Janusz Szyndler

Summary

Publications

  1. ncbi request reprint Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Krakowskie Przedmiescie 26 28, PL 00 927 Warszawa, Poland
    Pharmacol Rep 65:368-78. 2013
  2. ncbi request reprint Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, PL 00 927 Warszawa, Poland
    Pharmacol Rep 58:75-82. 2006
  3. ncbi request reprint Changes in the concentration of amino acids in the hippocampus of pentylenetetrazole-kindled rats
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Neurosci Lett 439:245-9. 2008
  4. doi request reprint Mapping of c-Fos expression in the rat brain during the evolution of pentylenetetrazol-kindled seizures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
    Epilepsy Behav 16:216-24. 2009
  5. doi request reprint Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    J Neural Transm 117:707-18. 2010
  6. pmc The effects of electrical hippocampal kindling of seizures on amino acids and kynurenic acid concentrations in brain structures
    J Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927, Warsaw, Poland
    J Neural Transm 119:141-9. 2012
  7. ncbi request reprint Fluoxetine attenuates the effects of pentylenetetrazol on rat freezing behavior and c-Fos expression in the dorsomedial periaqueductal gray
    Małgorzata Zienowicz
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, 00 927 Warsaw, Poland
    Neurosci Lett 414:252-6. 2007
  8. ncbi request reprint Hippocampal mGluR1 and consolidation of contextual fear conditioning
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957, Warsaw, Poland
    Brain Res Bull 62:39-45. 2003
  9. doi request reprint The effect of CRF and alpha-helical CRF((9-41)) on rat fear responses and amino acids release in the central nucleus of the amygdala
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Neuropharmacology 57:148-56. 2009
  10. ncbi request reprint Buspirone attenuates conditioned fear-induced c-Fos expression in the rat hippocampus
    Aleksandra Wisłowska-Stanek
    Department of Experimental and Clinical Pharmacology, Medical University, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Neurosci Lett 389:115-20. 2005

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Krakowskie Przedmiescie 26 28, PL 00 927 Warszawa, Poland
    Pharmacol Rep 65:368-78. 2013
    ..Some of immediate early genes (IEGs) as egr1 (zif268) or arc (arg3.1) are believed to play an important role in the process of epileptogenesis. However, how these genes are engaged in epilepsy is not fully elucidated...
  2. ncbi request reprint Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, PL 00 927 Warszawa, Poland
    Pharmacol Rep 58:75-82. 2006
    ..The intrinsic mechanisms of the reported behavioral effects may involve neuronal damage in the brain limbic structures, secondary to seizure-induced ischemia and hypoxia...
  3. ncbi request reprint Changes in the concentration of amino acids in the hippocampus of pentylenetetrazole-kindled rats
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Neurosci Lett 439:245-9. 2008
    ....
  4. doi request reprint Mapping of c-Fos expression in the rat brain during the evolution of pentylenetetrazol-kindled seizures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
    Epilepsy Behav 16:216-24. 2009
    ..Piriform cortex, entorhinal cortex, prefrontal cortex, lateral septal nuclei, and CA3 area of the hippocampus appeared to be the brain structures selectively involved in the process of chemically induced kindling of seizures...
  5. doi request reprint Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    J Neural Transm 117:707-18. 2010
    ..These new data indicate a pattern of changes in the basal activity of local monoaminergic innervation of brain limbic structures, accompanying the induction and propagation of seizures...
  6. pmc The effects of electrical hippocampal kindling of seizures on amino acids and kynurenic acid concentrations in brain structures
    J Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927, Warsaw, Poland
    J Neural Transm 119:141-9. 2012
    ..In conclusion, these new results suggest a modulatory influence of KYNA on the process of epileptogenesis, characterized by a negative relationship between the KYNA and glutamate systems in the amygdala...
  7. ncbi request reprint Fluoxetine attenuates the effects of pentylenetetrazol on rat freezing behavior and c-Fos expression in the dorsomedial periaqueductal gray
    Małgorzata Zienowicz
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, 00 927 Warsaw, Poland
    Neurosci Lett 414:252-6. 2007
    ..Our experiment based on PTZ-enhanced aversive conditioning revealed that acutely administered fluoxetine antagonized PTZ-induced panic-like behavior, and this phenomenon was accompanied by inhibition of activity of DMPAG...
  8. ncbi request reprint Hippocampal mGluR1 and consolidation of contextual fear conditioning
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957, Warsaw, Poland
    Brain Res Bull 62:39-45. 2003
    ..Furthermore, they indicate that changes of glutamatergic activity within brain limbic structures can affect the threshold for the induction of the long-term neuronal plasticity, involved in some forms of learning and memory...
  9. doi request reprint The effect of CRF and alpha-helical CRF((9-41)) on rat fear responses and amino acids release in the central nucleus of the amygdala
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Neuropharmacology 57:148-56. 2009
    ....
  10. ncbi request reprint Buspirone attenuates conditioned fear-induced c-Fos expression in the rat hippocampus
    Aleksandra Wisłowska-Stanek
    Department of Experimental and Clinical Pharmacology, Medical University, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Neurosci Lett 389:115-20. 2005
    ....
  11. doi request reprint Changes in the brain expression of alpha-2 subunits of the GABA-A receptor after chronic restraint stress in low- and high-anxiety rats
    Aleksandra Wisłowska-Stanek
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie, Warsaw, 00 927, Poland
    Behav Brain Res 253:337-45. 2013
    ....
  12. ncbi request reprint Behavioral, immunocytochemical and biochemical studies in rats differing in their sensitivity to pain
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Behav Brain Res 171:189-98. 2006
    ..It appears also that response to pain may determine other patterns of emotional behavior, probably reflecting different activation thresholds of some brain structures controlling anxiety, e.g. prefrontal and secondary motor cortex...
  13. doi request reprint Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled rats
    Piotr Maciejak
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Brain Res Bull 78:299-305. 2009
    ..This suggests that the depletion of KYNA within the hippocampus may be directly related to the development of kindled seizures in this model of epilepsy...
  14. ncbi request reprint Inhibition of neophobia-stimulated c-Fos expression in the dorsomedial part of the prefrontal cortex in rats pretreated with midazolam
    Aleksandra Wisłowska-Stanek
    Department of Experimental and Clinical Pharmacology, Warsaw Medical University, Krakowskie Przedmiescie 26 28, PL 00 927 Warszawa, Poland
    Pharmacol Rep 60:811-6. 2008
    ....
  15. ncbi request reprint Fluoxetine-induced anxiety and nervousness
    Małgorzata Zienowicz
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, PL 00 927 Warszawa, Poland
    Pharmacol Rep 58:115-9. 2006
    ..The present data describe a new animal model to study the central action of antidepressants reflecting dysphoric-like effects observed in the initial phase of the treatment...
  16. ncbi request reprint The relationship between pain sensitivity and conditioned fear response in rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 70:56-66. 2010
    ..These results indicate that pain sensitivity and conditioned emotional responses to pain are not directly correlated...
  17. ncbi request reprint Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis
    Helena Sienkiewicz-Jarosz
    First Department of Neurology, Medical University, Warsaw, Poland
    Behav Brain Res 145:17-22. 2003
    ..The present results indicate that the origin of emotions is a complex phenomenon, probably involving the interaction between GABA-ergic innervation of many brain structures...
  18. doi request reprint The effects of buspirone and diazepam on aversive context- and social isolation-induced ultrasonic vocalisation
    Adam Hamed
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 00 927 Warsaw, 26 28 Krakowskie Przedmiescie Street, Poland
    Physiol Behav 98:474-80. 2009
    ..These data indicate that long-term, isolation-induced 50-kHz USVs in adult rats represent a new behavioural parameter under control of the central GABAergic system, which can be used to study the effects of anxiolytic drugs...
  19. doi request reprint Effects of D-cycloserine and midazolam on the expression of the GABA-A alpha-2 receptor subunits in brain structures of fear conditioned rats
    Aleksandra Wisłowska-Stanek
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Behav Brain Res 225:655-9. 2011
    ..These results support a role of the GABA-A receptor alpha-2 subunit in processing of emotional cortico-hippocampal input to the BLA...
  20. ncbi request reprint Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Pharmacol Biochem Behav 81:15-23. 2005
    ..These results indicate that lithium-pilocarpine-induced SRS are also accompanied by profound alteration of animal emotional behavior...
  21. doi request reprint The effects of morphine and morphine conditioned context on 50 kHz ultrasonic vocalisation in rats
    Adam Hamed
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Behav Brain Res 229:447-50. 2012
    ..The context-induced 50 kHz USVs can be used as a sensitive test for drug dependency. The current study also shows that 50 kHz USVs can be useful tool for studying the mechanisms of long lasting central effects of morphine...
  22. doi request reprint Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat
    Ewa Taracha
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
    Drug Alcohol Depend 97:21-32. 2008
    ..In summary, this study revealed differing and relatively long-lasting effects of prolonged administration of morphine and methadone on the profile of behavioral and CNS neuronal activation responses to morphine challenge in the rat...
  23. ncbi request reprint Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26 28, 00 927, Warsaw, Poland
    Pharmacol Biochem Behav 73:851-61. 2002
    ....
  24. doi request reprint The influence of neonatal serotonin depletion on emotional and exploratory behaviours in rats
    Paulina Rok-Bujko
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmieście Str, 00 927 Warsaw, Poland
    Behav Brain Res 226:87-95. 2012
    ..There was no difference in the pain threshold between groups. These data demonstrate that neonatal 5-HT depletion resulted in subtle alterations in the locomotor, exploratory and conditioned fear response of adult animals...
  25. ncbi request reprint Valproate disturbs the balance between branched and aromatic amino acids in rats
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9, 02 957, Warsaw, Poland
    Neurotox Res 25:358-68. 2014
    ....
  26. ncbi request reprint The role of interleukin-1β in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus
    Karolina Kołosowska
    Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland Electronic address
    Eur J Pharmacol 731:31-7. 2014
    ..Although some evidence indicates a proconvulsant property of IL-1β activity, it cannot be ruled out that the alterations in IL-1 system reflect the activation of endogenous protective mechanisms with respect to the kindling of seizures...
  27. doi request reprint Time course of changes in the concentrations of amino acids in the brain structures of pentylenetetrazole-kindled rats
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Brain Res 1342:150-9. 2010
    ..Overall, these data suggest that there is a shift in the balance between neurotransmitters toward increased production of excitatory amino acids...
  28. doi request reprint The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Epilepsy Behav 18:193-200. 2010
    ....
  29. doi request reprint The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Brain Res 1282:20-7. 2009
    ..Overall, these data suggest that there is a shift in the balance between neurotransmitters towards increased production of excitatory amino acids, and this may be mediated by group III mGluRs during seizure kindling...
  30. doi request reprint Gustatory and olfactory function in patients with unipolar and bipolar depression
    Lukasz Swiecicki
    Department of Psychiatry II, Institute of Psychiatry and Neurology, Warsaw, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 33:827-34. 2009
    ....
  31. doi request reprint The role of the dorsomedial part of the prefrontal cortex serotonergic innervation in rat responses to the aversively conditioned context: behavioral, biochemical and immunocytochemical studies
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Behav Brain Res 192:203-15. 2008
    ....
  32. ncbi request reprint The effects of acute and chronic administration of corticosterone on rat behavior in two models of fear responses, plasma corticosterone concentration, and c-Fos expression in the brain structures
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Pharmacol Biochem Behav 85:522-34. 2006
    ....
  33. ncbi request reprint Age-dependent effects of 5,7-dihydroxytryptamine on serotonin transporter in different brain areas in the rat
    Wojciech Kostowski
    Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, PL 02 957 Warszawa, Poland
    Pol J Pharmacol 56:383-9. 2004
    ..Thus, it appears that the mesolimbic ventral tegmental area-nucleus accumbens systems are relatively more resistant to 5,7-DHT neurotoxicity in the early postnatal period...
  34. ncbi request reprint Exploratory activity and a conditioned fear response: correlation with cortical and subcortical binding of the alpha4beta2 nicotinic receptor agonist [3H]-epibatidine
    Halina Sienkiewicz-Jarosz
    Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pol J Pharmacol 55:17-23. 2003
    ..The presented data indicate also a significant, structure dependent correlation between rat conditioned emotional reaction and the alpha4beta2 nAChR ligand binding, in the rat cortical forebrain structures...
  35. ncbi request reprint Lack of changes in cortical [3H]-muscimol binding in rats sensitized to nicotine-induced enhancement of dopamine metabolism
    Halina Sienkiewicz-Jarosz
    Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02 957 Warszawa, Poland
    Pol J Pharmacol 55:165-70. 2003
    ..Thus, the hypothesis about the role of adaptive changes in GABAA receptors in the enhancement of the biochemical and behavioral effects of nicotine was not confirmed...
  36. ncbi request reprint Sensitivity to pain and c-Fos expression in brain structures in rats
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Neurosci Lett 370:74-9. 2004
    ..The reactivity of LHAB may be responsible for the genetically determined differences in sensitivity to pain...
  37. ncbi request reprint The effects of acute corticosterone administration on anxiety, endogenous corticosterone, and c-Fos expression in the rat brain
    Anna Skórzewska
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Horm Behav 52:317-25. 2007
    ....
  38. ncbi request reprint Expression of c-Fos and CRF in the brains of rats differing in the strength of a fear response
    Małgorzata Lehner
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
    Behav Brain Res 188:154-67. 2008
    ..It was shown that different natural patterns of responding to conditioned aversive stimuli are associated with different involvement of brain structures and with dissimilar neurochemical mechanisms...
  39. ncbi request reprint Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats
    Małgorzata Pietraszek
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Eur J Pharmacol 514:25-34. 2005
    ....
  40. ncbi request reprint Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, Al Sobieskiego 9, 02 957 Warsaw, Poland
    Pharmacol Biochem Behav 72:987-91. 2002
    ..The present data add also to the accumulating evidence suggesting a favorable pharmacological profile for some neurosteroids currently considered to have a future role in the management of epilepsy...
  41. ncbi request reprint Cycloheximide impairs acquisition but not extinction of cocaine self-administration
    Pawel Mierzejewski
    Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Sobieskiego 9 St, 02 957 Warsaw, Poland
    Neuropharmacology 51:367-73. 2006
    ..Our results suggest that: i) the acquisition and extinction of cocaine-reinforced behaviour have a different molecular basis; and ii) only the former process requires de novo protein synthesis...
  42. ncbi request reprint Neophobia and cortical and subcortical binding of the dopamine D2 receptor antagonist [3H]-raclopride
    Marek Siemiatkowski
    Department of Pharmacology and Physiology of the Nervous System, Poland
    Life Sci 76:753-61. 2004
    ..814 and 0.703 respectively), indicating that both phenomena are under control of a similar central process. The above data are discussed in relation to the structure dependent dopamine D2 receptor mechanisms in a rat response to novelty...