Stanley J Szefler

Summary

Publications

  1. doi request reprint Asthma across the ages: knowledge gaps in childhood asthma
    Stanley J Szefler
    Department of Pediatrics and Pharmacology, National Jewish Health, and the University of Colorado School of Medicine, Denver, Colo Electronic address
    J Allergy Clin Immunol 133:3-13; quiz 14. 2014
  2. doi request reprint Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma
    Stanley J Szefler
    The Division of Pediatric Clinical Pharmacology, National Jewish Health, Denver, Colo Electronic address
    J Allergy Clin Immunol Pract 1:58-64. 2013
  3. doi request reprint Advances in pediatric asthma in 2012: moving toward asthma prevention
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 131:36-46. 2013
  4. doi request reprint New insights into asthma pathogenesis and treatment
    Stanley J Szefler
    Helen Wohlberg and Herman Lambert Chair in Pharmacokinetics, Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    Curr Opin Immunol 23:801-7. 2011
  5. pmc Key observations from the NHLBI Asthma Clinical Research Network
    Stanley J Szefler
    Department of Pediatrics, National Jewish Health and University of Colorado Denver, School of Medicine, Denver, Colorado 80206, USA
    Thorax 67:450-5. 2012
  6. doi request reprint Advances in pediatric asthma in 2011: moving forward
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 129:60-8. 2012
  7. doi request reprint Achieving asthma control in the inner city: do the National Institutes of Health Asthma Guidelines really work?
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado Denver School of Medicine, Denver, Colo, USA
    J Allergy Clin Immunol 125:521-6; quiz 527-8. 2010
  8. doi request reprint Advances in pediatric asthma in 2009: gaining control of childhood asthma
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson St, Rm J304, Molly Blank Building, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:69-78. 2010
  9. pmc Lessons learned from variation in response to therapy in clinical trials
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:285-92; quiz 293-4. 2010
  10. pmc Advances in pediatric asthma in 2010: addressing the major issues
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 127:102-15. 2011

Detail Information

Publications69

  1. doi request reprint Asthma across the ages: knowledge gaps in childhood asthma
    Stanley J Szefler
    Department of Pediatrics and Pharmacology, National Jewish Health, and the University of Colorado School of Medicine, Denver, Colo Electronic address
    J Allergy Clin Immunol 133:3-13; quiz 14. 2014
    ....
  2. doi request reprint Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma
    Stanley J Szefler
    The Division of Pediatric Clinical Pharmacology, National Jewish Health, Denver, Colo Electronic address
    J Allergy Clin Immunol Pract 1:58-64. 2013
    ..Budesonide inhalation suspension (BIS) and montelukast provide acceptable asthma control, whereas overall measures favored BIS in children aged 2 to 8 years with mild persistent asthma...
  3. doi request reprint Advances in pediatric asthma in 2012: moving toward asthma prevention
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 131:36-46. 2013
    ....
  4. doi request reprint New insights into asthma pathogenesis and treatment
    Stanley J Szefler
    Helen Wohlberg and Herman Lambert Chair in Pharmacokinetics, Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    Curr Opin Immunol 23:801-7. 2011
    ....
  5. pmc Key observations from the NHLBI Asthma Clinical Research Network
    Stanley J Szefler
    Department of Pediatrics, National Jewish Health and University of Colorado Denver, School of Medicine, Denver, Colorado 80206, USA
    Thorax 67:450-5. 2012
    ..This review highlights the major research observations from the ACRN that have impacted the current management of asthma...
  6. doi request reprint Advances in pediatric asthma in 2011: moving forward
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 129:60-8. 2012
    ....
  7. doi request reprint Achieving asthma control in the inner city: do the National Institutes of Health Asthma Guidelines really work?
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado Denver School of Medicine, Denver, Colo, USA
    J Allergy Clin Immunol 125:521-6; quiz 527-8. 2010
    ..Based on the observations from the Asthma Control Evaluation study, we were impressed that a systematic guidelines-based approach improved asthma control significantly over the course of the 1-year treatment period...
  8. doi request reprint Advances in pediatric asthma in 2009: gaining control of childhood asthma
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson St, Rm J304, Molly Blank Building, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:69-78. 2010
    ....
  9. pmc Lessons learned from variation in response to therapy in clinical trials
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:285-92; quiz 293-4. 2010
    ..This information now assists the clinician in personalizing asthma treatment at the time of initiating long-term control therapy...
  10. pmc Advances in pediatric asthma in 2010: addressing the major issues
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 127:102-15. 2011
    ..Perhaps new directions in personalized medicine and improved health care access and communication will help maintain steady progress in alleviating the burden of this disease in children, especially young children...
  11. pmc Advancing asthma care: the glass is only half full!
    Stanley J Szefler
    Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Allergy Clin Immunol 128:485-94. 2011
    ..These advances should prompt the evolution of new strategies and new treatments to further reduce disease burden. It now becomes imperative to continue a focus on ways to further reduce the burden of asthma and prevent its onset...
  12. pmc Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
    ..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...
  13. ncbi request reprint Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
    ..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
  14. pmc Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children
    Ronina A Covar
    Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:741-747.e4. 2008
    ..Asthma exacerbations are a common cause of critical illness in children...
  15. ncbi request reprint Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma
    Robert S Zeiger
    Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:45-52. 2006
    ..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
  16. ncbi request reprint Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
    ..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
  17. pmc Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
    ..Clinical trials in children with moderate-to-severe persistent asthma are limited...
  18. doi request reprint Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
    Gary L Larsen
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:861-7.e1. 2009
    ..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...
  19. pmc Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
    Katherine Rivera-Spoljaric
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
    J Pediatr 154:877-81.e4. 2009
    ..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
  20. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  21. ncbi request reprint Safety and application of induced sputum analysis in childhood asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:575-82. 2004
    ..The Childhood Asthma Management Program (CAMP) study was designed to evaluate the long-term effects of budesonide and nedocromil compared with placebo in children with mild to moderate asthma across 8 centers...
  22. pmc Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Pediatr 154:682-7. 2009
    ..To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued...
  23. pmc Asthma outcomes: biomarkers
    Stanley J Szefler
    National Jewish Health, Denver, Colorado, USA
    J Allergy Clin Immunol 129:S9-23. 2012
    ..Measurement of biomarkers has been incorporated within clinical research studies of asthma to characterize the population and associate the disease with environmental and therapeutic effects...
  24. pmc Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin Madison, Wis 53716, USA
    J Allergy Clin Immunol 128:956-63.e1-7. 2011
    ..The effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial...
  25. ncbi request reprint Progression of asthma measured by lung function in the childhood asthma management program
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 170:234-41. 2004
    ..The course and mechanisms of lung function reduction or slow lung growth velocity in children with asthma must be defined...
  26. pmc Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity
    Caroline C Horner
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 128:977-82.e1-2. 2011
    ..Although nocturnal awakenings help categorize asthma severity and control, their clinical significance has not been thoroughly studied...
  27. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  28. pmc Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
    Stanley J Szefler
    National Jewish Health, Denver, CO, USA
    Lancet 372:1065-72. 2008
    ....
  29. ncbi request reprint Effect of montelukast on peripheral airflow obstruction in children with asthma
    Joseph D Spahn
    Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    Ann Allergy Asthma Immunol 96:541-9. 2006
    ..Montelukast is a widely used controller agent in childhood asthma. It is modestly effective in reducing symptoms, decreasing the need for rescue albuterol, and improving forced expiratory volume in 1 second (FEV1)...
  30. pmc Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma
    Leonard B Bacharier
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63017, USA
    J Allergy Clin Immunol 123:1077-82, 1082.e1-5. 2009
    ..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...
  31. pmc Predictors of remitting, periodic, and persistent childhood asthma
    Ronina A Covar
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:359-366.e3. 2010
    ..The course of mild to moderate persistent asthma in children is not clearly established...
  32. ncbi request reprint Comparative study of budesonide inhalation suspension and montelukast in young children with mild persistent asthma
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:1043-50. 2007
    ..Budesonide inhalation suspension and the leukotriene receptor antagonist montelukast have demonstrated efficacy in children with mild persistent asthma, but comparative long-term studies in young children are needed...
  33. ncbi request reprint Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids
    Monica Kraft
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 124:42-50. 2003
    ..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)...
  34. ncbi request reprint Minimizing attrition in a long-term clinical trial of pediatric asthma
    Bruce G Bender
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 91:168-76. 2003
    ..Despite increased attention focused on the need to prevent patient attrition in long-term clinical trials, high dropout rates have threatened the success of numerous studies...
  35. ncbi request reprint Mild to moderate asthma affects lung growth in children and adolescents
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Allergy Clin Immunol 118:1040-7. 2006
    ..The effect of childhood asthma on lung growth is unclear...
  36. ncbi request reprint Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Division of Allergy Clinical Immunology, Department of Pediatrics, Denver, Colorado, USA
    J Pediatr 142:469-75. 2003
    ..Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed...
  37. ncbi request reprint Progression of asthma in childhood
    Ronina A Covar
    Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:700-7. 2005
    ..Additional efforts are necessary to understand the mechanisms involved in this phenomenon and to discover specific modalities of treatment to target the structural changes of airway remodeling...
  38. pmc A trial of clarithromycin for the treatment of suboptimally controlled asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:747-53. 2010
    ..PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma...
  39. ncbi request reprint A comparison of the clinical characteristics of children and adults with severe asthma
    Henry A Jenkins
    Division of Clinical Pharmacology, the Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center and, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Chest 124:1318-24. 2003
    ..This study sought to better define the clinical characteristics of severe asthma in both children and adults, and to evaluate the effect of asthma duration on multiple parameters of disease severity...
  40. ncbi request reprint Fluticasone propionate plasma concentration and systemic effect: effect of delivery device and duration of administration
    Glenn J Whelan
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:525-30. 2005
    ..Dry powder inhalers (DPIs) generate a larger particle size compared with metered-dose inhalers (MDIs), which affects pulmonary deposition, bioavailability, and subsequent systemic effects of fluticasone propionate (fluticasone)...
  41. ncbi request reprint Budesonide inhalation suspension: a nebulized corticosteroid for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, USA
    J Allergy Clin Immunol 109:730-42. 2002
    ..This article reviews the results of these studies, as well as the pharmacokinetics, pharmacodynamics, and clinical use of budesonide inhalation suspension...
  42. ncbi request reprint Current concepts in asthma treatment in children
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pediatr 16:299-304. 2004
    ..The purpose of this review is to present current literature related to the management of childhood asthma...
  43. ncbi request reprint Steroid therapy for asthma in children
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Pediatr 19:300-5. 2007
    ..To highlight studies that have contributed significantly to our current knowledge of inhaled glucocorticoids in childhood asthma...
  44. ncbi request reprint Switching from conventional to extrafine aerosol beclomethasone dipropionate therapy in children: a 6-month, open- label, randomized trial
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 110:45-50. 2002
    ..In adults with asthma, hydrofluoralkane-134a beclomethasone dipropionate (HFA-BDP) extrafine aerosol provides equivalent asthma control at half the daily dose of conventional chlorofluorocarbon (CFC)-BDP...
  45. ncbi request reprint Correlates of household smoking bans in low-income families of children with and without asthma
    Frederick S Wamboldt
    Division of Psychosocial Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Fam Process 47:81-94. 2008
    ..Even in disadvantaged families, mutable factors were associated with strict smoking bans. Increased dissemination and use of established public health strategies are needed to reduce children's SHS exposures...
  46. ncbi request reprint Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  47. ncbi request reprint The need for pediatric studies of allergy and asthma medications
    Stanley J Szefler
    National Jewish Medical and Research Center, 1400 Jackson Street, Room J304, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 3:478-83. 2003
    ..In this review, we discuss the background for this effort and the continuing impact it will have on the future management of allergy and asthma in children...
  48. ncbi request reprint Safety profile of budesonide inhalation suspension in the pediatric population: worldwide experience
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 93:83-90. 2004
    ..To review the worldwide safety data for budesonide inhalation suspension (Pulmicort Respules) to provide a budesonide inhalation suspension pediatric tolerability profile...
  49. ncbi request reprint The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Denver, Colorado, USA
    J Allergy Clin Immunol 114:1241-56. 2004
    ....
  50. pmc Inhaled corticosteroids in lung diseases
    Hengameh H Raissy
    Department of Pediatrics, School of Medicine, University of New Mexico, Albuquerque, NM, USA
    Am J Respir Crit Care Med 187:798-803. 2013
    ....
  51. ncbi request reprint Individualizing asthma therapy: application of biomarkers
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    J Asthma 45:29-31. 2008
    ..As such, valuable lessons have been learned regarding the advantages and limitations of this biomarker for asthma care...
  52. ncbi request reprint Nocturnal awakening caused by asthma in children with mild-to-moderate asthma in the childhood asthma management program
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, Division of Allergy and Pulmonary Medicine, St Louis Children s Hospital, MO 63110, USA
    J Allergy Clin Immunol 110:395-403. 2002
    ..Nocturnal symptoms of asthma are a cause of significant morbidity and are included as a central feature in the categorization of asthma severity...
  53. ncbi request reprint Histopathology of severe childhood asthma: a case series
    Henry A Jenkins
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Division of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO, USA
    Chest 124:32-41. 2003
    ..The currently accepted model of asthma holds that persistent airway inflammation leads to various symptoms of asthma, airway hyperresponsiveness, and airway remodeling that ultimately results in permanent loss of lung function...
  54. doi request reprint Economic burden of impairment in children with severe or difficult-to-treat asthma
    Stanley J Szefler
    National Jewish Health, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 107:110-119.e1. 2011
    ..The cost associated with asthma impairment in children with severe asthma has not been determined...
  55. ncbi request reprint Pediatric asthma: an approach to pharmacogenetics analysis
    Stanley J Szefler
    Divisions of Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:434S-8S. 2003
  56. ncbi request reprint Medications as asthma triggers
    Ronina A Covar
    Department of Pediatrics, Division of Allergy Clinical Immunology, National Jewish Medical and Research Center, 1400 Jackson Street A303, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 25:169-90. 2005
    ..Fortunately, controller therapy for asthma and alternative or more selective medications for the treatment of these conditions are now available...
  57. ncbi request reprint Advances in childhood asthma: hygiene hypothesis, natural history, and management
    Andrew H Liu
    National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, Denver, CO, USA
    J Allergy Clin Immunol 111:S785-92. 2003
    ....
  58. ncbi request reprint Advances in pediatric and adult asthma
    Stanley J Szefler
    Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 115:470-7. 2005
    ..Asthma management is likely to change in the coming years from a strategy directed to the best outcome in groups of patients to an individualized approach to assessment and management...
  59. ncbi request reprint Managing severe asthma
    Sally Wenzel
    Division of Pulmonary Medicine, National Jewish Medical and Research Center, and the Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:508-11. 2006
  60. ncbi request reprint Prevalence and correlates of household exposures to tobacco smoke and pets in children with asthma
    Frederick S Wamboldt
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Pediatr 141:109-15. 2002
    ..To examine the prevalence rates of household smoking and ownership of a furred or feathered pet, the intercorrelation of these home environment measures, and their association with sociodemographic, family, and child asthma variables...
  61. ncbi request reprint Corticosteroid therapy in asthma: predictors of responsiveness
    Christopher M Mjaanes
    National Jewish Medical and Research Center, 1400 Jackson Street, Office J304, Denver, CO 80209, USA
    Clin Chest Med 27:119-32, vii. 2006
    ..Clinical factors associated with steroid insensitivity, strategies for managing patients with steroid insensitivity, and underlying molecular mechanisms responsible for variable responses to corticosteroids are described...
  62. ncbi request reprint Asthma progression: can we and should we measure it?
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:598-600. 2008
  63. doi request reprint Advances in pediatric asthma in 2007
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:614-9. 2008
    ..This review highlights journal articles that relate to these guideline topics...
  64. ncbi request reprint The natural history of asthma and early intervention
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 109:S549-53. 2002
    ..The progress in defining asthma and targeting treatment toward specific pathophysiologic mechanisms should lead to better-defined optimal strategies for treating asthma in children...
  65. doi request reprint Single-dose pharmacokinetics of roflumilast in children and adolescents
    Kathleen A Neville
    Department of Pediatrics, University of Missouri Kansas City and the Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64079, USA
    J Clin Pharmacol 48:978-85. 2008
    ..1 and 0.8 microg/L per 1 microg/kg dose for adolescents and children, respectively), pharmacokinetic parameters for roflumilast and roflumilast N-oxide were not different between age groups and were similar to adults...
  66. ncbi request reprint Identifying the child in need of asthma therapy
    Stanley J Szefler
    Department of Pediatrics, Division of Pediatric Clinical Pharmacology, National Jewish Medical and Research Center 1400 Jackson St, Room B121, Denver, CO 80206, USA
    Pediatr Clin North Am 50:577-91. 2003
    ..Recommendations have been made to integrate available resources in the United States to improve overall asthma outcomes for children...
  67. ncbi request reprint Advances in pediatric asthma 2006
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology, Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:558-62. 2007
    ..Application of biomarkers and genetics could be useful tools in individualizing our approach to the management of childhood asthma...
  68. ncbi request reprint Childhood asthma: new insights into management
    Joseph D Spahn
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 109:3-13. 2002
    ....
  69. ncbi request reprint Altering the course of asthma: Introduction
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 109:S519-20. 2002