Distinct phenotypes in mixed connective tissue disease: subgroups and survivalP Szodoray
Institute of Immunology, Oslo University Hospital, Oslo, Norway
Lupus 21:1412-22. 2012
..Cumulative survival assessment indicated cluster 1 patients having the worst prognosis. Cluster analysis is valuable to differentiate among various subsets of MCTD and useful prognostic factor regarding the disease course...
- Immunological reconstitution after autologous stem cell transplantation in patients with refractory systemic autoimmune diseases
P Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Norway
Scand J Rheumatol 41:110-5. 2012
..Our aim was to investigate the repopulation of different lymphocyte subsets in patients with systemic autoimmune diseases after AHSCT...
Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue diseasePal Soltesz
3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Moricz Zs, Str, 22, Debrecen 4032, Hungary
Arthritis Res Ther 12:R78. 2010
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- Vitamin D deficiency in undifferentiated connective tissue disease
Eva Zold
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Moricz Zs, Str, 22, Debrecen, 4032, Hungary
Arthritis Res Ther 10:R123. 2008
..The aim of the present study was to investigate the prevalence of vitamin D insufficiency in patients with undifferentiated connective tissue disease (UCTD)...
- Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand
Peter Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
Rheumatology (Oxford) 49:1867-77. 2010
..The aim of the present study was to describe a broad spectrum of T- and B-cell cytokines, growth factors and chemokines in patients with idiopathic inflammatory myopathies (IIMs) and healthy individuals...
- Identification of rare anti-phospholipid/protein co-factor autoantibodies in patients with systemic lupus erythematosus
Peter Szodoray
3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Hungary
Autoimmunity 42:497-506. 2009
..Rare anti-phospholipid/co-factor antibodies were found in 12% of an un-selected lupus patient population. Their presence was more frequent in patients with secondary APS, and further increased the risk of thrombotic complications...
- Cells with regulatory function of the innate and adaptive immune system in primary Sjögren's syndrome
P Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Clin Exp Immunol 157:343-9. 2009
..Negative correlation was found between IL-10 levels and the percentages of Tr1 cells. Changes in the investigated subsets of regulatory cells in pSS may contribute to the development and progression of the disease...
- The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome
Peter Szodoray
3rd Department of Medicine, Division of Clinical Immunology, Medical and Health Science Centre, University of Debrecen, Moricz Zs Str 22, 4032 Debrecen, Hungary
Rheumatology (Oxford) 49:211-7. 2010
..The aim of the present study was to investigate the immunomodulating role of fat-soluble vitamins in 25 patients with primary SS (pSS) and 15 healthy individuals...
Progressive Systemic Sclerosis- from the molecular background to innovative therapiesPeter Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
Front Biosci (Elite Ed) 2:521-5. 2010
..These therapies are also discussed in the review. Finally, we described certain novel immune-modulating possibilities, namely autologous stem-cell transplantation and extracorporeal photochemotherapy...
- The molecular and clinical rationale of extracorporeal photochemotherapy in autoimmune diseases, malignancies and transplantation
Peter Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
Autoimmun Rev 9:459-64. 2010
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- Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applications
P Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
Scand J Rheumatol 39:1-11. 2010
..In this review, we summarize certain aspects of the molecular background of autologous stem cell transplantation and also depict the response to therapy in various autoimmune and rheumatic diseases...
- Progressive divergent shifts in natural and induced T-regulatory cells signify the transition from undifferentiated to definitive connective tissue disease
Peter Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Int Immunol 20:971-9. 2008
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- The complex role of vitamin D in autoimmune diseases
P Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Scand J Immunol 68:261-9. 2008
..The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases...
- Sarcoidosis in patients with mixed connective tissue disease: clinical, genetic, serological and histological observations
Peter Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Rheumatol Int 28:743-7. 2008
..The assessment of the cytokine network in sarcoidosis-associated MCTD enables us to select the most effective, individualized therapy protocol for these patients...
- The immunopathological role of vitamin D in patients with SLE: data from a single centre registry in Hungary
P Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Norway
Scand J Rheumatol 40:122-6. 2011
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- Immunological features of primary anti-phospholipid syndrome in connection with endothelial dysfunction
P Soltesz
Third Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Rheumatology (Oxford) 47:1628-34. 2008
..To describe how certain peripheral immune parameters reflect the inflammatory alterations in patients with primary APS...
- Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease
E Zold
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Hungary
Scand J Rheumatol 39:490-7. 2010
..5 μg/day alfacalcidol supplementation...
- TH1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines--immunological alterations in acute coronary syndrome and stable coronary artery disease
P Szodoray
3rd Department of Internal Medicine, Division of Clinical Immunology, University of Debrecen, Moricz Zs Str 22, 4004 Debrecen, Hungary
Scand J Immunol 64:336-44. 2006
..Th1 to Th2 ratio shifted towards a Th1 dominance in both diseases. Both general proinflammatory markers and activated T cells signify CAD. The orchestrated proinflammatory cascade eventually leads to the development of the disease...
- Clinical and immunoserological characteristics of the transition from primary to overlap antiphospholipid syndrome
K Veres
Cardiovascular Unit, University of Debrecen Medical and Health Sciences Center, Debrecen, Debrecen, Hungary
Lupus 19:1520-6. 2010
..Recurrent thrombotic events were registered in 24% of patients. Our results suggest that primary APS may be considered as a potential early phase of a dynamic transition towards a well-defined systemic autoimmune disease...
- Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T-cell subsets and inflammatory cytokines
P Szodoray
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen
Scand J Rheumatol 37:205-12. 2008
..We determined lymphocyte subpopulations and their state of activation from peripheral blood, evaluating both soluble serum T-helper (Th)1/Th2-type cytokines and intracytoplasmic cytokines...
- Assessment of IgG antibodies to oxidized LDL in patients with acute coronary syndrome
R Laczik
Angiology and Intensive Care Unit, Third Department of Medicine, Institute of Internal Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
Lupus 20:730-5. 2011
..In this study, we investigated the prognostic value of IgG anti-oxLDL antibodies in patients with acute coronary syndrome (ACS)...
- Regulatory T cells in peripheral blood of patients with mixed connective tissue disease
S Barath
3rd Department of Internal Medicine, Medical and Health Science Centre, University of Debrecen, Moritz Zs Str 22, 4004 Debrecen, Hungary
Scand J Rheumatol 35:300-4. 2006
..To determine the percentage and absolute number of CD4+ regulatory T-cells (Treg) in 48 patients with mixed connective tissue disease (MCTD)...
- Impaired endothelial function and increased carotid intima-media thickness in association with elevated von Willebrand antigen level in primary antiphospholipid syndrome
H der
3rd Department of Medicine, Institute for Internal Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Lupus 16:497-503. 2007
..58 +/- 0.085 mm; P = 0.0037). Our results reflect ongoing endothelial damage and accelerated atherosclerosis in patients with primary APS, and suggest that vasoprotective therapy may be beneficial in the treatment of these patients...
- Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis
G Papp
Division of Clinical Immunology, Medical and Health Science Centre, University of Debrecen, Hungary
Scand J Rheumatol 40:205-10. 2011
..We also assessed visceral organ involvement and evaluated the relationship between cell proportions and clinical symptoms of the disease...
- Immunological parameters, including CXCL8 (IL-8) characterize cerebro- and cardiovascular events in patients with peripheral artery diseases
E Szomjak
3 Department of Medicine, Institute for Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Scand J Immunol 71:283-91. 2010
..We conclude that altered peripheral lymphocyte subsets and cytokine/chemokine imbalance play important roles in the proinflammatory cascade and reflect disease severity in patients with PAD...
- Aspects of B-cell non-Hodgkin's lymphoma development: a transition from immune-reactivity to malignancy
A Illes
Division of Immune Hematology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Scand J Immunol 69:387-400. 2009
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- Clinical and immunoserological characteristics of mixed connective tissue disease associated with pulmonary arterial hypertension
J Vegh
3rd Department of Internal Medicine, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary
Scand J Immunol 64:69-76. 2006
..550). In conclusion, our results suggest that in MCTD the presence of AECA and endothelial cell activation may play a role in the development of PAH and in the maintenance of obliterative vascular processes...
- Retrospective analysis of patients with lupus nephritis: data from a large clinical immunological center in Hungary
B Brugos
Division of Clinical Immunology, 3rd Department of Internal Medicine, University of Debrecen, Debrecen, Hungary
Scand J Immunol 64:433-7. 2006
..The authors would like to draw attention to the importance of systematic care of patients with systemic lupus erythematosus, which may lead to a better clinical outcome...
- Regulatory T cells in atopic dermatitis: epidermal dendritic cell clusters may contribute to their local expansion
A Szegedi
Department of Dermatology, University of Debrecen, Medical and Health Science Centre, 98 Nagyerdei körút, Debrecen 4012, Hungary
Br J Dermatol 160:984-93. 2009
..Regulatory T cells (Tregs) have an essential role in tolerance and immune regulation. However, few and controversial data have been published to date on the role and number of these cells in atopic dermatitis (AD)...
- Study of hepatitis C virus infection in 213 Hungarian patients with Sjögren's syndrome
P Szodoray
Third Dept of Internal Medicine, University of Debrecen, Medical and Health Science Centre, Hungary
Rheumatol Int 21:6-9. 2001
..On the basis of these findings, we conclude that HCV infection is more frequent in Hungarian SS patients than in the normal population and that the presence of this virus has a disease-modifying effect on SS...
- Functional and morphological evaluation of hand microcirculation with nailfold capillaroscopy and laser Doppler imaging in Raynaud's and Sjögren's syndrome and poly/dermatomyositis
N Szabo
3rd Department of Internal Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
Scand J Rheumatol 37:23-9. 2008
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- Genome-scale assessment of molecular pathology in systemic autoimmune diseases using microarray technology: a potential breakthrough diagnostic and individualized therapy-design tool
M Centola
Oklahoma Medical Research Foundation, Arthritis and Immunology Program, Oklahoma City, OK, USA
Scand J Immunol 64:236-42. 2006
..It is easy to envision a day when personalized medicine, which is the diagnosis and treatment of a given patient with agents and procedures tailored to that patient's genetics, physiology and pathology, will become the standard of care...
- The BAFF/APRIL system in systemic autoimmune diseases with a special emphasis on Sjögren's syndrome
P Szodoray
Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
Scand J Immunol 62:421-8. 2005
..We assume that prolonged BAFF signalization may contribute to GC formation and/or lymphoma development in the disease. Finally, we discuss possibilities of novel treatments targeting the BAFF-system in SS...
- Do autoantibodies predict autoimmune liver disease in primary Sjögren's syndrome? Data of 180 patients upon a 5 year follow-up
A Csepregi
Department of Gastroenterology, Hepatology, and Infectology, Otto von Guericke University in Magdeburg, Magdeburg, Germany
Scand J Immunol 56:623-9. 2002
..To evaluate the clinical value of autoantibodies as serological markers to predict autoimmune liver diseases in primary Sjögren's syndrome (SS)...
