Frank Tacke

Summary

Publications

  1. ncbi request reprint Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital Aachen, Germany
    Inflamm Allergy Drug Targets 10:509-36. 2011
  2. pmc Why high suPAR is not super - diagnostic, prognostic and potential pathogenic properties of a novel biomarker in the ICU
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:1020. 2011
  3. ncbi request reprint A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aschen, Germany
    Scand J Gastroenterol 42:374-82. 2007
  4. doi request reprint Inflammatory pathways in liver homeostasis and liver injury
    Frank Tacke
    Medical Clinic III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Clin Rev Allergy Immunol 36:4-12. 2009
  5. ncbi request reprint Migratory fate and differentiation of blood monocyte subsets
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, USA
    Immunobiology 211:609-18. 2006
  6. pmc Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R45. 2011
  7. doi request reprint Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques
    Frank Tacke
    Department of Medicine III RWTH, University Hospital Aachen, Aachen, Germany
    Expert Rev Gastroenterol Hepatol 6:67-80. 2012
  8. doi request reprint [Liver fibrosis - pathogenesis and novel therapeutic approaches]
    F Tacke
    Medizinische Klinik III, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland
    Internist (Berl) 51:21-9. 2010
  9. ncbi request reprint Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    J Gastroenterol Hepatol 22:1256-64. 2007
  10. doi request reprint [Monocyte subpopulations in inflammation processes: principles and perspectives]
    Frank Tacke
    Medizinische Klinik III, Universitatsklinikum Aachen, Aachen
    Dtsch Med Wochenschr 134:1645-8. 2009

Detail Information

Publications100

  1. ncbi request reprint Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital Aachen, Germany
    Inflamm Allergy Drug Targets 10:509-36. 2011
    ....
  2. pmc Why high suPAR is not super - diagnostic, prognostic and potential pathogenic properties of a novel biomarker in the ICU
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:1020. 2011
    ..This study expands our knowledge of the diagnostic power of suPAR, confirms its prognostic value, and raises the demand for future studies investigating the pathogenic involvement of suPAR...
  3. ncbi request reprint A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aschen, Germany
    Scand J Gastroenterol 42:374-82. 2007
    ..Stratifying high-risk patients for variceal bleeding is mainly based on endoscopic scoring. The purpose of this study was to develop a simple clinical score to assess the bleeding risk...
  4. doi request reprint Inflammatory pathways in liver homeostasis and liver injury
    Frank Tacke
    Medical Clinic III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Clin Rev Allergy Immunol 36:4-12. 2009
    ....
  5. ncbi request reprint Migratory fate and differentiation of blood monocyte subsets
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, USA
    Immunobiology 211:609-18. 2006
    ..Fortunately, the rate of progress in the study of monocyte fate is rapidly picking up pace, giving rise to the expectation that we will soon know much more about the biology of monocytes in the steady state and inflammation...
  6. pmc Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R45. 2011
    ..We aimed at evaluating the diagnostic and prognostic value of N-terminal pro-CNP (NT-proCNP) for predicting sepsis, disease severity and mortality in critically ill medical patients...
  7. doi request reprint Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques
    Frank Tacke
    Department of Medicine III RWTH, University Hospital Aachen, Aachen, Germany
    Expert Rev Gastroenterol Hepatol 6:67-80. 2012
    ..Novel isolation techniques, specifically HSC sorting by FACS via autofluorescence and antibodies, will provide us with further opportunities to advance our understanding of HSC biology in health and disease...
  8. doi request reprint [Liver fibrosis - pathogenesis and novel therapeutic approaches]
    F Tacke
    Medizinische Klinik III, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland
    Internist (Berl) 51:21-9. 2010
    ..Understanding the complex cellular interactions in liver fibrosis may help to develop novel antifibrotic therapies in the near future...
  9. ncbi request reprint Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    J Gastroenterol Hepatol 22:1256-64. 2007
    ..The aim of this study was to analyze the role of eotaxin in chronic liver disease...
  10. doi request reprint [Monocyte subpopulations in inflammation processes: principles and perspectives]
    Frank Tacke
    Medizinische Klinik III, Universitatsklinikum Aachen, Aachen
    Dtsch Med Wochenschr 134:1645-8. 2009
    ..These findings are expected to identify novel targets for future therapeutic strategies...
  11. pmc Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Gastroenterology 137:309-19, 319.e1-3. 2009
    ..We investigated the roles of the chemokine CXCL9 and its receptor CXCR3 in liver fibrosis...
  12. doi request reprint The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes
    Karlin Raja Karlmark
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Hepatology 52:1769-82. 2010
    ..Monocytes/macrophages lacking CX₃CR1 undergo increased cell death after liver injury, which then perpetuates inflammation, promotes prolonged inflammatory monocyte infiltration into the liver, and results in enhanced liver fibrosis...
  13. doi request reprint Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases
    Frank Tacke
    Medical Department III, University Hospital Aachen, Aachen, Germany
    Liver Int 31:840-9. 2011
    ....
  14. doi request reprint Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome
    Samad Amini-Bavil-Olyaee
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 51:647-54. 2009
    ..We aimed at assessing the prevalence of substitutions at rtQ215 of the HBV polymerase and determining the molecular and functional consequences using phenotypic analyses in vitro...
  15. doi request reprint miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis
    Christoph Roderburg
    Department of Medicine III, University of Aachen RWTH, 52074 Aachen, Germany
    J Hepatol 58:736-42. 2013
    ..miRNAs are novel regulators of organ fibrosis. miR-133a plays a role in cardiac and muscle remodeling, but its function in the liver is unclear. We therefore aimed at evaluating a possible function of miR-133a in hepatofibrogenesis...
  16. doi request reprint Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice
    Felix Heymann
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    Hepatology 55:898-909. 2012
    ..Liver fibrosis progression, but also subsequent T-cell alterations, could be restored by adoptively transferring CCR8-expressing monocytes/macrophages into ccr8(-/-) mice during experimental injury...
  17. pmc Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis
    Christoph Roderburg
    Department of Medicine III, University Hospital Rheinisch Westfaelische Technische Hochschule Aachen, Aachen, Germany
    PLoS ONE 8:e54612. 2013
    ..We thus aimed at evaluating the diagnostic and prognostic value of miR-150 serum levels in patients with critically illness and sepsis...
  18. doi request reprint Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis
    Alexander Wehr
    Department of Medicine III, University Hospital Aachen, 52074 Aachen, Germany
    J Immunol 190:5226-36. 2013
    ..Interfering with CXCR6/CXCL16 might therefore bear therapeutic potential in liver fibrosis...
  19. pmc Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R63. 2011
    ....
  20. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
    ..Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes. We investigated the potential role of RBP4 in critically ill patients...
  21. pmc Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    PLoS ONE 5:e11049. 2010
    ....
  22. doi request reprint The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, D 52074 Aachen, Germany
    Biol Chem 390:1039-45. 2009
    ..These results support the importance of post-translational chemokine regulation and describe a new mechanism of immune modulation within the liver...
  23. pmc Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital, Aachen, Germany
    PLoS ONE 6:e21381. 2011
    ..We investigated the regulation of IL-8, its receptors CXCR1 and CXCR2 and possible IL-8 responding cells in CLD patients...
  24. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  25. doi request reprint Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Crit Care 26:166-74. 2011
    ..We therefore investigated the potential pathogenic role and prognostic value of circulating adiponectin levels in critical illness...
  26. pmc Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R266. 2011
    ..We investigated liver stiffness as a potentially useful tool for early detection of patients with hepatic deterioration and risk stratification with respect to short- and long-term mortality...
  27. pmc Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    Leif E Sander
    Department of Medicine III, RWTH University Hospital, 52074 Aachen, Germany
    J Exp Med 207:1453-64. 2010
    ..Thus, gp130-dependent communication between the liver and MDSCs through APPs controls inflammatory responses during infection...
  28. ncbi request reprint Modulation of dendritic cell trafficking to and from the airways
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Immunol 176:3578-84. 2006
    ....
  29. pmc Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R95. 2009
    ..We aimed to examine the correlation of serum resistin concentrations to parameters of inflammation, organ function, metabolism, disease severity and survival in critically ill patients...
  30. doi request reprint Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Clin Biochem 45:429-35. 2012
    ..C-type natriuretic peptide (CNP) might be an important regulator of vasodilatation, fluid and sodium balance in liver cirrhosis. We aimed at assessing its regulation and prognostic relevance in liver disease patients...
  31. doi request reprint Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    Christer Baeck
    Department of Medicine III, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Gut 61:416-26. 2012
    ..Pharmacological inhibition of MCP-1 with mNOX-E36 was investigated in two murine models of chronic liver diseases...
  32. doi request reprint Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer
    Carlo Schneider
    Department of Medicine III, University Hospital, RWTH Aachen, Aachen, Germany
    Gut 61:1733-43. 2012
    ..Hepatocellular carcinoma (HCC) is a typical inflammation-associated cancer, but may also provoke antitumour immune responses whose significance and underlying mechanisms are incompletely understood...
  33. pmc Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis
    Christoph Roderburg
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    PLoS ONE 7:e32999. 2012
    ..Therefore, in the present study we performed a systematic screening approach in order to identify miRNAs with altered levels in the serum of patients with chronic liver disease and liver cirrhosis...
  34. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    ....
  35. pmc Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery
    Frank Tacke
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:583-97. 2006
    ..These data reveal that immature monocytes unexpectedly sample antigen from the bone marrow environment and that they can present these antigens after they leave the bone marrow...
  36. pmc Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes
    Sebastian Seidler
    Department of Medicine III, University Hospital, RWTH Aachen, Germany
    BMC Gastroenterol 12:38. 2012
    ....
  37. pmc Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains
    Samad Amini-Bavil-Olyaee
    Department of Medicine III, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Virol 84:1026-33. 2010
    ....
  38. pmc CXCL5 plasma levels decrease in patients with chronic liver disease
    Frank Tacke
    Department of Medicine III, University Hospital, Aachen, Germany
    J Gastroenterol Hepatol 26:523-9. 2011
    ..The aim of our study was to assess CXCL5 plasma levels in patients with chronic liver disease...
  39. doi request reprint Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, Aachen, Germany
    Hepatology 53:596-603. 2011
    ..001), whereas a level ≤ 220 pg/mL early after LT predicted the absence of F3 fibrosis during follow-up (P = 0.035)...
  40. doi request reprint Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis
    Yulia A Nevzorova
    Department of Medicine, RWTH Aachen University, Aachen, Germany
    Biochim Biophys Acta 1832:1765-75. 2013
    ..However, the impact of c-myc for initiating pathological precursor stages such as liver fibrosis is poorly characterized. In the present study we thus investigated the impact of c-myc for liver fibrogenesis...
  41. doi request reprint Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, Aachen, Germany
    J Crit Care 28:947-53. 2013
    ..We aimed at investigating ADMA levels as a potential diagnostic or prognostic biomarker in critically ill patients...
  42. ncbi request reprint Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, 52074 Aachen, Germany
    Diabetes Care 30:1168-72. 2007
    ..As insulin resistance is present in nearly all patients with liver cirrhosis, we evaluated RBP4 in patients with chronic liver disease (CLD)...
  43. doi request reprint High C5a levels are associated with increased mortality in sepsis patients--no enhancing effect by actin-free Gc-globulin
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, University Hospital Aachen, Aachen University RWTH, Aachen, Germany
    Clin Biochem 41:974-80. 2008
    ..Immune paralysis of phagocytic cells due to excess of the complement activation product C5a has been proposed as a critical pathomechanism in sepsis. In vitro studies suggest an interaction of C5a with Group-specific globulin (Gc-globulin)...
  44. pmc Met-CCL5 modifies monocyte subpopulations during liver fibrosis regression
    Miriam K Stock
    Department of Medicine III, RWTH University Hospital Aachen Pauwelsstrasse 30, D 52074 Aachen, Germany
    Int J Clin Exp Pathol 6:678-85. 2013
    ..Since a shift in monocyte subpopulations has recently been identified to contribute to fibrosis regression, our results help explaining the efficacy of CCL5 chemokine antagonism as a novel treatment option for fibrotic liver diseases...
  45. doi request reprint Peptide-functionalized gold nanorods increase liver injury in hepatitis
    Matthias Bartneck
    Department of Medicine III, Medical Faculty, RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    ACS Nano 6:8767-77. 2012
    ..Bioactively targeted gold nanoparticles are thus potentially harmful in clinically relevant settings of liver injury, as they can aggravate hepatitis severity...
  46. doi request reprint Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis
    Karlin Raja Karlmark
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    Hepatology 50:261-74. 2009
    ..Thus, they may represent an interesting novel target for antifibrotic strategies...
  47. ncbi request reprint Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    Dig Dis Sci 52:3404-15. 2007
    ..Elevated systemic and hepatic levels of BMP7 in patients with chronic liver disease may contribute to progression of liver fibrogenesis in vivo...
  48. doi request reprint Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient
    Samad Amini-Bavil-Olyaee
    Department of Medicine III, University Hospital Aachen, Germany
    AIDS 23:268-72. 2009
    ..HBV mutants carrying drug and vaccine resistance may represent a considerable individual risk and public health concern...
  49. pmc Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?
    Mihael Vucur
    Department of Internal Medicine III, University Hospital of RWTH Aachen, D 52074 Aachen, Germany
    Oncotarget 1:373-8. 2010
    ..Molecular findings in this mouse model and their possible significance for chemopreventive strategies against HCC are compared to other murine HCC models...
  50. pmc U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis
    Fabian Benz
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    Exp Mol Med 45:e42. 2013
    ..Further studies are warranted to identify specific regulatory processes of U6 levels in sepsis and liver fibrosis. ..
  51. ncbi request reprint Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Am J Gastroenterol 101:1244-52. 2006
    ..In experimental cirrhosis models, resistin expression is upregulated. We aimed to evaluate the potential clinical value of resistin in chronic liver diseases (CLD)...
  52. pmc Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
    Sebastian Seidler
    Department of Medicine III, University Hospital, RWTH Aachen, Germany
    BMC Immunol 11:30. 2010
    ..In analogy to murine studies, we hypothesized that human monocyte subsets dynamically change during ageing, potentially influencing their functionality and contributing to immunosenescence...
  53. doi request reprint Two distinct types of Langerhans cells populate the skin during steady state and inflammation
    Kristin Seré
    Institute for Biomedical Engineering, Department of Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    Immunity 37:905-16. 2012
    ..Our data demonstrate the presence of two types of LCs that develop through different pathways in inflammation and steady state...
  54. ncbi request reprint Monocytes and macrophages as cellular targets in liver fibrosis
    Felix Heymann
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Inflamm Allergy Drug Targets 8:307-18. 2009
    ....
  55. doi request reprint Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis
    Henning W Zimmermann
    Department of Medicine, RWTH University Hospital Aachen, Aachen, Germany
    Liver Int 32:500-9. 2012
    ..High serum concentrations of soluble uPAR (suPAR) are suggested to reflect activated immune cells...
  56. pmc Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:185-94. 2007
    ..Thus, antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their CCR2-dependent responses to inflammation overall...
  57. doi request reprint Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients
    Christoph Roderburg
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    J Crit Care 28:882.e1-11. 2013
    ..However, up to now, APRIL has not been investigated in critical illness or sepsis. We therefore analyzed APRIL serum concentrations in a large cohort of well-characterized intensive care unit patients...
  58. pmc Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Mediators Inflamm 2013:413826. 2013
    ..Thus, the significant increase of circulating SDMA in critically ill patients indicates a potential pathogenic involvement in endothelial dysfunction during sepsis and may be useful for mortality risk stratification at the ICU. ..
  59. doi request reprint Chemokines in liver inflammation and fibrosis
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
    Semin Liver Dis 30:215-25. 2010
    ..Here, we summarize current knowledge on the genetic and functional importance of the chemokine network in injury and highlight their potential for intervening in the inflammation and fibrosis that drives liver disease progression...
  60. doi request reprint Chemokine-directed immune cell infiltration in acute and chronic liver disease
    Karlin Raja Karlmark
    Medical Clinic III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Expert Rev Gastroenterol Hepatol 2:233-42. 2008
    ..Dissecting the exact functional contribution of immune cell subsets, chemokines and chemokine-receptor pathways in liver injury will hopefully identify novel targets for the treatment of acute liver failure, liver fibrosis or cirrhosis...
  61. pmc Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice
    Yulia A Nevzorova
    Department of Medicine III, University Hospital, RWTH Aachen, Aachen, Germany
    Hepatology 56:1140-9. 2012
    ..In contrast, CcnE2-deficient HSCs expressed an elevated level of CcnE1 and showed enhanced cell-cycle activity and proliferation, compared to WT cells...
  62. ncbi request reprint Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  63. ncbi request reprint A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells
    Glaucia C Furtado
    Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Immunol 177:6871-9. 2006
    ..We propose that alterations in the numbers or function of monocytes and DC coupled to dysregulated expression of chemokines in the neural tissues, favors development of CNS autoimmune disease...
  64. doi request reprint Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 75:185-96. 2009
    ..We show that YB-1 is a cell-type specific regulator of CCL5 expression in infiltrating T-cells and monocytes/macrophages and acts as an adaptive controller of inflammation during kidney allograft rejection...
  65. pmc Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice
    Eugene Trogan
    Marc and Ruti Bell Vascular Biology Program, Leon H Charney Division of Cardiology Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:3781-6. 2006
    ..Taken with the other gene expression data, these results in vivo point to complex relationships among the immune system, nuclear hormone receptors, and inflammation during regression...
  66. pmc Role of IL-17 and Th17 cells in liver diseases
    Linda Hammerich
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Clin Dev Immunol 2011:345803. 2011
    ..Understanding the chemokines and chemokine receptors promoting hepatic Th17 cell recruitment (possibly CCR6 or CCR4) might reveal new therapeutic targets interfering with Th17 migration or differentiation in liver disease...
  67. doi request reprint Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    J Hepatol 58:104-11. 2013
    ..FSAP is activated by damaged cells and its substrates include growth factors and hemostasis proteins...
  68. doi request reprint Effects of nanoparticle surface-coupled peptides, functional endgroups, and charge on intracellular distribution and functionality of human primary reticuloendothelial cells
    Matthias Bartneck
    Department of Medicine III, Medical Faculty, RWTH Aachen, Aachen, Germany
    Nanomedicine 8:1282-92. 2012
    ..These data suggest that the charge of NPs mainly influences their uptake, whereas conjugated peptides alter cell functions...
  69. pmc Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease
    Frank Tacke
    Department of Medicine III, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    BMC Cancer 11:185. 2011
    ..We recently described active secretion of a family member, denoted Y-box (YB) protein-1. We tested the clinical and diagnostic value of YB-1 protein fragment p18 (YB-1/p18) detection in blood for malignant diseases...
  70. doi request reprint TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer
    Kira Bettermann
    Department of Internal Medicine III, University Hospital RWTH Aachen, D 52074 Aachen, Germany
    Cancer Cell 17:481-96. 2010
    ..Therefore, TAK1 serves as a gatekeeper for a protumorigenic, NF-kappaB-independent function of NEMO in parenchymal liver cells...
  71. doi request reprint From proteomic multimarker profiling to interesting proteins: thymosin-β(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions
    Corinna Henkel
    Institute of Pathology, RWTH University Hospital Aachen, Aachen, Germany
    J Cell Mol Med 15:2176-88. 2011
    ..Based on the high throughput capability, the identified differential protein panel may serve as a diagnostic marker and warrants further validation in larger cohorts...
  72. doi request reprint Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
    Christoph Roderburg
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    Hepatology 53:209-18. 2011
    ..Furthermore, overexpression of miR-29b in murine HSC resulted in down-regulation of collagen expression...
  73. ncbi request reprint Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient
    Frank Tacke
    Medical Clinic III, RWTH University Hospital Aachen, Aachen, Germany
    J Clin Virol 38:353-7. 2007
    ..Hepatitis B Virus (HBV) infection is a leading cause of chronic hepatitis and liver cirrhosis worldwide, and efficient protection can usually be achieved by vaccination that is based on recombinant HBsAg protein from HBV genotype A and D...
  74. doi request reprint The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains
    Samad Amini-Bavil-Olyaee
    Department of Medicine III, RWTH University Hospital Aachen, Germany
    Hepatology 49:1158-65. 2009
    ..Clones harboring rtA194T showed partial resistance to tenofovir in vitro and also to LAM but remained susceptible to telbivudine and entecavir...
  75. doi request reprint Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration
    Yann Malato
    Medical Clinic III, University Hospital Aachen RWTH, Aachen, Germany
    Hepatology 47:2036-50. 2008
    ..Interestingly, despite faster G(1)/S progression, IKK2DeltaLPC mice exhibited an enduring mitosis phase, because mitotic bodies were still observed at later stages after PH...
  76. ncbi request reprint Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    Leif E Sander
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    J Immunol 181:3586-94. 2008
    ..We provide evidence that IL-6 cytokines acting via gp130 are required in the acute stages of intestinal inflammation by modulating the dynamics of innate immune cell recruitment and activation...
  77. ncbi request reprint Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
    Jordi C Ochando
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Nat Immunol 7:652-62. 2006
    ..Thus, alloantigen-presenting pDCs home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development and allograft tolerance...
  78. doi request reprint Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury
    Christian Liedtke
    Department of Medicine III, University Hospital, Aachen, Germany
    Gastroenterology 141:2176-87. 2011
    ..Activation of caspase-8 (Casp8) initiates death receptor-mediated apoptosis. We investigated the pathogenic role of this protease in NEMO(Δhepa) mice or after induction of acute liver injury...
  79. doi request reprint Assessment of inflammatory and fibrotic stenoses in patients with Crohn's disease using contrast-enhanced ultrasound and computerized algorithm: a pilot study
    Ramin Schirin-Sokhan
    Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Digestion 83:263-8. 2011
    ..The aim of the present study was to define objective quantitative measures of stricture characteristics (fibrostenotic/cicartricial vs. inflammatory) using contrast-enhanced ultrasound (CEUS) in patients with stenotic Crohn's disease...
  80. ncbi request reprint The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Hepatol 48:208-15. 2008
    ..The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis...
  81. ncbi request reprint Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, University Hospital Aachen UKA, Aachen University RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Clin Biochem 39:39-45. 2006
    ..Nepsilon-(carboxymethyl)lysine (CML)-modified advanced glycation end products (AGEs) in patients with CLD could reflect the degree of severity of the disease...
  82. pmc Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes
    Chunfeng Qu
    Dept of Gene and Cell Medicine, Mt Sinai School of Medicine, Box 1496, 1425 Madison Ave, New York, NY 10029, USA
    J Exp Med 200:1231-41. 2004
    ..When these monocyte-derived DCs exit skin to emigrate to LNs, they use not only CCR7 but also CCR8, which was not previously recognized to participate in migration to LNs...
  83. pmc Comparison of gene expression profiles between human and mouse monocyte subsets
    Molly A Ingersoll
    Department of Gene and Cell Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Blood 115:e10-9. 2010
    ..Thus, whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice...
  84. doi request reprint Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts
    Michael Bomble
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    Biochem Biophys Res Commun 396:342-7. 2010
    ..Based on our findings we conclude that HSC play a key role in hepatic immune function and that IFN-gamma treatment might mediate its beneficial therapeutic effects via activation of APC function in MFB...
  85. pmc Regulatory T cells and immune tolerance to coagulation factor IX in the context of intramuscular AAV1 gene transfer
    Meagan Kelly
    Division of Hematology Oncology, Cancer Institute, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Mol Ther 18:361-9. 2010
    ..Our results provide critical insight into the role and function of regulatory T cells in induction and maintenance/protection of immune tolerance in gene transfer, complementing the current paradigm of immune tolerance mechanism...
  86. doi request reprint Controlling autophagy: A new concept for clearing liver disease
    Frank Tacke
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Hepatology 53:356-8. 2011
    ..These results provide a basis for testing CBZ, which has an extensive clinical safety profile, in patients with AT deficiency and also provide a proof of principle for therapeutic use of autophagy enhancers. (Hepatology 2011;.)...
  87. ncbi request reprint Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases
    Konrad L Streetz
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 38:218-29. 2003
    ..Hepatology 2003;38:218-229)...
  88. ncbi request reprint Ghrelin in chronic liver disease
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatol 38:447-54. 2003
    ..We investigated the role of ghrelin and insulin-like growth factor-1 (IGF-1), the mediator of the GH axis, in patients with chronic liver diseases (CLD)...
  89. ncbi request reprint Plasma P-selectin levels are elevated in patients with chronic liver disease
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Blood Coagul Fibrinolysis 14:319-25. 2003
    ..In line with its role in acute liver damage, P-selectin elevation in chronic liver disease may suggest a possible pathogenetic role in the course of liver cirrhosis...
  90. ncbi request reprint The role of chemokines and their receptors in dendritic cell biology
    Veronika Lukacs-Kornek
    Institute for Molecular Medicine and Experimental Immunology, University of Bonn, Germany
    Front Biosci 13:2238-52. 2008
    ..In this review, we describe current knowledge on the role of chemokines and their receptors in the control of DC migratory behavior, as well as other influences on DC biology...
  91. ncbi request reprint Clinical and prognostic role of plasma coagulation factor XIII activity for bleeding disorders and 6-year survival in patients with chronic liver disease
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Int 26:173-81. 2006
    ..We aimed to define factor XIII's clinical and prognostic role in chronic liver disease...
  92. ncbi request reprint p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver
    Tom Luedde
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 37:833-41. 2003
    ..Additionally we provide evidence that timing and strength of DNA synthesis in hepatocytes after PH is regulated tightly through the collaboration of different cell cycle inhibitors...
  93. ncbi request reprint Quantification of hepatic thrombopoietin mRNA transcripts in patients with chronic liver diseases shows maintained gene expression in different etiologies of liver cirrhosis
    Frank Tacke
    Department of Gastroenterology and Hepatology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Liver 22:205-12. 2002
    ....
  94. ncbi request reprint Expression of inducible Bcl-X(S) in myeloid leukemia: compensatory upregulation of Bcl-X(L) and Bcl-2 prevents apoptosis and chemosensitization
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinolog, Hannover Medical School, Hannover, Germany
    Cancer Biol Ther 3:340-7. 2004
    ..These results suggest the existence of a regulatory mechanism aimed to protect leukemic cells from pro-apoptotic stimuli...
  95. ncbi request reprint Regulation of plasma erythropoietin in chronic liver disease
    Frank Tacke
    World J Gastroenterol 10:2922-3. 2004
  96. doi request reprint Liver function critically determines serum retinol-binding protein 4 (RBP4) levels in patients with chronic liver disease and cirrhosis
    Frank Tacke
    Hepatology 48:1724-5; author reply 1725-6. 2008
  97. ncbi request reprint CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection
    Daniel R Engel
    Institute for Molecular Medicine and Experimental Immunology, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    J Immunol 181:5579-86. 2008
    ..These findings demonstrate that CCR2 governs homeostatic and infection-triggered release of Gr1(high) monocytes from the BM into the blood but is dispensable for recruitment into a nonlymphoid tissue...
  98. ncbi request reprint C/EBP beta isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver
    Tom Luedde
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 40:356-65. 2004
    ..In the context of previous studies, our results demonstrate that LAP, through a dose-dependent effect, withholds a dual activating and inhibiting role on hepatocyte proliferation in vivo...
  99. ncbi request reprint High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatol 42:666-73. 2005
    ..Models of fatty liver diseases and fibrosis suggest a hepatoprotective effect of adiponectin, an adipocyte-derived hormone with antidiabetic, antiobesity, antiatherogenic and anti-inflammatory effects...
  100. ncbi request reprint Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease
    Patrick Schoffski
    Department of Hematology Oncology, Hannover Medical School, Carl Neuberg Strasse 1, Germany
    Liver 22:114-20. 2002
    ..Thrombocytopenia in patients with advanced liver disease may stem from a deficient hepatic thrombopoietin production...