Ta Chau Chang

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. pmc Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation
    Yu Lin Tsai
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    Nucleic Acids Res 39:e114. 2011
  2. pmc In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands
    Ting Yuan Tseng
    Institute of Biophotonics, National Yang Ming University, Taipei 11221, Taiwan, Republic of China, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, Republic of China and Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, Republic of China
    Nucleic Acids Res 41:10605-18. 2013
  3. pmc Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol
    Zi Fu Wang
    Department of Chemistry, National Taiwan University, Academia Sinica, Taipei 106, Taiwan, ROC
    Nucleic Acids Res 40:8711-20. 2012
  4. pmc Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity
    Chi Chih Kang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Integr Biol (Camb) 5:1217-28. 2013
  5. ncbi request reprint Structure conversion and structure separation of G-quadruplexes investigated by carbazole derivatives
    Ta Chau Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Curr Pharm Des 18:2002-13. 2012
  6. ncbi request reprint Structural isomers and binding sites of guanine-rich quadruplexes investigated by induced circular dichroism of thionin: loops and tails
    Jin Yi Wu
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, 106, Taiwan
    J Biomol Struct Dyn 21:135-40. 2003
  7. pmc Investigation of spectral conversion of d(TTAGGG)4 and d(TTAGGG)13 upon potassium titration by a G-quadruplex recognizer BMVC molecule
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, PO Box 23 166, Taipei, 106, Taiwan, Republic of China
    Nucleic Acids Res 35:2846-60. 2007
  8. doi request reprint A dual selective antitumor agent and fluorescence probe: the binary BMVC-porphyrin photosensitizer
    Chi Chih Kang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    ChemMedChem 3:725-8. 2008
  9. ncbi request reprint A fluorescent carbazole derivative: high sensitivity for quadruplex DNA
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, PO Box 23 166, Taipei, 10764, Taiwan, Republic of China
    Anal Chem 75:6177-83. 2003
  10. ncbi request reprint Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, 106, Taiwan, Republic of China
    Anal Chem 76:4490-4. 2004

Collaborators

  • Cheng Chung Chang
  • Chin Tin Chen
  • Tai Horng Young
  • Tzong Shyuan Lee
  • Sheh Yi Sheu
  • Jin Yuan Shih
  • Lin Lin
  • Shang Te Danny Hsu
  • Zi Fu Wang
  • Chi Chih Kang
  • Cheng Hao Chien
  • Pei Jen Lou
  • Ting Yuan Tseng
  • Wei Wen Chen
  • Chiung Lin Wang
  • Jen Fei Chu
  • Fong Chun Huang
  • Ming Hao Li
  • Tsung Lin Yang
  • Wei Chun Huang
  • Yu Lin Tsai
  • Li Jen Liao
  • I Ting Lin
  • Mei Ying Lin
  • Shih Wei Liu
  • Ya Shuan Chou
  • I Shiow Jan
  • June Tai Wu
  • Hung Wen Li
  • Chang Ting Lin
  • Chih Chien Cho
  • Jing Jer Lin
  • Dah Yen Yang
  • I Chun Kuo
  • Jin Yi Wu
  • Tzu Hsiu Tsai
  • Huey Dong Wu
  • Hao Chien Wang
  • Margaret Hsin Jui Kuo
  • Chiung Wen Kouh
  • Cheng Ting Tsai
  • Yuh Lin Wang
  • Hung Chih Fang
  • Lily Jun shen Huang
  • Shih Torng Ding
  • Huai Hsien Wang
  • Chen Hao Chien
  • Joachim Seemann
  • Jing Min Wang
  • Huei Chin Chen
  • Fu Ying Shieh
  • Yu Chen Lin
  • Chih Wei Chien
  • Wenjun Xie
  • Edward S Yeung
  • Chung Yuan Mou
  • Kuan Yu Chen
  • Cheng Sheng Yan

Detail Information

Publications31

  1. pmc Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation
    Yu Lin Tsai
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    Nucleic Acids Res 39:e114. 2011
    ..Together with NMR spectra, one can simplify the spectra for both the free DNA and the bound DNA to establish a spectrum-structure correlation for further structural analysis...
  2. pmc In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands
    Ting Yuan Tseng
    Institute of Biophotonics, National Yang Ming University, Taipei 11221, Taiwan, Republic of China, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, Republic of China and Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, Republic of China
    Nucleic Acids Res 41:10605-18. 2013
    ..These findings are valuable to the design and rationale behind the possible targeted drug delivery to specific cellular organelles using GROs. ..
  3. pmc Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol
    Zi Fu Wang
    Department of Chemistry, National Taiwan University, Academia Sinica, Taipei 106, Taiwan, ROC
    Nucleic Acids Res 40:8711-20. 2012
    ..In addition, our ligand work provides further confidence that the local water structure plays the key to induce conformational change of human telomere...
  4. pmc Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity
    Chi Chih Kang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Integr Biol (Camb) 5:1217-28. 2013
    ..Moreover, our results suggest that agents which can increase lysosomal membrane permeability may re-sensitize drug-resistant cancer cells to chemotherapeutic agents. ..
  5. ncbi request reprint Structure conversion and structure separation of G-quadruplexes investigated by carbazole derivatives
    Ta Chau Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Curr Pharm Des 18:2002-13. 2012
    ..Verification of the possible structural conversion and investigation of structural diversity among various G4 structures are essential for exploring their potential biological roles and for developing new anticancer drugs...
  6. ncbi request reprint Structural isomers and binding sites of guanine-rich quadruplexes investigated by induced circular dichroism of thionin: loops and tails
    Jin Yi Wu
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, 106, Taiwan
    J Biomol Struct Dyn 21:135-40. 2003
    ..Our results show that external stacking on the end surface of the G-quartet associated with electrostatic interaction with the loops or tails is the major binding mode of thionin with these G-quadruplexes...
  7. pmc Investigation of spectral conversion of d(TTAGGG)4 and d(TTAGGG)13 upon potassium titration by a G-quadruplex recognizer BMVC molecule
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, PO Box 23 166, Taipei, 106, Taiwan, Republic of China
    Nucleic Acids Res 35:2846-60. 2007
    ....
  8. doi request reprint A dual selective antitumor agent and fluorescence probe: the binary BMVC-porphyrin photosensitizer
    Chi Chih Kang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    ChemMedChem 3:725-8. 2008
  9. ncbi request reprint A fluorescent carbazole derivative: high sensitivity for quadruplex DNA
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, PO Box 23 166, Taipei, 10764, Taiwan, Republic of China
    Anal Chem 75:6177-83. 2003
    ..Moreover, the sensitivity assays show that as little as 0.2 pmol of quadruplex of d(T(2)AG(3))(4) can be revealed by BMVC...
  10. ncbi request reprint Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, 106, Taiwan, Republic of China
    Anal Chem 76:4490-4. 2004
    ..Together these results provide the first evidence for the presence of quadruplex structures in human telomeres...
  11. ncbi request reprint A novel carbazole derivative, BMVC: a potential antitumor agent and fluorescence marker of cancer cells
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, 106, Taiwan, Republic of China
    Chem Biodivers 1:1377-84. 2004
    ..Interestingly, similar fluorescence spots are hardly observed in the nuclei of the IMR90 and Detroit-551 normal cells, implying that BMVC might be a useful marker to distinguish tumor cells and normal cells...
  12. ncbi request reprint Verification of antiparallel G-quadruplex structure in human telomeres by using two-photon excitation fluorescence lifetime imaging microscopy of the 3,6-Bis(1-methyl-4-vinylpyridinium)carbazole diiodide molecule
    Cheng Chung Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, 106, Taiwan, Republic of China
    Anal Chem 78:2810-5. 2006
    ....
  13. ncbi request reprint Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy
    Ting Yuan Tseng
    National Yang Ming University, Institute of Biophotonics, Taipei 11221, Taiwan
    J Biomed Opt 18:101309. 2013
    ..Furthermore, by using fluorescence lifetime imaging microscopy, we demonstrated an innovative methodology for visualizing the localization of G4 structures as well as mapping the localization of different G4 structures in living cells...
  14. ncbi request reprint A handheld device for potential point-of-care screening of cancer
    Chi Chih Kang
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei, Taiwan 106, Republic of China
    Analyst 132:745-9. 2007
    ..Flow cytometry assay further supported the utility of this simple device, where a preliminary study of tissue biopsy showed highly encouraging results...
  15. ncbi request reprint G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells
    Fong Chun Huang
    Institute of Biopharmaceutical Science, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
    Mol Cancer Res 6:955-64. 2008
    ..Thus, BMVC repressed tumor progression through both telomere-dependent and telomere-independent pathways...
  16. doi request reprint Detection of G-quadruplexes in cells and investigation of G-quadruplex structure of d(T2AG3)4 in K+ solution by a carbazole derivative: BMVC
    Ta Chau Chang
    Institute of Atomic and Molecular Sciences, and Genomic Research Center, Academia Sinica, Taipei, Taiwan, Republic of China
    Methods Mol Biol 608:183-206. 2010
    ..Using fluorescence lifetime imaging microscopy, the longer decay time of BMVC in G-quadruplex H24 than in duplex DNA allowed us to map the G-quadruplex structure in human metaphase chromosomes...
  17. pmc Structural basis of sodium-potassium exchange of a human telomeric DNA quadruplex without topological conversion
    Zi Fu Wang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, Republic of China, Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, Republic of China, Institute of Biophotonics, National Yang Ming University, Taipei 112, Taiwan, Republic of China, Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China and Department of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan, Republic of China
    Nucleic Acids Res 42:4723-33. 2014
    ..These results offer a possible explanation of rapid spectral conversion of Na(+)/K(+) exchange and insight into the mechanism of Na(+)/K(+) structural conversion in human telomeric G4s. ..
  18. pmc Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity
    Fong Chun Huang
    Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei, Taiwan
    Br J Pharmacol 167:393-406. 2012
    ..Here, we characterize the cellular effects of a novel G-quadruplex stabilizing compound, 3,6-bis(4-methyl-2-vinylpyrazinium iodine) carbazole (BMVC4)...
  19. pmc Photo-induced antitumor effect of 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide
    Ya Shuan Chou
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10002, Taiwan
    Biomed Res Int 2013:930281. 2013
    ..Immunohistochemistry studies showed the microvascular density was significantly lower in the iPDT group. Taken together, our results demonstrated that BMVC may be a potent tumor-specific photosensitizer (PS) for PDT...
  20. doi request reprint Assaying the binding strength of G-quadruplex ligands using single-molecule TPM experiments
    Shih Wei Liu
    Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan
    Anal Biochem 436:101-8. 2013
    ....
  21. doi request reprint Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: the effect of potassium concentration and ion exchange
    Chang Ting Lin
    Institute of Atomic and Molecular Sciences, Academia Sinica, P O Box 23 166, Taipei 10617, Taiwan, Republic of China
    J Phys Chem B 115:2360-70. 2011
    ..In addition, this work reveals the conditions that would be useful for NMR studies of G-quadruplexes...
  22. pmc Single-molecule TPM studies on the conversion of human telomeric DNA
    Jen Fei Chu
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Biophys J 98:1608-16. 2010
    ..This study also demonstrates that TPM experiments can be used to study conformational changes in single-stranded DNA molecules...
  23. pmc BMVC test, an improved fluorescence assay for detection of malignant pleural effusions
    I Ting Lin
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan
    Cancer Med 3:162-73. 2014
    ..This is a convenient ancillary tool for detection of malignant pleural effusions...
  24. ncbi request reprint Interaction between human telomere and a carbazole derivative: a molecular dynamics simulation of a quadruplex stabilizer and telomerase inhibitor
    Dah Yen Yang
    Department of Life Sciences and Institute of Genome Sciences, Institute of Bioinformatics, and Structural Biology Program, National Yang Ming University, Taipei 112, Taiwan
    J Phys Chem A 111:9224-32. 2007
    ..Of particular interest is that one pyridinium ring and carbazole moiety of the BMVC can stack well at the end of G-quartet. This implies that BMVC is a good human quadruplex stabilizer and also a good telomerase inhibitor...
  25. ncbi request reprint Automated quantitative analysis of lipid accumulation and hydrolysis in living macrophages with label-free imaging
    Wei Wen Chen
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan
    Anal Bioanal Chem 405:8549-59. 2013
    ....
  26. doi request reprint Investigation of lipid homeostasis in living Drosophila by coherent anti-Stokes Raman scattering microscopy
    Cheng Hao Chien
    National Yang Ming University, Institute of Biophotonics, Taipei 112, Taiwan
    J Biomed Opt 17:126001. 2012
    ..Our results demonstrate in vivo observations of direct influences of Bmm and Lsd-2 on lipid homeostasis in Drosophila larvae...
  27. doi request reprint Selective photodynamic therapy based on aggregation-induced emission enhancement of fluorescent organic nanoparticles
    Cheng Chung Chang
    Graduate Institute of Biomedical Engineering, National Chung Hsing University 250, Taichung 402, Taiwan, ROC
    Biomaterials 33:897-906. 2012
    ..This improved photodynamic activity might be due to the aggregation of compounds in the cell that form FONs which can promote PDT (photodynamic therapy) and are observed in cancer cell but not normal cell...
  28. doi request reprint Label-free imaging of Drosophila in vivo by coherent anti-Stokes Raman scattering and two-photon excitation autofluorescence microscopy
    Cheng Hao Chien
    National Yang Ming University, Institute of Biophotonics, and National Taiwan University Hospital, Department of Medical Research, Taipei 100, Taiwan
    J Biomed Opt 16:016012. 2011
    ..Through in vivo imaging and direct monitoring, CARS microscopy may help elucidate how metamorphosis is regulated and study the lipid metabolism in Drosophila...
  29. pmc Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe
    Tsung Lin Yang
    Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 9:e86143. 2014
    ..These results demonstrate the ability of BMVC probes to detect cell transformation and indicate that BMVC is of promise for use as a probe in early cancer detection. ..
  30. doi request reprint Improved diagnostic accuracy of malignant neck lumps by a simple BMVC staining assay
    Li Jen Liao
    Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
    Analyst 134:708-11. 2009
    ..Moreover, an algorithm is proposed to improve the diagnostic accuracy of malignant neck lumps up to nearly 100%...
  31. doi request reprint Unfolding kinetics of human telomeric G-quadruplexes studied by NMR spectroscopy
    Ming Hao Li
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, R O C
    J Phys Chem B 118:931-6. 2014
    ..Our results raised an issue that the folding and unfolding kinetics is more relevant for better understanding of biological function of G4 structures. ..