Zoltan Szolnoki

Summary

Publications

  1. request reprint
    Szolnoki Z, Havasi V, Talian G, Bene J, Komlosi K, Somogyvari F, et al. Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers. J Mol Neurosci. 2006;28:285-90 pubmed
    ..1, p<0.001) infarction. On a pathophysiological basis, our results suggest the possibility that the AT1R A1166C polymorphism might give rise to ischemic stroke indirectly via an unfavorable effect on the cardiorespiratory function. ..
  2. request reprint
    Szolnoki Z. Evaluation of common unfavourable genetic variants in cerebrovascular diseases: recommendation for supportive genetic examinations and methodological approaches for common genetic variants. Curr Med Chem. 2009;16:3168-73 pubmed
    ..The development of a correct approach to genetic polymorphisms may have a great impact on the understanding and prevention of cerebrovascular diseases. ..
  3. Szolnoki Z, Szekeres M, Szaniszlo I, Balda G, Bodor A, Kondacs A, et al. Decreased Number of Mitochondria in Leukoaraiosis. Arch Med Res. 2015;46:604-8 pubmed publisher
    ..37 95% CI 0.05; controls: K 0.48, 95% CI 0.076, p < 0.001). Our study suggests that the ratio of the dmDNA and mDNA can be of great importance in the pathogenesis of LA. ..
  4. request reprint
    Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L. Evaluation of the interactions of common genetic mutations in stroke subtypes. J Neurol. 2002;249:1391-7 pubmed
    ..Common mutations which alone are minor or non-significant risk factors for ischemic stroke can yield, in specific combination patterns, a highly significant, moderate genetic risk of specific stroke subtypes. ..
  5. Szolnoki Z, Serly J, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke. J Stroke Cerebrovasc Dis. 2009;18:360-2 pubmed publisher
    ..The examined 3 genetic variants seem to influence the responses of the glial cells to a slight chronic hypoxia state, rather than the mechanisms resulting in cerebral infarcts themselves. ..
  6. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. Clin Biochem. 2009;42:630-3 pubmed publisher
    ..This draws attention to a need for stricter preventive measures in CC carriers. ..
  7. Szolnoki Z, Maasz A, Magyari L, Horvatovich K, Farago B, Kondacs A, et al. Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke. Clin Neurol Neurosurg. 2009;111:227-30 pubmed publisher
    ..56%) than in the controls (5.94%, p<0.00187; overall stroke group: crude OR: 0.25, 95% CI: 0.1-0.64; adjusted OR: 0.03, 95% CI: 0.025-0.71). This finding suggests a gene-gene interaction. ..
  8. request reprint
    Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant. Neuromolecular Med. 2007;9:335-9 pubmed
    ..0% vs. 9.7%, P < 0.02; crude OR: 0.19, 95% CI: 0.04-0.82, P < 0.05; adjusted OR: 0.21, 95% CI: 0.018-0.88, P < 0.05). Our results draw attention to possible roles of the cytoskeleton in MS. ..
  9. request reprint
    Szolnoki Z, Maasz A, Magyari L, Horvatovich K, Farago B, Somogyvari F, et al. The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke. J Mol Neurosci. 2007;31:201-7 pubmed
    ..Although the exact mechanism of action is not known, addition of the unfavourable effects on the endothelial function can be presumed. ..

More Information

Publications22

  1. request reprint
    Szolnoki Z, Somogyvari F, Szabo M, Kondacs A, Fodor L, Melegh B. [Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke]. Ideggyogy Sz. 2006;59:107-12 pubmed
    ..39; p < 0.001). The synergistic effect between the two MTHFR mutations may represent a new genetic stoke risk factor. ..
  2. request reprint
    Szolnoki Z, Havasi V, Talian G, Bene J, Komlosi K, Somogyvari F, et al. Lymphotoxin-alpha gene 252G allelic variant is a risk factor for large-vessel-associated ischemic stroke. J Mol Neurosci. 2005;27:205-11 pubmed
    ..These data show that besides the role in the development of myocardial infarction, the homozygous carriage of the LTA allele with 252G and 804A SNPs is a novel susceptibility factor for largevesselassociated ischemic stroke. ..
  3. request reprint
    Szolnoki Z, Havasi V, Bene J, Komlosi K, Szoke D, Somogyvari F, et al. Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke. Acta Neurol Scand. 2005;111:29-33 pubmed
    ..9%, P < 0.0001) than in the control group (5.4%). The eNOS G894T or eNOS 894TT genotypes in combination with the MTHFR 677TT or ACE D/D genotype increases the risk of ischaemic stroke. ..
  4. request reprint
    Szolnoki Z. Chemical events behind leukoaraiosis: medicinal chemistry offers new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype). Curr Med Chem. 2007;14:1027-36 pubmed
    ..This article discusses these hypothetical alternative molecular events behind LA. The review also illustrates how medicinal chemistry can offer new insight into a common, but still mysterious cerebral phenotype...
  5. request reprint
    Szolnoki Z, Melegh B. Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis. Curr Med Chem. 2006;13:1627-34 pubmed
    ..This may facilitate the choice of more effective and specific prevention on the basis of the genotype...
  6. request reprint
    Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization. J Mol Neurosci. 2007;33:173-9 pubmed
    ..76-fold in hypertensive smokers as compared with those not carrying this variant. This finding may be useful in everyday clinical practice by indicating the need for stricter preventive measures in CC carriers. ..
  7. request reprint
    Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis. Neurosci Lett. 2007;429:101-4 pubmed
    ..The present finding supports the involvement of the cytoskeleton in the development of vascular white matter damage, thereby opening up novel fields in the research into LA. ..
  8. Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. Neuromolecular Med. 2009;11:101-5 pubmed publisher
    ..0000089; OR, 0.32; 95% CI: 0.2-0.56, P < 0.005). The present findings indirectly raise the possibility that a shift or imbalance in the finally regulated MMP plays a role in the development of MS. ..
  9. request reprint
    Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L, Bene J, et al. Specific APO E genotypes in combination with the ACE D/D or MTHFR 677TT mutation yield an independent genetic risk of leukoaraiosis. Acta Neurol Scand. 2004;109:222-7 pubmed
    ..The interactions of certain unfavourable genetic mutations can contribute to the evolution of leukoaraiosis. ..
  10. Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L, Bene J, et al. Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke. J Neurol Neurosurg Psychiatry. 2003;74:1615-20 pubmed
    ..In certain combinations, pairing of common unfavourable genetic factors, which alone confer only minor or non-significant risk, with clinical risk factors can greatly increase the susceptibility to ischaemic stroke. ..
  11. Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F. A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis. Acta Neurol Scand. 2011;123:352-7 pubmed publisher
    ..The mUCPs are presumed to be of great importance in the regulation of the mitochondrial membrane potential (MMP) and the cellular energy metabolism...
  12. request reprint
    Szolnoki Z. Common genetic variants of the mitochondrial trafficking system and mitochondrial uncoupling proteins affect the development of two slowly developing demyelinating disorders, leukoaraiosis and multiple sclerosis. Curr Med Chem. 2010;17:3583-90 pubmed
    ..In this context, this article discusses the roles of genetic variants of the kinesin motor proteins and UCPs in slowly developing diseases of the white matter of the brain as multiple sclerosis and leukoaraiosis. ..
  13. request reprint
    Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L. Evaluation of the roles of common genetic mutations in leukoaraiosis. Acta Neurol Scand. 2001;104:281-7 pubmed
    ..These findings draw attention to the fact that genetic polymorphisms that alone are insignificant can be risk factors for leukoaraiosis if they cluster in the same subjects. ..