Tse Wen Chang

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. ncbi request reprint Monoclonal antibodies against the C(epsilon)mX domain of human membrane-bound IgE and their potential use for targeting IgE-expressing B cells
    Huan Yuan Chen
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, ROC
    Int Arch Allergy Immunol 128:315-24. 2002
  2. ncbi request reprint Developing antibodies for targeting immunoglobulin and membrane-bound immunoglobulin E
    Tse Wen Chang
    Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Allergy Asthma Proc 27:S7-14. 2006
  3. ncbi request reprint Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases
    Tse Wen Chang
    Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan
    Adv Immunol 93:63-119. 2007
  4. doi request reprint Unique epitopes on C epsilon mX in IgE-B cell receptors are potentially applicable for targeting IgE-committed B cells
    Jiun Bo Chen
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    J Immunol 184:1748-56. 2010
  5. ncbi request reprint Anti-IgE as a mast cell-stabilizing therapeutic agent
    Tse Wen Chang
    Institute of Biotechnology, National Tsing Hua University, Genomics Research Center, Academia Sinica, Taipei, Taiwan
    J Allergy Clin Immunol 117:1203-12; quiz 1213. 2006
  6. doi request reprint An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors
    Yu Yu Shiung
    Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan
    Immunobiology 217:676-83. 2012
  7. doi request reprint Manipulating mIgD-expressing B cells with anti-migis-δ monoclonal antibodies
    Nien Yi Chen
    Genomics Research Center, Academia Sinica, Taipei, Taiwan Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    Mol Immunol 53:187-97. 2013
  8. doi request reprint CɛmX peptide-carrying HBcAg virus-like particles induced antibodies that down-regulate mIgE-B lymphocytes
    Chien Jen Lin
    Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan
    Mol Immunol 52:190-9. 2012
  9. ncbi request reprint Comparative effects of human Ig alpha and Ig beta in inducing autoreactive antibodies against B cells in mice
    Jim J C Sheu
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    J Immunol 170:1158-66. 2003
  10. doi request reprint Accumulated immune complexes of IgE and omalizumab trap allergens in an in vitro model
    Chuan Long Hsu
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    Int Immunopharmacol 10:533-9. 2010

Collaborators

  • Carmay Lim
  • Tsen Fang Tsai
  • Christian Roos
  • Jiun Bo Chen
  • Alfur Fu Hsin Hung
  • Pheidias C Wu
  • Chien Jen Lin
  • Nien Yi Chen
  • Yu Yu Shiung
  • Hsing Mao Chu
  • Hui Ming Yu
  • Hwan You Chang
  • Rong Long Pan
  • Chien Sheng Lu
  • Chuan Long Hsu
  • Jim J C Sheu
  • Huan Yuan Chen
  • Jon Wright
  • Yueh Hsuan Chan
  • Shoji Kawamura
  • Ban Dar Hsu
  • Stefan Merker
  • Chen Yi Chiang
  • Chih Chin Shih
  • Donic Chien Sheng Lu
  • Chia Yu Chu
  • Bai Ling Lin
  • Huan Y Chen
  • Tammy Cheng
  • Janice S W Huang
  • Bhavya Bhavna Sharma
  • Charlie M H Hou
  • Fu Tong Liu

Detail Information

Publications14

  1. ncbi request reprint Monoclonal antibodies against the C(epsilon)mX domain of human membrane-bound IgE and their potential use for targeting IgE-expressing B cells
    Huan Yuan Chen
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, ROC
    Int Arch Allergy Immunol 128:315-24. 2002
    ..The epsilon-chain of human mIgE contains a membrane-anchoring peptide and an extra 52-amino-acid (a.a.)-long domain (referred to as C(epsilon)mX) between the membrane anchor and the CH4 domain...
  2. ncbi request reprint Developing antibodies for targeting immunoglobulin and membrane-bound immunoglobulin E
    Tse Wen Chang
    Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Allergy Asthma Proc 27:S7-14. 2006
    ..Studies on the unique structural mIgE CepsilonmX domain and on the regulatory effects of anti-CepsilonmX monoclonal antibodies will be an area for future investigation of the potential of long-term IgE regulation...
  3. ncbi request reprint Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases
    Tse Wen Chang
    Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan
    Adv Immunol 93:63-119. 2007
    ..Finally, it reviews other approaches that target IgE or IgE-expressing B cells...
  4. doi request reprint Unique epitopes on C epsilon mX in IgE-B cell receptors are potentially applicable for targeting IgE-committed B cells
    Jiun Bo Chen
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    J Immunol 184:1748-56. 2010
    ..These results suggest that 4B12 and 26H2 and an immunogen using the peptide segments recognized by these mAbs are potentially useful for targeting mIgE(+) B cells to control IgE production...
  5. ncbi request reprint Anti-IgE as a mast cell-stabilizing therapeutic agent
    Tse Wen Chang
    Institute of Biotechnology, National Tsing Hua University, Genomics Research Center, Academia Sinica, Taipei, Taiwan
    J Allergy Clin Immunol 117:1203-12; quiz 1213. 2006
    ..This mechanism contrasts with that of cromones, mast cell-stabilizing agents that retard Ca++ mobilization and the degranulation process, thus deflating the intracellular activation signal triggered by IgE-FcepsilonRI aggregation...
  6. doi request reprint An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors
    Yu Yu Shiung
    Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan
    Immunobiology 217:676-83. 2012
    ....
  7. doi request reprint Manipulating mIgD-expressing B cells with anti-migis-δ monoclonal antibodies
    Nien Yi Chen
    Genomics Research Center, Academia Sinica, Taipei, Taiwan Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    Mol Immunol 53:187-97. 2013
    ..CB17-Prkdc(scid)/IcrCrlBltw) mice could be suppressed by 20E6. These results encourage further investigation of the potential of anti-migis-δ mAbs to control mIgD(+) B cells, when such a manipulation may alleviate a disease state...
  8. doi request reprint CɛmX peptide-carrying HBcAg virus-like particles induced antibodies that down-regulate mIgE-B lymphocytes
    Chien Jen Lin
    Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan
    Mol Immunol 52:190-9. 2012
    ..These studies suggest that HBcAg-CɛmX peptide immunogens warrant further investigation as a therapeutic modality for modulating IgE in patients with IgE-mediated allergic diseases...
  9. ncbi request reprint Comparative effects of human Ig alpha and Ig beta in inducing autoreactive antibodies against B cells in mice
    Jim J C Sheu
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    J Immunol 170:1158-66. 2003
    ..These findings suggest that specific auto/cross-reactivity against self Ig alpha can be induced by a molecular mimicry presented by a foreign Ig alpha...
  10. doi request reprint Accumulated immune complexes of IgE and omalizumab trap allergens in an in vitro model
    Chuan Long Hsu
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    Int Immunopharmacol 10:533-9. 2010
    ..These results suggest that the rapidly accumulated IgE:omalizumab complexes in omalizumab-treated patients can capture allergens and consequently contribute to the pharmacological effects of omalizumab...
  11. doi request reprint Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformations
    Hsing Mao Chu
    The Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    Nat Commun 5:3139. 2014
    ....
  12. doi request reprint The IgE gene in primates exhibits extraordinary evolutionary diversity
    Pheidias C Wu
    Genomics Research Center, Academia Sinica, Nankang, Taipei, 115, Taiwan
    Immunogenetics 64:279-87. 2012
    ....
  13. doi request reprint Lipid rafts hinder binding of antibodies to the extracellular segment of the membrane-anchor peptide of mIgA
    Alfur Fu Hsin Hung
    Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan
    Mol Immunol 48:1975-82. 2011
    ..Further studies are in progress to evaluate the suitability of 29C11 or its affinity-improved variants for targeting mIgA-expressing B cells...
  14. doi request reprint Cumulative environmental changes, skewed antigen exposure, and the increase of allergy
    Tse Wen Chang
    Genomics Research Center, Academia Sinica, Nankang, Taipei 11529, Taiwan
    Adv Immunol 98:39-83. 2008
    ....