exert antimicrobial effects after overexpression in the O. niloticus muscle, and also play important roles in the regulation of immune-related gene expression. ..