Philip R Szeszko

Summary

Publications

  1. ncbi Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
  2. ncbi White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
  3. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
  4. doi Volumetric and shape analysis of the thalamus in first-episode schizophrenia
    Denise M Coscia
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Hum Brain Mapp 30:1236-45. 2009
  5. ncbi White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 62:782-90. 2005
  6. doi Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 165:1299-307. 2008
  7. doi Neurocognitive profile analysis in obsessive-compulsive disorder
    Katherine E Burdick
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Int Neuropsychol Soc 14:640-5. 2008
  8. pmc A voxel-based diffusion tensor imaging study of white matter in bipolar disorder
    Katie Mahon
    Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 34:1590-600. 2009
  9. ncbi Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
  10. ncbi White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005

Detail Information

Publications48

  1. ncbi Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
    ..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder...
  2. ncbi White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
    ..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset...
  3. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
    ....
  4. doi Volumetric and shape analysis of the thalamus in first-episode schizophrenia
    Denise M Coscia
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Hum Brain Mapp 30:1236-45. 2009
    ..Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates...
  5. ncbi White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 62:782-90. 2005
    ....
  6. doi Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 165:1299-307. 2008
    ....
  7. doi Neurocognitive profile analysis in obsessive-compulsive disorder
    Katherine E Burdick
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Int Neuropsychol Soc 14:640-5. 2008
    ..Findings of specific abnormalities on tasks of motor and processing speed are consistent with a hypothesized role of thalamocortical and basal ganglia regions in the pathogenesis of OCD...
  8. pmc A voxel-based diffusion tensor imaging study of white matter in bipolar disorder
    Katie Mahon
    Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 34:1590-600. 2009
    ..Our findings are consistent with models of bipolar disorder that implicate dysregulation of cortico-subcortical and cerebellar regions in the disorder and may have relevance for phenomenology...
  9. ncbi Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
    ..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia...
  10. ncbi White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005
    ..To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18)...
  11. ncbi Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
    Am J Psychiatry 160:1884-7. 2003
    ..Few studies, however, have examined the relationship between cerebellar size and neuropsychological functioning in schizophrenia. The authors' goal was to examine this relationship in patients and healthy comparison subjects...
  12. ncbi Increased stress and smaller anterior hippocampal volume
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Neuroreport 17:1825-8. 2006
    ..Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis...
  13. ncbi White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging study
    Manzar Ashtari
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neuroimage 35:501-10. 2007
    ..The authors investigated WM development in healthy adolescent males through age-associated changes in fractional anisotropy (FA), radial (lambda( perpendicular)) and axial (lambda(||)) diffusivity...
  14. pmc A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes
    Todd Lencz
    Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 35:2284-91. 2010
    ..05). The risk allele dosage also predicted impairments on a timed visuomotor performance task (trails A). Results support a role of ZNF804A in phenotypes reflecting altered neural connectivity...
  15. ncbi Genetic variation in DTNBP1 influences general cognitive ability
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
    Hum Mol Genet 15:1563-8. 2006
    ..These data suggest that DTNBP1 genetic variation influences human intelligence...
  16. ncbi Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:2190-7. 2003
    ..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects...
  17. ncbi Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography
    Manzar Ashtari
    Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York, USA
    Arch Gen Psychiatry 64:1270-80. 2007
    ..There is increasing evidence that schizophrenia is characterized by abnormalities in white matter...
  18. ncbi Sex differences in frontal lobe white matter microstructure: a DTI study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neuroreport 14:2469-73. 2003
    ..Our findings may be indicative of increased directional coherence and/or density of left hemisphere white matter fibers and a leftward asymmetry of this structural integrity among women compared to men...
  19. ncbi DISC1 and neurocognitive function in schizophrenia
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Neuroreport 16:1399-402. 2005
    ..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia...
  20. pmc White matter development in adolescence: diffusion tensor imaging and meta-analytic results
    Bart D Peters
    Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA
    Schizophr Bull 38:1308-17. 2012
    ..However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence...
  21. pmc A role for white matter abnormalities in the pathophysiology of bipolar disorder
    Katie Mahon
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Neurosci Biobehav Rev 34:533-54. 2010
    ..Taken together, the evidence supports and clarifies a model of BD that involves disconnectivity in regions implicated in emotion generation and regulation...
  22. ncbi Investigation of unirhinal olfactory identification in antipsychotic-free patients experiencing a first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, North Shore Long Island Jewish Health System, Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Schizophr Res 67:219-25. 2004
    ....
  23. pmc White matter changes associated with antipsychotic treatment in first-episode psychosis
    Philip R Szeszko
    1 Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA 2 Division of Psychiatry Research, Zucker Hillside Hospital, North Shore LIJ Health System, Glen Oaks, NY, USA 3 Department of Communication Sciences and Disorders, School of Applied Sciences, University of Mississippi, University, MS, USA
    Neuropsychopharmacology 39:1324-31. 2014
    ..Limitations of the current study, however, include a prior history of substance use among patients and our inability to exclude the possibility of disease progression. ..
  24. pmc Pituitary volume in first-episode schizophrenia
    PATRICIA GRUNER
    Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Psychiatry Res 203:100-2. 2012
    ..Fifty-nine healthy volunteers had baseline scans with 34 receiving a followup scan. There were no baseline group differences in pituitary volumes or changes in volume following antipsychotic treatment...
  25. ncbi Neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, Hillside Hospital, a division of North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:217-26. 2002
    ..This study investigated the neuropsychological correlates of hippocampal volume in 43 men and 32 women experiencing a first episode of schizophrenia...
  26. ncbi Reversed cerebellar asymmetry in men with first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Biol Psychiatry 53:450-9. 2003
    ..In this study, we investigated whether patients experiencing first-episode schizophrenia differed from healthy comparison subjects in regional cerebellar volumes or cerebellar asymmetry...
  27. ncbi Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hilside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:1049-56. 2004
    ..The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD)...
  28. pmc Positive correlations between corpus callosum thickness and intelligence
    Eileen Luders
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, and Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Neuroimage 37:1457-64. 2007
    ..Our findings emphasize the importance of incorporating posterior (callosal) regions into the theories and models proposed to explain the anatomical substrates of intelligence...
  29. pmc Resting-state FMRI connectivity impairment in schizophrenia and bipolar disorder
    Miklos Argyelan
    To whom correspondence should be addressed Psychiatry Research, Zucker Hillside Hospital, North Shore LIJ Health System, 75 59 263rd Street, Glen Oaks, NY 11004, US tel 718 470 4486, fax 718 343 1659, E mail
    Schizophr Bull 40:100-10. 2014
    ..Few studies have compared connectivity across the brain in these disorders or investigated their functional correlates...
  30. pmc Abnormal cingulum bundle development in autism: a probabilistic tractography study
    Toshikazu Ikuta
    Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA Division of Psychiatry Research, Zucker Hillside Hospital, North Shore LIJ Health System, Glen Oaks, NY 11004, USA Electronic address
    Psychiatry Res 221:63-8. 2014
    ....
  31. pmc Overlapping and distinct gray and white matter abnormalities in schizophrenia and bipolar I disorder
    Dana Anderson
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset
    Bipolar Disord 15:680-93. 2013
    ....
  32. pmc White matter abnormalities in pediatric obsessive-compulsive disorder
    PATRICIA GRUNER
    Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA
    Neuropsychopharmacology 37:2730-9. 2012
    ....
  33. ncbi Interferon-induced obsessive-compulsive disorder
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Gen Hosp Psychiatry 28:357-8. 2006
  34. ncbi Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:826-32. 2004
    ..These preliminary findings suggest that abnormal asymmetry of the amygdala may play a role in the pathogenesis of OCD and that paroxetine treatment may be associated with a reduction in amygdala volume...
  35. pmc DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia
    Philip R Szeszko
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Biol Psychol 79:103-10. 2008
    ..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology...
  36. pmc Asymmetries of cortical shape: Effects of handedness, sex and schizophrenia
    Katherine L Narr
    Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Neuroimage 34:939-48. 2007
    ....
  37. pmc Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Neuroreport 16:1455-9. 2005
    ..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia...
  38. ncbi Mapping cortical thickness and gray matter concentration in first episode schizophrenia
    Katherine L Narr
    Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Cereb Cortex 15:708-19. 2005
    ..Cortical thickness and gray matter concentration mapping produce similar results, although the concentration metric may be influenced by diagnostic differences in extra-cortical cerebrospinal fluid and surface curvature/complexity...
  39. ncbi Neurodevelopmental aspects of spatial navigation: a virtual reality fMRI study
    Daniel S Pine
    Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Building 10, Room 4N 222 MSC1381, Bethesda, Maryland 20892 1381, USA
    Neuroimage 15:396-406. 2002
    ..Consistent with developmental models, these findings relate maturation in the coding of spatial information to functional changes in a distributed, left-lateralized neural network...
  40. ncbi Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophrenia
    Claudia I Rupp
    Department of Psychiatry, Medical University Innsbruck, Austria
    Schizophr Res 74:149-61. 2005
    ..In this study, we examined the relationship between different olfactory functions and volumes of the hippocampus-amygdala complex (HAC) and the orbitofrontal brain region using magnetic resonance imaging (MRI)...
  41. pmc Greater regional cortical gray matter thickness in obsessive-compulsive disorder
    Veena M Narayan
    Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Neuroreport 19:1551-5. 2008
    ....
  42. ncbi Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression
    Shauna MacMillan
    Department of Psychiatry, 9B, Wayne State University School of Medicine, 4201 St Antoine Boulevard, Detroit, MI 48201, USA
    J Child Adolesc Psychopharmacol 13:65-73. 2003
    ..Although MDD commonly emerges during childhood and adolescence, to our knowledge, no prior study has examined temporal lobe anatomy in pediatric patients with MDD near the onset of illness before treatment...
  43. ncbi Neuroimaging studies of children with serious emotional disturbances: a selective review
    Jane Avery Serene
    Harvard Medical School, Boston, Massachusetts, USA
    Can J Psychiatry 52:135-45. 2007
    ....
  44. ncbi Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia
    Handan Gunduz-Bruce
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Res 94:281-7. 2007
    ..Larger scale studies are needed to conclude a link between the two measures, yet it is possible that the negative association that was previously shown in other disorders may not apply to schizophrenia...
  45. pmc Mapping the relationship between cortical convolution and intelligence: effects of gender
    Eileen Luders
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, USA
    Cereb Cortex 18:2019-26. 2008
    ..This might lead to the development of sexually dimorphic information processing strategies and affect the relationship between intelligence and cortical convolution...
  46. pmc CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia
    Handan Gunduz-Bruce
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 155:57-66. 2007
    ..These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia...
  47. pmc Asymmetries of cortical thickness: effects of handedness, sex, and schizophrenia
    Liberty S Hamilton
    Laboratory of Neuroimaging, Geffen School of Medicine at UCLA, Los Angeles, California 90095 7334, USA
    Neuroreport 18:1427-31. 2007
    ..Thus, dextrality relates to cortical thickness asymmetries, although schizophrenia may differentially affect asymmetry patterns across handedness...
  48. pmc Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder
    Matthew J Hoptman
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychiatry Res 140:133-45. 2005
    ..Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects...